iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003356

Ensembl Protein ID

ENSAPLP00000012594.1

UniProt Accession

R0LE64; R0LE64_ANAPL

Genbank Protein ID

EOA99809.1

Protein Name

Putative ubiquitin carboxyl-terminal hydrolase CYLD

Genbank Nucleotide ID

ADON01085540

Gene Name

CYLD; Anapl_12255

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000012780.1	ENSAPLT00000013337.1	ENSAPLP00000012594.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-24	85.7	591	947

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 591  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 677
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  +k++k +  +i++l+++++ ++ +k    ++c  ++  r+ + +++ 
   Q: 678  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMDKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKMF 764
           ****************99..88999999999999**************************9854144444799****999********9 PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++++ +   k+k++++      +lh kR          ++ ++ +++p+
   Q: 765  NKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYEDTDISAG-KIKQFCRtcntQVHLHPKRQ---------SHKFNPLSLPK 840
           999999988...***************987655**********85444.66666662224467777777.........33467788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  +++  Wl fd               +Vt+++e  e l+++ 
   Q: 841  DLpdwDWRHGCIP-------YQKMELFAVLCIET----SHYVAFVKYGRDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 918
           6511144444555.......99*********999....9********666567999999999999999999978888866567777665 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 919  eelhsldsrkiqgcarrllCDAYMCMYQS 947
           7788888888888999***********85 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MNSGLWSQEK ASSSYWEERI FYLLLQECSV IDKQTQKLLK VPKGSIGQFF QDRSSVGHSR 60
NIPCKGKKLQ IGLKILEQPH AILFVDEKDV IEINEKLAEL LLAITNCEER YSLFKSKSRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATTCAG GCTTATGGAG TCAAGAAAAA GCAAGTTCAT CATATTGGGA AGAGCGCATC 60
TTTTACTTGC TTCTCCAAGA ATGCAGTGTC ATAGACAAGC AGACTCAAAA GCTCTTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

apla:101792318

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	87.04	0.00e+00	1743.00
IUUC-Atr-003043	Amborella trichopoda	34.43	1.20e-01	29.60
IUUC-Aca-004402	Anolis carolinensis	84.19	0.00e+00	1568.00
IUUC-Aly-005916	Arabidopsis lyrata	32.76	3.20e-02	31.60
IUUC-Ath-007038	Arabidopsis thaliana	33.33	2.90e-01	28.50
IUUC-Acl-008216	Aspergillus clavatus	47.22	3.00e-04	38.50
IUUC-Afl-008534	Aspergillus flavus	35.94	6.00e-05	40.80
IUUC-Afu-008927	Aspergillus fumigatus	35.82	2.00e-04	38.90
IUUC-Ani-009283	Aspergillus nidulans	40.91	4.00e-04	38.10
IUUC-Ang-009564	Aspergillus niger	41.82	5.00e-05	40.80
IUUC-Aor-010034	Aspergillus oryzae	35.94	6.00e-05	40.80
IUUC-Ate-010424	Aspergillus terreus	38.67	2.00e-04	39.30
IUUC-Ame-011581	Astyanax mexicanus	67.97	0.00e+00	1252.00
IUUC-Bta-012359	Bos taurus	87.32	0.00e+00	1744.00
IUUC-Bol-015891	Brassica oleracea	38.30	1.50e-01	29.30
IUUC-Cel-018528	Caenorhabditis elegans	35.43	8.00e-58	219.00
IUUC-Cja-018797	Callithrix jacchus	86.94	0.00e+00	1744.00
IUUC-Cfa-020264	Canis familiaris	87.42	0.00e+00	1746.00
IUUC-Cpo-022057	Cavia porcellus	86.94	0.00e+00	1742.00
IUUC-Csa-023093	Chlorocebus sabaeus	87.74	0.00e+00	1753.00
IUUC-Cho-024486	Choloepus hoffmanni	85.95	9.00e-160	557.00
IUUC-Cin-025179	Ciona intestinalis	44.10	7.00e-119	420.00
IUUC-Csv-025811	Ciona savignyi	36.54	1.00e-03	36.20
IUUC-Cne-026867	Cryptococcus neoformans	45.10	1.00e-06	46.20
IUUC-Cme-027227	Cyanidioschyzon merolae	34.85	7.60e-02	30.40
IUUC-Dre-028233	Danio rerio	68.66	0.00e+00	1288.00
IUUC-Dno-029496	Dasypus novemcinctus	87.00	0.00e+00	1744.00
IUUC-Dor-030919	Dipodomys ordii	82.24	0.00e+00	1623.00
IUUC-Dse-031240	Dothistroma septosporum	37.74	7.00e-04	37.00
IUUC-Dme-032159	Drosophila melanogaster	46.34	2.00e-124	439.00
IUUC-Ete-032734	Echinops telfairi	82.24	0.00e+00	1622.00
IUUC-Eca-033350	Equus caballus	87.42	0.00e+00	1755.00
IUUC-Eeu-034566	Erinaceus europaeus	93.01	5.00e-109	388.00
IUUC-Fca-035632	Felis catus	84.22	0.00e+00	1184.00
IUUC-Fal-037313	Ficedula albicollis	91.93	0.00e+00	1740.00
IUUC-Gmo-039239	Gadus morhua	68.33	0.00e+00	1231.00
IUUC-Ggr-039751	Gaeumannomyces graminis	34.92	2.90e-02	32.00
IUUC-Gga-040668	Gallus gallus	97.69	0.00e+00	1877.00
IUUC-Gac-042630	Gasterosteus aculeatus	68.61	0.00e+00	1235.00
IUUC-Ggo-044462	Gorilla gorilla	87.25	0.00e+00	1747.00
IUUC-Hsa-045846	Homo sapiens	87.25	0.00e+00	1746.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	86.08	0.00e+00	772.00
IUUC-Kpa-049126	Komagataella pastoris	38.46	5.00e-04	37.40
IUUC-Lch-050303	Latimeria chalumnae	71.50	0.00e+00	1330.00
IUUC-Loc-052190	Lepisosteus oculatus	70.82	0.00e+00	1301.00
IUUC-Lma-052977	Leptosphaeria maculans	42.11	6.00e-05	40.80
IUUC-Laf-054480	Loxodonta africana	89.72	0.00e+00	741.00
IUUC-Mcc-055849	Macaca mulatta	87.67	0.00e+00	1751.00
IUUC-Meu-056755	Macropus eugenii	76.78	0.00e+00	823.00
IUUC-Mtr-058357	Medicago truncatula	35.71	7.00e-03	33.90
IUUC-Mla-059125	Melampsora laricipopulina	41.51	1.00e-03	36.60
IUUC-Mga-059561	Meleagris gallopavo	96.76	0.00e+00	1859.00
IUUC-Mvi-060558	Microbotryum violaceum	36.67	1.50e-02	32.70
IUUC-Mmr-060942	Microcebus murinus	87.36	0.00e+00	1737.00
IUUC-Mdo-062618	Monodelphis domestica	87.46	0.00e+00	1748.00
IUUC-Mmu-063843	Mus musculus	86.00	0.00e+00	1677.00
IUUC-Mac-065590	Musa acuminata	32.76	3.00e-03	35.00
IUUC-Mpu-066919	Mustela putorius furo	87.42	0.00e+00	1749.00
IUUC-Mlu-066983	Myotis lucifugus	84.28	0.00e+00	1667.00
IUUC-Nfi-068351	Neosartorya fischeri	45.00	9.00e-04	37.00
IUUC-Ncr-068854	Neurospora crassa	28.28	3.00e-03	35.00
IUUC-Nle-069893	Nomascus leucogenys	87.36	0.00e+00	1747.00
IUUC-Opr-071181	Ochotona princeps	79.46	0.00e+00	1456.00
IUUC-Ont-071697	Oreochromis niloticus	67.96	0.00e+00	1225.00
IUUC-Oan-073658	Ornithorhynchus anatinus	87.11	0.00e+00	1719.00
IUUC-Ocu-074954	Oryctolagus cuniculus	87.67	0.00e+00	1753.00
IUUC-Olo-080845	Oryza longistaminata	36.76	1.30e-01	32.30
IUUC-Ola-086523	Oryzias latipes	67.08	0.00e+00	1204.00
IUUC-Olu-087778	Ostreococcus lucimarinus	37.10	4.40e-02	31.20
IUUC-Oga-089003	Otolemur garnettii	87.46	0.00e+00	1755.00
IUUC-Oar-090376	Ovis aries	86.89	0.00e+00	1747.00
IUUC-Ptr-090520	Pan troglodytes	85.48	0.00e+00	1696.00
IUUC-Pan-092281	Papio anubis	87.74	0.00e+00	1753.00
IUUC-Psi-093047	Pelodiscus sinensis	94.81	0.00e+00	1718.00
IUUC-Pma-094575	Petromyzon marinus	54.34	4.00e-66	243.00
IUUC-Pno-094999	Phaeosphaeria nodorum	36.11	2.00e-04	39.30
IUUC-Pfo-096358	Poecilia formosa	67.49	0.00e+00	1172.00
IUUC-Pab-097740	Pongo abelii	87.04	0.00e+00	1741.00
IUUC-Pca-100461	Procavia capensis	78.24	0.00e+00	1400.00
IUUC-Ppe-101764	Prunus persica	37.70	7.00e-03	33.90
IUUC-Pva-102134	Pteropus vampyrus	78.27	0.00e+00	1536.00
IUUC-Pgr-103337	Puccinia graminis	33.93	7.00e-08	50.40
IUUC-Ptt-103764	Puccinia triticina	51.52	2.00e-04	40.00
IUUC-Pte-104265	Pyrenophora teres	34.72	2.00e-04	39.30
IUUC-Pyt-104528	Pyrenophora triticirepentis	34.72	9.00e-05	40.40
IUUC-Rno-105807	Rattus norvegicus	84.91	0.00e+00	1650.00
IUUC-Sha-107236	Sarcophilus harrisii	87.73	0.00e+00	1692.00
IUUC-Sja-107978	Schizosaccharomyces japonicus	50.00	3.00e-09	54.70
IUUC-Spo-108310	Schizosaccharomyces pombe	41.51	3.00e-05	42.00
IUUC-Sly-111811	Solanum lycopersicum	37.10	1.00e-02	33.10
IUUC-Stu-111984	Solanum tuberosum	37.10	1.40e-02	32.70
IUUC-Sar-113366	Sorex araneus	95.11	0.00e+00	913.00
IUUC-Sre-115083	Sporisorium reilianum	36.84	1.00e-03	36.60
IUUC-Ssc-116306	Sus scrofa	31.51	1.00e-03	36.20
IUUC-Tgu-117201	Taeniopygia guttata	93.93	0.00e+00	1784.00
IUUC-Tru-117953	Takifugu rubripes	68.89	0.00e+00	1225.00
IUUC-Tsy-119610	Tarsius syrichta	85.27	0.00e+00	1703.00
IUUC-Tni-120743	Tetraodon nigroviridis	54.10	8.00e-138	484.00
IUUC-Tca-121819	Theobroma cacao	36.84	3.00e-03	34.70
IUUC-Tme-127153	Tuber melanosporum	34.04	5.00e-04	37.70
IUUC-Tbe-128155	Tupaia belangeri	70.62	0.00e+00	679.00
IUUC-Ttr-128942	Tursiops truncatus	81.82	0.00e+00	1623.00
IUUC-Uma-129608	Ustilago maydis	38.24	4.00e-05	41.20
IUUC-Vpa-130281	Vicugna pacos	77.51	0.00e+00	1501.00
IUUC-Vvi-131178	Vitis vinifera	37.70	8.00e-03	33.50
IUUC-Xtr-132627	Xenopus tropicalis	78.70	0.00e+00	1453.00
IUUC-Xma-133449	Xiphophorus maculatus	66.19	0.00e+00	1133.00
IUUC-Yli-134439	Yarrowia lipolytica	47.17	4.00e-06	44.30

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence