iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-041215

UUCD1 version

UUC-GaG-00906

Ensembl Protein ID

ENSGALP00000014471.3

UniProt Accession

E1BY77; UBP13_CHICK

Protein Name

Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13

Genbank Nucleotide ID

AADN02020803

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000008909.5	ENSGALT00000014487.5	ENSGALP00000014471.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-54	185.6	331	859
UBD/Alpha-Helix/UBA	7.70e-19	67.6	725	762

Active Site

Position(s)	Description	Evidence
340	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
822	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+N+v+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 331  TGMKNLGNSCYLNAVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeeHKPQQNG 418
           7******************************788777765.79****************98888888888888777765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +sp+++++ ++k + efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 419  ISPQMFKAFISKDHTEFSSNRQQDAQEFFLHLINLVERNP-----------------------------VGSENPSDVFRFLVEERTQC 478
           ************************************9998.............................788899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++ ++e+   ++++  ++k+  +
   Q: 479  CQSRKVRYTERVDYIMQLPVAMEAATNKDeliayelkrreaeaarrappelvrakiPFSACLQAFSEPTNVED---FWSSALQAKSAGV 564
           *******99999999*****99998888799*****************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++P++L++++k+f+f  + + ++k++ ++++p+ Ld+s+  +                                         
   Q: 565  KTSRFASFPQYLVVQIKKFTFGLD-WIPKKLDVSIDMPDFLDISHLRAMglqpgeeelpdiappiiipedpkdrmmnnfvesldidess 652
           *********************997.*******************766667888888888888888888888888877777777777777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 653  vmqlaemgfpleacrkavyytgnlgaevafnwiiahmeepdfaeplvvpvfggaassgvaglgavgldnqppeemvsiiismgfqrsla 741
           77777777777777777777777777777777777777777777777766666666666666666666666666666666666666666 PP
   S: 268  ......peekqke....................................................kkkYeLiavvvHsG.slssGHYva 297
                 +     +                                                    + +YeL++ ++H+G s+ sGHYv+
   Q: 742  iqalkaT-----NnnleralewifshpeleeedgepalnvmdlenhtnanilaearsegprikdgPGRYELFGFISHMGtSTMSGHYVC 825
           6555550.....05555555666666666666666677777777777777888888888889999************************ PP
   S: 298  yvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           + k+ +g+W+ ++D +V ++  e+  +   + +Y++fY+r
   Q: 826  HLKK-EGRWVIYNDLRVCAS--ERPPK---DLGYIYFYHR 859
           ****.9***********999..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+++  +++MGF r++a+qaL a+nnnle+A+e+++++
   Q: 725  EEMVSIIISMGFQRSLAIQALKATNNNLERALEWIFSH 762
           899*********************************97 PP

Organism

Gallus gallus

Functional Description
(View)

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).

Protein Sequence
(Fasta)

MQRAALFGGG DAQMAAGDLG ELLVPYMPTI RVPKSGDRVY KTECAFSYDS PDSEGGLYVC 60
MNTFLGFGRE HIERHYRKTG QCVYLHLKRH VIEKVPGASG GALPKRRNAK LFLDLEANAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCCCGCCG TCCGGAGGCA GGCAGGCGGC ATGCAGCGGG CCGCGCTGTT CGGCGGCGGC 60
GACGCGCAGA TGGCGGCCGG GGACCTGGGC GAGCTGCTCG TCCCCTACAT GCCCACCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	83.31	0.00e+00	1400.00
IUUC-Apl-003712	Anas platyrhynchos	94.58	0.00e+00	1506.00
IUUC-Aca-004634	Anolis carolinensis	85.91	0.00e+00	1475.00
IUUC-Ame-011470	Astyanax mexicanus	75.38	0.00e+00	1287.00
IUUC-Bta-013349	Bos taurus	82.77	0.00e+00	1421.00
IUUC-Cja-019021	Callithrix jacchus	83.06	0.00e+00	1393.00
IUUC-Cfa-020614	Canis familiaris	83.45	0.00e+00	1404.00
IUUC-Cpo-022484	Cavia porcellus	83.37	0.00e+00	1324.00
IUUC-Csa-024078	Chlorocebus sabaeus	83.35	0.00e+00	1404.00
IUUC-Cho-024522	Choloepus hoffmanni	69.54	0.00e+00	1066.00
IUUC-Cme-027335	Cyanidioschyzon merolae	27.01	3.00e-49	190.00
IUUC-Dre-027651	Danio rerio	75.64	0.00e+00	1343.00
IUUC-Dno-028975	Dasypus novemcinctus	83.04	0.00e+00	1395.00
IUUC-Dor-030130	Dipodomys ordii	61.83	0.00e+00	904.00
IUUC-Ete-032251	Echinops telfairi	70.53	0.00e+00	1104.00
IUUC-Eca-033568	Equus caballus	84.09	0.00e+00	1325.00
IUUC-Eeu-034612	Erinaceus europaeus	68.02	0.00e+00	1009.00
IUUC-Fca-036280	Felis catus	84.20	0.00e+00	1325.00
IUUC-Fal-036610	Ficedula albicollis	93.64	0.00e+00	1473.00
IUUC-Gmo-038906	Gadus morhua	72.61	0.00e+00	1242.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.70	0.00e+00	1268.00
IUUC-Ggo-044446	Gorilla gorilla	83.47	0.00e+00	1406.00
IUUC-Hsa-046546	Homo sapiens	83.24	0.00e+00	1399.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	78.04	0.00e+00	1261.00
IUUC-Lch-050425	Latimeria chalumnae	78.87	0.00e+00	1377.00
IUUC-Loc-052072	Lepisosteus oculatus	75.93	0.00e+00	1304.00
IUUC-Laf-053909	Loxodonta africana	81.57	0.00e+00	1387.00
IUUC-Mcc-054686	Macaca mulatta	83.47	0.00e+00	1406.00
IUUC-Meu-056361	Macropus eugenii	76.12	0.00e+00	1259.00
IUUC-Mga-059972	Meleagris gallopavo	93.86	0.00e+00	1492.00
IUUC-Mmr-060916	Microcebus murinus	82.43	0.00e+00	1400.00
IUUC-Mdo-062302	Monodelphis domestica	83.58	0.00e+00	1477.00
IUUC-Mmu-063639	Mus musculus	83.37	0.00e+00	1413.00
IUUC-Mpu-066533	Mustela putorius furo	83.45	0.00e+00	1405.00
IUUC-Mlu-067786	Myotis lucifugus	79.91	0.00e+00	1300.00
IUUC-Nle-069997	Nomascus leucogenys	83.92	0.00e+00	1311.00
IUUC-Ont-071859	Oreochromis niloticus	71.98	0.00e+00	1260.00
IUUC-Oan-072959	Ornithorhynchus anatinus	85.77	5.00e-127	446.00
IUUC-Ocu-074265	Oryctolagus cuniculus	83.51	0.00e+00	1393.00
IUUC-Ola-087344	Oryzias latipes	72.39	0.00e+00	1274.00
IUUC-Oga-088734	Otolemur garnettii	83.97	0.00e+00	1372.00
IUUC-Oar-089636	Ovis aries	83.35	0.00e+00	1343.00
IUUC-Ptr-090982	Pan troglodytes	83.35	0.00e+00	1403.00
IUUC-Pan-091991	Papio anubis	83.47	0.00e+00	1406.00
IUUC-Psi-093509	Pelodiscus sinensis	89.11	0.00e+00	1549.00
IUUC-Pfo-096029	Poecilia formosa	74.48	0.00e+00	1313.00
IUUC-Pab-098672	Pongo abelii	79.31	0.00e+00	1305.00
IUUC-Pca-100860	Procavia capensis	69.14	0.00e+00	800.00
IUUC-Ppe-101315	Prunus persica	42.97	0.00e+00	658.00
IUUC-Pva-102545	Pteropus vampyrus	82.42	0.00e+00	1190.00
IUUC-Rno-105210	Rattus norvegicus	83.02	0.00e+00	1394.00
IUUC-Sar-113733	Sorex araneus	84.65	0.00e+00	704.00
IUUC-Tgu-116591	Taeniopygia guttata	92.69	0.00e+00	1580.00
IUUC-Tru-118627	Takifugu rubripes	71.64	0.00e+00	1283.00
IUUC-Tsy-119278	Tarsius syrichta	75.80	0.00e+00	1181.00
IUUC-Tni-120804	Tetraodon nigroviridis	73.59	0.00e+00	1303.00
IUUC-Tbe-127699	Tupaia belangeri	68.67	0.00e+00	761.00
IUUC-Ttr-128295	Tursiops truncatus	76.21	0.00e+00	1265.00
IUUC-Vpa-130170	Vicugna pacos	74.35	0.00e+00	1152.00
IUUC-Xtr-132809	Xenopus tropicalis	74.85	0.00e+00	1268.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence