iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035928

Ensembl Protein ID

ENSFCAP00000020448.1

UniProt Accession

M3X1F5; M3X1F5_FELCA

Genbank Protein ID

ENSFCAP00000020448

Protein Name

Estrogen receptor

Genbank Nucleotide ID

AANG02061460

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000031492.1	ENSFCAT00000027735.1	ENSFCAP00000020448.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	92.17	0.00e+00	788.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Felis catus

Protein Sequence
(Fasta)

FSRPTSDNRR QSGRERLAST GDKGSMAMES AKETRYCAVC NDYASGYHYG VWSCEGCKAF 60
FKRSIQGHND YMCPATNQCT IDKNRRKSCQ ACRLRKCYEV GMMKGGIRKD RRGGRMLKHK 120

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Nucleotide Sequence
(Fasta)

TTTTCCAGGC CCACTTCAGA CAATCGGCGC CAGAGTGGCA GAGAGAGATT GGCCAGTACT 60
GGTGATAAGG GAAGCATGGC CATGGAGTCT GCCAAGGAGA CCCGCTACTG TGCAGTATGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	96.66	0.00e+00	832.00
IUUC-Apl-003688	Anas platyrhynchos	88.69	0.00e+00	648.00
IUUC-Aca-005222	Anolis carolinensis	84.05	0.00e+00	701.00
IUUC-Ame-010731	Astyanax mexicanus	60.05	2.00e-130	459.00
IUUC-Bta-013112	Bos taurus	92.17	0.00e+00	797.00
IUUC-Cja-019408	Callithrix jacchus	93.74	0.00e+00	812.00
IUUC-Cfa-020694	Canis familiaris	95.75	0.00e+00	826.00
IUUC-Cpo-021426	Cavia porcellus	86.58	0.00e+00	751.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.00e+00	26.90
IUUC-Csa-023736	Chlorocebus sabaeus	93.29	0.00e+00	806.00
IUUC-Dre-027698	Danio rerio	63.05	2.00e-131	462.00
IUUC-Dno-029477	Dasypus novemcinctus	91.28	0.00e+00	731.00
IUUC-Dor-030572	Dipodomys ordii	90.32	0.00e+00	753.00
IUUC-Ete-032849	Echinops telfairi	82.08	3.00e-170	591.00
IUUC-Eca-033605	Equus caballus	91.50	0.00e+00	795.00
IUUC-Eeu-034683	Erinaceus europaeus	90.65	2.00e-109	389.00
IUUC-Fal-036754	Ficedula albicollis	87.16	0.00e+00	732.00
IUUC-Gmo-038872	Gadus morhua	56.68	7.00e-113	400.00
IUUC-Gga-040988	Gallus gallus	87.61	0.00e+00	719.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.66	3.00e-126	445.00
IUUC-Ggo-044749	Gorilla gorilla	92.84	0.00e+00	804.00
IUUC-Hsa-046944	Homo sapiens	92.17	0.00e+00	793.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	91.76	0.00e+00	792.00
IUUC-Loc-052414	Lepisosteus oculatus	68.30	5.00e-162	564.00
IUUC-Mcc-054781	Macaca mulatta	93.06	0.00e+00	805.00
IUUC-Meu-056232	Macropus eugenii	91.95	0.00e+00	776.00
IUUC-Mga-059319	Meleagris gallopavo	87.84	0.00e+00	720.00
IUUC-Mmr-061636	Microcebus murinus	93.18	4.00e-114	404.00
IUUC-Mdo-062661	Monodelphis domestica	91.50	0.00e+00	780.00
IUUC-Mmu-063330	Mus musculus	91.50	0.00e+00	755.00
IUUC-Mpu-065757	Mustela putorius furo	95.32	0.00e+00	822.00
IUUC-Mlu-067712	Myotis lucifugus	92.62	0.00e+00	794.00
IUUC-Nle-069283	Nomascus leucogenys	93.29	0.00e+00	805.00
IUUC-Opr-070391	Ochotona princeps	90.16	0.00e+00	821.00
IUUC-Ont-071369	Oreochromis niloticus	60.05	2.00e-115	409.00
IUUC-Oan-073734	Ornithorhynchus anatinus	74.93	2.00e-134	471.00
IUUC-Ocu-074292	Oryctolagus cuniculus	93.06	0.00e+00	803.00
IUUC-Oba-075103	Oryza barthii	28.21	9.00e-03	35.00
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.00
IUUC-Olo-080944	Oryza longistaminata	28.21	4.00e-03	34.70
IUUC-Oni-082560	Oryza nivara	28.21	7.00e-03	35.40
IUUC-Ola-087052	Oryzias latipes	57.44	7.00e-122	431.00
IUUC-Oga-088586	Otolemur garnettii	91.33	0.00e+00	788.00
IUUC-Oar-090156	Ovis aries	91.29	0.00e+00	824.00
IUUC-Ptr-091321	Pan troglodytes	93.06	0.00e+00	805.00
IUUC-Pan-092851	Papio anubis	93.06	0.00e+00	805.00
IUUC-Psi-093434	Pelodiscus sinensis	84.79	0.00e+00	764.00
IUUC-Pfo-097379	Poecilia formosa	62.94	1.00e-128	453.00
IUUC-Pab-097735	Pongo abelii	93.06	0.00e+00	805.00
IUUC-Pva-102125	Pteropus vampyrus	89.49	0.00e+00	769.00
IUUC-Rno-106121	Rattus norvegicus	91.50	0.00e+00	754.00
IUUC-Sha-107547	Sarcophilus harrisii	91.72	0.00e+00	780.00
IUUC-Sar-113650	Sorex araneus	85.93	1.00e-124	439.00
IUUC-Tgu-117175	Taeniopygia guttata	87.61	0.00e+00	733.00
IUUC-Tru-117545	Takifugu rubripes	62.37	3.00e-132	466.00
IUUC-Tsy-119586	Tarsius syrichta	79.19	0.00e+00	696.00
IUUC-Tni-120121	Tetraodon nigroviridis	61.82	3.00e-132	465.00
IUUC-Tbe-127548	Tupaia belangeri	82.21	0.00e+00	643.00
IUUC-Ttr-128374	Tursiops truncatus	85.46	0.00e+00	716.00
IUUC-Vpa-130464	Vicugna pacos	82.51	3.00e-155	541.00
IUUC-Xtr-132171	Xenopus tropicalis	75.62	9.00e-175	606.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence