iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020897

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03003439

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000012100.3	ENSCAFT00000019218.3	ENSCAFP00000017824.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.40e-07	31.4	377	416

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 377  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 416
           99********.******************....5.555555****8 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MAGNVKKSSG AGGGGGSGGS GGLIGLMKDA FQPHHHHHHL SPHPPGTDKK MVEKCWKLMD 60
KVVRLCQNPK LALKNSPPYI LDLLPDTYQH LRTILSRYEG KMETLGENEY FRVFMENLMK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGGCA ACGTGAAGAA GAGCTCCGGG GCCGGGGGCG GCGGCGGCTC CGGGGGCTCG 60
GGCGGCCTCA TCGGGCTCAT GAAGGACGCC TTCCAGCCGC ACCACCACCA CCACCACCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	94.71	0.00e+00	1508.00
IUUC-Apl-004041	Anas platyrhynchos	84.62	0.00e+00	1362.00
IUUC-Aca-004899	Anolis carolinensis	81.37	0.00e+00	1239.00
IUUC-Ame-010746	Astyanax mexicanus	59.76	0.00e+00	631.00
IUUC-Bta-012759	Bos taurus	92.91	0.00e+00	1533.00
IUUC-Cja-019207	Callithrix jacchus	91.75	0.00e+00	1535.00
IUUC-Cpo-021453	Cavia porcellus	90.89	0.00e+00	1493.00
IUUC-Csa-023136	Chlorocebus sabaeus	92.06	0.00e+00	1532.00
IUUC-Cho-024282	Choloepus hoffmanni	84.53	0.00e+00	1212.00
IUUC-Cin-025574	Ciona intestinalis	71.65	2.00e-176	612.00
IUUC-Csv-025938	Ciona savignyi	69.97	7.00e-172	596.00
IUUC-Dre-027644	Danio rerio	69.32	0.00e+00	1041.00
IUUC-Dno-030025	Dasypus novemcinctus	92.88	0.00e+00	1471.00
IUUC-Dme-032213	Drosophila melanogaster	75.26	0.00e+00	644.00
IUUC-Ete-033118	Echinops telfairi	79.32	0.00e+00	797.00
IUUC-Eca-033900	Equus caballus	94.62	0.00e+00	1506.00
IUUC-Eeu-035142	Erinaceus europaeus	86.62	0.00e+00	936.00
IUUC-Fca-035455	Felis catus	93.76	0.00e+00	1543.00
IUUC-Fal-037182	Ficedula albicollis	95.21	0.00e+00	906.00
IUUC-Gmo-038698	Gadus morhua	85.91	0.00e+00	843.00
IUUC-Gga-040438	Gallus gallus	84.64	0.00e+00	1397.00
IUUC-Gac-042166	Gasterosteus aculeatus	71.43	0.00e+00	878.00
IUUC-Ggo-045618	Gorilla gorilla	92.27	0.00e+00	1545.00
IUUC-Hsa-046177	Homo sapiens	91.94	0.00e+00	1532.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	95.19	0.00e+00	976.00
IUUC-Lch-050095	Latimeria chalumnae	80.79	0.00e+00	976.00
IUUC-Loc-052570	Lepisosteus oculatus	71.21	0.00e+00	1091.00
IUUC-Laf-054008	Loxodonta africana	90.00	0.00e+00	1493.00
IUUC-Mcc-054676	Macaca mulatta	91.95	0.00e+00	1528.00
IUUC-Mga-059239	Meleagris gallopavo	83.93	0.00e+00	1395.00
IUUC-Mmr-060907	Microcebus murinus	90.75	0.00e+00	1481.00
IUUC-Mdo-062595	Monodelphis domestica	88.89	0.00e+00	1398.00
IUUC-Mmu-063725	Mus musculus	91.18	0.00e+00	1551.00
IUUC-Mpu-066771	Mustela putorius furo	93.56	0.00e+00	1543.00
IUUC-Mlu-067206	Myotis lucifugus	77.26	0.00e+00	1091.00
IUUC-Nle-069285	Nomascus leucogenys	89.76	0.00e+00	1441.00
IUUC-Opr-071026	Ochotona princeps	90.64	0.00e+00	1444.00
IUUC-Ont-071954	Oreochromis niloticus	68.25	0.00e+00	1025.00
IUUC-Ocu-074657	Oryctolagus cuniculus	92.12	0.00e+00	1439.00
IUUC-Ola-087165	Oryzias latipes	65.94	0.00e+00	1045.00
IUUC-Oga-088198	Otolemur garnettii	81.39	0.00e+00	1316.00
IUUC-Oar-090258	Ovis aries	92.84	0.00e+00	1469.00
IUUC-Ptr-090710	Pan troglodytes	91.94	0.00e+00	1532.00
IUUC-Pan-092785	Papio anubis	91.95	0.00e+00	1528.00
IUUC-Pfo-096990	Poecilia formosa	88.74	0.00e+00	818.00
IUUC-Pab-098526	Pongo abelii	92.69	0.00e+00	1536.00
IUUC-Pca-100984	Procavia capensis	75.60	9.00e-160	557.00
IUUC-Pva-102352	Pteropus vampyrus	96.44	0.00e+00	887.00
IUUC-Rno-105876	Rattus norvegicus	89.55	0.00e+00	1513.00
IUUC-Sha-107588	Sarcophilus harrisii	86.86	0.00e+00	1214.00
IUUC-Sar-112959	Sorex araneus	88.24	0.00e+00	1415.00
IUUC-Ssc-115261	Sus scrofa	93.02	0.00e+00	1524.00
IUUC-Tgu-116580	Taeniopygia guttata	81.53	0.00e+00	1329.00
IUUC-Tru-118731	Takifugu rubripes	67.14	0.00e+00	1027.00
IUUC-Tsy-118982	Tarsius syrichta	83.31	0.00e+00	1017.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.34	0.00e+00	1041.00
IUUC-Tbe-128018	Tupaia belangeri	94.14	0.00e+00	1121.00
IUUC-Ttr-128927	Tursiops truncatus	93.48	0.00e+00	1558.00
IUUC-Vpa-130369	Vicugna pacos	93.05	0.00e+00	1414.00
IUUC-Xtr-132474	Xenopus tropicalis	73.60	0.00e+00	1145.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence