iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091048

Ensembl Protein ID

ENSPTRP00000035973.5

UniProt Accession

H2QXD7; H2QXD7_PANTR

Genbank Protein ID

JAA38747.1

Protein Name

Transducin-like enhancer of split 4

Genbank Nucleotide ID

AACZ03067536

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000021047.5	ENSPTRT00000038921.5	ENSPTRP00000035973.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-22	78.2	617	655
UBD/Beta-Prp	2.90e-40	138.3	485	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 617  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 655
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 485  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 572
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 573  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 655
           88888888999*********************************9.********************************997443 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGAGCGTG TTGTTAGAGC TGTGCTGAGC GGGTGTTTGG GTTGTTGGCT GCTTTCTTCC 60
CCCTTTCTCA CACACTTGTA TATTATTTTG AGGTGGTGTT CGCAGAGTTT GAAAGGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

KEGG

ptr:464544

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003434	Anas platyrhynchos	88.19	0.00e+00	1129.00
IUUC-Aca-005279	Anolis carolinensis	98.97	0.00e+00	1335.00
IUUC-Bta-012646	Bos taurus	98.97	0.00e+00	1367.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	2.00e-122	432.00
IUUC-Cja-019079	Callithrix jacchus	99.61	0.00e+00	1411.00
IUUC-Cfa-020987	Canis familiaris	99.33	0.00e+00	1354.00
IUUC-Cpo-021606	Cavia porcellus	97.26	0.00e+00	1322.00
IUUC-Csa-023445	Chlorocebus sabaeus	100.00	0.00e+00	1384.00
IUUC-Cho-024590	Choloepus hoffmanni	85.70	0.00e+00	1213.00
IUUC-Csv-026174	Ciona savignyi	58.16	4.00e-163	568.00
IUUC-Dno-028979	Dasypus novemcinctus	99.59	0.00e+00	1334.00
IUUC-Dor-030533	Dipodomys ordii	93.07	0.00e+00	1159.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	666.00
IUUC-Ete-032887	Echinops telfairi	88.71	0.00e+00	1222.00
IUUC-Eca-034397	Equus caballus	99.31	0.00e+00	1273.00
IUUC-Eeu-035237	Erinaceus europaeus	86.64	0.00e+00	1157.00
IUUC-Fca-036030	Felis catus	99.47	0.00e+00	1371.00
IUUC-Fal-037460	Ficedula albicollis	99.34	0.00e+00	1348.00
IUUC-Gga-040416	Gallus gallus	99.61	0.00e+00	1377.00
IUUC-Ggo-045633	Gorilla gorilla	95.82	0.00e+00	1348.00
IUUC-Hsa-046461	Homo sapiens	95.90	0.00e+00	1382.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	99.87	0.00e+00	1379.00
IUUC-Lch-049943	Latimeria chalumnae	96.15	0.00e+00	1241.00
IUUC-Loc-052835	Lepisosteus oculatus	95.62	0.00e+00	1275.00
IUUC-Laf-053425	Loxodonta africana	99.87	0.00e+00	1378.00
IUUC-Mcc-055766	Macaca mulatta	96.02	0.00e+00	1384.00
IUUC-Mmr-061317	Microcebus murinus	96.50	0.00e+00	1385.00
IUUC-Mdo-062956	Monodelphis domestica	98.97	0.00e+00	1366.00
IUUC-Mmu-063576	Mus musculus	99.74	0.00e+00	1373.00
IUUC-Mpu-066410	Mustela putorius furo	99.72	0.00e+00	1278.00
IUUC-Mlu-067456	Myotis lucifugus	97.55	0.00e+00	1296.00
IUUC-Nle-069495	Nomascus leucogenys	100.00	0.00e+00	1351.00
IUUC-Ont-071419	Oreochromis niloticus	85.97	0.00e+00	1188.00
IUUC-Oan-072842	Ornithorhynchus anatinus	95.97	0.00e+00	1354.00
IUUC-Ocu-074453	Oryctolagus cuniculus	98.58	0.00e+00	1359.00
IUUC-Ola-087090	Oryzias latipes	85.57	0.00e+00	1195.00
IUUC-Oga-087939	Otolemur garnettii	99.74	0.00e+00	1377.00
IUUC-Oar-090347	Ovis aries	99.16	0.00e+00	1248.00
IUUC-Pan-091973	Papio anubis	95.34	0.00e+00	1328.00
IUUC-Pfo-097518	Poecilia formosa	84.85	0.00e+00	1139.00
IUUC-Pab-097539	Pongo abelii	95.69	0.00e+00	1253.00
IUUC-Pca-101137	Procavia capensis	88.47	0.00e+00	1142.00
IUUC-Pva-103037	Pteropus vampyrus	93.41	0.00e+00	1367.00
IUUC-Rno-105314	Rattus norvegicus	99.73	0.00e+00	1304.00
IUUC-Sar-113267	Sorex araneus	88.45	0.00e+00	731.00
IUUC-Ssc-116408	Sus scrofa	99.10	0.00e+00	1395.00
IUUC-Tgu-117068	Taeniopygia guttata	98.54	0.00e+00	1342.00
IUUC-Tru-118782	Takifugu rubripes	82.60	0.00e+00	1138.00
IUUC-Tsy-118884	Tarsius syrichta	86.10	0.00e+00	1086.00
IUUC-Tni-120404	Tetraodon nigroviridis	84.08	0.00e+00	1184.00
IUUC-Tbe-128013	Tupaia belangeri	91.74	0.00e+00	1275.00
IUUC-Vpa-130577	Vicugna pacos	90.81	0.00e+00	717.00
IUUC-Xtr-132974	Xenopus tropicalis	96.53	0.00e+00	1290.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence