iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093586

Ensembl Protein ID

ENSPSIP00000014403.1

UniProt Accession

K7G292; K7G292_PELSI

Genbank Protein ID

ENSPSIP00000014403

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01087312

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000012795.1	ENSPSIT00000014471.1	ENSPSIP00000014403.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-23	80.2	512	550
UBD/Beta-Prp	1.90e-40	138.9	380	550

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 512  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 550
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 380  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 467
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 468  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 550
           88888888999*********************************9.********************************997443 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

HQQQVVQAVE RAKQVTMAEL NAIIGQQQLQ AQHLSHGHGL PVPLTPHPSG LQPPAIPPIG 60
SSAGLLALSS ALGGQSHLPI KDEKKHHEND HQRDRDSIKS SSVSPSASFR TAEKHRNSTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCAGCAAC AAGTGGTGCA GGCTGTGGAA CGTGCCAAGC AAGTGACCAT GGCAGAACTG 60
AACGCAATCA TTGGGGTATG TGGTCTTTCC ATTTTAGCTC TAATAGTATT TGTAATTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001359	Ailuropoda melanoleuca	93.87	0.00e+00	1184.00
IUUC-Cel-018361	Caenorhabditis elegans	58.71	8.00e-122	430.00
IUUC-Cho-024590	Choloepus hoffmanni	89.64	0.00e+00	1113.00
IUUC-Csv-026174	Ciona savignyi	58.26	3.00e-163	568.00
IUUC-Dor-030533	Dipodomys ordii	91.36	0.00e+00	1070.00
IUUC-Dme-031576	Drosophila melanogaster	86.31	0.00e+00	666.00
IUUC-Eca-034397	Equus caballus	98.01	0.00e+00	1141.00
IUUC-Eeu-035237	Erinaceus europaeus	87.42	0.00e+00	1033.00
IUUC-Lch-049943	Latimeria chalumnae	96.33	0.00e+00	1127.00
IUUC-Mpu-066410	Mustela putorius furo	98.47	0.00e+00	1172.00
IUUC-Mlu-067456	Myotis lucifugus	98.47	0.00e+00	1138.00
IUUC-Opr-070645	Ochotona princeps	91.08	0.00e+00	1130.00
IUUC-Oar-090347	Ovis aries	98.17	0.00e+00	1156.00
IUUC-Pan-091973	Papio anubis	98.80	0.00e+00	1178.00
IUUC-Pab-097539	Pongo abelii	94.17	0.00e+00	1145.00
IUUC-Pca-101137	Procavia capensis	89.52	0.00e+00	1113.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence