iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067542

Ensembl Protein ID

ENSMLUP00000002225.2

UniProt Accession

G1NXV8; G1NXV8_MYOLU

Genbank Protein ID

ENSMLUP00000002225

Protein Name

Protein HIRA

Genbank Nucleotide ID

AAPE02038848

Gene Name

HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000002434.2	ENSMLUT00000002449.2	ENSMLUP00000002225.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-19	69.6	68	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 68   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 97
           8899******955699*************7 PP

Organism

Myotis lucifugus

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

RLLSPTFILS SSKPIFSVDI HPDGTKFATG GQGQDSGKVV IWNMSPVLQE DDEKDENIPK 60
MLCQMDNHLA CVNCVRWSNS GMYLASGGDD KLIMVWKRAT YIGPSTVFGS SGKLANVEQW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGATTGCTTA GTCCCACTTT TATACTTTCA TCTAGTTAAT GTCACTTGGA CAGTGTTCCA 60
GCAGTTTATA CTTTAAAACT TAGATCACTC CGCCCTCACT GTCAGGTGAG TGTACATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	39.19	6.00e-86	312.00
IUUC-Aml-001723	Ailuropoda melanoleuca	97.52	0.00e+00	1786.00
IUUC-Atr-003132	Amborella trichopoda	41.01	3.00e-85	310.00
IUUC-Apl-003197	Anas platyrhynchos	84.49	0.00e+00	1643.00
IUUC-Aca-004733	Anolis carolinensis	81.27	0.00e+00	1593.00
IUUC-Aly-005446	Arabidopsis lyrata	34.88	2.00e-79	290.00
IUUC-Ath-007627	Arabidopsis thaliana	36.07	1.00e-82	301.00
IUUC-Ago-007766	Ashbya gossypii	31.30	6.00e-57	215.00
IUUC-Acl-008104	Aspergillus clavatus	32.98	8.00e-60	225.00
IUUC-Afl-008591	Aspergillus flavus	29.96	5.00e-60	226.00
IUUC-Afu-008781	Aspergillus fumigatus	33.51	4.00e-58	220.00
IUUC-Ani-009272	Aspergillus nidulans	32.31	6.00e-53	202.00
IUUC-Ang-009655	Aspergillus niger	33.42	1.00e-60	228.00
IUUC-Aor-010119	Aspergillus oryzae	29.96	1.00e-60	228.00
IUUC-Ate-010530	Aspergillus terreus	27.43	1.00e-53	205.00
IUUC-Ame-011147	Astyanax mexicanus	77.78	2.00e-47	179.00
IUUC-Bgr-012237	Blumeria graminis	32.33	2.00e-58	221.00
IUUC-Bta-013320	Bos taurus	91.56	0.00e+00	1781.00
IUUC-Bci-013795	Botrytis cinerea	33.77	1.00e-63	238.00
IUUC-Bdi-014075	Brachypodium distachyon	41.94	9.00e-89	321.00
IUUC-Bol-016440	Brassica oleracea	35.18	2.00e-85	310.00
IUUC-Bra-016651	Brassica rapa	40.31	8.00e-84	305.00
IUUC-Cel-018692	Caenorhabditis elegans	37.99	1.00e-75	278.00
IUUC-Cja-018987	Callithrix jacchus	95.69	0.00e+00	1687.00
IUUC-Cfa-020132	Canis familiaris	97.51	0.00e+00	1782.00
IUUC-Cpo-021484	Cavia porcellus	94.98	0.00e+00	1765.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	36.02	4.00e-59	223.00
IUUC-Csa-023081	Chlorocebus sabaeus	95.67	0.00e+00	1772.00
IUUC-Cin-025182	Ciona intestinalis	55.14	1.00e-151	531.00
IUUC-Csv-026154	Ciona savignyi	54.94	5.00e-148	518.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	29.85	5.00e-62	233.00
IUUC-Cne-026891	Cryptococcus neoformans	41.55	3.00e-80	293.00
IUUC-Cme-027349	Cyanidioschyzon merolae	29.01	6.00e-52	199.00
IUUC-Dre-027655	Danio rerio	68.29	0.00e+00	1351.00
IUUC-Dno-029557	Dasypus novemcinctus	85.41	0.00e+00	1116.00
IUUC-Dor-030687	Dipodomys ordii	80.51	0.00e+00	724.00
IUUC-Dse-031334	Dothistroma septosporum	30.21	5.00e-60	226.00
IUUC-Dme-031746	Drosophila melanogaster	54.35	8.00e-155	541.00
IUUC-Ete-032384	Echinops telfairi	89.24	0.00e+00	1630.00
IUUC-Eca-033430	Equus caballus	97.51	0.00e+00	1776.00
IUUC-Fca-036121	Felis catus	97.51	0.00e+00	1784.00
IUUC-Fal-036817	Ficedula albicollis	83.38	0.00e+00	1640.00
IUUC-Fox-037906	Fusarium oxysporum	35.09	2.00e-65	243.00
IUUC-Fso-038409	Fusarium solani	33.83	2.00e-63	237.00
IUUC-Gmo-039151	Gadus morhua	84.32	0.00e+00	684.00
IUUC-Ggr-040016	Gaeumannomyces graminis	31.66	2.00e-66	248.00
IUUC-Gga-040936	Gallus gallus	84.56	0.00e+00	1705.00
IUUC-Gac-041405	Gasterosteus aculeatus	62.11	0.00e+00	1195.00
IUUC-Gma-044252	Glycine max	36.25	8.00e-88	318.00
IUUC-Ggo-045430	Gorilla gorilla	95.38	0.00e+00	1764.00
IUUC-Hsa-046442	Homo sapiens	95.37	0.00e+00	1771.00
IUUC-Hvu-047587	Hordeum vulgare	37.34	2.00e-80	293.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	100.00	2.00e-175	607.00
IUUC-Kpa-049145	Komagataella pastoris	31.36	4.00e-59	223.00
IUUC-Lch-050474	Latimeria chalumnae	75.60	0.00e+00	1422.00
IUUC-Lpe-051209	Leersia perrieri	35.24	2.00e-80	294.00
IUUC-Loc-052119	Lepisosteus oculatus	71.83	0.00e+00	1374.00
IUUC-Lma-053237	Leptosphaeria maculans	31.23	2.00e-65	244.00
IUUC-Laf-053718	Loxodonta africana	94.39	0.00e+00	1756.00
IUUC-Mcc-055621	Macaca mulatta	96.00	0.00e+00	1693.00
IUUC-Meu-055914	Macropus eugenii	78.99	0.00e+00	1454.00
IUUC-Mor-057090	Magnaporthe oryzae	34.09	2.00e-63	238.00
IUUC-Mpo-057364	Magnaporthe poae	32.28	8.00e-69	255.00
IUUC-Mtr-057744	Medicago truncatula	37.55	5.00e-88	319.00
IUUC-Mla-058914	Melampsora laricipopulina	40.16	1.00e-80	295.00
IUUC-Mga-060181	Meleagris gallopavo	83.56	0.00e+00	1674.00
IUUC-Mvi-060432	Microbotryum violaceum	38.50	7.00e-73	269.00
IUUC-Mmr-060871	Microcebus murinus	95.18	0.00e+00	1821.00
IUUC-Mdo-062301	Monodelphis domestica	85.01	0.00e+00	1623.00
IUUC-Mmu-063888	Mus musculus	93.41	0.00e+00	1729.00
IUUC-Mac-065137	Musa acuminata	37.39	2.00e-86	313.00
IUUC-Mpu-066732	Mustela putorius furo	97.13	0.00e+00	1823.00
IUUC-Nfi-068396	Neosartorya fischeri	34.18	4.00e-58	219.00
IUUC-Ncr-068842	Neurospora crassa	31.58	3.00e-64	240.00
IUUC-Nle-070156	Nomascus leucogenys	95.57	0.00e+00	1784.00
IUUC-Opr-070808	Ochotona princeps	94.56	0.00e+00	1428.00
IUUC-Ont-072105	Oreochromis niloticus	67.15	0.00e+00	1321.00
IUUC-Ocu-074962	Oryctolagus cuniculus	96.12	0.00e+00	1779.00
IUUC-Oba-075178	Oryza barthii	41.43	1.00e-87	318.00
IUUC-Obr-076399	Oryza brachyantha	36.67	9.00e-89	322.00
IUUC-Ogu-078797	Oryza glumaepatula	41.43	1.00e-87	318.00
IUUC-Oin-080085	Oryza indica	40.80	6.00e-78	285.00
IUUC-Olo-081048	Oryza longistaminata	41.04	3.00e-66	247.00
IUUC-Ome-081324	Oryza meridionalis	41.43	1.00e-87	318.00
IUUC-Oni-082548	Oryza nivara	41.43	1.00e-87	317.00
IUUC-Opu-084008	Oryza punctata	41.43	1.00e-87	317.00
IUUC-Oru-084339	Oryza rufipogon	41.18	4.00e-87	316.00
IUUC-Osa-085782	Oryza sativa	41.18	4.00e-87	316.00
IUUC-Ola-087302	Oryzias latipes	66.72	0.00e+00	786.00
IUUC-Olu-087611	Ostreococcus lucimarinus	35.62	3.00e-87	316.00
IUUC-Oga-087935	Otolemur garnettii	94.84	0.00e+00	1735.00
IUUC-Oar-089229	Ovis aries	69.22	0.00e+00	1062.00
IUUC-Ptr-090715	Pan troglodytes	95.47	0.00e+00	1772.00
IUUC-Pan-092318	Papio anubis	96.32	0.00e+00	1762.00
IUUC-Psi-094053	Pelodiscus sinensis	83.79	0.00e+00	1635.00
IUUC-Pno-094985	Phaeosphaeria nodorum	33.51	9.00e-57	215.00
IUUC-Ppa-095819	Physcomitrella patens	34.98	9.00e-86	311.00
IUUC-Pfo-096857	Poecilia formosa	65.77	0.00e+00	1273.00
IUUC-Pab-098047	Pongo abelii	95.57	0.00e+00	1771.00
IUUC-Pop-099587	Populus trichocarpa	35.77	1.00e-86	315.00
IUUC-Pca-100558	Procavia capensis	93.65	0.00e+00	738.00
IUUC-Ppe-101261	Prunus persica	37.73	1.00e-87	318.00
IUUC-Pva-102683	Pteropus vampyrus	96.85	0.00e+00	1811.00
IUUC-Pgr-103660	Puccinia graminis	39.61	2.00e-74	274.00
IUUC-Ptt-103900	Puccinia triticina	41.16	2.00e-76	280.00
IUUC-Pte-104209	Pyrenophora teres	34.15	1.00e-61	231.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	30.56	1.00e-61	231.00
IUUC-Rno-105566	Rattus norvegicus	92.81	0.00e+00	1749.00
IUUC-Sce-106291	Saccharomyces cerevisiae	32.90	7.00e-60	225.00
IUUC-Sha-107514	Sarcophilus harrisii	80.63	0.00e+00	1506.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	34.81	3.00e-77	283.00
IUUC-Spo-108162	Schizosaccharomyces pombe	36.93	3.00e-76	280.00
IUUC-Smo-109533	Selaginella moellendorffii	36.38	1.00e-87	318.00
IUUC-Sit-109980	Setaria italica	37.20	2.00e-89	323.00
IUUC-Sly-111547	Solanum lycopersicum	37.83	7.00e-91	328.00
IUUC-Stu-112705	Solanum tuberosum	37.83	4.00e-91	329.00
IUUC-Sar-113222	Sorex araneus	90.58	0.00e+00	1558.00
IUUC-Sbi-114272	Sorghum bicolor	37.35	4.00e-90	326.00
IUUC-Sre-115061	Sporisorium reilianum	27.28	6.00e-95	342.00
IUUC-Ssc-116364	Sus scrofa	94.69	0.00e+00	1857.00
IUUC-Tgu-116645	Taeniopygia guttata	84.04	0.00e+00	1666.00
IUUC-Tru-117590	Takifugu rubripes	65.71	0.00e+00	1290.00
IUUC-Tsy-119212	Tarsius syrichta	91.70	0.00e+00	1002.00
IUUC-Tni-119915	Tetraodon nigroviridis	66.03	0.00e+00	1271.00
IUUC-Tca-121765	Theobroma cacao	37.00	1.00e-87	318.00
IUUC-Tre-121887	Trichoderma reesei	33.25	9.00e-57	215.00
IUUC-Tvi-122262	Trichoderma virens	33.25	1.00e-56	215.00
IUUC-Tae-124148	Triticum aestivum	42.86	4.00e-35	143.00
IUUC-Tur-126483	Triticum urartu	42.46	5.00e-90	325.00
IUUC-Tme-127202	Tuber melanosporum	29.65	3.00e-53	203.00
IUUC-Tbe-127350	Tupaia belangeri	83.66	0.00e+00	647.00
IUUC-Ttr-129077	Tursiops truncatus	92.03	0.00e+00	1798.00
IUUC-Uma-129465	Ustilago maydis	35.89	1.00e-76	281.00
IUUC-Vda-129844	Verticillium dahliae	34.70	1.00e-62	234.00
IUUC-Vvi-131397	Vitis vinifera	37.10	2.00e-88	320.00
IUUC-Xtr-132057	Xenopus tropicalis	75.37	0.00e+00	1422.00
IUUC-Xma-134139	Xiphophorus maculatus	67.56	0.00e+00	797.00
IUUC-Yli-134424	Yarrowia lipolytica	31.96	3.00e-63	237.00
IUUC-Zma-135839	Zea mays	37.00	6.00e-89	322.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence