iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033430

Ensembl Protein ID

ENSECAP00000000272.1

UniProt Accession

H9GZN5; H9GZN5_HORSE

Protein Name

Protein HIRA

Gene Name

HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000000286.1	ENSECAT00000000350.1	ENSECAP00000000272.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.10e-20	70.5	57	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 57   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 86
           8899******955699*************7 PP

Organism

Equus caballus

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

GKPIFSVDIH PDGTKFATGG QGQDSGKVVI WNMSPVLQED DEKDENIPKM LCQMDNHLAC 60
VNCVRWSNSG MYLASGGDDK LIMVWKRATY IGPSTVFGSS GKLANVEQWR CVSILRSHSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAAGCCAA TTTTTTCAGT TGATATTCAC CCTGACGGGA CCAAGTTCGC AACTGGAGGA 60
CAAGGTACGT TAATGGACTA ACAGAGGGAA CGTTCATAGC CCTGCCACCT TGCTCTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	39.61	3.00e-85	310.00
IUUC-Aml-001723	Ailuropoda melanoleuca	98.01	0.00e+00	1794.00
IUUC-Atr-003132	Amborella trichopoda	41.24	1.00e-84	308.00
IUUC-Apl-003197	Anas platyrhynchos	83.98	0.00e+00	1609.00
IUUC-Aca-004733	Anolis carolinensis	82.45	0.00e+00	1564.00
IUUC-Aly-005446	Arabidopsis lyrata	35.44	6.00e-79	289.00
IUUC-Ath-007627	Arabidopsis thaliana	36.55	1.00e-82	301.00
IUUC-Ago-007766	Ashbya gossypii	31.05	2.00e-56	214.00
IUUC-Acl-008104	Aspergillus clavatus	29.05	3.00e-59	224.00
IUUC-Afl-008591	Aspergillus flavus	29.56	1.00e-59	224.00
IUUC-Afu-008781	Aspergillus fumigatus	32.80	8.00e-58	218.00
IUUC-Ani-009272	Aspergillus nidulans	28.57	1.00e-53	204.00
IUUC-Ang-009655	Aspergillus niger	32.98	9.00e-61	228.00
IUUC-Aor-010119	Aspergillus oryzae	29.56	4.00e-60	226.00
IUUC-Ate-010530	Aspergillus terreus	30.75	7.00e-53	202.00
IUUC-Ame-011147	Astyanax mexicanus	85.23	8.00e-46	174.00
IUUC-Bgr-012237	Blumeria graminis	32.81	7.00e-58	219.00
IUUC-Bta-013320	Bos taurus	91.68	0.00e+00	1775.00
IUUC-Bci-013795	Botrytis cinerea	33.51	3.00e-63	236.00
IUUC-Bdi-014075	Brachypodium distachyon	42.19	5.00e-88	319.00
IUUC-Bol-016440	Brassica oleracea	34.80	7.00e-85	308.00
IUUC-Bra-016651	Brassica rapa	40.58	3.00e-84	306.00
IUUC-Cel-018692	Caenorhabditis elegans	38.04	2.00e-73	270.00
IUUC-Cja-018987	Callithrix jacchus	96.10	0.00e+00	1696.00
IUUC-Cfa-020132	Canis familiaris	97.91	0.00e+00	1793.00
IUUC-Cpo-021484	Cavia porcellus	95.72	0.00e+00	1765.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	36.00	1.00e-59	224.00
IUUC-Csa-023081	Chlorocebus sabaeus	96.62	0.00e+00	1769.00
IUUC-Cin-025182	Ciona intestinalis	54.64	2.00e-149	523.00
IUUC-Csv-026154	Ciona savignyi	55.49	6.00e-146	511.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	33.25	1.00e-60	228.00
IUUC-Cne-026891	Cryptococcus neoformans	41.26	4.00e-80	292.00
IUUC-Cme-027349	Cyanidioschyzon merolae	28.68	1.00e-51	198.00
IUUC-Dre-027655	Danio rerio	68.64	0.00e+00	1320.00
IUUC-Dno-029557	Dasypus novemcinctus	85.15	0.00e+00	1108.00
IUUC-Dor-030687	Dipodomys ordii	85.42	0.00e+00	724.00
IUUC-Dse-031334	Dothistroma septosporum	30.30	2.00e-58	221.00
IUUC-Dme-031746	Drosophila melanogaster	55.12	4.00e-152	532.00
IUUC-Ete-032384	Echinops telfairi	88.75	0.00e+00	1628.00
IUUC-Fca-036121	Felis catus	97.71	0.00e+00	1790.00
IUUC-Fal-036817	Ficedula albicollis	83.66	0.00e+00	1611.00
IUUC-Fox-037906	Fusarium oxysporum	34.59	4.00e-65	242.00
IUUC-Fso-038409	Fusarium solani	33.33	4.00e-63	236.00
IUUC-Gmo-039151	Gadus morhua	86.35	0.00e+00	679.00
IUUC-Ggr-040016	Gaeumannomyces graminis	31.16	1.00e-66	248.00
IUUC-Gga-040936	Gallus gallus	84.68	0.00e+00	1671.00
IUUC-Gac-041405	Gasterosteus aculeatus	62.81	0.00e+00	1172.00
IUUC-Gma-044252	Glycine max	36.16	2.00e-86	313.00
IUUC-Ggo-045430	Gorilla gorilla	96.12	0.00e+00	1760.00
IUUC-Hsa-046442	Homo sapiens	96.22	0.00e+00	1764.00
IUUC-Hvu-047587	Hordeum vulgare	36.90	6.00e-80	292.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	99.33	4.00e-175	606.00
IUUC-Kpa-049145	Komagataella pastoris	31.11	2.00e-58	221.00
IUUC-Lch-050474	Latimeria chalumnae	75.51	0.00e+00	1389.00
IUUC-Lpe-051209	Leersia perrieri	34.62	6.00e-80	292.00
IUUC-Loc-052119	Lepisosteus oculatus	71.92	0.00e+00	1340.00
IUUC-Lma-053237	Leptosphaeria maculans	30.73	7.00e-64	239.00
IUUC-Laf-053718	Loxodonta africana	95.12	0.00e+00	1754.00
IUUC-Mcc-055621	Macaca mulatta	96.20	0.00e+00	1699.00
IUUC-Meu-055914	Macropus eugenii	78.89	0.00e+00	1429.00
IUUC-Mor-057090	Magnaporthe oryzae	33.58	3.00e-63	237.00
IUUC-Mpo-057364	Magnaporthe poae	31.71	3.00e-69	256.00
IUUC-Mtr-057744	Medicago truncatula	37.88	6.00e-88	318.00
IUUC-Mla-058914	Melampsora laricipopulina	35.95	5.00e-80	292.00
IUUC-Mga-060181	Meleagris gallopavo	82.92	0.00e+00	1636.00
IUUC-Mvi-060432	Microbotryum violaceum	38.24	2.00e-72	267.00
IUUC-Mmr-060871	Microcebus murinus	95.92	0.00e+00	1818.00
IUUC-Mdo-062301	Monodelphis domestica	85.74	0.00e+00	1595.00
IUUC-Mmu-063888	Mus musculus	94.33	0.00e+00	1725.00
IUUC-Mac-065137	Musa acuminata	37.99	2.00e-85	310.00
IUUC-Mpu-066732	Mustela putorius furo	97.61	0.00e+00	1828.00
IUUC-Mlu-067542	Myotis lucifugus	97.51	0.00e+00	1757.00
IUUC-Nfi-068396	Neosartorya fischeri	33.43	1.00e-57	218.00
IUUC-Ncr-068842	Neurospora crassa	31.75	9.00e-64	238.00
IUUC-Nle-070156	Nomascus leucogenys	96.52	0.00e+00	1782.00
IUUC-Opr-070808	Ochotona princeps	94.92	0.00e+00	1434.00
IUUC-Ont-072105	Oreochromis niloticus	67.49	0.00e+00	1297.00
IUUC-Ocu-074962	Oryctolagus cuniculus	96.52	0.00e+00	1785.00
IUUC-Oba-075178	Oryza barthii	41.67	8.00e-87	315.00
IUUC-Obr-076399	Oryza brachyantha	36.96	8.00e-88	318.00
IUUC-Ogu-078797	Oryza glumaepatula	41.67	8.00e-87	315.00
IUUC-Oin-080085	Oryza indica	40.52	8.00e-78	285.00
IUUC-Olo-081048	Oryza longistaminata	40.72	5.00e-66	246.00
IUUC-Ome-081324	Oryza meridionalis	41.67	8.00e-87	315.00
IUUC-Oni-082548	Oryza nivara	41.67	8.00e-87	315.00
IUUC-Opu-084008	Oryza punctata	41.67	6.00e-87	315.00
IUUC-Oru-084339	Oryza rufipogon	41.41	3.00e-86	313.00
IUUC-Osa-085782	Oryza sativa	41.41	3.00e-86	313.00
IUUC-Ola-087302	Oryzias latipes	67.88	0.00e+00	782.00
IUUC-Olu-087611	Ostreococcus lucimarinus	36.20	3.00e-87	316.00
IUUC-Oga-087935	Otolemur garnettii	95.24	0.00e+00	1742.00
IUUC-Oar-089229	Ovis aries	69.77	0.00e+00	1055.00
IUUC-Ptr-090715	Pan troglodytes	96.32	0.00e+00	1767.00
IUUC-Pan-092318	Papio anubis	96.52	0.00e+00	1768.00
IUUC-Psi-094053	Pelodiscus sinensis	83.61	0.00e+00	1616.00
IUUC-Pno-094985	Phaeosphaeria nodorum	32.98	4.00e-56	213.00
IUUC-Ppa-095819	Physcomitrella patens	35.65	3.00e-86	313.00
IUUC-Pfo-096857	Poecilia formosa	66.12	0.00e+00	1253.00
IUUC-Pab-098047	Pongo abelii	96.52	0.00e+00	1770.00
IUUC-Pop-099587	Populus trichocarpa	36.91	8.00e-86	311.00
IUUC-Pca-100558	Procavia capensis	94.35	0.00e+00	743.00
IUUC-Ppe-101261	Prunus persica	37.39	2.00e-87	317.00
IUUC-Pva-102683	Pteropus vampyrus	97.51	0.00e+00	1806.00
IUUC-Pgr-103660	Puccinia graminis	40.63	2.00e-73	270.00
IUUC-Ptt-103900	Puccinia triticina	41.33	6.00e-75	275.00
IUUC-Pte-104209	Pyrenophora teres	33.91	3.00e-61	230.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	31.03	7.00e-61	229.00
IUUC-Rno-105137	Rattus norvegicus	94.13	0.00e+00	1754.00
IUUC-Sce-106291	Saccharomyces cerevisiae	32.64	2.00e-59	224.00
IUUC-Sha-107514	Sarcophilus harrisii	80.75	0.00e+00	1485.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	35.17	7.00e-77	281.00
IUUC-Spo-108162	Schizosaccharomyces pombe	36.68	4.00e-76	279.00
IUUC-Smo-109186	Selaginella moellendorffii	40.83	4.00e-86	312.00
IUUC-Sit-110730	Setaria italica	37.53	1.00e-87	317.00
IUUC-Sly-111547	Solanum lycopersicum	37.58	6.00e-89	322.00
IUUC-Stu-112705	Solanum tuberosum	37.58	4.00e-89	323.00
IUUC-Sar-113222	Sorex araneus	91.10	0.00e+00	1562.00
IUUC-Sbi-114272	Sorghum bicolor	37.27	5.00e-89	322.00
IUUC-Sre-115061	Sporisorium reilianum	26.44	1.00e-91	331.00
IUUC-Ssc-116364	Sus scrofa	96.13	0.00e+00	1867.00
IUUC-Tgu-116645	Taeniopygia guttata	83.66	0.00e+00	1637.00
IUUC-Tru-117590	Takifugu rubripes	66.12	0.00e+00	1267.00
IUUC-Tsy-119212	Tarsius syrichta	90.83	0.00e+00	993.00
IUUC-Tni-119915	Tetraodon nigroviridis	66.36	0.00e+00	1243.00
IUUC-Tca-121765	Theobroma cacao	36.76	9.00e-87	315.00
IUUC-Tre-121887	Trichoderma reesei	29.85	4.00e-57	216.00
IUUC-Tvi-122262	Trichoderma virens	33.76	5.00e-56	213.00
IUUC-Tae-124148	Triticum aestivum	44.57	1.00e-34	142.00
IUUC-Tur-126483	Triticum urartu	42.97	3.00e-89	323.00
IUUC-Tme-127202	Tuber melanosporum	30.90	8.00e-54	205.00
IUUC-Tbe-127350	Tupaia belangeri	83.66	0.00e+00	648.00
IUUC-Ttr-129077	Tursiops truncatus	91.83	0.00e+00	1794.00
IUUC-Uma-129465	Ustilago maydis	33.78	7.00e-78	285.00
IUUC-Vda-129844	Verticillium dahliae	34.45	1.00e-62	234.00
IUUC-Vvi-131397	Vitis vinifera	37.22	7.00e-88	318.00
IUUC-Xtr-132057	Xenopus tropicalis	75.50	0.00e+00	1407.00
IUUC-Xma-134139	Xiphophorus maculatus	67.65	0.00e+00	801.00
IUUC-Yli-134424	Yarrowia lipolytica	31.96	2.00e-63	238.00
IUUC-Zma-135839	Zea mays	36.92	6.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence