iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067049

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPE02031042

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000022530.1	ENSMLUT00000030414.1	ENSMLUP00000022196.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-84	281.5	191	816

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp............kepkgellkslqklfeelwkskkkav 68
           +G++NlgNtC++N+v+Q L++   l el++e                   p             ++ g+l+++l  +++++ +++k++ 
   Q: 191  KGITNLGNTCFFNAVMQNLAQSYILIELMNEikengtilkI--------FPssdsqmdplmveLSSPGPLTSALVLFLHSMKETDKGSL 271
           59*****************************6545544441........2233334444555577788********************* PP
   S: 69   sprellkalkkeaee..fsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgq 149
           sp++l+++l++ ++   f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d++ +kk k +       ++i+++F g+
   Q: 272  SPKALFNQLCQNQRAprFKDFQQQDSQELLHYLLDSVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGsegvkmNFIDRIFIGE 360
           *********98754444************************99888888888888888888775555544444556666********** PP
   S: 150  lksqikclecdnvssreepfldlslpvpgkeetkke..................................................... 185
           l+s+++c+ec+n+s+ ++pf+d+slp+ +++ +k+                                                      
   Q: 361  LTSTLMCEECANISTVKDPFIDISLPIIEERVSKPVlwgrinkyrslqetqngqysgpvtienthqpratrkqspskdknqlihgrkra 449
           *******************************98777***************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 450  rkfssgedkavdmyrkngnmevngdssafasimntesnlaenptdgsekeasrcesgvdadseasesesaskqtllprsrsgccvhtng 538
           ***************************************************************************************** PP
   S: 186  ....................................................................................slqdc 190
                                                                                               s+q+c
   Q: 539  hhypsarelptkktdsgvegvaeaiselhlsstvtgdrdfdgenqplslpnnlyfseekhttshspqnafqtlsqsyittskecSIQSC 627
           ***************************************************************************************** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           L +ft+ e l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  +++++s +k+n++v+fpl Ld
   Q: 628  LYQFTSMELLMGNNKLLCENCTEKKQkyqretcsaekkaegiytnARKQLLISAVPVILILHLKRF--HQAGSSLRKVNRHVDFPLILD 714
           **********************99999999************************************..9999***************** PP
   S: 261  lspfctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeee 321
           l+pfc+ ++++++   k+ Y L+++v HsGs+++GHY+ayvk                           + g+W++++D++V+ev+e++
   Q: 715  LAPFCSATCKNVSAgeKVLYGLYGIVEHSGSMRGGHYTAYVKVrtpsrklleqitgkksvpglkepdseSPGQWFHVSDTYVQEVPESR 803
           *******99888767799*************************999999999999999999999887766778**************** PP
   S: 322  vleetgstaYvlfYkr 337
            l+   ++aY+lfY+r
   Q: 804  ALS---AQAYLLFYER 816
           ***...********98 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MRVKEPSKVL SEKAKRSKRP TIPHDEDSSD DIAVGFTCQH VSHAVSVNHV KKAIAENLWS 60
ACSECLKERR FHDGQPVLSS EIWLCLKCGF QGCGRNSESQ HSLKHFKSWR TELHCIIISL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGGTGA AAGAGCCATC CAAAGTTTTA TCTGAGAAAG CCAAAAGAAG TAAAAGGCCG 60
ACAATACCTC ATGATGAAGA CTCTTCAGAT GACATTGCTG GTACGTTGTG ACTGGCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	74.85	0.00e+00	1107.00
IUUC-Apl-003512	Anas platyrhynchos	66.34	0.00e+00	1003.00
IUUC-Aca-004284	Anolis carolinensis	59.90	0.00e+00	926.00
IUUC-Ame-010735	Astyanax mexicanus	60.98	2.00e-89	322.00
IUUC-Bta-012880	Bos taurus	84.62	0.00e+00	1296.00
IUUC-Cja-019144	Callithrix jacchus	81.22	0.00e+00	1285.00
IUUC-Cfa-020971	Canis familiaris	81.47	0.00e+00	716.00
IUUC-Cpo-022497	Cavia porcellus	67.07	0.00e+00	1009.00
IUUC-Csa-023910	Chlorocebus sabaeus	81.08	0.00e+00	1188.00
IUUC-Cho-024358	Choloepus hoffmanni	79.05	5.00e-57	215.00
IUUC-Dre-028106	Danio rerio	59.85	4.00e-137	482.00
IUUC-Dno-029456	Dasypus novemcinctus	75.73	0.00e+00	716.00
IUUC-Dor-030438	Dipodomys ordii	63.81	0.00e+00	954.00
IUUC-Dme-031870	Drosophila melanogaster	40.70	5.00e-36	147.00
IUUC-Ete-032736	Echinops telfairi	63.42	0.00e+00	902.00
IUUC-Eca-034211	Equus caballus	83.17	0.00e+00	1340.00
IUUC-Eeu-034797	Erinaceus europaeus	74.13	2.00e-82	300.00
IUUC-Fca-035947	Felis catus	80.56	0.00e+00	1171.00
IUUC-Fal-037199	Ficedula albicollis	66.67	0.00e+00	879.00
IUUC-Gmo-039228	Gadus morhua	60.20	1.00e-131	463.00
IUUC-Gga-040823	Gallus gallus	64.30	1.00e-168	586.00
IUUC-Gac-042406	Gasterosteus aculeatus	52.59	0.00e+00	743.00
IUUC-Ggo-045402	Gorilla gorilla	81.61	0.00e+00	1280.00
IUUC-Hsa-046430	Homo sapiens	80.98	0.00e+00	1280.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	80.67	0.00e+00	757.00
IUUC-Lch-049547	Latimeria chalumnae	57.98	0.00e+00	869.00
IUUC-Loc-052842	Lepisosteus oculatus	56.92	0.00e+00	857.00
IUUC-Laf-053988	Loxodonta africana	81.39	0.00e+00	1283.00
IUUC-Mcc-055491	Macaca mulatta	77.32	0.00e+00	1193.00
IUUC-Meu-056256	Macropus eugenii	64.88	3.00e-180	625.00
IUUC-Mla-059026	Melampsora laricipopulina	31.07	1.00e-16	81.30
IUUC-Mga-059833	Meleagris gallopavo	61.25	6.00e-171	593.00
IUUC-Mmr-060952	Microcebus murinus	79.88	0.00e+00	1248.00
IUUC-Mdo-062642	Monodelphis domestica	69.57	0.00e+00	1033.00
IUUC-Mmu-063945	Mus musculus	76.83	0.00e+00	1192.00
IUUC-Mpu-065944	Mustela putorius furo	78.27	0.00e+00	1201.00
IUUC-Nle-069828	Nomascus leucogenys	81.49	0.00e+00	1272.00
IUUC-Ont-072121	Oreochromis niloticus	59.02	5.00e-127	448.00
IUUC-Oan-073656	Ornithorhynchus anatinus	63.48	0.00e+00	967.00
IUUC-Ocu-074323	Oryctolagus cuniculus	78.29	0.00e+00	1192.00
IUUC-Ola-087238	Oryzias latipes	51.48	0.00e+00	772.00
IUUC-Oga-088379	Otolemur garnettii	75.72	0.00e+00	1174.00
IUUC-Oar-089718	Ovis aries	84.74	0.00e+00	1302.00
IUUC-Ptr-091358	Pan troglodytes	81.71	0.00e+00	1285.00
IUUC-Pan-092023	Papio anubis	81.34	0.00e+00	1271.00
IUUC-Psi-093256	Pelodiscus sinensis	63.25	0.00e+00	938.00
IUUC-Pfo-097285	Poecilia formosa	49.22	0.00e+00	692.00
IUUC-Pab-098539	Pongo abelii	81.71	0.00e+00	1281.00
IUUC-Pca-100610	Procavia capensis	65.35	0.00e+00	858.00
IUUC-Pva-102985	Pteropus vampyrus	90.05	0.00e+00	660.00
IUUC-Rno-105538	Rattus norvegicus	75.61	0.00e+00	1178.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.40	4.00e-21	96.70
IUUC-Sar-113637	Sorex araneus	70.37	0.00e+00	1035.00
IUUC-Ssc-115870	Sus scrofa	83.39	0.00e+00	1343.00
IUUC-Tgu-116907	Taeniopygia guttata	66.50	0.00e+00	1004.00
IUUC-Tru-117835	Takifugu rubripes	51.74	2.00e-96	346.00
IUUC-Tsy-118869	Tarsius syrichta	74.51	0.00e+00	1124.00
IUUC-Tni-119716	Tetraodon nigroviridis	54.55	2.00e-91	330.00
IUUC-Tbe-128041	Tupaia belangeri	65.12	0.00e+00	937.00
IUUC-Ttr-128901	Tursiops truncatus	81.68	0.00e+00	1282.00
IUUC-Vpa-130331	Vicugna pacos	83.11	0.00e+00	1207.00
IUUC-Xtr-131794	Xenopus tropicalis	61.07	5.00e-129	455.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence