iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020721

UUCD1 version

UUC-CaF-00611

Ensembl Protein ID

ENSCAFP00000001328.3

UniProt Accession

Q5TJF3; Q5TJF4; RING1_CANLF

Genbank Protein ID

CAI11434.1; CAI11435.1

Protein Name

E3 ubiquitin-protein ligase RING1; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1; RING1a

Genbank Nucleotide ID

AJ630366; AJ630366

Gene Name

RING1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000933.4	ENSCAFT00000001442.4	ENSCAFP00000001328.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.50e-07	30.1	48	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+ dC+  ++       s++  CP+Cr
   Q: 48   CPICLDMLKNTMTTKECLHRFCSDCIvTAL------RSGNKECPTCR 88
           **********555555**********7777......**********8 PP

Organism

Canis familiaris

Functional Description
(View)

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).

Protein Sequence
(Fasta)

MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT 60
TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH 120

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Nucleotide Sequence
(Fasta)

GGCCCCAGCG CCCGGGCCAT GGCGGCGGCG GCGGCGGGAG CTGCTGTCTG AGCAGCGGCT 60
GCGGACCGAG CGGACTGGGG CCGGGAGCCC GGGCCGGGAG AGAGGCGCTG CGGCAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0016740--F:transferase activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0048593--P:camera-type eye morphogenesis
GO:0035518--P:histone H2A monoubiquitination
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

cfa:607905

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001831	Ailuropoda melanoleuca	100.00	3.00e-99	355.00
IUUC-Aca-005261	Anolis carolinensis	59.31	1.00e-119	422.00
IUUC-Bta-012493	Bos taurus	100.00	1.00e-83	303.00
IUUC-Cja-019447	Callithrix jacchus	99.41	9.00e-99	353.00
IUUC-Cpo-022273	Cavia porcellus	99.41	9.00e-99	353.00
IUUC-Csa-023422	Chlorocebus sabaeus	99.41	9.00e-99	353.00
IUUC-Dno-028911	Dasypus novemcinctus	100.00	4.00e-99	355.00
IUUC-Dor-030457	Dipodomys ordii	82.94	3.00e-76	278.00
IUUC-Eca-033576	Equus caballus	100.00	3.00e-99	355.00
IUUC-Eeu-034880	Erinaceus europaeus	99.34	5.00e-87	314.00
IUUC-Fca-035789	Felis catus	100.00	3.00e-99	355.00
IUUC-Gmo-038890	Gadus morhua	54.83	2.00e-91	328.00
IUUC-Gma-044107	Glycine max	44.26	1.00e-23	104.00
IUUC-Ggo-045070	Gorilla gorilla	99.41	9.00e-99	353.00
IUUC-Hsa-045680	Homo sapiens	99.41	9.00e-99	353.00
IUUC-Itr-048166	Ictidomys tridecemlineatus	100.00	3.00e-99	355.00
IUUC-Laf-054431	Loxodonta africana	100.00	3.00e-99	355.00
IUUC-Mcc-055268	Macaca mulatta	99.41	9.00e-99	353.00
IUUC-Meu-056000	Macropus eugenii	92.16	8.00e-154	536.00
IUUC-Mmr-061509	Microcebus murinus	99.41	2.00e-98	352.00
IUUC-Mdo-063069	Monodelphis domestica	91.90	3.00e-147	514.00
IUUC-Mmu-063462	Mus musculus	96.55	9.00e-151	526.00
IUUC-Mac-064893	Musa acuminata	46.94	3.00e-24	106.00
IUUC-Mpu-066818	Mustela putorius furo	100.00	3.00e-99	355.00
IUUC-Mlu-067266	Myotis lucifugus	100.00	4.00e-79	288.00
IUUC-Nle-069778	Nomascus leucogenys	99.41	9.00e-99	353.00
IUUC-Opr-070456	Ochotona princeps	89.37	6.00e-56	211.00
IUUC-Oga-088881	Otolemur garnettii	100.00	3.00e-99	355.00
IUUC-Oar-089484	Ovis aries	100.00	3.00e-99	355.00
IUUC-Ptr-091151	Pan troglodytes	99.29	1.00e-80	293.00
IUUC-Pan-092254	Papio anubis	99.41	9.00e-99	353.00
IUUC-Pab-098086	Pongo abelii	98.82	3.00e-98	351.00
IUUC-Pca-100649	Procavia capensis	97.06	3.00e-92	332.00
IUUC-Pte-104165	Pyrenophora teres	39.29	6.00e-06	45.10
IUUC-Rno-105941	Rattus norvegicus	97.04	3.00e-151	527.00
IUUC-Sha-106734	Sarcophilus harrisii	91.67	2.00e-166	578.00
IUUC-Stu-112805	Solanum tuberosum	51.28	4.00e-20	92.80
IUUC-Ssc-116072	Sus scrofa	100.00	3.00e-99	355.00
IUUC-Ttr-128591	Tursiops truncatus	100.00	3.00e-83	302.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence