iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028540

Ensembl Protein ID

ENSDARP00000037198.7

UniProt Accession

F1RDG9; Q4KMJ8; FYNB_DANRE

Genbank Protein ID

AAH98534.1

Protein Name

Tyrosine-protein kinase fynb; Proto-oncogene c-Fynb

Genbank Nucleotide ID

AL954744

Gene Name

fynb

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000025319.8	ENSDART00000036635.7	ENSDARP00000037198.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.40e-15	55.6	94	149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ ++i  ++++++W+ + + ++g  G +P+n+v+ ++
   Q: 94   FVALYDYEARTEDDLSFRKGEKFQII--NSTEGDWWDARSLTTGGTGYIPSNYVAPVD 149
           789***********************..8999**********************9987 PP

Organism

Danio rerio

Functional Description
(View)

Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity).

Protein Sequence
(Fasta)

MGCVQCKDKE AAKLTDDRDT SLSQSGVGYR YGVDPTPQHY PAFSGTGTAV AAIPNYNNFH 60
GAAVSQGMTV FGGISTSTHQ GTLRTRGGTG VTLFVALYDY EARTEDDLSF RKGEKFQIIN 120

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Nucleotide Sequence
(Fasta)

ACCAGCCAGC CGCTAGTAGC AGTGAATGAT ATCCCGTTGA AAACGCTGTT TACTTCGGTC 60
GTCTGATACT CTTTATAGCA CCGCGGAGAT CTGTGTGAAT AATTTGTGTA CGATGGAAAA 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0464--Manganese
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0007417--P:central nervous system development
GO:0060027--P:convergent extension involved in gastrulation
GO:0031101--P:fin regeneration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0045859--P:regulation of protein kinase activity
GO:0042110--P:T cell activation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

dre:574422

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence