iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008288

Ensembl Protein ID

CADACLAP00002612

UniProt Accession

A1CRJ9; A1CRJ9_ASPCL

Genbank Protein ID

EAW08270.1

Protein Name

Ubiquitin-protein ligase (Hul4), putative

Genbank Nucleotide ID

DS027059

Gene Name

ACLA_030030

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00002659	CADACLAT00002659	CADACLAP00002612

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.70e-74	247.9	854	1198

Active Site

Position(s)	Description	Evidence
1167	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           ++++kk l++efvgEeg+d+gG+ +e++ ll++e+++p  glfly+e+++ + + np  +    e  + F ++G+llg+a++++ +ld+ l
   Q: 854  EEEIKKGLRIEFVGEEGVDAGGLRKEWFLLLVREIFDPHHGLFLYDEDSQFC-YFNPFCF----ESSEQFFLVGVLLGLAIYNSTILDIAL 939
           578999***************************************9976655.6789887....5678888******************** PP
   S: 93   sksfyklllgk................klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
           +++ +k+ll                  k++l+dl+e  p l+k l  ++e  + d+ ++ ++  f ++ + +ge+ ++ L+pgGe+ pVtn
   Q: 940  PPFAFKKLLAAapptsgpqpttsrsnfKCTLDDLAEYRPALAKGLRGLLEF-DGDVMDT-FCYDFVAHVDRYGEVVAVPLCPGGEKRPVTN 1028
           ********99988888888888888888*********************99.6788887.9999*99************************ PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketky...kggytedspaiqwFwevle 254
           +N++e+v+l+v+y l + +++q+e f++Gf +v+  + lslF++ee+ell+ G+ e +dv +l++ ++y    +   e+ p+++wFw+++e
   Q: 1029 ANRREFVDLYVHYMLDTAVARQFEPFKRGFFTVCGGNALSLFRPEEIELLVRGSdEALDVASLRAVATYdnwSHPRPENVPVVRWFWDFFE 1119
           ******************************************************999**********995555666689999********* PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           + + + ++++L F+Tgs+r+P+ G  +l  r+ ++ +  +++r+P + TCfn+L L +Y + ++l+++L  A+ +++gF+l
   Q: 1120 QADPQAQRKILSFITGSDRIPAMGATSLTIRVACLGD--DTSRYPIARTCFNTLGLYRYATRQTLERMLWDAVGNSEGFGL 1198
           *****************************88888877..88**************************************98 PP

Organism

Aspergillus clavatus

Protein Sequence
(Fasta)

MPSRSAYNQP HPPTLSSTAI FPDATLLSST ERTAPHHIRQ DVPNLPAMTG NIAASPPAHR 60
AHSRSISHPF PAPFGKRRNQ SALHQEFLDS DDDDDDGLEV SRMPDLLSSS PRKGPSRPMP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGTCAC GGTCCGCGTA CAACCAGCCT CACCCTCCGA CTCTGAGCTC AACCGCCATC 60
TTCCCGGACG CCACACTCCT TTCGTCGACG GAGAGGACTG CACCACACCA TATTCGGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

act:ACLA_030030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	35.46	3.00e-100	357.00
IUUC-Atr-003144	Amborella trichopoda	37.85	3.00e-82	297.00
IUUC-Apl-003589	Anas platyrhynchos	34.21	5.00e-92	330.00
IUUC-Aca-004350	Anolis carolinensis	40.18	2.00e-94	338.00
IUUC-Ago-007908	Ashbya gossypii	33.08	5.00e-101	360.00
IUUC-Afl-008402	Aspergillus flavus	78.77	0.00e+00	1114.00
IUUC-Afu-008762	Aspergillus fumigatus	76.72	0.00e+00	1837.00
IUUC-Ani-009176	Aspergillus nidulans	71.74	0.00e+00	936.00
IUUC-Ang-009791	Aspergillus niger	68.78	0.00e+00	1394.00
IUUC-Aor-009921	Aspergillus oryzae	80.48	0.00e+00	1019.00
IUUC-Ate-010295	Aspergillus terreus	68.82	0.00e+00	1505.00
IUUC-Ame-011166	Astyanax mexicanus	37.69	3.00e-81	294.00
IUUC-Bgr-011981	Blumeria graminis	47.71	0.00e+00	983.00
IUUC-Bta-012945	Bos taurus	40.84	3.00e-97	347.00
IUUC-Bci-013697	Botrytis cinerea	55.74	0.00e+00	882.00
IUUC-Cel-018150	Caenorhabditis elegans	31.75	1.00e-53	203.00
IUUC-Cja-019263	Callithrix jacchus	39.74	9.00e-94	336.00
IUUC-Cfa-020486	Canis familiaris	35.53	1.00e-100	358.00
IUUC-Cpo-021755	Cavia porcellus	35.36	2.00e-101	361.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	41.59	6.00e-58	215.00
IUUC-Csa-023814	Chlorocebus sabaeus	39.66	1.00e-83	302.00
IUUC-Cho-025059	Choloepus hoffmanni	30.72	1.00e-69	256.00
IUUC-Cin-025643	Ciona intestinalis	30.81	2.00e-67	248.00
IUUC-Csv-026282	Ciona savignyi	35.42	3.00e-60	224.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	46.14	0.00e+00	900.00
IUUC-Cme-027151	Cyanidioschyzon merolae	35.48	3.00e-74	271.00
IUUC-Dre-028551	Danio rerio	40.58	1.00e-94	338.00
IUUC-Dno-029497	Dasypus novemcinctus	40.40	3.00e-96	344.00
IUUC-Dor-030867	Dipodomys ordii	35.16	7.00e-74	270.00
IUUC-Dse-031239	Dothistroma septosporum	49.95	0.00e+00	855.00
IUUC-Dme-032035	Drosophila melanogaster	32.87	2.00e-68	252.00
IUUC-Ete-032902	Echinops telfairi	33.06	6.00e-91	327.00
IUUC-Eca-033678	Equus caballus	35.69	2.00e-101	361.00
IUUC-Eeu-035109	Erinaceus europaeus	36.58	3.00e-71	261.00
IUUC-Fca-035590	Felis catus	36.02	4.00e-103	367.00
IUUC-Fal-037123	Ficedula albicollis	33.66	4.00e-84	304.00
IUUC-Fox-037941	Fusarium oxysporum	44.64	0.00e+00	938.00
IUUC-Fso-038388	Fusarium solani	44.74	0.00e+00	924.00
IUUC-Gmo-039553	Gadus morhua	39.47	1.00e-81	295.00
IUUC-Ggr-040110	Gaeumannomyces graminis	44.44	0.00e+00	888.00
IUUC-Gga-040406	Gallus gallus	34.38	3.00e-95	341.00
IUUC-Gac-042141	Gasterosteus aculeatus	33.88	4.00e-90	323.00
IUUC-Ggo-045504	Gorilla gorilla	39.51	8.00e-94	336.00
IUUC-Hsa-045786	Homo sapiens	39.51	7.00e-94	336.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	37.01	3.00e-76	278.00
IUUC-Kpa-049152	Komagataella pastoris	35.24	3.00e-98	351.00
IUUC-Lch-049824	Latimeria chalumnae	40.98	7.00e-83	299.00
IUUC-Loc-052173	Lepisosteus oculatus	35.36	6.00e-102	363.00
IUUC-Laf-054017	Loxodonta africana	40.40	3.00e-96	344.00
IUUC-Mcc-055713	Macaca mulatta	39.74	7.00e-94	336.00
IUUC-Meu-056061	Macropus eugenii	37.45	8.00e-77	280.00
IUUC-Mor-057045	Magnaporthe oryzae	44.65	0.00e+00	915.00
IUUC-Mla-059187	Melampsora laricipopulina	42.28	1.00e-93	334.00
IUUC-Mga-059884	Meleagris gallopavo	39.81	2.00e-87	315.00
IUUC-Mmr-061344	Microcebus murinus	34.87	4.00e-100	357.00
IUUC-Mdo-062653	Monodelphis domestica	40.84	3.00e-96	344.00
IUUC-Mmu-063775	Mus musculus	40.75	1.00e-97	349.00
IUUC-Mpu-066069	Mustela putorius furo	35.53	3.00e-101	360.00
IUUC-Mlu-067925	Myotis lucifugus	41.06	3.00e-98	351.00
IUUC-Nfi-068439	Neosartorya fischeri	74.73	0.00e+00	1727.00
IUUC-Ncr-068903	Neurospora crassa	45.01	0.00e+00	870.00
IUUC-Nle-070046	Nomascus leucogenys	34.64	2.00e-97	348.00
IUUC-Opr-070570	Ochotona princeps	32.68	4.00e-59	221.00
IUUC-Ont-072126	Oreochromis niloticus	35.03	4.00e-97	347.00
IUUC-Oan-072933	Ornithorhynchus anatinus	39.60	1.00e-93	335.00
IUUC-Ocu-073800	Oryctolagus cuniculus	39.96	5.00e-94	337.00
IUUC-Ola-086988	Oryzias latipes	34.32	6.00e-93	333.00
IUUC-Oga-088117	Otolemur garnettii	39.96	5.00e-94	336.00
IUUC-Oar-089371	Ovis aries	40.84	9.00e-97	345.00
IUUC-Ptr-090551	Pan troglodytes	39.51	9.00e-94	336.00
IUUC-Pan-092067	Papio anubis	39.74	8.00e-94	336.00
IUUC-Psi-092963	Pelodiscus sinensis	40.18	2.00e-93	335.00
IUUC-Pma-094643	Petromyzon marinus	32.56	5.00e-80	290.00
IUUC-Ppa-095354	Physcomitrella patens	37.86	6.00e-84	304.00
IUUC-Pfo-096562	Poecilia formosa	34.21	2.00e-94	338.00
IUUC-Pab-098680	Pongo abelii	39.51	9.00e-94	336.00
IUUC-Pca-100869	Procavia capensis	36.80	7.00e-78	283.00
IUUC-Pva-102219	Pteropus vampyrus	38.67	6.00e-78	283.00
IUUC-Pgr-103315	Puccinia graminis	41.49	1.00e-102	365.00
IUUC-Ptt-103736	Puccinia triticina	42.59	2.00e-102	365.00
IUUC-Rno-105270	Rattus norvegicus	40.84	1.00e-98	352.00
IUUC-Sce-106306	Saccharomyces cerevisiae	32.38	5.00e-84	303.00
IUUC-Sha-106819	Sarcophilus harrisii	35.96	7.00e-102	363.00
IUUC-Sja-107974	Schizosaccharomyces japonicus	34.01	1.00e-59	222.00
IUUC-Spo-108271	Schizosaccharomyces pombe	35.30	3.00e-110	390.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	55.10	0.00e+00	913.00
IUUC-Smo-108858	Selaginella moellendorffii	40.00	4.00e-84	303.00
IUUC-Sar-113134	Sorex araneus	36.44	2.00e-79	288.00
IUUC-Ssc-115441	Sus scrofa	40.75	1.00e-96	345.00
IUUC-Tgu-117166	Taeniopygia guttata	34.87	2.00e-92	332.00
IUUC-Tru-118368	Takifugu rubripes	36.59	8.00e-79	286.00
IUUC-Tsy-118898	Tarsius syrichta	36.24	4.00e-77	280.00
IUUC-Tni-120143	Tetraodon nigroviridis	36.81	5.00e-79	287.00
IUUC-Tre-122108	Trichoderma reesei	44.44	0.00e+00	903.00
IUUC-Tvi-122644	Trichoderma virens	45.14	0.00e+00	897.00
IUUC-Tme-127004	Tuber melanosporum	47.47	0.00e+00	774.00
IUUC-Tbe-127640	Tupaia belangeri	36.79	8.00e-65	240.00
IUUC-Ttr-128352	Tursiops truncatus	37.97	5.00e-86	310.00
IUUC-Vda-129969	Verticillium dahliae	44.64	0.00e+00	875.00
IUUC-Vpa-130448	Vicugna pacos	34.51	7.00e-68	250.00
IUUC-Xtr-132594	Xenopus tropicalis	39.17	3.00e-83	301.00
IUUC-Xma-134157	Xiphophorus maculatus	34.58	2.00e-85	308.00
IUUC-Yli-134470	Yarrowia lipolytica	35.26	5.00e-107	380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence