iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098024

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01271082

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000014924.1	ENSPPYT00000017343.1	ENSPPYP00000016664.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-89	301.3	549	868

Active Site

Position(s)	Description	Evidence
839	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            d+ k+l vef +E   + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F ++G+l+g++l++ ++ +lp
   Q: 549  TDFCKVLVVEFINEIRPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKL----EKKRYF-LFGMLCGLSLFNLNVANLP 632
           688899**************************************************998....677888.55***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++ ++yk+ll++k sledl+e+ p l ksl+e+++ + +di ++ l+++fs++     ++++++L+p+G +i V ++Nk++Yv+++++y
   Q: 633  FPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLNDDADDIGDA-LCIRFSIH----WDQNDVDLIPNGISILVDQSNKKDYVSKYIDY 716
           **********************************9999999997.*****855....5779999************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           +++ ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ ky++gy++++p+iq Fw+++++++ +e+k+fL F+T
   Q: 717  IFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLT 805
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           g++rl ++G+++++  +f +++  s+++ P+s TC   L LP+Ys++e ++e L++Ai++++gF
   Q: 806  GRDRLHARGIQKME-IVFRCPETFSERDHPTSITCHCILYLPKYSTMERMEEALQVAINNNRGF 868
           **************.77888889****************************************9 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MYFCWGADSR ELQRRRTAGS PAAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRAQ 60
RGELPEPIQA LETLIVDLVS CGKEHSLAVC HKGRVFAWGA GSEGQLGIGE FKEISFTPKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACTTCT GTTGGGGCGC CGACTCCAGG GAGCTGCAGC GCCGGAGGAC GGCGGGCAGC 60
CCCGCGGCTG AGCTACTGCA GGCGGCCAGC GGGGAGCGCC ACTCTCTGCT GCTGCTGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	57.91	0.00e+00	944.00
IUUC-Bta-013080	Bos taurus	57.74	0.00e+00	973.00
IUUC-Cja-018891	Callithrix jacchus	70.75	0.00e+00	1205.00
IUUC-Cfa-020763	Canis familiaris	58.82	0.00e+00	872.00
IUUC-Cpo-022346	Cavia porcellus	56.92	0.00e+00	972.00
IUUC-Csa-023049	Chlorocebus sabaeus	76.35	0.00e+00	1349.00
IUUC-Cho-025101	Choloepus hoffmanni	53.91	1.00e-146	514.00
IUUC-Dno-029093	Dasypus novemcinctus	61.23	0.00e+00	1061.00
IUUC-Ete-032531	Echinops telfairi	53.01	3.00e-122	433.00
IUUC-Eca-034098	Equus caballus	62.67	0.00e+00	1081.00
IUUC-Eeu-035282	Erinaceus europaeus	42.18	1.00e-118	420.00
IUUC-Fca-036283	Felis catus	59.10	0.00e+00	968.00
IUUC-Ggo-045553	Gorilla gorilla	72.67	0.00e+00	1246.00
IUUC-Hsa-046396	Homo sapiens	77.44	0.00e+00	1350.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	44.23	0.00e+00	699.00
IUUC-Laf-054433	Loxodonta africana	57.84	0.00e+00	970.00
IUUC-Mcc-055014	Macaca mulatta	74.63	0.00e+00	1350.00
IUUC-Mmr-060783	Microcebus murinus	44.21	0.00e+00	670.00
IUUC-Mdo-061839	Monodelphis domestica	48.02	0.00e+00	670.00
IUUC-Mmu-064378	Mus musculus	51.24	0.00e+00	844.00
IUUC-Mpu-066293	Mustela putorius furo	57.80	0.00e+00	919.00
IUUC-Mlu-067407	Myotis lucifugus	57.11	0.00e+00	987.00
IUUC-Nle-069978	Nomascus leucogenys	76.44	0.00e+00	1346.00
IUUC-Ocu-074640	Oryctolagus cuniculus	70.85	0.00e+00	882.00
IUUC-Oga-088780	Otolemur garnettii	58.67	0.00e+00	989.00
IUUC-Oar-090307	Ovis aries	58.22	0.00e+00	984.00
IUUC-Ptr-091567	Pan troglodytes	75.22	0.00e+00	1339.00
IUUC-Pan-091802	Papio anubis	81.53	0.00e+00	1346.00
IUUC-Pca-100320	Procavia capensis	47.90	0.00e+00	785.00
IUUC-Pva-102382	Pteropus vampyrus	55.04	0.00e+00	901.00
IUUC-Rno-105768	Rattus norvegicus	48.70	0.00e+00	785.00
IUUC-Sha-106525	Sarcophilus harrisii	48.05	0.00e+00	755.00
IUUC-Ssc-116223	Sus scrofa	74.25	6.00e-158	550.00
IUUC-Tsy-119565	Tarsius syrichta	78.11	9.00e-177	613.00
IUUC-Tbe-127787	Tupaia belangeri	44.55	0.00e+00	683.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence