iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053451

UUCD1 version

UUC-LoA-00085

Ensembl Protein ID

ENSLAFP00000002210.3

UniProt Accession

G3SQV9; G3SQV9_LOXAF

Protein Name

Uncharacterized protein

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000002644.3	ENSLAFT00000002644.3	ENSLAFP00000002210.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-31	107.8	407	440
E3 activity/RING/U-box	1.80e-15	57.1	3	64
UBD/Beta-Prp	1.20e-53	182.5	249	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 407  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 440
           8**********976699**************986 PP

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +P+++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPINNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
            d++ ++tg++d+ + v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+ v+ ls++++gd+
   Q: 249  ADTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 337
           58899************************************************************************************ PP
   S: 109  lvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelv 196
           l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l+
   Q: 338  LLSSSDDQYWAFSDIQTGRVLTKvTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYLA 425
           *********************997777777789************************************9.****************** PP
   S: 197  sgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           ++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 426  TAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 478
           **************999999999866527*******************99987 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWVSSPEAPA SPSPQRFSQD AVMLHSFTLR QQLQTTRQEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCTGA TCTGCTCAAG TGAGTAGCGC CTGCGGCCGA TCGTGGGTTG CAGGAGGCTG 60
GAGAGCGGAG CGGGAGAATG CGCCAGCTGC TGAGACACCG GCTTCTGGAG GAGGCGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50231--RICIN_B_LECTIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	37.85	9.00e-94	338.00
IUUC-Aml-001230	Ailuropoda melanoleuca	93.02	0.00e+00	947.00
IUUC-Atr-002594	Amborella trichopoda	42.67	1.00e-115	410.00
IUUC-Apl-003686	Anas platyrhynchos	88.08	0.00e+00	737.00
IUUC-Aca-005272	Anolis carolinensis	93.86	0.00e+00	988.00
IUUC-Aly-005586	Arabidopsis lyrata	42.70	1.00e-116	412.00
IUUC-Ath-007696	Arabidopsis thaliana	42.78	9.00e-113	400.00
IUUC-Acl-008335	Aspergillus clavatus	34.17	9.00e-65	241.00
IUUC-Afl-008527	Aspergillus flavus	36.86	4.00e-70	258.00
IUUC-Afu-008957	Aspergillus fumigatus	37.20	2.00e-76	279.00
IUUC-Ani-009280	Aspergillus nidulans	36.22	1.00e-63	237.00
IUUC-Ang-009746	Aspergillus niger	35.03	7.00e-64	238.00
IUUC-Aor-009905	Aspergillus oryzae	36.66	9.00e-74	270.00
IUUC-Ate-010412	Aspergillus terreus	36.66	1.00e-62	233.00
IUUC-Ame-011561	Astyanax mexicanus	78.99	1.00e-107	382.00
IUUC-Bgr-012283	Blumeria graminis	31.53	4.00e-53	202.00
IUUC-Bta-013242	Bos taurus	96.16	0.00e+00	1004.00
IUUC-Bci-013901	Botrytis cinerea	32.69	1.00e-61	230.00
IUUC-Bdi-014277	Brachypodium distachyon	42.19	3.00e-120	425.00
IUUC-Bol-016207	Brassica oleracea	44.09	1.00e-115	410.00
IUUC-Bra-017902	Brassica rapa	42.13	5.00e-114	404.00
IUUC-Cel-018271	Caenorhabditis elegans	49.90	4.00e-149	521.00
IUUC-Cja-019879	Callithrix jacchus	95.98	0.00e+00	999.00
IUUC-Cfa-020175	Canis familiaris	96.16	0.00e+00	1003.00
IUUC-Cpo-022379	Cavia porcellus	95.78	0.00e+00	1000.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	38.86	5.00e-96	344.00
IUUC-Csa-023500	Chlorocebus sabaeus	96.35	0.00e+00	1005.00
IUUC-Cho-025065	Choloepus hoffmanni	82.93	2.00e-145	508.00
IUUC-Cin-025699	Ciona intestinalis	65.34	2.00e-172	598.00
IUUC-Csv-026128	Ciona savignyi	62.94	0.00e+00	670.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.13	5.00e-62	231.00
IUUC-Cne-026860	Cryptococcus neoformans	36.36	2.00e-90	326.00
IUUC-Dre-028187	Danio rerio	81.99	0.00e+00	852.00
IUUC-Dno-029453	Dasypus novemcinctus	96.16	0.00e+00	1003.00
IUUC-Dor-030150	Dipodomys ordii	98.32	6.00e-128	450.00
IUUC-Dse-031220	Dothistroma septosporum	31.78	1.00e-55	210.00
IUUC-Dme-031906	Drosophila melanogaster	63.98	0.00e+00	657.00
IUUC-Ete-033035	Echinops telfairi	83.88	0.00e+00	848.00
IUUC-Eca-033478	Equus caballus	95.97	0.00e+00	1001.00
IUUC-Eeu-034974	Erinaceus europaeus	99.39	0.00e+00	681.00
IUUC-Fca-036194	Felis catus	95.38	0.00e+00	992.00
IUUC-Fal-037417	Ficedula albicollis	93.67	0.00e+00	986.00
IUUC-Fox-037922	Fusarium oxysporum	33.21	1.00e-61	230.00
IUUC-Fso-038256	Fusarium solani	33.53	2.00e-63	236.00
IUUC-Gmo-038713	Gadus morhua	83.14	0.00e+00	867.00
IUUC-Ggr-039854	Gaeumannomyces graminis	31.84	1.00e-51	197.00
IUUC-Gga-041143	Gallus gallus	94.05	0.00e+00	989.00
IUUC-Gac-042129	Gasterosteus aculeatus	81.80	0.00e+00	880.00
IUUC-Gma-044273	Glycine max	44.32	2.00e-118	419.00
IUUC-Ggo-045262	Gorilla gorilla	96.35	0.00e+00	1005.00
IUUC-Hsa-046036	Homo sapiens	96.35	0.00e+00	1005.00
IUUC-Hvu-047442	Hordeum vulgare	40.36	4.00e-65	241.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	95.78	0.00e+00	960.00
IUUC-Lch-050105	Latimeria chalumnae	86.76	0.00e+00	927.00
IUUC-Lpe-050976	Leersia perrieri	43.02	9.00e-117	413.00
IUUC-Loc-052042	Lepisosteus oculatus	71.40	0.00e+00	654.00
IUUC-Lma-053143	Leptosphaeria maculans	33.20	3.00e-61	230.00
IUUC-Mcc-055786	Macaca mulatta	96.35	0.00e+00	1005.00
IUUC-Meu-056161	Macropus eugenii	98.34	2.00e-140	492.00
IUUC-Mor-057215	Magnaporthe oryzae	32.58	3.00e-54	206.00
IUUC-Mpo-057419	Magnaporthe poae	30.90	4.00e-48	185.00
IUUC-Mtr-057756	Medicago truncatula	42.48	8.00e-113	400.00
IUUC-Mla-059085	Melampsora laricipopulina	36.72	5.00e-83	301.00
IUUC-Mga-060158	Meleagris gallopavo	88.85	0.00e+00	886.00
IUUC-Mvi-060441	Microbotryum violaceum	36.80	7.00e-76	278.00
IUUC-Mmr-061085	Microcebus murinus	96.35	0.00e+00	1005.00
IUUC-Mdo-061804	Monodelphis domestica	95.97	0.00e+00	1002.00
IUUC-Mmu-063608	Mus musculus	96.37	0.00e+00	1010.00
IUUC-Mac-064972	Musa acuminata	42.83	3.00e-114	405.00
IUUC-Mpu-065700	Mustela putorius furo	96.16	0.00e+00	1003.00
IUUC-Mlu-068223	Myotis lucifugus	95.01	0.00e+00	994.00
IUUC-Nfi-068504	Neosartorya fischeri	36.52	5.00e-76	278.00
IUUC-Ncr-068729	Neurospora crassa	35.02	9.00e-61	227.00
IUUC-Nle-069754	Nomascus leucogenys	96.35	0.00e+00	1005.00
IUUC-Opr-070621	Ochotona princeps	92.22	0.00e+00	938.00
IUUC-Ont-071377	Oreochromis niloticus	81.80	0.00e+00	859.00
IUUC-Oan-073498	Ornithorhynchus anatinus	70.21	3.00e-121	427.00
IUUC-Ocu-074182	Oryctolagus cuniculus	97.52	0.00e+00	1021.00
IUUC-Oba-075509	Oryza barthii	42.19	2.00e-118	419.00
IUUC-Obr-076480	Oryza brachyantha	43.12	1.00e-119	423.00
IUUC-Ogl-077052	Oryza glaberrima	42.19	2.00e-118	419.00
IUUC-Ogu-078919	Oryza glumaepatula	42.19	2.00e-118	419.00
IUUC-Oin-079357	Oryza indica	41.50	1.00e-111	396.00
IUUC-Olo-080376	Oryza longistaminata	41.87	2.00e-106	379.00
IUUC-Ome-081973	Oryza meridionalis	41.39	2.00e-106	379.00
IUUC-Oni-082849	Oryza nivara	42.38	4.00e-119	421.00
IUUC-Opu-083243	Oryza punctata	42.01	9.00e-118	417.00
IUUC-Oru-084613	Oryza rufipogon	42.46	2.00e-118	419.00
IUUC-Osa-085407	Oryza sativa	42.16	7.00e-118	417.00
IUUC-Ola-086566	Oryzias latipes	81.02	0.00e+00	850.00
IUUC-Olu-087757	Ostreococcus lucimarinus	37.84	3.00e-91	328.00
IUUC-Oga-089010	Otolemur garnettii	91.79	0.00e+00	950.00
IUUC-Oar-089638	Ovis aries	96.16	0.00e+00	1004.00
IUUC-Ptr-091141	Pan troglodytes	96.35	0.00e+00	1005.00
IUUC-Pan-092662	Papio anubis	96.35	0.00e+00	1005.00
IUUC-Psi-093777	Pelodiscus sinensis	96.90	0.00e+00	822.00
IUUC-Pno-095115	Phaeosphaeria nodorum	33.67	1.00e-61	230.00
IUUC-Ppa-095841	Physcomitrella patens	43.18	6.00e-117	414.00
IUUC-Pfo-096390	Poecilia formosa	81.03	0.00e+00	858.00
IUUC-Pab-098250	Pongo abelii	94.62	0.00e+00	938.00
IUUC-Pop-099854	Populus trichocarpa	43.66	5.00e-117	414.00
IUUC-Pca-100553	Procavia capensis	96.16	0.00e+00	998.00
IUUC-Ppe-101383	Prunus persica	42.80	3.00e-111	395.00
IUUC-Pva-102189	Pteropus vampyrus	95.97	0.00e+00	1003.00
IUUC-Pgr-103304	Puccinia graminis	35.85	2.00e-81	296.00
IUUC-Ptt-103984	Puccinia triticina	36.70	7.00e-87	314.00
IUUC-Pte-104385	Pyrenophora teres	31.98	1.00e-65	243.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	32.18	8.00e-67	247.00
IUUC-Rno-105581	Rattus norvegicus	95.78	0.00e+00	1001.00
IUUC-Sha-107071	Sarcophilus harrisii	96.20	0.00e+00	1014.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	30.38	4.00e-32	132.00
IUUC-Spo-108315	Schizosaccharomyces pombe	31.17	4.00e-42	166.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	33.90	3.00e-61	229.00
IUUC-Smo-109648	Selaginella moellendorffii	43.71	5.00e-119	421.00
IUUC-Sit-109873	Setaria italica	42.19	1.00e-116	413.00
IUUC-Sly-111673	Solanum lycopersicum	44.28	2.00e-110	392.00
IUUC-Stu-112125	Solanum tuberosum	44.09	1.00e-109	390.00
IUUC-Sbi-114696	Sorghum bicolor	41.05	3.00e-105	375.00
IUUC-Sre-115134	Sporisorium reilianum	30.72	3.00e-69	255.00
IUUC-Ssc-116260	Sus scrofa	95.97	0.00e+00	1002.00
IUUC-Tgu-116533	Taeniopygia guttata	94.05	0.00e+00	989.00
IUUC-Tru-117800	Takifugu rubripes	81.23	0.00e+00	883.00
IUUC-Tsy-118980	Tarsius syrichta	90.93	0.00e+00	913.00
IUUC-Tni-120334	Tetraodon nigroviridis	65.52	0.00e+00	692.00
IUUC-Tca-121807	Theobroma cacao	42.72	1.00e-117	416.00
IUUC-Tre-121920	Trichoderma reesei	32.24	4.00e-60	225.00
IUUC-Tvi-122294	Trichoderma virens	31.91	2.00e-52	199.00
IUUC-Tae-125713	Triticum aestivum	42.57	2.00e-121	429.00
IUUC-Tur-126664	Triticum urartu	38.40	5.00e-111	395.00
IUUC-Tme-127026	Tuber melanosporum	33.33	1.00e-65	244.00
IUUC-Tbe-127582	Tupaia belangeri	99.70	0.00e+00	680.00
IUUC-Ttr-128313	Tursiops truncatus	95.78	0.00e+00	993.00
IUUC-Uma-129626	Ustilago maydis	32.49	7.00e-72	264.00
IUUC-Vda-129699	Verticillium dahliae	34.14	2.00e-64	239.00
IUUC-Vpa-130593	Vicugna pacos	95.12	0.00e+00	889.00
IUUC-Vvi-131668	Vitis vinifera	42.80	7.00e-117	414.00
IUUC-Xtr-132186	Xenopus tropicalis	82.46	0.00e+00	760.00
IUUC-Xma-133212	Xiphophorus maculatus	80.84	0.00e+00	853.00
IUUC-Yli-134607	Yarrowia lipolytica	51.01	3.00e-38	150.00
IUUC-Zma-135662	Zea mays	43.39	1.00e-118	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence