iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004165

Ensembl Protein ID

ENSAPLP00000003808.1

UniProt Accession

U3I987; U3I987_ANAPL

Genbank Protein ID

ENSAPLP00000003808

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01011488

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004191.1	ENSAPLT00000004415.1	ENSAPLP00000003808.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-79	266.7	2453	2775

Active Site

Position(s)	Description	Evidence
2745	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2453 ENRKRHGSSRSVVDMELDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2535
           556777999999999999999988777888234444777777777765....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+++G nipVt +N +eYv++++e+r+  
   Q: 2536 LGRKVNWHDFAFFDPVMYESlRQLILASQstDADAVFAAMDLAFAIDLCKEEGGGQVELISNGVNIPVTPQNVYEYVRKYAEHRMLV 2622
           ********************5555666655566889999************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2623 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2709
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2710 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2775
           *********999******..799999.99**********************************9.99875 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE 60
LGKPDNNDGS KLSSGSGAGR TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATTAAGGG AAGTTTCAGA GAAGCTGAAC AAATATAATT TAAACAGGTA AGACGTATTA 60
CGTGATGCTG CATGTAATTT AGGAAAGGGT GATTTTAATG ATGCCAACAG GAATTAGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	97.73	0.00e+00	4534.00
IUUC-Aca-004577	Anolis carolinensis	97.13	0.00e+00	3951.00
IUUC-Ame-010702	Astyanax mexicanus	84.90	0.00e+00	2486.00
IUUC-Bta-012313	Bos taurus	96.59	0.00e+00	4530.00
IUUC-Cel-018165	Caenorhabditis elegans	26.33	2.00e-87	318.00
IUUC-Cja-019858	Callithrix jacchus	96.44	0.00e+00	4543.00
IUUC-Cfa-020973	Canis familiaris	96.73	0.00e+00	4532.00
IUUC-Cpo-022108	Cavia porcellus	96.78	0.00e+00	1910.00
IUUC-Csa-023985	Chlorocebus sabaeus	97.48	0.00e+00	4560.00
IUUC-Cho-025034	Choloepus hoffmanni	85.76	0.00e+00	970.00
IUUC-Cin-025715	Ciona intestinalis	40.41	0.00e+00	931.00
IUUC-Csv-026088	Ciona savignyi	39.93	1.00e-158	553.00
IUUC-Dre-027730	Danio rerio	87.45	0.00e+00	4001.00
IUUC-Dno-029123	Dasypus novemcinctus	94.15	0.00e+00	4368.00
IUUC-Dor-030757	Dipodomys ordii	92.12	0.00e+00	2850.00
IUUC-Dme-032192	Drosophila melanogaster	51.75	5.00e-175	609.00
IUUC-Ete-032292	Echinops telfairi	94.61	0.00e+00	2162.00
IUUC-Eca-034347	Equus caballus	96.41	0.00e+00	4480.00
IUUC-Eeu-034873	Erinaceus europaeus	92.02	0.00e+00	4294.00
IUUC-Fca-036485	Felis catus	95.37	0.00e+00	4436.00
IUUC-Fal-037071	Ficedula albicollis	98.70	0.00e+00	4553.00
IUUC-Gmo-039589	Gadus morhua	88.53	0.00e+00	3993.00
IUUC-Gga-041195	Gallus gallus	96.37	0.00e+00	4437.00
IUUC-Gac-042538	Gasterosteus aculeatus	89.01	0.00e+00	4005.00
IUUC-Ggo-045351	Gorilla gorilla	96.37	0.00e+00	4601.00
IUUC-Hsa-045941	Homo sapiens	96.48	0.00e+00	4563.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	96.37	0.00e+00	4520.00
IUUC-Lch-050480	Latimeria chalumnae	93.22	0.00e+00	4330.00
IUUC-Loc-052664	Lepisosteus oculatus	89.01	0.00e+00	4111.00
IUUC-Laf-053935	Loxodonta africana	97.98	0.00e+00	1599.00
IUUC-Mcc-054703	Macaca mulatta	97.48	0.00e+00	4563.00
IUUC-Meu-056431	Macropus eugenii	88.28	0.00e+00	800.00
IUUC-Mga-059289	Meleagris gallopavo	98.24	0.00e+00	3656.00
IUUC-Mmr-061737	Microcebus murinus	96.08	0.00e+00	4453.00
IUUC-Mdo-062499	Monodelphis domestica	96.84	0.00e+00	4499.00
IUUC-Mmu-063273	Mus musculus	95.43	0.00e+00	4429.00
IUUC-Mpu-066907	Mustela putorius furo	97.49	0.00e+00	4186.00
IUUC-Mlu-067942	Myotis lucifugus	97.38	0.00e+00	4559.00
IUUC-Nle-069527	Nomascus leucogenys	96.48	0.00e+00	4572.00
IUUC-Opr-070626	Ochotona princeps	85.71	0.00e+00	1425.00
IUUC-Ont-071951	Oreochromis niloticus	87.80	0.00e+00	3954.00
IUUC-Oan-072958	Ornithorhynchus anatinus	97.96	0.00e+00	4182.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.54	0.00e+00	4440.00
IUUC-Ola-086757	Oryzias latipes	88.51	0.00e+00	4026.00
IUUC-Oga-088781	Otolemur garnettii	96.37	0.00e+00	4512.00
IUUC-Oar-089274	Ovis aries	97.41	0.00e+00	4517.00
IUUC-Ptr-090669	Pan troglodytes	96.98	0.00e+00	3972.00
IUUC-Pan-092226	Papio anubis	96.48	0.00e+00	4535.00
IUUC-Psi-093502	Pelodiscus sinensis	97.56	0.00e+00	4537.00
IUUC-Pma-094454	Petromyzon marinus	83.00	0.00e+00	735.00
IUUC-Pfo-096173	Poecilia formosa	87.71	0.00e+00	3761.00
IUUC-Pab-098355	Pongo abelii	96.86	0.00e+00	3157.00
IUUC-Pca-100570	Procavia capensis	97.32	0.00e+00	1164.00
IUUC-Pva-102572	Pteropus vampyrus	93.63	0.00e+00	1348.00
IUUC-Rno-104916	Rattus norvegicus	94.46	0.00e+00	3919.00
IUUC-Sha-106653	Sarcophilus harrisii	97.09	0.00e+00	4526.00
IUUC-Sar-113517	Sorex araneus	87.31	0.00e+00	1265.00
IUUC-Ssc-115470	Sus scrofa	97.34	0.00e+00	2510.00
IUUC-Tgu-116932	Taeniopygia guttata	98.42	0.00e+00	4536.00
IUUC-Tru-117682	Takifugu rubripes	88.29	0.00e+00	2590.00
IUUC-Tsy-119417	Tarsius syrichta	92.70	0.00e+00	2451.00
IUUC-Tni-120442	Tetraodon nigroviridis	84.03	0.00e+00	3654.00
IUUC-Tbe-127456	Tupaia belangeri	85.27	0.00e+00	2083.00
IUUC-Ttr-128606	Tursiops truncatus	91.78	0.00e+00	1529.00
IUUC-Vpa-130112	Vicugna pacos	94.52	0.00e+00	3705.00
IUUC-Xtr-131929	Xenopus tropicalis	94.46	0.00e+00	4417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence