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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105807
UUCD1 version UUC-RaN-01121
Ensembl Protein ID ENSRNOP00000018888.7
UniProt Accession F1LPJ6; F1LPJ6_RAT
Genbank Protein ID ENSRNOP00000018888
Protein Name Ubiquitin carboxyl-terminal hydrolase CYLD
Genbank Nucleotide ID AABR07043075
Gene Name Cyld
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000014048.7 ENSRNOT00000018888.7 ENSRNOP00000018888.7
ENSRNOG00000014048.7 ENSRNOT00000091626.1 ENSRNOP00000070060.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 5.60e-24 85.3 587 943
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL+++++  + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 587  GIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 673
           999**************************989999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ ++++  ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 674  KDPEEFLNILFHDILRVE--PLLKIRSAGQKVQDCNFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 760
           ****************99..8899999999999***************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh  R          ++    v++p+
   Q: 761  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcstQVHLHPRRL---------NHTYHPVSLPK 836
           ****99998...***************987655********9985544.77777772212455555555.........56677888886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 837  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 914
           6511134444444.......9**********999....9********777788*****9999*******99999999976678888776 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 915  edlhsldsrriqgcarrllCDAYMCMYQS 943
           899999999999999************85 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MSSGLWNQEK VTSPYWEERL FYLLLQECSV TDKQTQKLLR VPKGSIGQYI QDRSVGHSRV 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERL SLFRNRIRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105807|DUB,USP|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTTCAG GCCTGTGGAA CCAAGAGAAA GTTACTTCAC CCTACTGGGA AGAACGGCTT 60
TTTTATCTGC TTCTTCAAGA ATGCAGTGTA ACAGACAAAC AGACACAGAA GCTCCTGAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105807|DUB,USP|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 93.10 0.00e+00 1818.00
IUUC-Apl-003356 Anas platyrhynchos 84.91 0.00e+00 1613.00
IUUC-Aca-004402 Anolis carolinensis 78.23 0.00e+00 1429.00
IUUC-Ame-011581 Astyanax mexicanus 66.98 0.00e+00 1187.00
IUUC-Bta-012359 Bos taurus 93.28 0.00e+00 1809.00
IUUC-Cel-018528 Caenorhabditis elegans 34.88 1.00e-55 211.00
IUUC-Cja-018797 Callithrix jacchus 92.15 0.00e+00 1793.00
IUUC-Cfa-020264 Canis familiaris 93.28 0.00e+00 1823.00
IUUC-Cpo-022057 Cavia porcellus 93.83 0.00e+00 1823.00
IUUC-Csa-023093 Chlorocebus sabaeus 93.07 0.00e+00 1806.00
IUUC-Cho-024486 Choloepus hoffmanni 79.95 5.00e-172 598.00
IUUC-Cin-025179 Ciona intestinalis 43.48 5.00e-115 407.00
IUUC-Dre-028233 Danio rerio 66.53 0.00e+00 1227.00
IUUC-Dno-029496 Dasypus novemcinctus 92.76 0.00e+00 1807.00
IUUC-Dor-030919 Dipodomys ordii 87.45 0.00e+00 1677.00
IUUC-Dme-032159 Drosophila melanogaster 45.74 8.00e-123 434.00
IUUC-Ete-032734 Echinops telfairi 87.24 0.00e+00 1674.00
IUUC-Eca-033350 Equus caballus 93.70 0.00e+00 1823.00
IUUC-Eeu-034566 Erinaceus europaeus 96.77 3.00e-113 402.00
IUUC-Fca-035632 Felis catus 92.02 0.00e+00 1254.00
IUUC-Fal-037313 Ficedula albicollis 79.77 0.00e+00 1501.00
IUUC-Gmo-039239 Gadus morhua 66.42 0.00e+00 1164.00
IUUC-Gga-040668 Gallus gallus 85.12 0.00e+00 1613.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.33 0.00e+00 1166.00
IUUC-Ggo-044462 Gorilla gorilla 92.78 0.00e+00 1805.00
IUUC-Hsa-045846 Homo sapiens 92.78 0.00e+00 1805.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 91.65 0.00e+00 785.00
IUUC-Lch-050303 Latimeria chalumnae 69.19 0.00e+00 1242.00
IUUC-Loc-052190 Lepisosteus oculatus 68.37 0.00e+00 1236.00
IUUC-Laf-054480 Loxodonta africana 90.98 0.00e+00 748.00
IUUC-Mcc-055849 Macaca mulatta 92.68 0.00e+00 1802.00
IUUC-Meu-056755 Macropus eugenii 78.84 0.00e+00 799.00
IUUC-Mga-059561 Meleagris gallopavo 84.54 0.00e+00 1605.00
IUUC-Mmr-060942 Microcebus murinus 93.62 0.00e+00 1806.00
IUUC-Mdo-062618 Monodelphis domestica 89.02 0.00e+00 1742.00
IUUC-Mmu-063843 Mus musculus 97.07 0.00e+00 1839.00
IUUC-Mpu-066919 Mustela putorius furo 93.39 0.00e+00 1821.00
IUUC-Mlu-066983 Myotis lucifugus 89.09 0.00e+00 1712.00
IUUC-Nle-069893 Nomascus leucogenys 92.89 0.00e+00 1806.00
IUUC-Opr-071181 Ochotona princeps 84.02 0.00e+00 1495.00
IUUC-Ont-071697 Oreochromis niloticus 66.70 0.00e+00 1165.00
IUUC-Oan-073658 Ornithorhynchus anatinus 87.62 0.00e+00 1699.00
IUUC-Ocu-074954 Oryctolagus cuniculus 93.31 0.00e+00 1816.00
IUUC-Ola-086523 Oryzias latipes 65.92 0.00e+00 1151.00
IUUC-Oga-089003 Otolemur garnettii 93.41 0.00e+00 1819.00
IUUC-Oar-090376 Ovis aries 92.92 0.00e+00 1813.00
IUUC-Ptr-090520 Pan troglodytes 91.11 0.00e+00 1759.00
IUUC-Pan-092281 Papio anubis 93.07 0.00e+00 1806.00
IUUC-Psi-093047 Pelodiscus sinensis 85.88 0.00e+00 1529.00
IUUC-Pma-094575 Petromyzon marinus 54.59 1.00e-65 242.00
IUUC-Pfo-096358 Poecilia formosa 66.35 0.00e+00 1103.00
IUUC-Pab-097740 Pongo abelii 92.68 0.00e+00 1801.00
IUUC-Pca-100461 Procavia capensis 83.91 0.00e+00 1459.00
IUUC-Pva-102134 Pteropus vampyrus 83.68 0.00e+00 1592.00
IUUC-Sha-107236 Sarcophilus harrisii 89.96 0.00e+00 1717.00
IUUC-Sar-113366 Sorex araneus 97.33 0.00e+00 927.00
IUUC-Tgu-117201 Taeniopygia guttata 81.69 0.00e+00 1533.00
IUUC-Tru-117953 Takifugu rubripes 67.43 0.00e+00 1163.00
IUUC-Tsy-119610 Tarsius syrichta 91.00 0.00e+00 1766.00
IUUC-Tni-120743 Tetraodon nigroviridis 39.71 7.00e-155 541.00
IUUC-Tbe-128155 Tupaia belangeri 75.49 0.00e+00 701.00
IUUC-Ttr-128942 Tursiops truncatus 87.97 0.00e+00 1692.00
IUUC-Vpa-130281 Vicugna pacos 82.51 0.00e+00 1556.00
IUUC-Xtr-132627 Xenopus tropicalis 74.74 0.00e+00 1363.00
IUUC-Xma-133449 Xiphophorus maculatus 65.14 0.00e+00 1066.00
Created Date 25-Jun-2017

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