iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093509

Ensembl Protein ID

ENSPSIP00000011248.1

UniProt Accession

K7FT88; K7FT88_PELSI

Genbank Protein ID

ENSPSIP00000011248

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01198670

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000010053.1	ENSPSIT00000011304.1	ENSPSIP00000011248.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.90e-53	180.8	332	859
UBD/Alpha-Helix/UBA	2.80e-18	65.4	726	763

Active Site

Position(s)	Description	Evidence
341	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
822	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+  v+Q+ ++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 332  TGMKNLGNSCYLSTVMQAVFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQITKLGHGLlsgqyskppmkselieqvmkeeHKPQHNG 419
           7******************************777777765.7999**99999999999998888888887777777665443377777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 420  ISPRMFKAFVSKGHPEFSSNRQQDAQEFFLHLINLVERNR-----------------------------IGTENPSDVFRFLVEERTQC 479
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 480  CQSRKVRYTERVDYLMQLPVAMEAATNKDeliayelkrreaeaarrpppelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 565
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + + ++k++ +v++p+ Ld+++  ++                                        
   Q: 566  KTSRFASFPEYLVVQIKKFTFGLD-WIPQKLDVSVDMPDLLDINHLRATglqpgeeelpdiappivipddpkdrmmnhfmeppdidess 653
           *********************997.*******************988888999999999999999999998888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 654  vmqlaemgfpleacrkavyytgnmgaevafnwiiahmeepdfaeplaipgyggvasaraaglgaigldnqppeemvalitsmgfqrnva 742
           88888888888888888888888888888888888888777777777777777777777777777777777777777777777777777 PP
   S: 268  .......................peekqke..................................kkkYeLiavvvHsG.slssGHYvay 298
                                  p     e                                  + +YeL++ ++H+G s+ sGHYv++
   Q: 743  lqslkatnnnleraldwifshpdP-----EesseaasdvmdmennananilaeagpegprikdgSGRYELFGFISHMGtSTMSGHYVCH 826
           766666666666666666666551.....04455566777777777778888889999999999************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +g+W+ ++D kV ++  e+  +   + +Y++fY+r
   Q: 827  LKK-EGRWVIYNDLKVCAS--ERPPR---DLGYIYFYHR 859
           ***.9***********999..67777...89******87 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r+ alq L a+nnnle+A+++++++
   Q: 726  EEMVALITSMGFQRNVALQSLKATNNNLERALDWIFSH 763
           89**********************************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MQRAALFGSG REAQMAAGDL GELLVPYMPT IRVPKSGDRV YKTECAFSYE SPDSEGGLYV 60
CMNTFLGFGR EHVESHYRKT GQCVYMHLKR HVREKVPGAS GGVLPKRRNA VLFLDLETNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCCCTCC TTGCTGTCCA CCCTCCCCTC CCCACACATC CTCTCTGGGC GCTGCCCTCC 60
ATCCATCTTC CCCGAGGCTC CTCCTCTCCG TCGCCCCCGC CCCAGGGCTT CCCCCCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	86.33	0.00e+00	1451.00
IUUC-Apl-003712	Anas platyrhynchos	90.51	0.00e+00	1470.00
IUUC-Aca-004634	Anolis carolinensis	89.13	0.00e+00	1525.00
IUUC-Ame-011470	Astyanax mexicanus	76.55	0.00e+00	1342.00
IUUC-Bta-013349	Bos taurus	86.13	0.00e+00	1478.00
IUUC-Cja-019021	Callithrix jacchus	85.71	0.00e+00	1439.00
IUUC-Cfa-020614	Canis familiaris	86.24	0.00e+00	1452.00
IUUC-Cpo-022484	Cavia porcellus	86.78	0.00e+00	1379.00
IUUC-Csa-024078	Chlorocebus sabaeus	86.49	0.00e+00	1456.00
IUUC-Cho-024522	Choloepus hoffmanni	72.47	0.00e+00	1092.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.71	1.00e-58	221.00
IUUC-Dre-027651	Danio rerio	76.81	0.00e+00	1408.00
IUUC-Dno-028975	Dasypus novemcinctus	86.18	0.00e+00	1447.00
IUUC-Dor-030130	Dipodomys ordii	64.47	0.00e+00	961.00
IUUC-Ete-032251	Echinops telfairi	73.46	0.00e+00	1162.00
IUUC-Eca-033568	Equus caballus	87.53	0.00e+00	1381.00
IUUC-Eeu-034612	Erinaceus europaeus	69.96	0.00e+00	1057.00
IUUC-Fca-036280	Felis catus	87.39	0.00e+00	1380.00
IUUC-Fal-036610	Ficedula albicollis	90.26	0.00e+00	1442.00
IUUC-Gmo-038906	Gadus morhua	72.84	0.00e+00	1285.00
IUUC-Gga-041215	Gallus gallus	89.11	0.00e+00	1533.00
IUUC-Gac-042441	Gasterosteus aculeatus	73.08	0.00e+00	1314.00
IUUC-Ggo-044446	Gorilla gorilla	86.37	0.00e+00	1459.00
IUUC-Hsa-046546	Homo sapiens	86.37	0.00e+00	1458.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	80.23	0.00e+00	1318.00
IUUC-Lch-050425	Latimeria chalumnae	81.16	0.00e+00	1445.00
IUUC-Loc-052072	Lepisosteus oculatus	77.75	0.00e+00	1358.00
IUUC-Laf-053909	Loxodonta africana	84.78	0.00e+00	1436.00
IUUC-Mcc-054686	Macaca mulatta	86.49	0.00e+00	1456.00
IUUC-Meu-056361	Macropus eugenii	78.45	0.00e+00	1318.00
IUUC-Mga-059972	Meleagris gallopavo	83.07	0.00e+00	1373.00
IUUC-Mmr-060916	Microcebus murinus	85.66	0.00e+00	1444.00
IUUC-Mdo-062302	Monodelphis domestica	86.30	0.00e+00	1544.00
IUUC-Mmu-063639	Mus musculus	86.33	0.00e+00	1470.00
IUUC-Mpu-066533	Mustela putorius furo	86.46	0.00e+00	1454.00
IUUC-Mlu-067786	Myotis lucifugus	81.29	0.00e+00	1351.00
IUUC-Nle-069997	Nomascus leucogenys	87.27	0.00e+00	1370.00
IUUC-Ont-071859	Oreochromis niloticus	73.04	0.00e+00	1315.00
IUUC-Oan-072959	Ornithorhynchus anatinus	87.87	3.00e-130	456.00
IUUC-Ocu-074265	Oryctolagus cuniculus	86.78	0.00e+00	1444.00
IUUC-Ola-087344	Oryzias latipes	72.84	0.00e+00	1327.00
IUUC-Oga-088734	Otolemur garnettii	87.07	0.00e+00	1427.00
IUUC-Oar-089636	Ovis aries	86.67	0.00e+00	1434.00
IUUC-Ptr-090982	Pan troglodytes	86.49	0.00e+00	1460.00
IUUC-Pan-091991	Papio anubis	86.61	0.00e+00	1457.00
IUUC-Pfo-096029	Poecilia formosa	74.86	0.00e+00	1362.00
IUUC-Pab-098672	Pongo abelii	82.45	0.00e+00	1360.00
IUUC-Pca-100860	Procavia capensis	67.49	0.00e+00	960.00
IUUC-Ppe-101315	Prunus persica	44.43	0.00e+00	685.00
IUUC-Pva-102545	Pteropus vampyrus	80.00	0.00e+00	1330.00
IUUC-Rno-105210	Rattus norvegicus	85.73	0.00e+00	1441.00
IUUC-Sar-113733	Sorex araneus	86.88	0.00e+00	718.00
IUUC-Tgu-116591	Taeniopygia guttata	89.91	0.00e+00	1546.00
IUUC-Tru-118627	Takifugu rubripes	72.70	0.00e+00	1341.00
IUUC-Tsy-119278	Tarsius syrichta	79.36	0.00e+00	1248.00
IUUC-Tni-120804	Tetraodon nigroviridis	74.60	0.00e+00	1360.00
IUUC-Tbe-127699	Tupaia belangeri	72.29	0.00e+00	813.00
IUUC-Ttr-128295	Tursiops truncatus	79.68	0.00e+00	1320.00
IUUC-Vpa-130170	Vicugna pacos	76.91	0.00e+00	1206.00
IUUC-Xtr-132809	Xenopus tropicalis	76.46	0.00e+00	1328.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence