iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034328

UUCD1 version

UUC-EqC-00190

Ensembl Protein ID

ENSECAP00000010777.1

UniProt Accession

F6SLV5; F6SLV5_HORSE

Protein Name

Uncharacterized protein

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000012924.1	ENSECAT00000013565.1	ENSECAP00000010777.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.60e-10	39.7	297	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl+++  +e p+ + w C++C 
   Q: 297  DECAVCRDGGE----LICCDGCPRAFHLACLSPP-LQEIPSGT-WRCTSCL 341
           57*********....*******************.*******6.******6 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

AGGDASLRRL LRLHRTEIAV AVDSAFPLLH ALADHDVVPE DKFQETLRLK EKEGCPQAFH 60
ALLSWLLTQD AAVILDFWRV LFKDFNLEKY ARLQPILDSF PKDVDLSQPR KGRKPPAGPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGCGGGG ATGCGTCGCT GCGCCGCCTC CTGAGGCTGC ACCGCACCGA GATCGCCGTG 60
GCCGTGGACA GCGCCTTCCC GCTGCTGCAC GCGCTGGCCG ACCACGACGT GGTCCCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0006955--P:immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	80.07	0.00e+00	679.00
IUUC-Aca-004543	Anolis carolinensis	66.13	3.00e-23	99.40
IUUC-Ang-009553	Aspergillus niger	41.11	2.00e-13	71.60
IUUC-Bgr-012025	Blumeria graminis	40.62	1.00e-09	58.90
IUUC-Bta-012988	Bos taurus	77.38	0.00e+00	710.00
IUUC-Bci-013636	Botrytis cinerea	48.00	5.00e-10	60.50
IUUC-Bdi-014663	Brachypodium distachyon	58.82	2.00e-14	75.90
IUUC-Cja-019486	Callithrix jacchus	63.39	2.00e-80	292.00
IUUC-Cfa-021069	Canis familiaris	76.95	0.00e+00	658.00
IUUC-Cpo-021649	Cavia porcellus	66.90	1.00e-158	553.00
IUUC-Csa-023960	Chlorocebus sabaeus	75.65	3.00e-176	611.00
IUUC-Dre-028583	Danio rerio	40.40	8.00e-61	228.00
IUUC-Dno-029869	Dasypus novemcinctus	64.59	2.00e-136	479.00
IUUC-Dor-030263	Dipodomys ordii	86.17	4.00e-46	177.00
IUUC-Dse-031258	Dothistroma septosporum	45.45	1.00e-10	62.00
IUUC-Ete-032778	Echinops telfairi	90.82	5.00e-49	188.00
IUUC-Fca-035400	Felis catus	76.77	0.00e+00	693.00
IUUC-Fal-036644	Ficedula albicollis	51.76	3.00e-73	269.00
IUUC-Fox-038014	Fusarium oxysporum	34.29	6.00e-10	60.10
IUUC-Fso-038262	Fusarium solani	32.99	1.00e-09	59.30
IUUC-Gma-044357	Glycine max	65.52	6.00e-06	47.00
IUUC-Ggo-045250	Gorilla gorilla	74.39	9.00e-172	596.00
IUUC-Hsa-046603	Homo sapiens	75.14	1.00e-172	599.00
IUUC-Hvu-047073	Hordeum vulgare	60.87	2.00e-14	75.10
IUUC-Itr-048977	Ictidomys tridecemlineatus	69.35	5.00e-158	550.00
IUUC-Lch-050310	Latimeria chalumnae	40.15	2.00e-90	325.00
IUUC-Loc-052508	Lepisosteus oculatus	48.49	3.00e-83	302.00
IUUC-Lma-053053	Leptosphaeria maculans	35.90	1.00e-13	72.00
IUUC-Laf-054028	Loxodonta africana	83.02	5.00e-146	511.00
IUUC-Mcc-054935	Macaca mulatta	75.28	0.00e+00	633.00
IUUC-Mtr-058487	Medicago truncatula	62.07	2.00e-05	45.40
IUUC-Mga-059318	Meleagris gallopavo	42.33	4.00e-54	204.00
IUUC-Mmr-061557	Microcebus murinus	59.63	2.00e-128	452.00
IUUC-Mdo-062475	Monodelphis domestica	49.35	4.00e-117	415.00
IUUC-Mmu-063994	Mus musculus	68.95	0.00e+00	684.00
IUUC-Mpu-066347	Mustela putorius furo	75.18	0.00e+00	707.00
IUUC-Mlu-068239	Myotis lucifugus	60.74	1.00e-87	316.00
IUUC-Nle-069544	Nomascus leucogenys	90.74	1.00e-25	109.00
IUUC-Opr-071199	Ochotona princeps	75.81	1.00e-74	273.00
IUUC-Ont-072571	Oreochromis niloticus	31.71	3.00e-37	149.00
IUUC-Oan-073739	Ornithorhynchus anatinus	53.68	8.00e-144	503.00
IUUC-Ogl-077865	Oryza glaberrima	56.52	6.00e-13	70.10
IUUC-Olo-080499	Oryza longistaminata	56.52	5.00e-13	70.90
IUUC-Opu-083209	Oryza punctata	56.52	7.00e-13	70.10
IUUC-Ola-086528	Oryzias latipes	35.37	7.00e-43	168.00
IUUC-Oga-088353	Otolemur garnettii	73.92	0.00e+00	696.00
IUUC-Oar-090065	Ovis aries	78.96	8.00e-166	576.00
IUUC-Ptr-091347	Pan troglodytes	74.95	1.00e-165	576.00
IUUC-Pan-092423	Papio anubis	73.58	8.00e-179	619.00
IUUC-Psi-093798	Pelodiscus sinensis	50.19	8.00e-121	427.00
IUUC-Pfo-096145	Poecilia formosa	33.60	3.00e-26	112.00
IUUC-Pab-098369	Pongo abelii	83.59	5.00e-131	461.00
IUUC-Pca-100537	Procavia capensis	68.96	9.00e-172	596.00
IUUC-Ppe-101215	Prunus persica	58.33	7.00e-14	72.80
IUUC-Pva-102639	Pteropus vampyrus	76.26	0.00e+00	647.00
IUUC-Pte-104185	Pyrenophora teres	43.64	3.00e-12	68.60
IUUC-Pyt-104775	Pyrenophora triticirepentis	43.64	2.00e-12	68.20
IUUC-Rno-105285	Rattus norvegicus	70.22	0.00e+00	682.00
IUUC-Sha-107159	Sarcophilus harrisii	47.32	3.00e-115	408.00
IUUC-Sit-110355	Setaria italica	57.69	1.00e-13	72.80
IUUC-Sbi-113930	Sorghum bicolor	57.69	6.00e-14	73.60
IUUC-Ssc-115773	Sus scrofa	75.71	0.00e+00	685.00
IUUC-Tgu-116922	Taeniopygia guttata	49.56	1.00e-71	263.00
IUUC-Tru-118263	Takifugu rubripes	30.80	1.00e-51	197.00
IUUC-Tsy-119270	Tarsius syrichta	71.59	1.00e-94	339.00
IUUC-Tni-120138	Tetraodon nigroviridis	30.40	2.00e-57	216.00
IUUC-Tca-121757	Theobroma cacao	60.87	9.00e-14	73.20
IUUC-Tae-123610	Triticum aestivum	60.42	1.00e-13	73.20
IUUC-Tur-126422	Triticum urartu	57.45	9.00e-13	70.10
IUUC-Tme-127204	Tuber melanosporum	57.45	9.00e-15	75.90
IUUC-Tbe-128077	Tupaia belangeri	68.06	0.00e+00	662.00
IUUC-Ttr-128781	Tursiops truncatus	83.78	1.00e-82	300.00
IUUC-Xma-133054	Xiphophorus maculatus	31.14	3.00e-49	189.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence