iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Sce-106162

Ensembl Protein ID

YLL042C

UniProt Accession

Q07879; D6VXW4; ATG10_YEAST

Genbank Protein ID

CAA97493.1; AAS56516.1; DAA09280.1

Protein Name

Ubiquitin-like-conjugating enzyme ATG10; Autophagy-related protein 10

Genbank Nucleotide ID

Z73147; AY558190; BK006945

Gene Name

ATG10; APG10; YLL042C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YLL042C	YLL042C	YLL042C

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/Autophagy_C	Autophagy_C	21193819

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule.

Protein Sequence
(Fasta)

MIPYQEWHSQ LQSLYDSQIF HNWALCQDVH LNDEKDGLLL RLIPTRQLQK NTERIENKLL 60
NHIELYLTYS KVYNEPLLLL RIWEEKSIDG IPMTKLMLPT DIESLLDVQG KFQLGLDTII 120

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Nucleotide Sequence
(Fasta)

ATGATTCCTT ACCAGGAGTG GCATAGCCAA CTGCAATCGT TGTATGACTC CCAGATTTTC 60
CATAACTGGG CCCTTTGCCA AGATGTCCAT TTGAATGATG AAAAGGATGG ACTTCTTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR016524--Atg10
IPR007135--Autophagy-rel_prot_3

Pfam

PF03987--Autophagy_act_C

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0019777--F:Atg12 transferase activity
GO:0016874--F:ligase activity
GO:0006464--P:cellular protein modification process
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus

KEGG

sce:YLL042C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007740	Ashbya gossypii	28.70	1.00e-06	44.30
IUUC-Ang-009552	Aspergillus niger	27.78	8.00e-03	33.50
IUUC-Ame-011901	Astyanax mexicanus	29.55	2.00e-01	31.20
IUUC-Cre-022874	Chlamydomonas reinhardtii	26.06	7.00e-05	39.70
IUUC-Dno-028960	Dasypus novemcinctus	37.74	1.90e-02	30.00
IUUC-Gmo-038496	Gadus morhua	42.11	4.00e-02	30.80
IUUC-Gac-042366	Gasterosteus aculeatus	37.78	2.20e-02	32.70
IUUC-Itr-048156	Ictidomys tridecemlineatus	29.76	4.40e-02	30.80
IUUC-Lch-050102	Latimeria chalumnae	38.78	4.50e-02	31.60
IUUC-Loc-052912	Lepisosteus oculatus	30.30	1.40e-01	30.40
IUUC-Laf-053573	Loxodonta africana	35.85	6.40e-02	28.10
IUUC-Meu-055987	Macropus eugenii	39.62	2.10e-02	29.30
IUUC-Mmr-061585	Microcebus murinus	35.85	3.50e-02	28.90
IUUC-Mmu-063385	Mus musculus	31.03	4.00e-03	31.60
IUUC-Oan-073646	Ornithorhynchus anatinus	34.38	1.10e-01	28.50
IUUC-Ptr-091128	Pan troglodytes	27.27	5.00e-02	31.20
IUUC-Spo-108096	Schizosaccharomyces pombe	35.56	1.70e-01	27.70
IUUC-Sit-110109	Setaria italica	28.07	6.30e-02	30.00
IUUC-Sar-113683	Sorex araneus	29.41	1.40e-01	28.90
IUUC-Tru-118067	Takifugu rubripes	40.00	8.90e-02	30.80
IUUC-Vpa-130463	Vicugna pacos	29.03	3.50e-02	29.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence