iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21155715

Classification

Family	E-value	Score	Start	End
DUB/USP	1.90e-82	278.3	51	347

Active Site

Position(s)	Description	Evidence
60	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU01035, ECO:0000305\|PubMed:11468161}
307	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU01035}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsg 86
           +Gl+N gN+CY+N++LQcL+++p+l++++l+ ++++++      +p+g+ +++++  +++ +  +++  +++p+++l++       f++
   Q: 51   CGLQNTGNSCYLNAALQCLTHTPPLADYMLSqEYSQTC-----CSPEGCKMCAMEAHVTQSLlhSHSGDVMKPSQILTSA------FHK 128
           7******************************4444444.....4678888888887777766578888899**9998765......889 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
            +q+Da+Efl+f l++++e++                  l+ +++++++++ +s+i+d+F+g ++sqikcl+c+ +s +++ fld++l+
   Q: 129  HQQEDAHEFLMFTLETMHESC------------------LQVHRQSEPTSEDSSPIHDIFGGLWRSQIKCLHCQGTSDTYDRFLDVPLD 199
           9********************..................778889999***************************************** PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +++ +     s++++L +  k eel+gen+yyc +c++k  a+k+l +++ P+vL l LkRf    +  + +k+++kv++p+ Ldl+p+
   Q: 200  ISSAQ-----SVNQALWDTEKSEELRGENAYYCGRCRQKMPASKTLHIHSAPKVLLLVLKRF----SAFMGNKLDRKVSYPEFLDLKPY 279
           *****.....9***************************************************....348999***************** PP
   S: 265  ctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++p+ +   +  Y L+av+vH+G +++sGHY++yvk  +gkW+++dD+kVt+++ ++vl+   ++aYvlfY +
   Q: 280  LSQPTGG---PLPYALYAVLVHEGaTCHSGHYFSYVKAGHGKWYKMDDTKVTSCDVTSVLN---ENAYVLFYVQ 347
           ***9988...89*************************************************...********87 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Protein Sequence
(Fasta)

MVVSLSFPEA DPALSSPGAQ QLHQDEAQVV VELTANDKPS LSWECPQGPG CGLQNTGNSC 60
YLNAALQCLT HTPPLADYML SQEYSQTCCS PEGCKMCAME AHVTQSLLHS HSGDVMKPSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGTTT CTCTTTCCTT CCCAGAAGGT AAGTCTCACT GTAAGGTCTT TATGTCTTGT 60
GTGTCCCCCA GCAGCCTTGT CATCTCTGGC TGCCCTAGAC CTGCATAAGG ACAAATTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:384701

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Eeu-035019	Erinaceus europaeus	51.16	5.00e-87	313.00
IUUC-Oar-089605	Ovis aries	53.67	2.00e-107	382.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence