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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063706
UUCD1 version UUC-MuM-00426
Ensembl Protein ID ENSMUSP00000041049.7
UniProt Accession Q4VBE8; WDR18_MOUSE
Genbank Protein ID BAE21796.1; BAE35966.1; BAE40536.1; AAH95984.1
Protein Name WD repeat-containing protein 18
Genbank Nucleotide ID AK133716; AK160713; AK168691; BC095984
Gene Name Wdr18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035754.7 ENSMUST00000045247.7 ENSMUSP00000041049.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-14 55.0 267 306
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH + vtcl+  +d   l+sGs+D ++++WD+++  +l++
   Q: 267  GHRNQVTCLSVsTDgSVLLSGSHDESVRLWDVKSKQCLRT 306
           8**********988899****************9999875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
 May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Protein Sequence
(Fasta)
MAAPMEVVVC TDAAAQLWSC VVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQQGKN 60
YICAWELQRK DQLQQKIMCP GPVTCLTTAP NGLYVLAGIA ESIYLWEVCT GNLLVILSRH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063706|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCAGAGCAA GATGGCGGCG CCCATGGAAG TGGTGGTGTG TACTGACGCC GCGGCACAGC 60
TCTGGAGCTG CGTGGTGTGG GAGCTTCATT CGGGCGCCAA CCTGCTCACC TACCGAGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063706|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR026987--Wdr18_C_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PF14077--WD40_alt
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0007275--P:multicellular organism development
KEGG mmu:216156
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001040 Aegilops tauschii 33.74 3.00e-29 122.00
IUUC-Aml-001819 Ailuropoda melanoleuca 83.33 0.00e+00 680.00
IUUC-Atr-002688 Amborella trichopoda 35.29 3.00e-40 159.00
IUUC-Apl-004023 Anas platyrhynchos 53.18 4.00e-93 334.00
IUUC-Aca-004879 Anolis carolinensis 70.47 3.00e-52 197.00
IUUC-Aly-006061 Arabidopsis lyrata 31.21 5.00e-35 142.00
IUUC-Ath-007111 Arabidopsis thaliana 31.31 4.00e-33 135.00
IUUC-Ame-010912 Astyanax mexicanus 61.72 1.00e-156 546.00
IUUC-Bgr-012242 Blumeria graminis 25.25 2.00e-12 67.00
IUUC-Bta-013402 Bos taurus 85.88 0.00e+00 720.00
IUUC-Bci-013791 Botrytis cinerea 25.27 1.00e-12 67.40
IUUC-Bdi-015054 Brachypodium distachyon 32.29 1.00e-35 144.00
IUUC-Bol-016342 Brassica oleracea 30.36 4.00e-31 129.00
IUUC-Bra-016967 Brassica rapa 30.69 1.00e-31 130.00
IUUC-Cja-019758 Callithrix jacchus 81.73 0.00e+00 650.00
IUUC-Cfa-020495 Canis familiaris 82.09 1.00e-166 579.00
IUUC-Cpo-021438 Cavia porcellus 86.04 3.00e-168 584.00
IUUC-Csa-023416 Chlorocebus sabaeus 83.10 0.00e+00 699.00
IUUC-Csv-025918 Ciona savignyi 33.26 9.00e-61 227.00
IUUC-Cgl-026618 Colletotrichum gloeosporioides 26.53 9.00e-15 74.70
IUUC-Cne-026843 Cryptococcus neoformans 27.56 8.00e-19 88.60
IUUC-Dre-027560 Danio rerio 59.86 2.00e-152 531.00
IUUC-Dno-029315 Dasypus novemcinctus 81.63 0.00e+00 715.00
IUUC-Dor-030935 Dipodomys ordii 83.41 0.00e+00 720.00
IUUC-Dse-031492 Dothistroma septosporum 23.79 6.00e-17 82.40
IUUC-Dme-032059 Drosophila melanogaster 32.74 2.00e-56 213.00
IUUC-Fca-036068 Felis catus 78.46 0.00e+00 645.00
IUUC-Fal-037467 Ficedula albicollis 68.73 2.00e-149 521.00
IUUC-Fox-037903 Fusarium oxysporum 27.06 5.00e-17 82.00
IUUC-Gmo-039323 Gadus morhua 51.05 2.00e-112 399.00
IUUC-Ggr-040050 Gaeumannomyces graminis 26.55 4.00e-11 62.80
IUUC-Gga-040563 Gallus gallus 69.15 2.00e-142 498.00
IUUC-Gac-042641 Gasterosteus aculeatus 55.79 2.00e-139 489.00
IUUC-Gma-044265 Glycine max 31.60 6.00e-38 151.00
IUUC-Ggo-045137 Gorilla gorilla 83.33 0.00e+00 676.00
IUUC-Hsa-046335 Homo sapiens 83.33 0.00e+00 676.00
IUUC-Hvu-047685 Hordeum vulgare 33.04 1.00e-32 134.00
IUUC-Itr-048032 Ictidomys tridecemlineatus 83.56 0.00e+00 729.00
IUUC-Kpa-049129 Komagataella pastoris 29.80 1.00e-29 124.00
IUUC-Lch-049532 Latimeria chalumnae 64.10 5.00e-168 583.00
IUUC-Lpe-051321 Leersia perrieri 30.28 7.00e-28 118.00
IUUC-Loc-052471 Lepisosteus oculatus 59.82 1.00e-145 509.00
IUUC-Lma-053091 Leptosphaeria maculans 26.54 7.00e-24 105.00
IUUC-Laf-054331 Loxodonta africana 80.32 0.00e+00 657.00
IUUC-Mcc-055803 Macaca mulatta 83.10 0.00e+00 699.00
IUUC-Meu-056090 Macropus eugenii 73.38 0.00e+00 650.00
IUUC-Mor-057160 Magnaporthe oryzae 27.47 8.00e-16 78.60
IUUC-Mtr-058800 Medicago truncatula 32.52 3.00e-38 152.00
IUUC-Mla-058943 Melampsora laricipopulina 37.66 2.00e-25 110.00
IUUC-Mga-059282 Meleagris gallopavo 61.77 1.00e-130 459.00
IUUC-Mvi-060315 Microbotryum violaceum 36.26 8.00e-25 108.00
IUUC-Mmr-061127 Microcebus murinus 86.11 0.00e+00 726.00
IUUC-Mdo-062350 Monodelphis domestica 73.38 0.00e+00 649.00
IUUC-Mac-065554 Musa acuminata 30.00 3.00e-27 116.00
IUUC-Mpu-066711 Mustela putorius furo 83.56 0.00e+00 738.00
IUUC-Mlu-068121 Myotis lucifugus 81.22 1.00e-162 565.00
IUUC-Ncr-068914 Neurospora crassa 27.80 1.00e-14 74.30
IUUC-Nle-069518 Nomascus leucogenys 82.32 0.00e+00 628.00
IUUC-Ont-071435 Oreochromis niloticus 58.93 3.00e-145 508.00
IUUC-Oan-073532 Ornithorhynchus anatinus 68.93 4.00e-40 155.00
IUUC-Oba-075873 Oryza barthii 31.74 2.00e-38 153.00
IUUC-Obr-076097 Oryza brachyantha 26.51 3.00e-25 109.00
IUUC-Ogl-077840 Oryza glaberrima 31.74 1.00e-38 154.00
IUUC-Ogu-077988 Oryza glumaepatula 31.74 2.00e-38 153.00
IUUC-Oin-079237 Oryza indica 33.48 1.00e-25 110.00
IUUC-Olo-080415 Oryza longistaminata 30.55 2.00e-30 128.00
IUUC-Ome-081952 Oryza meridionalis 31.75 2.00e-37 149.00
IUUC-Oni-082300 Oryza nivara 31.74 2.00e-38 153.00
IUUC-Opu-083436 Oryza punctata 34.70 2.00e-24 107.00
IUUC-Oru-085164 Oryza rufipogon 32.05 2.00e-38 153.00
IUUC-Osa-086129 Oryza sativa 31.74 5.00e-39 155.00
IUUC-Ola-086571 Oryzias latipes 55.56 2.00e-134 472.00
IUUC-Oga-088561 Otolemur garnettii 84.95 0.00e+00 717.00
IUUC-Oar-090131 Ovis aries 74.83 5.00e-170 590.00
IUUC-Ptr-091301 Pan troglodytes 66.21 2.00e-148 518.00
IUUC-Pan-092810 Papio anubis 82.87 0.00e+00 697.00
IUUC-Psi-093091 Pelodiscus sinensis 59.78 1.00e-116 412.00
IUUC-Pno-095047 Phaeosphaeria nodorum 23.86 5.00e-17 82.80
IUUC-Ppa-095317 Physcomitrella patens 39.34 4.00e-33 135.00
IUUC-Pfo-096996 Poecilia formosa 58.00 1.00e-137 483.00
IUUC-Pab-097747 Pongo abelii 84.13 0.00e+00 678.00
IUUC-Pop-099609 Populus trichocarpa 33.53 5.00e-42 165.00
IUUC-Pca-100972 Procavia capensis 78.42 2.00e-173 601.00
IUUC-Ppe-101904 Prunus persica 33.85 3.00e-41 162.00
IUUC-Pva-102700 Pteropus vampyrus 70.92 2.00e-149 521.00
IUUC-Pgr-103616 Puccinia graminis 37.01 7.00e-23 102.00
IUUC-Ptt-103954 Puccinia triticina 36.36 1.00e-21 97.80
IUUC-Pte-104120 Pyrenophora teres 26.10 1.00e-24 107.00
IUUC-Pyt-104558 Pyrenophora triticirepentis 25.62 4.00e-25 109.00
IUUC-Rno-104933 Rattus norvegicus 95.82 0.00e+00 817.00
IUUC-Sha-107636 Sarcophilus harrisii 72.92 0.00e+00 647.00
IUUC-Sja-107783 Schizosaccharomyces japonicus 33.02 8.00e-34 138.00
IUUC-Spo-108192 Schizosaccharomyces pombe 27.13 4.00e-24 105.00
IUUC-Ssl-108384 Sclerotinia sclerotiorum 27.86 2.00e-17 83.60
IUUC-Smo-109498 Selaginella moellendorffii 35.99 4.00e-37 149.00
IUUC-Sit-110770 Setaria italica 33.44 8.00e-37 147.00
IUUC-Sly-111453 Solanum lycopersicum 32.87 2.00e-41 163.00
IUUC-Stu-112384 Solanum tuberosum 32.84 5.00e-41 162.00
IUUC-Sbi-113952 Sorghum bicolor 33.13 3.00e-35 142.00
IUUC-Sre-115223 Sporisorium reilianum 26.42 1.00e-23 105.00
IUUC-Ssc-115627 Sus scrofa 85.65 0.00e+00 721.00
IUUC-Tgu-117404 Taeniopygia guttata 68.45 3.00e-141 494.00
IUUC-Tru-117629 Takifugu rubripes 57.03 7.00e-125 440.00
IUUC-Tni-119839 Tetraodon nigroviridis 54.84 2.00e-121 429.00
IUUC-Tca-121766 Theobroma cacao 32.65 4.00e-41 162.00
IUUC-Tae-125634 Triticum aestivum 33.92 6.00e-34 138.00
IUUC-Tur-126673 Triticum urartu 31.70 4.00e-25 108.00
IUUC-Tme-127070 Tuber melanosporum 24.16 3.00e-16 80.10
IUUC-Tbe-127452 Tupaia belangeri 75.54 2.00e-93 335.00
IUUC-Ttr-128735 Tursiops truncatus 82.18 0.00e+00 672.00
IUUC-Uma-129521 Ustilago maydis 30.95 5.00e-22 99.40
IUUC-Vvi-130872 Vitis vinifera 30.49 5.00e-40 158.00
IUUC-Xtr-131838 Xenopus tropicalis 62.94 2.00e-136 478.00
IUUC-Xma-134106 Xiphophorus maculatus 64.63 5.00e-115 407.00
IUUC-Yli-134551 Yarrowia lipolytica 28.70 9.00e-21 94.70
IUUC-Zma-134703 Zea mays 32.62 2.00e-34 140.00
Created Date 25-Jun-2017

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