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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063791
UUCD1 version UUC-MuM-01040
Ensembl Protein ID ENSMUSP00000118751.1
UniProt Accession Q810B6; B1ATS3; O54807; Q80TG6; Q80UH8; ANFY1_MOUSE
Genbank Protein ID BAA24980.2; BAC67211.1; BAC67389.1; BAC67388.1; CAI25188.1; CAI25188.1; CAI25205.1; CAI25205.1; AAI39232.1; BAC65761.1
Protein Name Rabankyrin-5; Ankyrin repeat and FYVE domain-containing protein 1; Ankyrin repeats hooked to a zinc finger motif
Genbank Nucleotide ID AB011370; AB098329; AB098157; AB098157; AL663082; AL808023; AL808023; AL663082; BC139231; AK122479
Gene Name Ankfy1; Ankhzn; Kiaa1255
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020790.14 ENSMUST00000155998.1 ENSMUSP00000118751.1
ENSMUSG00000020790.14 ENSMUST00000127610.7 ENSMUSP00000118252.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.60e-06 28.8 68 127
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D  ++vg+++++ahk vLaa+S+  +   l+      s+++++++d  pev  ++l+ +Yt++l+
   Q: 68   SDLKIKVGDRHISAHKFVLAARSDSWSLANLS------STEEIDLSDANPEVTMTMLRWIYTDELE 127
           5889*******************987655443......366889*******************997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP.
 Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP.
Protein Sequence
(Fasta)
MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCTLLAAQ ANKENSNESF ISRLLAIVAG 60
LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS TEEIDLSDAN PEVTMTMLRW 120
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Protein Fasta Sequence


>IUUC-Mmu-063791|E3,BTB_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
AGGCAGGGCC GGGCCCGACA TGGCGGAAGG TAGGTTTTTT GTGGGGTGGC ACGGGAAGAC 60
GCGAAGCAAT AGGGGTACCA CTGGCCGGGC ACAGAAGCCC CTGGAAGGGT TGTCCGGCTG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063791|E3,BTB_Other|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB
PS50178--ZF_FYVE
Pfam

PF00023--Ank
PF12796--Ank_2
PF00651--BTB
PF01363--FYVE
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00225--BTB
SM00064--FYVE
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005765--C:lysosomal membrane
GO:0044354--C:macropinosome
GO:0016020--C:membrane
GO:0030904--C:retromer complex
GO:0046872--F:metal ion binding
GO:1901981--F:phosphatidylinositol phosphate binding
GO:0017137--F:Rab GTPase binding
GO:0006897--P:endocytosis
GO:0034058--P:endosomal vesicle fusion
GO:0032439--P:endosome localization
GO:0090160--P:Golgi to lysosome transport
GO:0048549--P:positive regulation of pinocytosis
GO:0042147--P:retrograde transport, endosome to Golgi
KEGG mmu:11736
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001682 Ailuropoda melanoleuca 93.66 0.00e+00 2141.00
IUUC-Apl-003732 Anas platyrhynchos 90.23 0.00e+00 2106.00
IUUC-Aca-004355 Anolis carolinensis 86.92 0.00e+00 1972.00
IUUC-Ame-010634 Astyanax mexicanus 70.83 0.00e+00 1544.00
IUUC-Cel-018263 Caenorhabditis elegans 30.10 3.00e-120 426.00
IUUC-Cja-019470 Callithrix jacchus 94.54 0.00e+00 2130.00
IUUC-Cfa-020532 Canis familiaris 94.17 0.00e+00 2142.00
IUUC-Cpo-021895 Cavia porcellus 94.60 0.00e+00 2064.00
IUUC-Csa-023282 Chlorocebus sabaeus 95.38 0.00e+00 2208.00
IUUC-Dme-031775 Drosophila melanogaster 26.74 3.00e-39 157.00
IUUC-Ete-032462 Echinops telfairi 93.02 0.00e+00 895.00
IUUC-Eca-033586 Equus caballus 94.87 0.00e+00 2157.00
IUUC-Eeu-034587 Erinaceus europaeus 89.35 0.00e+00 977.00
IUUC-Fca-036266 Felis catus 92.22 0.00e+00 2065.00
IUUC-Fal-037151 Ficedula albicollis 89.62 0.00e+00 2100.00
IUUC-Gga-041225 Gallus gallus 90.82 0.00e+00 2121.00
IUUC-Ggo-045343 Gorilla gorilla 95.28 0.00e+00 2043.00
IUUC-Loc-052515 Lepisosteus oculatus 31.23 2.00e-33 137.00
IUUC-Laf-053959 Loxodonta africana 84.98 0.00e+00 1815.00
IUUC-Mcc-055564 Macaca mulatta 95.11 0.00e+00 2194.00
IUUC-Mga-059747 Meleagris gallopavo 90.57 0.00e+00 2115.00
IUUC-Mmr-061103 Microcebus murinus 96.49 0.00e+00 2191.00
IUUC-Mpu-066395 Mustela putorius furo 92.21 0.00e+00 2093.00
IUUC-Mlu-067251 Myotis lucifugus 94.26 0.00e+00 2170.00
IUUC-Nfi-068574 Neosartorya fischeri 26.69 6.00e-11 62.80
IUUC-Nle-069993 Nomascus leucogenys 95.04 0.00e+00 2201.00
IUUC-Opr-071215 Ochotona princeps 90.59 0.00e+00 1264.00
IUUC-Ont-071407 Oreochromis niloticus 83.59 0.00e+00 1924.00
IUUC-Oan-072736 Ornithorhynchus anatinus 50.86 7.00e-86 310.00
IUUC-Oga-088772 Otolemur garnettii 96.05 0.00e+00 2111.00
IUUC-Oar-089385 Ovis aries 24.17 8.00e-30 126.00
IUUC-Ptr-091429 Pan troglodytes 94.87 0.00e+00 2163.00
IUUC-Pan-092110 Papio anubis 95.03 0.00e+00 2191.00
IUUC-Psi-093787 Pelodiscus sinensis 91.27 0.00e+00 2135.00
IUUC-Pma-094245 Petromyzon marinus 70.54 0.00e+00 1652.00
IUUC-Pab-097869 Pongo abelii 95.04 0.00e+00 2153.00
IUUC-Pca-100672 Procavia capensis 23.35 2.00e-28 121.00
IUUC-Pva-103200 Pteropus vampyrus 94.02 0.00e+00 2110.00
IUUC-Rno-105261 Rattus norvegicus 98.20 0.00e+00 2268.00
IUUC-Sha-106932 Sarcophilus harrisii 29.02 4.00e-31 129.00
IUUC-Ssc-115682 Sus scrofa 94.65 0.00e+00 1970.00
IUUC-Tgu-117165 Taeniopygia guttata 90.31 0.00e+00 2115.00
IUUC-Tsy-119348 Tarsius syrichta 84.40 0.00e+00 1878.00
IUUC-Vpa-130622 Vicugna pacos 93.83 0.00e+00 902.00
Created Date 25-Jun-2017

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