iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121436

Ensembl Protein ID

EOY34573

UniProt Accession

A0A061H0D1; A0A061H0D1_THECC

Genbank Protein ID

EOY34573.1; EOY34574.1

Protein Name

Ubiquitin activating enzyme 2, 2 isoform 1

Genbank Nucleotide ID

CM001887; CM001887

Gene Name

TCM_042198

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_042198	EOY34573	EOY34573

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	4.80e-170	567.2	499	986

Active Site

Position(s)	Description	Evidence
680	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahees 96
           YD Qi ++G++ qekl+ akv++vG g+lGcE+lKn++l+Gv     g++t++D+d +e+snl+rqFLfr++++ + K+ vaa a++ +np  n+ea +++
   Q: 499  YDAQISVFGSKLQEKLEDAKVFIVGSGALGCEFLKNIALMGVscgeqGKLTITDDDVIEKSNLSRQFLFRDWNIRQAKSTVAASAAASINPRLNIEALQNR 599
           ***************************************************************************************************** PP
   S: 97   iteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.... 190
           + +++e+++   F ++++vVv+aldn+ ar++v+++cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+++wa    
   Q: 600  VGPETENVFddtFWENLTVVVNALDNVNARLYVDQRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWArsef 700
           *******99******************************************************************************************** PP
   S: 191  ........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv......... 274
                   + +n +l+   + ++ + +   ++ ++ +++v + l++e+ e+f+++i++a+  f+ ++ n +kql+  f+ d  t+ ++pfw+         
   Q: 701  egllektpAEVNAFLSSPVEYKTAQRNAGDAQARDNLERVLECLEKEKCETFQDCITWARLRFEDYFVNRVKQLIYTFPEDAATSTGAPFWSapkrfprpl 801
           ******9989999999999999999999999********************************************************************** PP
   S: 275  ................................................sfcsnaealqvpekvekdeevvkasap....lylllralerfekkkgrkpgel 323
                                                            f+++++a+ v +  +    + +++++      ++++ l   +  +g k++ +
   Q: 802  qfsaadpshlqfvmaasilraetfgipipdfvkhpkmlaeavekvivpDFEPLKDAKIVTDEKATTLSTASVDDAavinELIFKLELCMENLPQGFKMKPI 902
           ********************************99999999999999998888888887776666666666666667844344444444455569999**** PP
   S: 324  sfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           +fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++K+++g  k e ++n+f ++a+
   Q: 903  QFEKDDDTnyHMDFIAGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKALDGghKLEDYRNTFANLAL 986
           ******************************.*************************************************99875 PP

Organism

Theobroma cacao

Protein Sequence
(Fasta)

MLPRKRAADD GEVVIETDTE TTTTNNNNNN NNNAAASSFK KHRLDNCIIA ADAATESTAK 60
NGDNGARIGG NSDQTNSRVV ESSPSIMALG DANHTEIDED LHSRQLAVYG RETMRRLFAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACACTTATA GAGTAATATA TTTTTCAAAT ACTCTTTTTC TTCTGTTTCC TTATTTTGTT 60
AGGGGTAAGC CGAGGTAAAT GTGCCAGTAA TAAAAGCTGA ATTTTCGCTT TTTACCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	79.88	0.00e+00	1662.00
IUUC-Atr-002684	Amborella trichopoda	81.10	0.00e+00	1683.00
IUUC-Apl-004158	Anas platyrhynchos	39.03	0.00e+00	669.00
IUUC-Aca-004620	Anolis carolinensis	43.77	0.00e+00	848.00
IUUC-Aly-005418	Arabidopsis lyrata	84.56	0.00e+00	1798.00
IUUC-Ath-006992	Arabidopsis thaliana	83.97	0.00e+00	1751.00
IUUC-Ago-007873	Ashbya gossypii	45.98	0.00e+00	832.00
IUUC-Bta-012767	Bos taurus	45.89	0.00e+00	882.00
IUUC-Bdi-014843	Brachypodium distachyon	78.77	0.00e+00	1618.00
IUUC-Bol-015880	Brassica oleracea	84.37	0.00e+00	1797.00
IUUC-Bra-017252	Brassica rapa	84.76	0.00e+00	1799.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	59.48	0.00e+00	1152.00
IUUC-Cho-024682	Choloepus hoffmanni	35.14	5.00e-101	361.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	46.87	0.00e+00	874.00
IUUC-Eeu-035323	Erinaceus europaeus	38.87	2.00e-148	519.00
IUUC-Fal-036848	Ficedula albicollis	39.33	0.00e+00	682.00
IUUC-Gmo-039338	Gadus morhua	43.43	0.00e+00	813.00
IUUC-Gga-040747	Gallus gallus	39.19	0.00e+00	667.00
IUUC-Gma-043198	Glycine max	84.22	0.00e+00	1833.00
IUUC-Hvu-047418	Hordeum vulgare	80.40	0.00e+00	1641.00
IUUC-Laf-053948	Loxodonta africana	45.83	0.00e+00	861.00
IUUC-Mtr-058572	Medicago truncatula	86.46	0.00e+00	1776.00
IUUC-Mga-059721	Meleagris gallopavo	39.64	0.00e+00	655.00
IUUC-Mac-065505	Musa acuminata	80.86	0.00e+00	1667.00
IUUC-Oan-073268	Ornithorhynchus anatinus	39.24	3.00e-180	625.00
IUUC-Oba-075120	Oryza barthii	80.12	0.00e+00	1630.00
IUUC-Obr-076557	Oryza brachyantha	81.75	0.00e+00	1651.00
IUUC-Ogl-077887	Oryza glaberrima	80.12	0.00e+00	1632.00
IUUC-Oin-079370	Oryza indica	77.94	0.00e+00	1615.00
IUUC-Ome-081942	Oryza meridionalis	80.41	0.00e+00	1640.00
IUUC-Oni-082365	Oryza nivara	80.51	0.00e+00	1641.00
IUUC-Opu-083301	Oryza punctata	80.16	0.00e+00	1635.00
IUUC-Osa-085949	Oryza sativa	80.12	0.00e+00	1660.00
IUUC-Olu-087687	Ostreococcus lucimarinus	58.19	0.00e+00	1103.00
IUUC-Oar-090068	Ovis aries	45.50	0.00e+00	873.00
IUUC-Ptr-090609	Pan troglodytes	38.61	0.00e+00	667.00
IUUC-Psi-093489	Pelodiscus sinensis	38.59	0.00e+00	671.00
IUUC-Pma-094214	Petromyzon marinus	46.78	9.00e-34	135.00
IUUC-Ppa-095227	Physcomitrella patens	71.74	0.00e+00	1500.00
IUUC-Pop-098934	Populus trichocarpa	84.19	0.00e+00	1823.00
IUUC-Ppe-102012	Prunus persica	85.56	0.00e+00	1816.00
IUUC-Pva-102584	Pteropus vampyrus	45.50	0.00e+00	899.00
IUUC-Smo-109211	Selaginella moellendorffii	73.27	0.00e+00	1522.00
IUUC-Sit-110281	Setaria italica	82.02	0.00e+00	1674.00
IUUC-Sly-110914	Solanum lycopersicum	79.42	0.00e+00	1758.00
IUUC-Stu-112001	Solanum tuberosum	79.80	0.00e+00	1737.00
IUUC-Sbi-114089	Sorghum bicolor	80.84	0.00e+00	1661.00
IUUC-Tgu-116565	Taeniopygia guttata	39.10	0.00e+00	676.00
IUUC-Tsy-119436	Tarsius syrichta	34.03	1.00e-158	553.00
IUUC-Tre-122009	Trichoderma reesei	48.35	0.00e+00	823.00
IUUC-Tae-125113	Triticum aestivum	80.57	0.00e+00	1607.00
IUUC-Tur-126330	Triticum urartu	79.78	0.00e+00	1664.00
IUUC-Tbe-127714	Tupaia belangeri	36.13	1.00e-136	480.00
IUUC-Vvi-130857	Vitis vinifera	85.51	0.00e+00	1859.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence