iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033408

UUCD1 version

UUC-EqC-00421

Ensembl Protein ID

ENSECAP00000014728.1

UniProt Accession

F6WY43; F6WY43_HORSE

Protein Name

Uncharacterized protein

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000017053.1	ENSECAT00000018078.1	ENSECAP00000014728.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	7.70e-145	484.2	962	1514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ f+eql++++++f      y+++           +++w+++i+ed +++ll+l+++l  a+R+++++++ +l++ +++    
   Q: 962  PTFWPVFQEQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLHGALRHEQNFADGFLPDNEAA---- 1026
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       + 
   Q: 1027 ----QALGKTCWEALVSPLVQNITSPDEDGVSPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEVP-------PL 1102
           ....9*************************************************************************.......99 PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           +va++r +++++ +++++L++r+l+  ++++l++++ ++++eq++++lt++++++d   +V+r++e++n lqk++se+F+++a+Fl 
   Q: 1103 VVATPRPQGRNRSHDWSSLATRGLPssIMRNLTRCWGAVVEEQVNNFLTSHWRDDD---FVPRYCEHFNNLQKSSSELFGPRAAFLL 1186
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k s+lkaa+++E++Ar+iDq++++s ++g++++e++aql+++l+ + ++s++++   Fe yY++++a+RLl   + 
   Q: 1187 ALQNGCAGALLKLSFLKAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETVLVFSGLEIattFEYYYQHYMADRLLG--VG 1271
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+++l++Se+l+rqF+                                            
   Q: 1272 SSWLEGAVLEQI----GLCFPNRLpQQMLRSLSTSEELQRQFHvyqlqrldqellkledtekkmqvggghgasgkeyereneeeaee 1354
           ************....*********************************************************************** PP
   S: 453  .................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRk 510
                            e+++ ++e +++e+svlvLs+++Wp a  ++t  +k++LP++l+ t++++++fY         e++++R+
   Q: 1355 agaaaaaadkaeveeeeENEDLYYEGAMPEVSVLVLSPRCWPIAsiCHTlnPKICLPSYLRGTLNRYSNFYnksqsypvVERGPQRR 1441
           ***************98889999*********************9999899***************************99******* PP
   S: 511  LqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkke 586
           LqW++ lgrael++    g ++l+Vst+Qm++LL++n+ ++vsve+l + ++l++++L++++++L+s +   ++++++
   Q: 1442 LQWTW-LGRAELQF----GDQTLHVSTVQMWLLLYLNDLKEVSVESLLALSGLSQDMLNQAIGPLTSLRgpLDLHEQK 1514
           *****.********....************************************************977566666655 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GEGGSGQVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQETGGEAG ALDKSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGGG AGCTCCGCTA CAGGGAATTC AGAGTGCCCC TGGGGCCCGG CTTGCACGCC 60
TACCCTGATG AGCTGATCCG CCAGCGGGTG GGCCACGATG GGCATCCTGA GTACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011030--Vitellinogen_superhlx
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	91.16	0.00e+00	2902.00
IUUC-Bta-013285	Bos taurus	87.95	0.00e+00	2855.00
IUUC-Cja-019033	Callithrix jacchus	84.72	0.00e+00	2701.00
IUUC-Cfa-020695	Canis familiaris	86.57	0.00e+00	1803.00
IUUC-Cpo-021513	Cavia porcellus	79.29	0.00e+00	2516.00
IUUC-Csa-023798	Chlorocebus sabaeus	87.60	0.00e+00	2805.00
IUUC-Dor-030234	Dipodomys ordii	84.60	0.00e+00	2807.00
IUUC-Ete-032612	Echinops telfairi	78.56	0.00e+00	923.00
IUUC-Fca-035483	Felis catus	90.42	0.00e+00	2904.00
IUUC-Gmo-038795	Gadus morhua	44.07	0.00e+00	1008.00
IUUC-Gac-041628	Gasterosteus aculeatus	45.67	0.00e+00	1305.00
IUUC-Ggo-044721	Gorilla gorilla	88.26	0.00e+00	2771.00
IUUC-Hsa-046406	Homo sapiens	88.26	0.00e+00	2811.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	87.96	0.00e+00	2770.00
IUUC-Lch-049956	Latimeria chalumnae	43.97	0.00e+00	1066.00
IUUC-Laf-054068	Loxodonta africana	87.60	0.00e+00	2835.00
IUUC-Mcc-055464	Macaca mulatta	87.96	0.00e+00	2795.00
IUUC-Meu-056198	Macropus eugenii	57.72	0.00e+00	1318.00
IUUC-Mmr-061464	Microcebus murinus	88.21	0.00e+00	2811.00
IUUC-Mdo-062018	Monodelphis domestica	59.98	0.00e+00	1399.00
IUUC-Mmu-063413	Mus musculus	77.62	0.00e+00	2397.00
IUUC-Mpu-066146	Mustela putorius furo	91.15	0.00e+00	2825.00
IUUC-Mlu-067036	Myotis lucifugus	88.54	0.00e+00	2872.00
IUUC-Opr-070670	Ochotona princeps	78.67	0.00e+00	2492.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.36	0.00e+00	1158.00
IUUC-Ocu-074155	Oryctolagus cuniculus	84.91	0.00e+00	2695.00
IUUC-Oga-089084	Otolemur garnettii	87.69	0.00e+00	2863.00
IUUC-Oar-090029	Ovis aries	90.11	0.00e+00	2875.00
IUUC-Ptr-091282	Pan troglodytes	86.80	0.00e+00	2794.00
IUUC-Pan-091883	Papio anubis	88.01	0.00e+00	2819.00
IUUC-Pab-098383	Pongo abelii	85.01	0.00e+00	2720.00
IUUC-Pca-100519	Procavia capensis	77.19	0.00e+00	853.00
IUUC-Pva-102417	Pteropus vampyrus	87.97	0.00e+00	2324.00
IUUC-Rno-105962	Rattus norvegicus	79.68	0.00e+00	2510.00
IUUC-Sar-113750	Sorex araneus	81.75	3.00e-175	609.00
IUUC-Ssc-115899	Sus scrofa	82.42	0.00e+00	2502.00
IUUC-Tsy-118860	Tarsius syrichta	84.46	0.00e+00	1131.00
IUUC-Tbe-127660	Tupaia belangeri	87.54	0.00e+00	1433.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence