iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-021056

Ensembl Protein ID

ENSCAFP00000011788.3

UniProt Accession

E2R5S6; E2R5S6_CANLF

Genbank Protein ID

ENSCAFP00000011788

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03014320

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000007963.3	ENSCAFT00000012727.3	ENSCAFP00000011788.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.50e-14	51.6	56	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + v +lydy+++nd +L++ kG++++++   ++ ++W+ + +  +g++G +P+nFv+++e
   Q: 56   RFVVALYDYSSVNDRDLQMLKGEKLQIL---KEAGDWWWARSLITGREGYVPSNFVTRVE 112
           6789************************...88899**********************97 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGVGSSKKQV KEKEKGQWSP VKVSTQSKDP PPLPPLILFN HLTPAPPDAC LDQEERFVVA 60
LYDYSSVNDR DLQMLKGEKL QILKEAGDWW WARSLITGRE GYVPSNFVTR VETLEVEKWF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGTGGCAG AGGGTCATTG GAACAGTGGC CCAGGGCTTG AGAAAGACCA GCTGCTTATG 60
GTCCTTCCTC ACAGGTTTTT CTGGGTCAGC GGTGCCCACT GGACCCAGCA AACCCACAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

cfa:486080

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	96.00	0.00e+00	959.00
IUUC-Apl-003307	Anas platyrhynchos	75.67	0.00e+00	738.00
IUUC-Aca-004357	Anolis carolinensis	69.53	0.00e+00	670.00
IUUC-Ame-010642	Astyanax mexicanus	69.78	0.00e+00	682.00
IUUC-Bta-012400	Bos taurus	90.62	0.00e+00	917.00
IUUC-Cja-019717	Callithrix jacchus	84.58	0.00e+00	694.00
IUUC-Cpo-021779	Cavia porcellus	86.00	0.00e+00	871.00
IUUC-Csa-023557	Chlorocebus sabaeus	90.10	0.00e+00	912.00
IUUC-Dre-027517	Danio rerio	71.11	0.00e+00	692.00
IUUC-Eca-034218	Equus caballus	92.34	0.00e+00	916.00
IUUC-Eeu-035095	Erinaceus europaeus	69.40	0.00e+00	678.00
IUUC-Fca-036015	Felis catus	93.60	0.00e+00	953.00
IUUC-Fal-036946	Ficedula albicollis	75.96	0.00e+00	733.00
IUUC-Gga-040822	Gallus gallus	74.19	0.00e+00	744.00
IUUC-Ggo-044608	Gorilla gorilla	91.08	0.00e+00	827.00
IUUC-Hsa-046719	Homo sapiens	89.48	0.00e+00	907.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	88.80	0.00e+00	897.00
IUUC-Lch-050114	Latimeria chalumnae	73.36	0.00e+00	702.00
IUUC-Loc-052326	Lepisosteus oculatus	71.58	0.00e+00	707.00
IUUC-Laf-053387	Loxodonta africana	89.00	0.00e+00	912.00
IUUC-Mcc-055026	Macaca mulatta	89.90	0.00e+00	912.00
IUUC-Mga-059427	Meleagris gallopavo	75.28	0.00e+00	730.00
IUUC-Mmr-061660	Microcebus murinus	88.00	0.00e+00	898.00
IUUC-Mdo-062318	Monodelphis domestica	77.14	0.00e+00	798.00
IUUC-Mmu-063325	Mus musculus	87.20	0.00e+00	900.00
IUUC-Mpu-066582	Mustela putorius furo	95.60	0.00e+00	955.00
IUUC-Nle-069624	Nomascus leucogenys	89.88	0.00e+00	890.00
IUUC-Opr-070656	Ochotona princeps	83.00	0.00e+00	812.00
IUUC-Ont-072266	Oreochromis niloticus	69.38	0.00e+00	676.00
IUUC-Ocu-073907	Oryctolagus cuniculus	86.80	0.00e+00	875.00
IUUC-Oga-088057	Otolemur garnettii	88.22	0.00e+00	905.00
IUUC-Oar-089332	Ovis aries	85.63	0.00e+00	871.00
IUUC-Ptr-091551	Pan troglodytes	88.41	0.00e+00	865.00
IUUC-Pan-092173	Papio anubis	89.28	0.00e+00	895.00
IUUC-Psi-093895	Pelodiscus sinensis	74.46	0.00e+00	741.00
IUUC-Pfo-096608	Poecilia formosa	69.27	0.00e+00	679.00
IUUC-Pab-097598	Pongo abelii	89.07	0.00e+00	874.00
IUUC-Pva-102135	Pteropus vampyrus	93.32	0.00e+00	916.00
IUUC-Rno-104891	Rattus norvegicus	87.40	0.00e+00	887.00
IUUC-Sha-107192	Sarcophilus harrisii	77.93	0.00e+00	812.00
IUUC-Ssc-115696	Sus scrofa	91.42	0.00e+00	936.00
IUUC-Tgu-117056	Taeniopygia guttata	75.00	0.00e+00	726.00
IUUC-Tru-117621	Takifugu rubripes	68.82	0.00e+00	649.00
IUUC-Tbe-127520	Tupaia belangeri	90.77	0.00e+00	695.00
IUUC-Ttr-128457	Tursiops truncatus	91.22	0.00e+00	934.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence