iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008057

Ensembl Protein ID

CADACLAP00007007

UniProt Accession

A1C5V1; A1C5V1_ASPCL

Genbank Protein ID

EAW13772.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

DS027045

Gene Name

ACLA_067990

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00007167	CADACLAT00007167	CADACLAP00007007

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-54	182.7	290	771
UBD/Alpha-Helix/UBA	3.00e-22	77.0	636	675

Active Site

Position(s)	Description	Evidence
299	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
726	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenpkepkgellkslqklfeel.......wkskkk........... 66
           tGl NlgN+CY+ Sv+QcL+++pe+++ + +         k            p ++l ++++kl   +            +           
   Q: 290  TGLANLGNSCYLSSVIQCLFSLPEFQQRYYRggdeppltaK------------PAEDLETQMEKLADGIlsgryskP----Nvdvfaspdsae 366
           7******************************5443333332............556666666666666633333330....133333333344 PP
   S: 67   .....avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqi 154
                   p++++  +++ +eefs+++qqDa Efl +l++ l++                             ++++k++i + Fq+ l++++
   Q: 367  vppqkGLLPSMFKFLVGSGHEEFSTMRQQDAFEFLLHLFKLLQRMQ--------------------------CPEEGKNPI-ECFQFALEQRL 432
           44444999999*******************************9966..........................456666766.69********* PP
   S: 155  kclecdnvssreepfldlslpvpgkeetkke............slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLk 235
           +c++c++v  r ++   +s+pvp ++    +            +l +cL++ft+ e++e    ++c+ c +k   +k+ ++k++P+ L+++  
   Q: 433  QCQSCRKVRYRLDEQDNVSIPVPVRRLPV-SgdttsvaqfgtvTLFECLAAFTASETVE----LSCPACGSKDGFSKRSSFKTFPQELVINAR 520
           ***********************888553.258888999*******************9....9***************************** PP
   S: 236  Rfsfseeqksrekinkkvefple.Ldlspfcts.........................peekqke............................ 274
           Rf  +  +++++k++  v++ +  Ld +p+++s                               +                            
   Q: 521  RF--EVVNWVPTKLDIPVDVSDApLDFTPYLSSdrehgeeslpdedisnsvflpdhdaL-----Dqllamgfprirceralystgnsnaedam 606
           **..5577*************************55555555555555555555555550.....05555555555555555555555555556 PP
   S: 275  ............................................................................................. 274
                                                                                                        
   Q: 607  nwlfahvddpdidepvvrdqvsagahmdqqdpqavaqlsemgidekrarkalaasdgdvnraidwvfshpddasdshtsesqsgsrlgshgrt 699
           666666666666666666666666666666666666666777777777777777777777777777777777777788888888999999999 PP
   S: 275  ......kkkYeLiavvvHsG.slssGHYvayvkn.....ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                 +  Y+L a+v+H+G s++ GHYva+v++     +  +W+ f+D+kV +v  ++++e++ + aY++f+ r
   Q: 700  pgsfdtPAMYQLRAIVCHKGsSVHAGHYVAFVRKvlpgeDASSWVMFNDEKVVKV--DDIQEMK-KYAYLYFFSR 771
           999999****************************998865666*********999..5666644.8******987 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +d ++++ql eMG+d+++a++aL+a+++++++A+++++++
   Q: 636  QDPQAVAQLSEMGIDEKRARKALAASDGDVNRAIDWVFSH 675
           6899**********************************97 PP

Organism

Aspergillus clavatus

Protein Sequence
(Fasta)

MLIYKLFIHP RNPKLSIVKI DDDAGLNVCL SCFNGGCAGD RNHAELHYKR FGHPLALNMK 60
RSRKKVQRDE PPPKISKLAI AAETDEDRYD TATYVVCYQC HSDRIDPSSG NLPDVIGGVM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTAATCT ACAAGGTTTG TTGGTGATCT TCTCCCATCC TCACCCTTGA GAAGTAATCC 60
ATGGTTGATA CTTGGTTTGA TAGCTCTTCA TCCACCCTCG GAATCCCAAG CTGTCTATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

act:ACLA_067990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.19	3.00e-101	361.00
IUUC-Aml-002104	Ailuropoda melanoleuca	33.53	5.00e-122	430.00
IUUC-Atr-002580	Amborella trichopoda	32.94	1.00e-111	395.00
IUUC-Apl-003774	Anas platyrhynchos	34.57	6.00e-124	436.00
IUUC-Aca-005368	Anolis carolinensis	35.74	2.00e-128	451.00
IUUC-Aly-005727	Arabidopsis lyrata	33.67	5.00e-114	403.00
IUUC-Ath-006974	Arabidopsis thaliana	34.09	1.00e-114	405.00
IUUC-Ago-007890	Ashbya gossypii	33.50	4.00e-106	377.00
IUUC-Afl-008547	Aspergillus flavus	72.64	0.00e+00	1010.00
IUUC-Afu-008805	Aspergillus fumigatus	71.06	0.00e+00	1071.00
IUUC-Ani-009441	Aspergillus nidulans	64.19	0.00e+00	895.00
IUUC-Ang-009720	Aspergillus niger	69.21	0.00e+00	1063.00
IUUC-Aor-010111	Aspergillus oryzae	73.17	0.00e+00	1164.00
IUUC-Ate-010531	Aspergillus terreus	64.78	0.00e+00	984.00
IUUC-Ame-011893	Astyanax mexicanus	34.27	5.00e-106	376.00
IUUC-Bgr-012183	Blumeria graminis	52.89	0.00e+00	825.00
IUUC-Bta-013179	Bos taurus	33.37	1.00e-120	425.00
IUUC-Bci-013858	Botrytis cinerea	58.33	0.00e+00	921.00
IUUC-Bdi-014904	Brachypodium distachyon	34.64	1.00e-100	358.00
IUUC-Bol-015536	Brassica oleracea	34.34	8.00e-114	402.00
IUUC-Bra-017619	Brassica rapa	34.51	1.00e-114	405.00
IUUC-Cel-018625	Caenorhabditis elegans	30.68	2.00e-85	308.00
IUUC-Cja-019063	Callithrix jacchus	33.49	1.00e-119	422.00
IUUC-Cfa-020976	Canis familiaris	34.96	7.00e-126	442.00
IUUC-Cpo-022265	Cavia porcellus	34.76	6.00e-126	443.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	31.74	5.00e-65	240.00
IUUC-Csa-024078	Chlorocebus sabaeus	33.21	2.00e-111	395.00
IUUC-Cho-024702	Choloepus hoffmanni	33.10	2.00e-79	288.00
IUUC-Cin-025411	Ciona intestinalis	32.55	3.00e-98	351.00
IUUC-Csv-026347	Ciona savignyi	30.67	5.00e-98	350.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	56.03	0.00e+00	815.00
IUUC-Cne-026831	Cryptococcus neoformans	45.32	2.00e-178	617.00
IUUC-Cme-027335	Cyanidioschyzon merolae	32.94	3.00e-57	214.00
IUUC-Dre-027982	Danio rerio	33.65	7.00e-108	383.00
IUUC-Dno-029034	Dasypus novemcinctus	34.07	8.00e-125	439.00
IUUC-Dor-030479	Dipodomys ordii	36.19	3.00e-58	218.00
IUUC-Dse-031467	Dothistroma septosporum	51.75	0.00e+00	811.00
IUUC-Dme-032075	Drosophila melanogaster	35.07	4.00e-112	397.00
IUUC-Ete-032865	Echinops telfairi	30.41	7.00e-99	353.00
IUUC-Eca-034059	Equus caballus	33.49	3.00e-121	427.00
IUUC-Eeu-035304	Erinaceus europaeus	34.60	1.00e-116	412.00
IUUC-Fca-035515	Felis catus	33.61	7.00e-123	432.00
IUUC-Fal-037271	Ficedula albicollis	35.88	2.00e-123	434.00
IUUC-Fox-037745	Fusarium oxysporum	56.77	0.00e+00	895.00
IUUC-Fso-038158	Fusarium solani	57.42	0.00e+00	884.00
IUUC-Gmo-039071	Gadus morhua	33.57	9.00e-112	396.00
IUUC-Ggr-040098	Gaeumannomyces graminis	56.08	0.00e+00	826.00
IUUC-Gga-040635	Gallus gallus	34.11	5.00e-125	440.00
IUUC-Gac-042528	Gasterosteus aculeatus	34.66	5.00e-116	410.00
IUUC-Gma-043614	Glycine max	34.13	1.00e-110	392.00
IUUC-Ggo-044602	Gorilla gorilla	33.69	9.00e-123	432.00
IUUC-Hsa-045959	Homo sapiens	33.69	9.00e-123	432.00
IUUC-Hvu-047563	Hordeum vulgare	36.59	1.00e-104	372.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	33.65	3.00e-123	434.00
IUUC-Kpa-049156	Komagataella pastoris	39.38	1.00e-159	555.00
IUUC-Lch-049648	Latimeria chalumnae	34.50	4.00e-119	420.00
IUUC-Lpe-051523	Leersia perrieri	34.54	3.00e-106	377.00
IUUC-Loc-052072	Lepisosteus oculatus	32.65	8.00e-113	399.00
IUUC-Lma-053216	Leptosphaeria maculans	58.17	0.00e+00	878.00
IUUC-Laf-054327	Loxodonta africana	33.49	3.00e-122	431.00
IUUC-Mcc-055443	Macaca mulatta	33.61	1.00e-122	432.00
IUUC-Meu-056361	Macropus eugenii	35.17	2.00e-81	295.00
IUUC-Mor-057106	Magnaporthe oryzae	56.45	0.00e+00	869.00
IUUC-Mpo-057589	Magnaporthe poae	56.79	0.00e+00	827.00
IUUC-Mtr-058680	Medicago truncatula	36.05	9.00e-118	416.00
IUUC-Mla-058903	Melampsora laricipopulina	43.26	2.00e-174	604.00
IUUC-Mga-059669	Meleagris gallopavo	34.12	4.00e-120	423.00
IUUC-Mvi-060476	Microbotryum violaceum	42.44	3.00e-160	556.00
IUUC-Mmr-060575	Microcebus murinus	33.26	1.00e-122	432.00
IUUC-Mdo-062183	Monodelphis domestica	34.29	3.00e-123	434.00
IUUC-Mmu-063592	Mus musculus	33.57	2.00e-123	434.00
IUUC-Mac-065634	Musa acuminata	31.88	6.00e-103	367.00
IUUC-Mpu-066082	Mustela putorius furo	34.65	6.00e-126	443.00
IUUC-Mlu-067345	Myotis lucifugus	33.49	1.00e-119	422.00
IUUC-Nfi-068558	Neosartorya fischeri	75.86	0.00e+00	1167.00
IUUC-Ncr-068960	Neurospora crassa	58.82	0.00e+00	857.00
IUUC-Nle-070173	Nomascus leucogenys	34.93	2.00e-125	441.00
IUUC-Opr-070556	Ochotona princeps	33.53	2.00e-122	431.00
IUUC-Ont-071502	Oreochromis niloticus	34.34	6.00e-117	413.00
IUUC-Oan-072959	Ornithorhynchus anatinus	43.86	1.00e-48	184.00
IUUC-Ocu-074861	Oryctolagus cuniculus	34.63	3.00e-125	440.00
IUUC-Oba-075109	Oryza barthii	34.77	2.00e-112	398.00
IUUC-Obr-076292	Oryza brachyantha	35.15	8.00e-107	379.00
IUUC-Ogl-077065	Oryza glaberrima	35.73	3.00e-118	417.00
IUUC-Ogu-078776	Oryza glumaepatula	35.28	2.00e-115	408.00
IUUC-Oin-080048	Oryza indica	35.73	3.00e-116	410.00
IUUC-Olo-080711	Oryza longistaminata	34.69	6.00e-108	383.00
IUUC-Ome-081506	Oryza meridionalis	35.06	1.00e-110	392.00
IUUC-Oni-082320	Oryza nivara	33.95	2.00e-110	391.00
IUUC-Opu-083801	Oryza punctata	34.77	2.00e-103	368.00
IUUC-Oru-085139	Oryza rufipogon	33.62	1.00e-110	392.00
IUUC-Osa-085713	Oryza sativa	35.86	2.00e-119	421.00
IUUC-Ola-086951	Oryzias latipes	33.10	7.00e-111	393.00
IUUC-Olu-087822	Ostreococcus lucimarinus	31.41	9.00e-91	326.00
IUUC-Oga-088625	Otolemur garnettii	33.22	4.00e-122	430.00
IUUC-Oar-089995	Ovis aries	33.57	2.00e-120	424.00
IUUC-Ptr-090640	Pan troglodytes	34.45	4.00e-125	440.00
IUUC-Pan-091974	Papio anubis	33.68	2.00e-122	431.00
IUUC-Psi-093957	Pelodiscus sinensis	34.47	1.00e-126	445.00
IUUC-Pma-094242	Petromyzon marinus	38.96	2.00e-69	254.00
IUUC-Pno-094835	Phaeosphaeria nodorum	59.04	0.00e+00	847.00
IUUC-Ppa-095901	Physcomitrella patens	35.07	1.00e-121	429.00
IUUC-Pfo-097148	Poecilia formosa	34.22	3.00e-116	410.00
IUUC-Pab-098068	Pongo abelii	31.55	3.00e-102	364.00
IUUC-Pop-098943	Populus trichocarpa	34.89	1.00e-112	399.00
IUUC-Pca-100738	Procavia capensis	34.73	2.00e-92	332.00
IUUC-Ppe-101315	Prunus persica	33.29	9.00e-107	379.00
IUUC-Pva-102154	Pteropus vampyrus	33.02	8.00e-119	419.00
IUUC-Pgr-103343	Puccinia graminis	42.09	6.00e-141	492.00
IUUC-Ptt-103928	Puccinia triticina	36.57	1.00e-133	468.00
IUUC-Pte-104306	Pyrenophora teres	57.11	0.00e+00	850.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	57.65	0.00e+00	866.00
IUUC-Rno-105801	Rattus norvegicus	33.80	3.00e-124	437.00
IUUC-Sce-106304	Saccharomyces cerevisiae	34.18	4.00e-112	397.00
IUUC-Sha-107635	Sarcophilus harrisii	33.94	5.00e-122	430.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	41.52	7.00e-164	568.00
IUUC-Spo-108144	Schizosaccharomyces pombe	39.84	1.00e-161	561.00
IUUC-Smo-108703	Selaginella moellendorffii	36.36	2.00e-114	404.00
IUUC-Sit-110728	Setaria italica	34.22	3.00e-114	404.00
IUUC-Sly-111523	Solanum lycopersicum	34.47	1.00e-118	419.00
IUUC-Sar-113733	Sorex araneus	36.98	6.00e-66	243.00
IUUC-Sbi-114419	Sorghum bicolor	34.39	4.00e-113	400.00
IUUC-Sre-115225	Sporisorium reilianum	41.13	8.00e-170	588.00
IUUC-Ssc-115686	Sus scrofa	33.57	3.00e-122	430.00
IUUC-Tgu-117346	Taeniopygia guttata	34.15	3.00e-121	427.00
IUUC-Tru-118350	Takifugu rubripes	32.83	4.00e-114	404.00
IUUC-Tsy-119278	Tarsius syrichta	32.92	5.00e-97	347.00
IUUC-Tni-120658	Tetraodon nigroviridis	33.61	2.00e-109	388.00
IUUC-Tca-121585	Theobroma cacao	33.33	9.00e-107	379.00
IUUC-Tre-122043	Trichoderma reesei	54.95	0.00e+00	835.00
IUUC-Tvi-122303	Trichoderma virens	56.14	0.00e+00	849.00
IUUC-Tae-123798	Triticum aestivum	34.26	7.00e-111	392.00
IUUC-Tur-126732	Triticum urartu	32.06	3.00e-100	357.00
IUUC-Tme-126909	Tuber melanosporum	55.80	0.00e+00	855.00
IUUC-Tbe-127261	Tupaia belangeri	30.19	2.00e-72	265.00
IUUC-Ttr-129119	Tursiops truncatus	34.17	4.00e-54	204.00
IUUC-Uma-129599	Ustilago maydis	42.15	5.00e-172	596.00
IUUC-Vda-129688	Verticillium dahliae	55.36	0.00e+00	823.00
IUUC-Vpa-130170	Vicugna pacos	36.62	2.00e-53	202.00
IUUC-Vvi-131116	Vitis vinifera	34.21	2.00e-110	391.00
IUUC-Xtr-131953	Xenopus tropicalis	32.86	3.00e-110	390.00
IUUC-Xma-133837	Xiphophorus maculatus	34.22	4.00e-116	410.00
IUUC-Yli-134510	Yarrowia lipolytica	42.93	7.00e-171	592.00
IUUC-Zma-135786	Zea mays	33.84	9.00e-108	382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence