iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063978

Ensembl Protein ID

ENSMUSP00000145462.1

UniProt Accession

Q3UND0; Q8BK74; Q9Z2K4; SKAP2_MOUSE

Genbank Protein ID

AAC99297.1; BAA77253.1; BAC36111.1; BAE25817.1; AAH03711.1

Protein Name

Src kinase-associated phosphoprotein 2; Pyk2/RAFTK-associated protein; SKAP55 homolog; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains

Genbank Nucleotide ID

AF051324; AB014485; AK076000; AK144289; BC003711

Gene Name

Skap2; Prap; Ra70; Saps; Scap2; Skap55r

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000059182.7	ENSMUST00000204778.2	ENSMUSP00000145462.1
ENSMUSG00000059182.7	ENSMUST00000078214.7	ENSMUSP00000077342.6
ENSMUSG00000059182.7	ENSMUST00000203948.1	ENSMUSP00000145275.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.80e-11	43.6	301	354

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            q l+d +++ +deL++k+Gdv+++++ke +  gW++g  e +g  Gl+P+ +  +
   Q: 301  YQGLWDCTGALSDELSFKRGDVIYILSKEYNRYGWWVG--EMKGAIGLVPKAYLME 354
           57789999999***************************..9**********99765 PP

Organism

Mus musculus

Functional Description
(View)

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.

Protein Sequence
(Fasta)

MPNPSCTSSP GPLPEEIRNL LADVETFVAD TLKGENLSKK AKEKRESLIK KIKDVKSVYL 60
QEFQDKGDAE DGDEYDDPFA GPADTISLAS ERYDKDDDGP SDGNQFPPIA AQDLPFVIKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGGGGGC AGGGCCCGGC GTCCAGCGAC CGCTGGCTGG AGAGCTAGTG ACTTCCTTGT 60
TGGCAGTCTC GGACGGGCCG TGTCCGGAGT CGTAGCCTCT CGGTGCTTAC TCGGACCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0075--B-cell activation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005070--F:SH3/SH2 adaptor activity
GO:0042113--P:B cell activation
GO:0002757--P:immune response-activating signal transduction
GO:0008285--P:negative regulation of cell proliferation

KEGG

mmu:54353

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001212	Ailuropoda melanoleuca	89.14	0.00e+00	627.00
IUUC-Apl-003565	Anas platyrhynchos	70.00	2.00e-99	355.00
IUUC-Aca-005159	Anolis carolinensis	70.06	6.00e-124	436.00
IUUC-Ame-011510	Astyanax mexicanus	60.00	4.00e-106	377.00
IUUC-Bta-013222	Bos taurus	89.66	2.00e-177	615.00
IUUC-Cja-019091	Callithrix jacchus	86.11	2.00e-180	624.00
IUUC-Cfa-020492	Canis familiaris	89.14	2.00e-177	614.00
IUUC-Cpo-021974	Cavia porcellus	86.67	5.00e-165	573.00
IUUC-Csa-023195	Chlorocebus sabaeus	89.80	5.00e-125	440.00
IUUC-Cho-024462	Choloepus hoffmanni	80.83	1.00e-162	565.00
IUUC-Dre-027975	Danio rerio	47.53	2.00e-55	209.00
IUUC-Dno-029759	Dasypus novemcinctus	85.28	1.00e-174	605.00
IUUC-Dor-030116	Dipodomys ordii	79.89	3.00e-155	541.00
IUUC-Eca-034293	Equus caballus	85.79	4.00e-174	603.00
IUUC-Fca-036423	Felis catus	87.71	9.00e-177	612.00
IUUC-Fal-037146	Ficedula albicollis	65.80	3.00e-108	384.00
IUUC-Gmo-039059	Gadus morhua	56.42	2.00e-83	302.00
IUUC-Gga-040385	Gallus gallus	66.76	4.00e-111	394.00
IUUC-Gac-042122	Gasterosteus aculeatus	57.70	4.00e-95	341.00
IUUC-Ggo-044961	Gorilla gorilla	90.53	0.00e+00	628.00
IUUC-Hsa-046197	Homo sapiens	90.53	0.00e+00	630.00
IUUC-Lch-049485	Latimeria chalumnae	69.29	7.00e-107	379.00
IUUC-Loc-052335	Lepisosteus oculatus	62.18	1.00e-107	382.00
IUUC-Laf-053622	Loxodonta africana	89.47	1.00e-179	622.00
IUUC-Mcc-055725	Macaca mulatta	90.81	0.00e+00	631.00
IUUC-Meu-056098	Macropus eugenii	78.51	6.00e-153	533.00
IUUC-Mga-059932	Meleagris gallopavo	73.83	1.00e-107	382.00
IUUC-Mmr-061781	Microcebus murinus	83.57	6.00e-161	560.00
IUUC-Mdo-062502	Monodelphis domestica	74.44	7.00e-146	509.00
IUUC-Mpu-065930	Mustela putorius furo	87.74	3.00e-177	614.00
IUUC-Mlu-067603	Myotis lucifugus	86.77	1.00e-110	392.00
IUUC-Nle-069223	Nomascus leucogenys	89.69	4.00e-180	623.00
IUUC-Opr-070422	Ochotona princeps	65.92	3.00e-114	404.00
IUUC-Ont-072351	Oreochromis niloticus	57.23	1.00e-104	373.00
IUUC-Oan-073125	Ornithorhynchus anatinus	85.99	3.00e-123	434.00
IUUC-Ocu-074410	Oryctolagus cuniculus	85.52	6.00e-160	556.00
IUUC-Ola-087314	Oryzias latipes	52.57	2.00e-89	322.00
IUUC-Oga-087912	Otolemur garnettii	87.74	7.00e-176	609.00
IUUC-Oar-089480	Ovis aries	90.50	2.00e-178	618.00
IUUC-Ptr-091579	Pan troglodytes	90.53	0.00e+00	630.00
IUUC-Pan-092200	Papio anubis	83.84	3.00e-161	560.00
IUUC-Psi-093510	Pelodiscus sinensis	75.29	6.00e-103	366.00
IUUC-Pfo-096925	Poecilia formosa	56.65	9.00e-99	353.00
IUUC-Pab-097723	Pongo abelii	89.42	1.00e-179	622.00
IUUC-Pca-100318	Procavia capensis	88.33	0.00e+00	629.00
IUUC-Pva-102860	Pteropus vampyrus	86.63	3.00e-176	610.00
IUUC-Rno-105825	Rattus norvegicus	93.85	0.00e+00	633.00
IUUC-Sha-107224	Sarcophilus harrisii	77.49	4.00e-129	454.00
IUUC-Sar-112982	Sorex araneus	80.65	4.00e-141	494.00
IUUC-Ssc-115926	Sus scrofa	88.02	1.00e-178	618.00
IUUC-Tgu-116935	Taeniopygia guttata	70.31	9.00e-103	365.00
IUUC-Tru-118152	Takifugu rubripes	50.84	2.00e-90	325.00
IUUC-Tsy-119643	Tarsius syrichta	83.84	5.00e-162	563.00
IUUC-Tni-120040	Tetraodon nigroviridis	56.02	3.00e-99	355.00
IUUC-Tbe-127242	Tupaia belangeri	87.47	3.00e-151	527.00
IUUC-Ttr-128482	Tursiops truncatus	77.99	1.00e-142	498.00
IUUC-Vpa-130355	Vicugna pacos	43.84	1.00e-69	256.00
IUUC-Xtr-132597	Xenopus tropicalis	57.06	3.00e-96	345.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence