iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117953

UUCD1 version

UUC-TaR-01170

Ensembl Protein ID

ENSTRUP00000021930.1

UniProt Accession

H2TB90; H2TB90_TAKRU

Protein Name

Uncharacterized protein

Gene Name

cylda; cyld

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000008733.1	ENSTRUT00000022020.1	ENSTRUP00000021930.1
ENSTRUG00000008733.1	ENSTRUT00000022021.1	ENSTRUP00000021931.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-21	77.9	593	949

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + ++k++ e + e+++ l +++ + ++     + +k+++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYRETQELLRTEIVNPLRIHGyVCATKVMKLRRILEKVEAASGF--TSEE 679
           999***************************99999999999999999999999999877679***************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.sqik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  +kk+k +  +i++l+++++  s++k    ++c  ++  r+ + +++ 
   Q: 680  KDPEEFLNILFHHILRVD--PLLKLRSAGQKVQDCYFYQIFMDKKDKVGVPTIQQLLEWSFInSDLKfaeAPSCLIIQmPRFGKDFKMF 766
           **************9977..778889999999999*************************9843444334899****999********* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
            ++  + e    +++d+Le+  +e++++g  + y+c+ c+++ + +   k+k+++e   ++           ++++ ++k+ +p+eL+ 
   Q: 767  NKIFPSLEL---DITDLLEDTPRECRICGGLAlYECRDCYEDGDITAG-KIKQFCEKCNIQVHLH---P--RRKSHRHSKLCVPKELQD 846
           **9999988...****************99888********9986665.9999999665555444...1..233455778888977766 PP
   S: 262  spfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg....... 327
              + ++++    +++ eL+av++ +      HYva+vk  + +  Wl fd               +V++++e e  l++t        
   Q: 847  G--TGRQSSFP--RQRMELFAVLCIET----SHYVAFVKYGSADssWLFFDSmadrdggqngfniPQVSPCPEvEAYLKMTPeelhtld 927
           5..45544444..99*********999....9********6555669999999999999999999888888765777776668888888 PP
   S: 328  ............staYvlfYkr 337
                       ++aY+++Y++
   Q: 928  pksiqgqarrllCDAYMCMYQS 949
           888888999***********95 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MSSALWSQEK PSGGFRDDWR FYMVIKECTV EKPSQKTLRI PRGSLGQACQ ERNSLGRTLT 60
PCKGKKSLRI LDQTNVVLSL DERDVLELDE NLAELLFPIT NCEERYALLC NKSRLDRVRD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTCTG CCCTGTGGAG CCAGGAGAAG CCCAGTGGTG GCTTCAGGGA CGACTGGCGC 60
TTTTACATGG TCATAAAGGA GTGTACGGTT GAGAAGCCTT CCCAGAAAAC CCTGAGGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005829--C:cytosol
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0021551--P:central nervous system morphogenesis
GO:0070266--P:necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0007346--P:regulation of mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

tru:101066719

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	68.19	0.00e+00	1306.00
IUUC-Apl-003356	Anas platyrhynchos	69.13	0.00e+00	1284.00
IUUC-Aca-004402	Anolis carolinensis	63.46	0.00e+00	1130.00
IUUC-Ame-011581	Astyanax mexicanus	87.30	0.00e+00	1563.00
IUUC-Bta-012359	Bos taurus	68.30	0.00e+00	1304.00
IUUC-Cel-018528	Caenorhabditis elegans	31.65	2.00e-57	218.00
IUUC-Cja-018797	Callithrix jacchus	68.19	0.00e+00	1296.00
IUUC-Cfa-020264	Canis familiaris	68.09	0.00e+00	1303.00
IUUC-Cpo-022057	Cavia porcellus	68.70	0.00e+00	1308.00
IUUC-Csa-023093	Chlorocebus sabaeus	68.50	0.00e+00	1299.00
IUUC-Cho-024486	Choloepus hoffmanni	74.18	2.00e-134	473.00
IUUC-Cin-025179	Ciona intestinalis	45.34	1.00e-119	422.00
IUUC-Dre-028233	Danio rerio	84.42	0.00e+00	1583.00
IUUC-Dno-029496	Dasypus novemcinctus	68.19	0.00e+00	1303.00
IUUC-Dor-030919	Dipodomys ordii	81.86	0.00e+00	828.00
IUUC-Dme-032159	Drosophila melanogaster	47.34	3.00e-126	445.00
IUUC-Ete-032734	Echinops telfairi	64.35	0.00e+00	1196.00
IUUC-Eca-033350	Equus caballus	68.19	0.00e+00	1307.00
IUUC-Eeu-034566	Erinaceus europaeus	76.34	7.00e-86	312.00
IUUC-Fca-035632	Felis catus	62.97	0.00e+00	828.00
IUUC-Fal-037313	Ficedula albicollis	65.45	0.00e+00	1187.00
IUUC-Gmo-039239	Gadus morhua	89.47	0.00e+00	1600.00
IUUC-Gga-040668	Gallus gallus	69.06	0.00e+00	1283.00
IUUC-Gac-042630	Gasterosteus aculeatus	94.87	0.00e+00	1671.00
IUUC-Ggo-044462	Gorilla gorilla	68.19	0.00e+00	1291.00
IUUC-Hsa-045846	Homo sapiens	68.19	0.00e+00	1291.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	70.34	2.00e-168	584.00
IUUC-Lch-050303	Latimeria chalumnae	65.20	0.00e+00	1145.00
IUUC-Loc-052190	Lepisosteus oculatus	81.88	0.00e+00	1509.00
IUUC-Laf-054480	Loxodonta africana	76.69	0.00e+00	634.00
IUUC-Mcc-055849	Macaca mulatta	68.29	0.00e+00	1293.00
IUUC-Meu-056755	Macropus eugenii	55.90	1.00e-155	543.00
IUUC-Mga-059561	Meleagris gallopavo	68.43	0.00e+00	1274.00
IUUC-Mmr-060942	Microcebus murinus	68.08	0.00e+00	1289.00
IUUC-Mdo-062618	Monodelphis domestica	67.74	0.00e+00	1293.00
IUUC-Mmu-063843	Mus musculus	68.08	0.00e+00	1264.00
IUUC-Mpu-066919	Mustela putorius furo	68.30	0.00e+00	1308.00
IUUC-Mlu-066983	Myotis lucifugus	67.78	0.00e+00	1288.00
IUUC-Nle-069893	Nomascus leucogenys	68.19	0.00e+00	1291.00
IUUC-Opr-071181	Ochotona princeps	61.39	0.00e+00	1048.00
IUUC-Ont-071697	Oreochromis niloticus	95.19	0.00e+00	1658.00
IUUC-Oan-073658	Ornithorhynchus anatinus	68.30	0.00e+00	1298.00
IUUC-Ocu-074954	Oryctolagus cuniculus	68.60	0.00e+00	1303.00
IUUC-Ola-086523	Oryzias latipes	90.60	0.00e+00	1604.00
IUUC-Oga-089003	Otolemur garnettii	68.39	0.00e+00	1305.00
IUUC-Oar-090376	Ovis aries	68.01	0.00e+00	1305.00
IUUC-Ptr-090520	Pan troglodytes	66.63	0.00e+00	1244.00
IUUC-Pan-092281	Papio anubis	68.50	0.00e+00	1299.00
IUUC-Psi-093047	Pelodiscus sinensis	71.69	0.00e+00	1246.00
IUUC-Pma-094575	Petromyzon marinus	55.30	4.00e-66	243.00
IUUC-Pfo-096358	Poecilia formosa	89.85	0.00e+00	1514.00
IUUC-Pab-097740	Pongo abelii	67.98	0.00e+00	1290.00
IUUC-Pca-100461	Procavia capensis	60.84	0.00e+00	1016.00
IUUC-Pva-102134	Pteropus vampyrus	61.72	0.00e+00	1147.00
IUUC-Rno-105807	Rattus norvegicus	67.88	0.00e+00	1251.00
IUUC-Sha-107236	Sarcophilus harrisii	67.72	0.00e+00	1263.00
IUUC-Sar-113366	Sorex araneus	81.78	0.00e+00	784.00
IUUC-Tgu-117201	Taeniopygia guttata	65.98	0.00e+00	1206.00
IUUC-Tsy-119610	Tarsius syrichta	66.42	0.00e+00	1258.00
IUUC-Tni-120743	Tetraodon nigroviridis	53.48	8.00e-135	474.00
IUUC-Tbe-128155	Tupaia belangeri	58.30	2.00e-154	539.00
IUUC-Ttr-128942	Tursiops truncatus	63.42	0.00e+00	1187.00
IUUC-Vpa-130281	Vicugna pacos	60.48	0.00e+00	1102.00
IUUC-Xtr-132627	Xenopus tropicalis	62.88	0.00e+00	1108.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence