iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046851

UUCD1 version

UUC-HoS-00297

Ensembl Protein ID

ENSP00000392395.2

UniProt Accession

Q96EP1; A6NEN5; B4DZ77; B4E2L6; Q96SL3; Q9NRT4; Q9NT32; Q9NVD5; CHFR_HUMAN

Genbank Protein ID

AAF91084.1; BAA91817.1; BAB55297.1; BAG63989.1; BAG65178.1; AAH12072.1; CAB70812.1

Protein Name

E3 ubiquitin-protein ligase CHFR; Checkpoint with forkhead and RING finger domains protein; RING finger protein 196; RING-type E3 ubiquitin transferase CHFR

Genbank Nucleotide ID

AF170724; AK001658; AK027687; AK302785; AK304333; AC127070; AL137561

Gene Name

CHFR; RNF196

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000072609.17	ENST00000266880.11	ENSP00000266880.8
ENSG00000072609.17	ENST00000443047.6	ENSP00000416431.2
ENSG00000072609.17	ENST00000450056.6	ENSP00000398735.2
ENSG00000072609.17	ENST00000315585.11	ENSP00000320557.8
ENSG00000072609.17	ENST00000432561.6	ENSP00000392395.2
ENSG00000072609.17	ENST00000544093.5	ENSP00000483699.1
ENSG00000072609.17	ENST00000535527.5	ENSP00000478791.1
ENSG00000072609.17	ENST00000540537.5	ENSP00000443237.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19690564; 11807090; 19321445; 20388495

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00025	23.2	304	343

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++ + d++ + pC H+f+a C   w        ++ +CP+Cr
   Q: 304  CIICQDLLHDCVSLQPCMHTFCAACYSGW------MERSSLCPTCR 343
           ********998999***************......9*********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Protein Sequence
(Fasta)

MERPEEGKQS PPPQPWGRLL RLGAEEGEPH VLLRKREWTI GRRRGCDLSF PSNKLVSGDH 60
CRIVVDEKSG QVTLEDTSTS GTVINKLKVV KKQTCPLQTG DVIYLVYRKN EPEHNVAYLY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCTGCGC GTTCACGTCC CCGATCGGGC CGTGTCCGCC GCGGCCCTGC GAGGTCCGAG 60
GGGTAAGGGA GCGTGCAGCG GGGGCGGGAC CACGAGGCGG CGGGGCTGGG GGCGGCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0013--ADP-ribosylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0000166--F:nucleotide binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0007093--P:mitotic cell cycle checkpoint
GO:0007067--P:mitotic nuclear division
GO:0019941--P:modification-dependent protein catabolic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:55743

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001235	Ailuropoda melanoleuca	83.87	0.00e+00	991.00
IUUC-Apl-003848	Anas platyrhynchos	71.94	0.00e+00	912.00
IUUC-Aca-004525	Anolis carolinensis	66.72	0.00e+00	832.00
IUUC-Aly-005401	Arabidopsis lyrata	26.94	1.00e-26	114.00
IUUC-Afl-008661	Aspergillus flavus	28.10	1.00e-09	59.30
IUUC-Ang-009542	Aspergillus niger	30.61	1.00e-09	58.90
IUUC-Aor-010000	Aspergillus oryzae	28.10	6.00e-10	60.10
IUUC-Ate-010344	Aspergillus terreus	29.13	4.00e-09	57.00
IUUC-Ame-011701	Astyanax mexicanus	94.44	1.00e-37	147.00
IUUC-Bgr-012082	Blumeria graminis	30.91	2.00e-09	58.20
IUUC-Bta-012623	Bos taurus	84.21	0.00e+00	1014.00
IUUC-Bci-013931	Botrytis cinerea	27.27	2.00e-10	62.00
IUUC-Bdi-014581	Brachypodium distachyon	25.53	3.00e-26	113.00
IUUC-Cfa-020239	Canis familiaris	84.37	0.00e+00	1050.00
IUUC-Cpo-021431	Cavia porcellus	83.76	0.00e+00	1041.00
IUUC-Csa-023886	Chlorocebus sabaeus	93.39	0.00e+00	1092.00
IUUC-Cho-025103	Choloepus hoffmanni	66.24	0.00e+00	761.00
IUUC-Cgl-026521	Colletotrichum gloeosporioides	29.57	1.00e-11	65.90
IUUC-Dno-030027	Dasypus novemcinctus	80.71	0.00e+00	919.00
IUUC-Dor-030283	Dipodomys ordii	88.66	1.00e-157	550.00
IUUC-Dse-031151	Dothistroma septosporum	33.96	1.00e-11	65.50
IUUC-Ete-032539	Echinops telfairi	72.63	0.00e+00	875.00
IUUC-Eca-033261	Equus caballus	85.09	0.00e+00	1057.00
IUUC-Eeu-034729	Erinaceus europaeus	61.95	9.00e-93	334.00
IUUC-Fca-035722	Felis catus	78.58	0.00e+00	931.00
IUUC-Fal-037014	Ficedula albicollis	71.04	0.00e+00	892.00
IUUC-Ggr-039814	Gaeumannomyces graminis	33.64	1.00e-13	72.40
IUUC-Gga-040342	Gallus gallus	62.72	7.00e-128	450.00
IUUC-Ggo-045266	Gorilla gorilla	89.60	0.00e+00	931.00
IUUC-Itr-049059	Ictidomys tridecemlineatus	86.44	0.00e+00	1048.00
IUUC-Loc-052356	Lepisosteus oculatus	60.12	0.00e+00	775.00
IUUC-Lma-053260	Leptosphaeria maculans	30.70	4.00e-10	60.50
IUUC-Laf-053663	Loxodonta africana	80.92	0.00e+00	969.00
IUUC-Mcc-054606	Macaca mulatta	90.27	0.00e+00	1107.00
IUUC-Meu-056164	Macropus eugenii	71.98	0.00e+00	808.00
IUUC-Mor-056977	Magnaporthe oryzae	28.83	1.00e-10	62.40
IUUC-Mtr-058792	Medicago truncatula	25.40	4.00e-28	119.00
IUUC-Mga-059744	Meleagris gallopavo	73.03	0.00e+00	919.00
IUUC-Mmr-061346	Microcebus murinus	87.46	0.00e+00	1052.00
IUUC-Mdo-061834	Monodelphis domestica	75.04	0.00e+00	917.00
IUUC-Mmu-063090	Mus musculus	82.98	0.00e+00	1012.00
IUUC-Mpu-066200	Mustela putorius furo	84.03	0.00e+00	951.00
IUUC-Mlu-067417	Myotis lucifugus	79.20	0.00e+00	954.00
IUUC-Nfi-068546	Neosartorya fischeri	26.05	2.00e-08	55.10
IUUC-Ncr-068857	Neurospora crassa	30.25	8.00e-12	66.60
IUUC-Nle-069154	Nomascus leucogenys	90.81	0.00e+00	1038.00
IUUC-Opr-070317	Ochotona princeps	76.29	0.00e+00	821.00
IUUC-Ont-071760	Oreochromis niloticus	70.48	6.00e-152	531.00
IUUC-Oan-073419	Ornithorhynchus anatinus	71.85	0.00e+00	882.00
IUUC-Ocu-074763	Oryctolagus cuniculus	87.93	0.00e+00	1046.00
IUUC-Obr-076345	Oryza brachyantha	26.34	3.00e-26	113.00
IUUC-Ogl-077562	Oryza glaberrima	25.23	2.00e-27	117.00
IUUC-Oin-080164	Oryza indica	34.00	6.00e-16	77.40
IUUC-Opu-083277	Oryza punctata	25.44	2.00e-25	110.00
IUUC-Osa-086171	Oryza sativa	25.23	1.00e-27	117.00
IUUC-Oga-088680	Otolemur garnettii	85.91	0.00e+00	1053.00
IUUC-Oar-089757	Ovis aries	84.41	0.00e+00	1013.00
IUUC-Ptr-090909	Pan troglodytes	98.87	0.00e+00	787.00
IUUC-Pan-092235	Papio anubis	92.56	0.00e+00	1068.00
IUUC-Psi-093106	Pelodiscus sinensis	68.74	0.00e+00	805.00
IUUC-Pab-098261	Pongo abelii	97.74	0.00e+00	1084.00
IUUC-Pca-100392	Procavia capensis	85.54	1.00e-121	430.00
IUUC-Pva-102435	Pteropus vampyrus	76.37	0.00e+00	909.00
IUUC-Pte-104339	Pyrenophora teres	32.98	2.00e-11	64.70
IUUC-Pyt-104522	Pyrenophora triticirepentis	30.97	1.00e-11	65.90
IUUC-Rno-105158	Rattus norvegicus	81.56	0.00e+00	1031.00
IUUC-Sha-106696	Sarcophilus harrisii	58.43	0.00e+00	666.00
IUUC-Ssl-108645	Sclerotinia sclerotiorum	27.27	3.00e-11	64.30
IUUC-Sar-113392	Sorex araneus	67.31	0.00e+00	697.00
IUUC-Ssc-115596	Sus scrofa	84.77	0.00e+00	986.00
IUUC-Tgu-117207	Taeniopygia guttata	71.63	0.00e+00	904.00
IUUC-Tsy-119248	Tarsius syrichta	65.17	4.00e-115	409.00
IUUC-Tvi-122458	Trichoderma virens	31.13	6.00e-09	57.00
IUUC-Tur-126062	Triticum urartu	29.58	2.00e-13	70.90
IUUC-Tme-126931	Tuber melanosporum	31.37	2.00e-09	57.80
IUUC-Ttr-128219	Tursiops truncatus	75.00	0.00e+00	877.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence