iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091849

Ensembl Protein ID

ENSPANP00000017766.1

UniProt Accession

A0A096NXH2; A0A096NXH2_PAPAN

Genbank Protein ID

ENSPANP00000017766

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01028545

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000017149.1	ENSPANT00000024693.1	ENSPANP00000017766.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-124	415.7	2149	2593

Active Site

Position(s)	Description	Evidence
2562	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   glk+p                     
   Q: 2149 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2234
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2235 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqsdfeedsksefildppkpkppa 2321
           *************************************88888888888888888888888777777777777777776666666666 PP
   S: 101  .lgkklsledleevdpelykslkeikenaes..................................dieelgldltfsvseeilgetk 152
            ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+++f++s++i+g t+
   Q: 2322 wFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnkglsedekntklqelvlknpsgsgpplSIEDLGLNFQFCPSSRIYGFTA 2408
           66668***********************9334455555666777788899999999999***************************9 PP
   S: 153  eeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket..ky.. 235
           ++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +++++++e+  +y  
   Q: 2409 VD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---QSPSWAAEDiiNYte 2491
           99.******************************************************************...666666666555555 PP
   S: 236  .kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilk 320
            k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++yLkLPeYss+ei++
   Q: 2492 pKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVHYLKLPEYSSEEIMR 2578
           5************************************************************************************** PP
   S: 321  ekLlyAieetkgFels 336
           e+Ll+A++e kgF+l+
   Q: 2579 ERLLAATME-KGFHLN 2593
           *********.****86 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGACCCAGA TACATTGCTG GAATGGCTAC AGATGGGACA GGGAGATGAA 60
AGGGACATGC AACTAATAGC CCTTGAACAG CTATGCATGC TGCTTTTGAT GTCTGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	96.82	0.00e+00	4516.00
IUUC-Apl-003493	Anas platyrhynchos	92.94	0.00e+00	4350.00
IUUC-Aca-004521	Anolis carolinensis	93.31	0.00e+00	2687.00
IUUC-Ame-011258	Astyanax mexicanus	87.53	0.00e+00	2265.00
IUUC-Bta-012835	Bos taurus	96.93	0.00e+00	4535.00
IUUC-Cel-018153	Caenorhabditis elegans	48.86	3.00e-163	570.00
IUUC-Cja-019174	Callithrix jacchus	96.02	0.00e+00	4444.00
IUUC-Cfa-021115	Canis familiaris	96.97	0.00e+00	4509.00
IUUC-Cpo-022382	Cavia porcellus	94.47	0.00e+00	4373.00
IUUC-Csa-023230	Chlorocebus sabaeus	97.28	0.00e+00	4536.00
IUUC-Cho-024711	Choloepus hoffmanni	94.64	0.00e+00	1613.00
IUUC-Cin-025342	Ciona intestinalis	51.26	0.00e+00	1298.00
IUUC-Csv-026031	Ciona savignyi	49.54	0.00e+00	1316.00
IUUC-Dre-027435	Danio rerio	84.54	0.00e+00	3960.00
IUUC-Dno-029954	Dasypus novemcinctus	96.74	0.00e+00	4481.00
IUUC-Dor-030734	Dipodomys ordii	98.07	0.00e+00	1499.00
IUUC-Dme-031739	Drosophila melanogaster	56.91	0.00e+00	1516.00
IUUC-Ete-033192	Echinops telfairi	84.27	0.00e+00	1062.00
IUUC-Eca-033434	Equus caballus	96.25	0.00e+00	4477.00
IUUC-Eeu-035031	Erinaceus europaeus	76.15	0.00e+00	949.00
IUUC-Fca-035998	Felis catus	95.29	0.00e+00	4406.00
IUUC-Fal-037468	Ficedula albicollis	92.30	0.00e+00	2676.00
IUUC-Gmo-038495	Gadus morhua	84.14	0.00e+00	1243.00
IUUC-Gga-040736	Gallus gallus	94.26	0.00e+00	2692.00
IUUC-Gac-041777	Gasterosteus aculeatus	87.73	0.00e+00	2282.00
IUUC-Ggo-044677	Gorilla gorilla	92.66	0.00e+00	4246.00
IUUC-Hsa-045879	Homo sapiens	97.28	0.00e+00	4536.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	97.01	0.00e+00	4531.00
IUUC-Lch-050444	Latimeria chalumnae	89.46	0.00e+00	4042.00
IUUC-Loc-051986	Lepisosteus oculatus	85.76	0.00e+00	4006.00
IUUC-Laf-054230	Loxodonta africana	96.26	0.00e+00	4427.00
IUUC-Mcc-054787	Macaca mulatta	97.28	0.00e+00	4536.00
IUUC-Meu-056502	Macropus eugenii	87.67	0.00e+00	1304.00
IUUC-Mga-059409	Meleagris gallopavo	90.12	0.00e+00	2038.00
IUUC-Mmr-061667	Microcebus murinus	96.37	0.00e+00	4486.00
IUUC-Mdo-061960	Monodelphis domestica	94.64	0.00e+00	4423.00
IUUC-Mmu-063941	Mus musculus	95.61	0.00e+00	4433.00
IUUC-Mpu-065939	Mustela putorius furo	96.93	0.00e+00	4524.00
IUUC-Mlu-068112	Myotis lucifugus	96.51	0.00e+00	4475.00
IUUC-Nle-069001	Nomascus leucogenys	97.20	0.00e+00	4533.00
IUUC-Opr-071222	Ochotona princeps	89.87	0.00e+00	1971.00
IUUC-Ont-072101	Oreochromis niloticus	89.18	0.00e+00	2363.00
IUUC-Oan-072814	Ornithorhynchus anatinus	94.98	0.00e+00	4418.00
IUUC-Ocu-074011	Oryctolagus cuniculus	97.01	0.00e+00	4524.00
IUUC-Ola-086412	Oryzias latipes	87.66	0.00e+00	2279.00
IUUC-Oar-089668	Ovis aries	97.01	0.00e+00	4533.00
IUUC-Ptr-090517	Pan troglodytes	96.63	0.00e+00	4480.00
IUUC-Psi-093390	Pelodiscus sinensis	90.97	0.00e+00	2594.00
IUUC-Pma-094628	Petromyzon marinus	83.40	0.00e+00	1582.00
IUUC-Pfo-097075	Poecilia formosa	88.45	0.00e+00	2325.00
IUUC-Pab-098176	Pongo abelii	97.28	0.00e+00	4536.00
IUUC-Pca-101123	Procavia capensis	93.05	0.00e+00	2446.00
IUUC-Pva-103008	Pteropus vampyrus	94.83	0.00e+00	1918.00
IUUC-Rno-105885	Rattus norvegicus	96.25	0.00e+00	4493.00
IUUC-Sha-107048	Sarcophilus harrisii	93.18	0.00e+00	4330.00
IUUC-Sar-113071	Sorex araneus	91.48	0.00e+00	1229.00
IUUC-Ssc-115963	Sus scrofa	96.63	0.00e+00	4507.00
IUUC-Tgu-117167	Taeniopygia guttata	92.91	0.00e+00	2581.00
IUUC-Tru-118626	Takifugu rubripes	88.81	0.00e+00	2348.00
IUUC-Tsy-119504	Tarsius syrichta	96.43	0.00e+00	2302.00
IUUC-Tni-119877	Tetraodon nigroviridis	87.98	0.00e+00	2289.00
IUUC-Tbe-127602	Tupaia belangeri	87.99	0.00e+00	867.00
IUUC-Ttr-128394	Tursiops truncatus	97.81	0.00e+00	3115.00
IUUC-Vpa-130280	Vicugna pacos	95.84	0.00e+00	4279.00
IUUC-Xtr-131787	Xenopus tropicalis	83.55	0.00e+00	2473.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence