iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000005901.1	ENSLACT00000006706.1	ENSLACP00000006652.1
ENSLACG00000005901.1	ENSLACT00000006707.1	ENSLACP00000006653.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.70e-42	144.2	77	266

Active Site

Position(s)	Description	Evidence
84	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
87	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
260		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
            i+ t+gDGnC++rA++++                                                          ll  f+d+  sd
   Q: 77   SIRRTRGDGNCFYRALAFAhleslignnveikkfkdvviqsrnelvsagfedrafqntfirfqgvidlveaensivsLLSAFNDQDCSD 165
           5899*************************************************************************9999999988** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts++lq+++dff++fie+++++k+fc ++vep+a  +++i+i+a++q+L+++++v++vd+ ++     ++ ++fpe + +
   Q: 166  HIVQYLRLLTSAFLQNRKDFFHHFIEGGMNIKDFCAQEVEPMAMeCDHIQIVAISQALEVSVQVEYVDEADT----EVNNHIFPEGA-R 249
           **********************************************************************95....8899*******.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HYd+L+a
   Q: 250  PSVYLLYKTAHYDILYA 266
           ***************97 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

LNTLKSSSDE GNAAPLELPD APYFSIIRKQ WKKKENNVIC ASLVSDKCDI SVLVDGYPED 60
GIYKRKLQKD LQKKYISIRR TRGDGNCFYR ALAFAHLESL IGNNVEIKKF KDVVIQSRNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCAGTA CTCGGTTCTC GGAGGGGCTC TCAGAAACGT TGAGAAAGTG AAACTAAAGC 60
ATGCCAGGGG AAGTCGCCCG ACGCAAGAGA TCTGTGTCAC TGCGCTAGAG TTTGGGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	60.44	3.00e-83	300.00
IUUC-Bta-012766	Bos taurus	61.78	2.00e-83	301.00
IUUC-Cja-019480	Callithrix jacchus	60.53	2.00e-84	304.00
IUUC-Cfa-021106	Canis familiaris	60.89	4.00e-83	300.00
IUUC-Cpo-022187	Cavia porcellus	61.33	2.00e-83	301.00
IUUC-Csa-023493	Chlorocebus sabaeus	60.89	2.00e-83	301.00
IUUC-Cho-024411	Choloepus hoffmanni	47.76	4.00e-48	183.00
IUUC-Dno-029346	Dasypus novemcinctus	61.33	1.00e-83	302.00
IUUC-Dor-031012	Dipodomys ordii	60.44	1.00e-82	299.00
IUUC-Ete-032266	Echinops telfairi	57.14	5.00e-77	280.00
IUUC-Eca-033356	Equus caballus	61.33	5.00e-83	300.00
IUUC-Eeu-034775	Erinaceus europaeus	61.33	3.00e-83	300.00
IUUC-Fca-035363	Felis catus	60.27	8.00e-82	296.00
IUUC-Ggo-045023	Gorilla gorilla	60.89	2.00e-83	301.00
IUUC-Hsa-046984	Homo sapiens	60.89	2.00e-83	301.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	61.78	7.00e-84	303.00
IUUC-Loc-052003	Lepisosteus oculatus	51.12	8.00e-63	233.00
IUUC-Laf-054382	Loxodonta africana	62.22	6.00e-85	306.00
IUUC-Mcc-055516	Macaca mulatta	60.89	3.00e-83	301.00
IUUC-Meu-056038	Macropus eugenii	60.32	2.00e-68	251.00
IUUC-Mmr-060918	Microcebus murinus	61.33	2.00e-83	301.00
IUUC-Mdo-062638	Monodelphis domestica	58.67	1.00e-79	288.00
IUUC-Mmu-063973	Mus musculus	56.08	7.00e-84	303.00
IUUC-Mpu-066013	Mustela putorius furo	60.44	7.00e-83	299.00
IUUC-Mlu-067509	Myotis lucifugus	61.16	7.00e-82	296.00
IUUC-Nle-069673	Nomascus leucogenys	60.89	2.00e-83	301.00
IUUC-Opr-070761	Ochotona princeps	49.07	6.00e-43	166.00
IUUC-Oan-072922	Ornithorhynchus anatinus	57.78	6.00e-81	293.00
IUUC-Ocu-074643	Oryctolagus cuniculus	60.89	5.00e-83	300.00
IUUC-Oga-088936	Otolemur garnettii	61.78	1.00e-83	302.00
IUUC-Oar-089460	Ovis aries	61.78	3.00e-83	301.00
IUUC-Ptr-090805	Pan troglodytes	61.33	1.00e-83	301.00
IUUC-Pan-091969	Papio anubis	60.89	2.00e-83	301.00
IUUC-Pab-098476	Pongo abelii	60.44	7.00e-83	299.00
IUUC-Pca-100252	Procavia capensis	52.13	3.00e-27	114.00
IUUC-Pva-102204	Pteropus vampyrus	60.00	3.00e-82	297.00
IUUC-Pgr-103552	Puccinia graminis	42.31	7.10e-02	29.60
IUUC-Rno-105062	Rattus norvegicus	61.23	4.00e-84	303.00
IUUC-Sha-106968	Sarcophilus harrisii	58.67	1.00e-79	289.00
IUUC-Sar-113295	Sorex araneus	61.33	3.00e-82	297.00
IUUC-Ssc-115288	Sus scrofa	61.33	2.00e-83	301.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.56	2.00e-41	162.00
IUUC-Uma-129443	Ustilago maydis	34.48	1.00e-21	97.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence