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Tag Content
iUUCD ID IUUC-Loc-052476
Ensembl Protein ID ENSLOCP00000005311.1
UniProt Accession W5MAA2; W5MAA2_LEPOC
Genbank Protein ID ENSLOCP00000005311
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AHAT01005737
Gene Name pafah1b1a; PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLOCG00000004448.1 ENSLOCT00000005319.1 ENSLOCP00000005311.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.20e-58 189.8 190 228
UBD/Beta-Prp 3.60e-94 315.5 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH v+++a ++ +++vs+s+D+tik+W++ tg ++k
   Q: 190 GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVATGYCVK 228
    899*******99777********************9987 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg ll+s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLLASSSNDQTVRVWVVANKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v ++p ++++vs+++D+++riWd++++
   Q: 283 SWAPESsystileatgsenkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLVHPGGKFIVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLSAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
    *****************.99*****************985 PP
   

Organism Lepisosteus oculatus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
TKYSYKDNQV GNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Loc-052476|E3,WD_repeat;UBD,Beta-Prp|Lepisosteus oculatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCAAATACA GTTACAAAGA TAACCAAGTA GGGTAATCAA GATTATTCAC TAGCTTTTCT 60
TTCATTTTTC AGAAATCGAG CGATAGCTGA TTACCTTCGT TCCAATGGAT ATGAAGAAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Loc-052476|E3,WD_repeat;UBD,Beta-Prp|Lepisosteus oculatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0048854--P:brain morphogenesis
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 95.99 0.00e+00 804.00
IUUC-Apl-004024 Anas platyrhynchos 95.74 0.00e+00 803.00
IUUC-Aca-004564 Anolis carolinensis 94.99 0.00e+00 795.00
IUUC-Ago-007862 Ashbya gossypii 26.93 2.00e-36 146.00
IUUC-Acl-008360 Aspergillus clavatus 46.19 5.00e-101 361.00
IUUC-Afl-008502 Aspergillus flavus 45.95 6.00e-95 340.00
IUUC-Afu-008848 Aspergillus fumigatus 47.12 9.00e-103 367.00
IUUC-Ani-009173 Aspergillus nidulans 43.88 3.00e-89 322.00
IUUC-Ang-009873 Aspergillus niger 44.94 1.00e-91 330.00
IUUC-Aor-009973 Aspergillus oryzae 44.04 9.00e-90 323.00
IUUC-Ate-010523 Aspergillus terreus 42.38 6.00e-88 317.00
IUUC-Ame-010969 Astyanax mexicanus 97.24 0.00e+00 815.00
IUUC-Bgr-011972 Blumeria graminis 46.94 1.00e-100 360.00
IUUC-Bta-013106 Bos taurus 95.99 0.00e+00 804.00
IUUC-Bci-013615 Botrytis cinerea 44.83 8.00e-96 343.00
IUUC-Cel-018459 Caenorhabditis elegans 57.25 6.00e-145 506.00
IUUC-Cja-018755 Callithrix jacchus 95.99 0.00e+00 804.00
IUUC-Cfa-020749 Canis familiaris 95.99 0.00e+00 804.00
IUUC-Cpo-022371 Cavia porcellus 95.99 0.00e+00 804.00
IUUC-Csa-023524 Chlorocebus sabaeus 94.78 0.00e+00 691.00
IUUC-Cho-024764 Choloepus hoffmanni 85.44 0.00e+00 652.00
IUUC-Cin-025753 Ciona intestinalis 70.50 2.00e-174 605.00
IUUC-Csv-025817 Ciona savignyi 68.92 2.00e-177 615.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 47.22 1.00e-94 340.00
IUUC-Cne-027087 Cryptococcus neoformans 49.87 5.00e-110 390.00
IUUC-Dre-027554 Danio rerio 96.24 0.00e+00 807.00
IUUC-Dno-029050 Dasypus novemcinctus 95.74 0.00e+00 804.00
IUUC-Dor-030222 Dipodomys ordii 87.72 0.00e+00 723.00
IUUC-Dse-031164 Dothistroma septosporum 43.18 2.00e-98 352.00
IUUC-Dme-031745 Drosophila melanogaster 69.75 4.00e-167 580.00
IUUC-Ete-032508 Echinops telfairi 94.58 3.00e-161 561.00
IUUC-Eca-034288 Equus caballus 95.49 0.00e+00 800.00
IUUC-Eeu-034984 Erinaceus europaeus 87.47 0.00e+00 719.00
IUUC-Fca-036498 Felis catus 95.99 0.00e+00 804.00
IUUC-Fal-036920 Ficedula albicollis 95.74 0.00e+00 803.00
IUUC-Fox-037996 Fusarium oxysporum 45.95 3.00e-101 362.00
IUUC-Fso-038160 Fusarium solani 43.45 1.00e-95 343.00
IUUC-Gmo-038983 Gadus morhua 95.24 0.00e+00 800.00
IUUC-Ggr-040051 Gaeumannomyces graminis 46.51 1.00e-96 347.00
IUUC-Gga-040623 Gallus gallus 95.74 0.00e+00 803.00
IUUC-Gac-041363 Gasterosteus aculeatus 93.73 0.00e+00 794.00
IUUC-Ggo-045410 Gorilla gorilla 85.21 0.00e+00 695.00
IUUC-Hsa-046358 Homo sapiens 95.74 0.00e+00 802.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 95.99 0.00e+00 804.00
IUUC-Kpa-049351 Komagataella pastoris 29.19 2.00e-41 163.00
IUUC-Lch-049936 Latimeria chalumnae 95.74 0.00e+00 805.00
IUUC-Lma-053170 Leptosphaeria maculans 48.16 7.00e-98 350.00
IUUC-Laf-053713 Loxodonta africana 95.04 0.00e+00 806.00
IUUC-Mcc-054628 Macaca mulatta 95.49 0.00e+00 802.00
IUUC-Meu-055927 Macropus eugenii 81.59 1.00e-133 468.00
IUUC-Mor-056962 Magnaporthe oryzae 44.96 6.00e-95 341.00
IUUC-Mpo-057583 Magnaporthe poae 46.67 9.00e-93 333.00
IUUC-Mla-058819 Melampsora laricipopulina 48.05 2.00e-114 405.00
IUUC-Mga-059945 Meleagris gallopavo 95.49 0.00e+00 802.00
IUUC-Mvi-060403 Microbotryum violaceum 49.20 2.00e-122 432.00
IUUC-Mmr-061289 Microcebus murinus 95.99 0.00e+00 804.00
IUUC-Mdo-061912 Monodelphis domestica 95.24 0.00e+00 797.00
IUUC-Mmu-063253 Mus musculus 95.99 0.00e+00 804.00
IUUC-Mpu-066638 Mustela putorius furo 95.99 0.00e+00 804.00
IUUC-Mlu-067267 Myotis lucifugus 94.33 0.00e+00 803.00
IUUC-Nfi-068571 Neosartorya fischeri 45.71 1.00e-95 343.00
IUUC-Ncr-068895 Neurospora crassa 49.87 3.00e-103 368.00
IUUC-Nle-069087 Nomascus leucogenys 96.30 0.00e+00 654.00
IUUC-Opr-070579 Ochotona princeps 95.74 0.00e+00 804.00
IUUC-Ont-072432 Oreochromis niloticus 95.74 0.00e+00 805.00
IUUC-Oan-073072 Ornithorhynchus anatinus 95.99 0.00e+00 804.00
IUUC-Ocu-074180 Oryctolagus cuniculus 95.74 0.00e+00 804.00
IUUC-Ola-086772 Oryzias latipes 95.49 0.00e+00 802.00
IUUC-Oga-088219 Otolemur garnettii 95.99 0.00e+00 805.00
IUUC-Oar-090394 Ovis aries 95.99 0.00e+00 804.00
IUUC-Ptr-091517 Pan troglodytes 95.99 0.00e+00 804.00
IUUC-Pan-092421 Papio anubis 95.49 0.00e+00 802.00
IUUC-Psi-093370 Pelodiscus sinensis 95.49 0.00e+00 801.00
IUUC-Pma-094319 Petromyzon marinus 86.53 0.00e+00 633.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.94 1.00e-100 359.00
IUUC-Pfo-097089 Poecilia formosa 95.24 0.00e+00 803.00
IUUC-Pab-098421 Pongo abelii 95.99 0.00e+00 804.00
IUUC-Pca-100120 Procavia capensis 70.68 2.00e-156 545.00
IUUC-Pva-102960 Pteropus vampyrus 95.74 0.00e+00 800.00
IUUC-Pgr-103538 Puccinia graminis 46.68 9.00e-114 403.00
IUUC-Ptt-103990 Puccinia triticina 41.74 6.00e-41 162.00
IUUC-Pte-104261 Pyrenophora teres 47.19 2.00e-100 359.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.43 9.00e-101 360.00
IUUC-Rno-105123 Rattus norvegicus 95.99 0.00e+00 804.00
IUUC-Sce-106208 Saccharomyces cerevisiae 29.80 7.00e-36 145.00
IUUC-Sha-107010 Sarcophilus harrisii 94.99 0.00e+00 796.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.02 1.00e-63 237.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 45.07 5.00e-96 344.00
IUUC-Sar-113309 Sorex araneus 95.24 0.00e+00 795.00
IUUC-Sre-115003 Sporisorium reilianum 49.30 5.00e-119 421.00
IUUC-Ssc-116148 Sus scrofa 95.99 0.00e+00 804.00
IUUC-Tgu-117299 Taeniopygia guttata 95.49 0.00e+00 800.00
IUUC-Tru-117721 Takifugu rubripes 94.49 0.00e+00 795.00
IUUC-Tsy-119493 Tarsius syrichta 94.99 0.00e+00 791.00
IUUC-Tni-120355 Tetraodon nigroviridis 94.49 0.00e+00 770.00
IUUC-Tre-121977 Trichoderma reesei 43.41 2.00e-99 355.00
IUUC-Tvi-122661 Trichoderma virens 45.48 6.00e-99 354.00
IUUC-Tme-127031 Tuber melanosporum 47.72 3.00e-99 355.00
IUUC-Tbe-127492 Tupaia belangeri 78.46 1.00e-109 389.00
IUUC-Ttr-128929 Tursiops truncatus 95.99 0.00e+00 803.00
IUUC-Uma-129347 Ustilago maydis 47.20 3.00e-117 415.00
IUUC-Vda-129837 Verticillium dahliae 45.79 1.00e-97 349.00
IUUC-Vpa-130532 Vicugna pacos 81.33 3.00e-178 617.00
IUUC-Xtr-131985 Xenopus tropicalis 94.99 0.00e+00 800.00
IUUC-Xma-133314 Xiphophorus maculatus 95.49 0.00e+00 803.00
IUUC-Yli-134403 Yarrowia lipolytica 41.31 2.00e-74 272.00
Created Date 25-Jun-2017

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