iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066383

Ensembl Protein ID

ENSMPUP00000009883.1

UniProt Accession

M3YEX6; M3YEX6_MUSPF

Genbank Protein ID

ENSMPUP00000009883

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01019277

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000009958.1	ENSMPUT00000010043.1	ENSMPUP00000009883.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.50e-218	726.3	19	614

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqv.kkkveesedeq.lLktynreWekfreqlkvlrkif 87
           l+eav++i++++s+++++eely+av+nlc++kv+  lYk+l++v+e+++ +q+ ++   +s d+  +Lk++n++W+++++q+ ++r+if
   Q: 19   LHEAVRAIQSRTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVqAQIlQQICTDSLDSVlFLKKINTCWQDHCRQMIMIRSIF 107
           789**********************************************9787356678999*99************************ PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r++i++d  ++++ ++ +l lie+eR+geavdr+ll+++ ++l++L     ++yk+sFE kfle
   Q: 108  LFLDRTYVLQNSMLPSIWDMGLELFRNHIISDkmVQSKSIDGILLLIERERNGEAVDRSLLRSLLSMLSDL-----QVYKDSFELKFLE 191
           *******************************************************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+ +y+ae ++++qe+ev eYl++v +rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+
   Q: 192  ETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILhKGLDHLLDENRVPDLTQMYQLF 280
           ***************************************************************9988********************** PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll++++ +ik+ g+++++++ek+kd   +V++ll++k++++++++ +F+ ++kF++ ++++fetf+nk+     +++p E
   Q: 281  SRVKGGQQVLLQHWSDYIKTFGTTIVINPEKDKD---MVQDLLDFKDRVDHVIEVCFQRNEKFINLMKESFETFINKR-----PNKPaE 361
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+++D++Lr+++k++t+eele++ldkv+++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 362  LIAKHVDSKLRAGNKEATDEELERILDKVMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 450
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d++ qFk+ ++n++e  s++l+v++L++g+Wpt++ +e v+L++e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+
   Q: 451  DMELSKDIMVQFKQYMQNQSEPGSIDLTVNILTMGYWPTYTPME-VHLTPEMVKLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKAEFKE 538
           ****************************************9999.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+e+qVs fQ++vLL+fn+ +++s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++ke+e++d+f++N ef
   Q: 539  GKKEFQVSLFQTLVLLMFNEGDAFSFEEIKMATGIEDSELRRTLQSLACGKARVLVKSPKGKEVEDGDTFTFNGEF 614
           *************************************************************************999 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

FADRPRLPDN YTRDTWQQLH EAVRAIQSRT SIRYNLEELY QAVENLCSHK VSPTLYKQLR 60
QVCEDHVQAQ ILQQICTDSL DSVLFLKKIN TCWQDHCRQM IMIRSIFLFL DRTYVLQNSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCGCAGACA GACCGCGGCT GCCGGACAAC TACACGCGGG ACACGTGGCA GCAGCTGCAC 60
GAGGCCGTCA GGGCCATCCA GAGCCGCACG TCCATCCGCT ACAACCTGGA GGAGCTCTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001592	Ailuropoda melanoleuca	97.90	0.00e+00	1419.00
IUUC-Apl-003269	Anas platyrhynchos	91.98	0.00e+00	1327.00
IUUC-Bta-012355	Bos taurus	94.55	0.00e+00	1378.00
IUUC-Cja-019861	Callithrix jacchus	93.41	0.00e+00	1357.00
IUUC-Cfa-021009	Canis familiaris	98.04	0.00e+00	1412.00
IUUC-Cpo-021867	Cavia porcellus	93.97	0.00e+00	1363.00
IUUC-Csa-024139	Chlorocebus sabaeus	94.11	0.00e+00	1364.00
IUUC-Cho-024899	Choloepus hoffmanni	97.02	0.00e+00	1019.00
IUUC-Cin-025727	Ciona intestinalis	62.54	0.00e+00	768.00
IUUC-Cme-027355	Cyanidioschyzon merolae	31.98	5.00e-110	392.00
IUUC-Dno-028879	Dasypus novemcinctus	88.33	0.00e+00	1279.00
IUUC-Dor-030698	Dipodomys ordii	93.97	0.00e+00	1347.00
IUUC-Ete-033101	Echinops telfairi	89.47	0.00e+00	1273.00
IUUC-Eca-033696	Equus caballus	95.13	0.00e+00	1377.00
IUUC-Fca-036333	Felis catus	97.33	0.00e+00	1409.00
IUUC-Fal-036995	Ficedula albicollis	91.87	0.00e+00	1332.00
IUUC-Gga-040358	Gallus gallus	91.67	0.00e+00	1343.00
IUUC-Hsa-045679	Homo sapiens	94.11	0.00e+00	1365.00
IUUC-Itr-048182	Ictidomys tridecemlineatus	93.19	0.00e+00	1277.00
IUUC-Laf-054100	Loxodonta africana	94.57	0.00e+00	1366.00
IUUC-Mcc-055168	Macaca mulatta	94.54	0.00e+00	1257.00
IUUC-Meu-056492	Macropus eugenii	83.47	1.00e-162	566.00
IUUC-Mga-059866	Meleagris gallopavo	92.56	0.00e+00	1347.00
IUUC-Mmr-061551	Microcebus murinus	93.69	0.00e+00	1358.00
IUUC-Mdo-062215	Monodelphis domestica	94.67	0.00e+00	1382.00
IUUC-Mmu-063402	Mus musculus	94.25	0.00e+00	1364.00
IUUC-Mlu-067450	Myotis lucifugus	91.34	0.00e+00	1315.00
IUUC-Nle-069606	Nomascus leucogenys	93.97	0.00e+00	1365.00
IUUC-Opr-070671	Ochotona princeps	84.50	2.00e-115	409.00
IUUC-Oan-073299	Ornithorhynchus anatinus	90.46	0.00e+00	1318.00
IUUC-Ocu-074731	Oryctolagus cuniculus	95.09	0.00e+00	1376.00
IUUC-Oar-089346	Ovis aries	93.83	0.00e+00	1370.00
IUUC-Ptr-091177	Pan troglodytes	94.11	0.00e+00	1365.00
IUUC-Pan-092191	Papio anubis	94.13	0.00e+00	1371.00
IUUC-Pab-097622	Pongo abelii	93.83	0.00e+00	1362.00
IUUC-Pca-100391	Procavia capensis	85.29	0.00e+00	1008.00
IUUC-Rno-105829	Rattus norvegicus	94.11	0.00e+00	1362.00
IUUC-Sha-106762	Sarcophilus harrisii	94.13	0.00e+00	1325.00
IUUC-Sre-114943	Sporisorium reilianum	37.50	1.00e-129	457.00
IUUC-Ssc-116133	Sus scrofa	93.83	0.00e+00	1348.00
IUUC-Tgu-116961	Taeniopygia guttata	92.02	0.00e+00	1340.00
IUUC-Tre-121907	Trichoderma reesei	39.89	7.00e-126	444.00
IUUC-Tvi-122568	Trichoderma virens	39.47	9.00e-129	454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence