iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055885

UUCD1 version

UUC-MaM-01115

Ensembl Protein ID

ENSMMUP00000003128.3

UniProt Accession

G7MHB3; F7C644; G7MHB3_MACMU

Genbank Protein ID

AFE66561.1; AFH28313.1; AFI34759.1; EHH14846.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 1

Genbank Nucleotide ID

JSUE03001535; JU471509; JV044688; CM001253

Gene Name

USP1; EGK_00834

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000002339.3	ENSMMUT00000003313.3	ENSMMUP00000003128.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.30e-86	290.3	81	784

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w..... 61
           +Gl+NlgNtCY+NS+LQ+L+++p +++ +++      +kke+l++e+++++kg          el++slq+l+ ++       +     
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHlfnvisRKKEALKDEANQKDKGnckedslasyELICSLQSLIISVeqlqasfLlnpek 169
           6***********************************9999999999999999999999*****99999999999995555555144555 PP
   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde.... 129
           ++++ a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++                  e  ++k             e    
   Q: 170  YTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLlkkeevknvaelptkveEIPHQK-------------Eemsg 245
           88888*****************************************4444455555554444444444444.............14555 PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 246  insmemdsvrhsedckeklpkgngkrksdtefgnmkkkvkvskehqsleenqrqtrskrkatsdtleippkiipkcisenesprpsqkk 334
           555666666******************************************************************************** PP
   S: 130  ..........................................................................aeekkkkknk..... 139
                                                                                     +e k+ +k++     
   Q: 335  srvkinwlksatkqpsilskfcslgkittnqgakgqskeneydpeedlgkyendntthacgfespgntvtpvnvNEVKPINKGEeqigf 423
           ************************************************************************99555555555556666 PP
   S: 140  slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkk 214
           +l+++lFqgql  +++clec++ ++r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c+++
   Q: 424  ELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHY 512
           *****************************************99998******************************************* PP
   S: 215  qeaekklklkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYva 297
           +eae++l ++k+Pev+++hLk+f     +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a
   Q: 513  TEAERSLLFDKMPEVITIHLKCFaasglEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTA 596
           **********************************************************99.....678********************* PP
   S: 298  yvkn..................................................................................... 301
            vk                                                                                      
   Q: 597  SVKVtdlnsleldkgnfvvdqmceigkpeplneeeargvvenyddeevsirvggntqpskvlnkknveaigllggqkskadyelynkas 685
           ***************************************************************************************** PP
   S: 302  .........................................................ekgkWllfdDskVtevkeeevleetg...... 327
                                                                     +gkWllfdDs+V++++e+++l++ +      
   Q: 686  npdkvastafaenrnsetndtngthesdrnkessdqtgvnisgfenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstspt 774
           *********************9999999999999999999999988888888877766999*******************888****** PP
   S: 328  staYvlfYkr 337
           st+Y+lfYk+
   Q: 775  STPYLLFYKK 784
           ********97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS EYRASEIDQV 60
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNVISRKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATAATTGA TTACAACTTT CCTCTATAAA TTAATTATTG ACAACTCCTT GGGATTTGAG 60
AAAAAAATGC CTGGTGTCAT ACCTAGTGAA AGTAATGGAC TTTCAAGAGG TAGCCCATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:695157

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	94.02	0.00e+00	1430.00
IUUC-Apl-004204	Anas platyrhynchos	73.28	0.00e+00	946.00
IUUC-Aca-004637	Anolis carolinensis	65.66	0.00e+00	933.00
IUUC-Ame-011718	Astyanax mexicanus	48.79	2.00e-173	602.00
IUUC-Bta-012552	Bos taurus	92.48	0.00e+00	1417.00
IUUC-Cja-019588	Callithrix jacchus	97.20	0.00e+00	1517.00
IUUC-Cfa-020211	Canis familiaris	94.78	0.00e+00	1452.00
IUUC-Cpo-021551	Cavia porcellus	84.84	0.00e+00	1279.00
IUUC-Csa-024186	Chlorocebus sabaeus	99.24	0.00e+00	1565.00
IUUC-Cho-024739	Choloepus hoffmanni	83.19	0.00e+00	758.00
IUUC-Dre-028184	Danio rerio	50.18	2.00e-178	619.00
IUUC-Dno-029669	Dasypus novemcinctus	90.48	0.00e+00	1397.00
IUUC-Dor-030168	Dipodomys ordii	87.44	0.00e+00	1273.00
IUUC-Dme-031732	Drosophila melanogaster	28.77	5.00e-18	87.00
IUUC-Ete-032825	Echinops telfairi	87.15	0.00e+00	967.00
IUUC-Eca-033595	Equus caballus	93.82	0.00e+00	1357.00
IUUC-Eeu-034877	Erinaceus europaeus	80.50	2.00e-162	566.00
IUUC-Fca-035381	Felis catus	93.35	0.00e+00	1007.00
IUUC-Fal-037592	Ficedula albicollis	69.26	0.00e+00	966.00
IUUC-Gmo-039680	Gadus morhua	44.59	1.00e-152	533.00
IUUC-Gga-041196	Gallus gallus	72.35	0.00e+00	1061.00
IUUC-Gac-042292	Gasterosteus aculeatus	44.61	2.00e-152	532.00
IUUC-Ggo-044671	Gorilla gorilla	97.96	0.00e+00	1537.00
IUUC-Hsa-047020	Homo sapiens	97.45	0.00e+00	1528.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	85.62	0.00e+00	1278.00
IUUC-Lch-050543	Latimeria chalumnae	57.76	0.00e+00	706.00
IUUC-Loc-052338	Lepisosteus oculatus	52.61	0.00e+00	704.00
IUUC-Laf-053707	Loxodonta africana	90.87	0.00e+00	1412.00
IUUC-Meu-056573	Macropus eugenii	66.88	0.00e+00	949.00
IUUC-Mga-059346	Meleagris gallopavo	73.12	0.00e+00	1012.00
IUUC-Mmr-061612	Microcebus murinus	94.14	0.00e+00	1411.00
IUUC-Mdo-062887	Monodelphis domestica	72.56	0.00e+00	1060.00
IUUC-Mmu-064044	Mus musculus	88.42	0.00e+00	1375.00
IUUC-Mpu-066847	Mustela putorius furo	94.90	0.00e+00	1446.00
IUUC-Mlu-067684	Myotis lucifugus	91.74	0.00e+00	1427.00
IUUC-Nle-070057	Nomascus leucogenys	97.83	0.00e+00	1537.00
IUUC-Opr-070463	Ochotona princeps	84.31	0.00e+00	1263.00
IUUC-Ont-071975	Oreochromis niloticus	45.63	2.00e-151	530.00
IUUC-Oan-073062	Ornithorhynchus anatinus	85.71	9.00e-47	179.00
IUUC-Ocu-074840	Oryctolagus cuniculus	93.89	0.00e+00	1444.00
IUUC-Ola-087088	Oryzias latipes	46.63	7.00e-174	604.00
IUUC-Oga-088472	Otolemur garnettii	93.25	0.00e+00	1437.00
IUUC-Oar-089498	Ovis aries	92.74	0.00e+00	1423.00
IUUC-Ptr-091395	Pan troglodytes	97.83	0.00e+00	1533.00
IUUC-Pan-092462	Papio anubis	99.87	0.00e+00	1573.00
IUUC-Psi-093583	Pelodiscus sinensis	72.51	0.00e+00	913.00
IUUC-Pma-094644	Petromyzon marinus	36.78	2.00e-28	119.00
IUUC-Pfo-096314	Poecilia formosa	46.27	1.00e-168	587.00
IUUC-Pab-098568	Pongo abelii	98.47	0.00e+00	1543.00
IUUC-Pca-100948	Procavia capensis	81.70	0.00e+00	1241.00
IUUC-Pva-102853	Pteropus vampyrus	93.49	0.00e+00	1444.00
IUUC-Rno-105573	Rattus norvegicus	88.66	0.00e+00	1362.00
IUUC-Sha-107495	Sarcophilus harrisii	72.05	0.00e+00	892.00
IUUC-Sar-113545	Sorex araneus	77.55	0.00e+00	1107.00
IUUC-Ssc-115962	Sus scrofa	94.04	0.00e+00	1461.00
IUUC-Tgu-116731	Taeniopygia guttata	69.57	0.00e+00	981.00
IUUC-Tru-117893	Takifugu rubripes	47.20	1.00e-159	556.00
IUUC-Tsy-119644	Tarsius syrichta	84.57	0.00e+00	1256.00
IUUC-Tni-119819	Tetraodon nigroviridis	45.40	1.00e-169	590.00
IUUC-Tbe-127272	Tupaia belangeri	88.89	0.00e+00	1263.00
IUUC-Ttr-128404	Tursiops truncatus	94.01	0.00e+00	1458.00
IUUC-Vpa-130205	Vicugna pacos	93.49	0.00e+00	1448.00
IUUC-Xtr-132613	Xenopus tropicalis	56.12	0.00e+00	745.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence