iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067456

Ensembl Protein ID

ENSMLUP00000005085.2

UniProt Accession

G1P523; G1P523_MYOLU

Genbank Protein ID

ENSMLUP00000005085

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02013697

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000005564.2	ENSMLUT00000005569.2	ENSMLUP00000005085.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-22	78.2	621	659
UBD/Beta-Prp	3.20e-40	138.2	489	659

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 621  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 659
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 489  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 576
           5666788889998885.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 577  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 659
           88888888999*********************************9.********************************997443 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MIMDLSKMYL QPRHPAPHQP AQPFNFTISE SCDRIKESFS FYRLISQVLN SLKLECEKLA 60
SEKTEMQRHY VMYYEMSYGL NIEMHKQAEI VKRLNAICAQ VIPFLSQEHQ QQVVQAVERA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGATGATTA TGGACCTGAG CAAGATGTAC CTGCAGCCCA GACACCCGGT GAGTGCGGGC 60
GGCGGGGGCG CAGGGCTCGC CGAGCACGGG CGTGCGGTTT CCCCCGCGTC GCCCCTCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003434	Anas platyrhynchos	88.05	0.00e+00	1127.00
IUUC-Aca-005279	Anolis carolinensis	96.65	0.00e+00	1295.00
IUUC-Bta-012646	Bos taurus	97.30	0.00e+00	1340.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	1.00e-122	433.00
IUUC-Cja-019079	Callithrix jacchus	97.17	0.00e+00	1367.00
IUUC-Cfa-020987	Canis familiaris	97.75	0.00e+00	1325.00
IUUC-Cpo-021606	Cavia porcellus	96.07	0.00e+00	1297.00
IUUC-Csa-023445	Chlorocebus sabaeus	97.55	0.00e+00	1342.00
IUUC-Cho-024590	Choloepus hoffmanni	89.04	0.00e+00	1192.00
IUUC-Csv-026174	Ciona savignyi	57.99	1.00e-162	566.00
IUUC-Dno-028979	Dasypus novemcinctus	97.31	0.00e+00	1294.00
IUUC-Dor-030533	Dipodomys ordii	92.52	0.00e+00	1150.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	665.00
IUUC-Eca-034397	Equus caballus	99.31	0.00e+00	1268.00
IUUC-Fca-036030	Felis catus	98.16	0.00e+00	1352.00
IUUC-Fal-037460	Ficedula albicollis	97.24	0.00e+00	1313.00
IUUC-Gga-040416	Gallus gallus	97.17	0.00e+00	1335.00
IUUC-Ggo-045633	Gorilla gorilla	93.83	0.00e+00	1315.00
IUUC-Hsa-046461	Homo sapiens	93.57	0.00e+00	1340.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	97.68	0.00e+00	1348.00
IUUC-Lch-049943	Latimeria chalumnae	95.37	0.00e+00	1234.00
IUUC-Loc-052835	Lepisosteus oculatus	93.84	0.00e+00	1249.00
IUUC-Laf-053425	Loxodonta africana	98.03	0.00e+00	1346.00
IUUC-Mcc-055766	Macaca mulatta	93.70	0.00e+00	1342.00
IUUC-Mmr-061317	Microcebus murinus	94.16	0.00e+00	1342.00
IUUC-Mdo-062956	Monodelphis domestica	97.04	0.00e+00	1337.00
IUUC-Mmu-063576	Mus musculus	97.30	0.00e+00	1331.00
IUUC-Mpu-066410	Mustela putorius furo	99.72	0.00e+00	1273.00
IUUC-Nle-069495	Nomascus leucogenys	97.90	0.00e+00	1316.00
IUUC-Opr-070645	Ochotona princeps	91.97	0.00e+00	1208.00
IUUC-Ont-071419	Oreochromis niloticus	85.00	0.00e+00	1160.00
IUUC-Oan-072842	Ornithorhynchus anatinus	93.98	0.00e+00	1316.00
IUUC-Ocu-074453	Oryctolagus cuniculus	96.78	0.00e+00	1326.00
IUUC-Ola-087090	Oryzias latipes	84.36	0.00e+00	1157.00
IUUC-Oga-087939	Otolemur garnettii	97.55	0.00e+00	1346.00
IUUC-Oar-090347	Ovis aries	99.44	0.00e+00	1256.00
IUUC-Ptr-091048	Pan troglodytes	97.55	0.00e+00	1342.00
IUUC-Pan-091973	Papio anubis	92.92	0.00e+00	1285.00
IUUC-Psi-093586	Pelodiscus sinensis	98.51	0.00e+00	1181.00
IUUC-Pfo-097518	Poecilia formosa	83.76	0.00e+00	1114.00
IUUC-Pab-097539	Pongo abelii	95.16	0.00e+00	1243.00
IUUC-Pca-101137	Procavia capensis	88.21	0.00e+00	1135.00
IUUC-Rno-105314	Rattus norvegicus	97.17	0.00e+00	1261.00
IUUC-Ssc-116408	Sus scrofa	97.81	0.00e+00	1374.00
IUUC-Tgu-117068	Taeniopygia guttata	96.95	0.00e+00	1320.00
IUUC-Tru-118782	Takifugu rubripes	80.93	0.00e+00	1103.00
IUUC-Tsy-118884	Tarsius syrichta	84.22	0.00e+00	1076.00
IUUC-Tni-120404	Tetraodon nigroviridis	82.48	0.00e+00	1160.00
IUUC-Vpa-130577	Vicugna pacos	87.58	0.00e+00	677.00
IUUC-Xtr-132974	Xenopus tropicalis	94.62	0.00e+00	1257.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence