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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063995
UUCD1 version UUC-MuM-01173
Ensembl Protein ID ENSMUSP00000086779.2
UniProt Accession Q8BUH8; Q6P398; Q80TA3; SENP7_MOUSE
Genbank Protein ID BAC65824.1; BAC39352.1; AAH58593.1
Protein Name Sentrin-specific protease 7; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7
Genbank Nucleotide ID AK122542; AK085060; BC058593
Gene Name Senp7; Kiaa1707; Susp2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000052917.14 ENSMUST00000089362.8 ENSMUSP00000086779.2
ENSMUSG00000052917.14 ENSMUST00000202000.1 ENSMUSP00000144116.1
ENSMUSG00000052917.14 ENSMUST00000049128.9 ENSMUSP00000043023.5
ENSMUSG00000052917.14 ENSMUST00000089360.9 ENSMUSP00000086776.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
iRefIndex
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/ULP 2.80e-70 237.1 748 990
Active Site
Position(s) Description Evidence
847 N/A {ECO:0000250}
979 {ECO:0000250}
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerr................rvktwtrkvdlfekd 74
            vtnedl+cLeegeflnDviidfylkyl+lek+++e ver hifssffyk+l++ke++                rv+twtr++++f+kd
   Q: 748  GVTNEDLECLEEGEFLNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNltednpdlsvaqrrhrRVRTWTRHINIFNKD 836
           69******************************************************99******************************* PP
   S: 75   lifvpineaaHWslavvcf..............................................................kkksilll 101
           +ifvp+ne++HW+lav+cf                                                              k+++il+l
   Q: 837  YIFVPVNESSHWYLAVICFpwleeavyedcpqtvsqqfqgqqsqhdhkmtdndphttstvstsaedsqstevnmsvpkkmcKRPCILIL 925
           ***************************************************************************************** PP
   S: 102  DSlrgasksnvvkklreylev..evkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyvesl 164
           DSl++as +n+v++lreylev  evk+k++refsk+++ + +pkvp+Q+NssDCGvy+lqyves+
   Q: 926  DSLKAASIQNTVQNLREYLEVewEVKRKTHREFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESF 990
           *********************999***************************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).
 Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).
Protein Sequence
(Fasta)
MDRARPGRRR ASSEIVTEGK RKKSSPADLQ KITKLLTVKS EDVLAQSPLS KLRGSECWWT 60
RSLRNKVICL DHKKPKAARG CPPKGLPKRH LRVMLTNVLW TDLGREFRKT LPRKDANLCA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063995|DUB,ULP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCTCTTGCT CTTGCTCCTG CTCCTTCGCC TGCTTGCTGC GTGAGACTGA GTAACTGCTA 60
GATCCTTGGA CTTCCATTCA CAGCTGTGAC TGAACAATTG TTGGGAATTG AGCTGCCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063995|DUB,ULP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008234--F:cysteine-type peptidase activity
GO:0004930--F:G-protein coupled receptor activity
GO:0007188--P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
KEGG mmu:66315
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001517 Ailuropoda melanoleuca 70.95 0.00e+00 1377.00
IUUC-Atr-002817 Amborella trichopoda 31.73 4.00e-24 107.00
IUUC-Apl-003302 Anas platyrhynchos 53.26 0.00e+00 637.00
IUUC-Aca-005089 Anolis carolinensis 49.07 2.00e-166 580.00
IUUC-Aly-005759 Arabidopsis lyrata 26.50 1.00e-26 115.00
IUUC-Ath-006613 Arabidopsis thaliana 26.78 4.00e-28 120.00
IUUC-Ago-007729 Ashbya gossypii 27.00 2.00e-19 91.30
IUUC-Acl-008018 Aspergillus clavatus 40.52 1.00e-20 95.50
IUUC-Afl-008482 Aspergillus flavus 36.11 3.00e-20 94.70
IUUC-Ani-009366 Aspergillus nidulans 38.98 6.00e-21 96.70
IUUC-Aor-010192 Aspergillus oryzae 35.83 2.00e-14 75.10
IUUC-Ate-010553 Aspergillus terreus 38.00 1.00e-15 79.30
IUUC-Ame-011446 Astyanax mexicanus 50.28 1.00e-99 357.00
IUUC-Bgr-012266 Blumeria graminis 33.87 2.00e-19 92.00
IUUC-Bta-012652 Bos taurus 70.26 0.00e+00 1315.00
IUUC-Bci-013906 Botrytis cinerea 39.01 3.00e-19 92.00
IUUC-Bdi-014139 Brachypodium distachyon 32.36 3.00e-25 110.00
IUUC-Bol-016126 Brassica oleracea 30.52 1.00e-25 112.00
IUUC-Bra-017420 Brassica rapa 30.46 2.00e-28 121.00
IUUC-Cja-018890 Callithrix jacchus 69.60 0.00e+00 1226.00
IUUC-Cfa-020923 Canis familiaris 69.82 0.00e+00 1336.00
IUUC-Cpo-022468 Cavia porcellus 63.81 0.00e+00 1076.00
IUUC-Csa-024235 Chlorocebus sabaeus 71.34 0.00e+00 1269.00
IUUC-Cho-024942 Choloepus hoffmanni 69.12 0.00e+00 735.00
IUUC-Cin-025522 Ciona intestinalis 41.38 1.00e-66 247.00
IUUC-Cgl-026623 Colletotrichum gloeosporioides 30.19 2.00e-26 115.00
IUUC-Dre-027818 Danio rerio 38.49 1.00e-104 374.00
IUUC-Dno-029935 Dasypus novemcinctus 55.30 4.00e-137 481.00
IUUC-Dor-030139 Dipodomys ordii 59.93 1.00e-79 291.00
IUUC-Dme-031729 Drosophila melanogaster 40.60 6.00e-56 212.00
IUUC-Ete-032892 Echinops telfairi 64.97 0.00e+00 890.00
IUUC-Eca-033398 Equus caballus 71.28 0.00e+00 1264.00
IUUC-Eeu-034595 Erinaceus europaeus 63.76 0.00e+00 1118.00
IUUC-Fca-036245 Felis catus 70.04 0.00e+00 1328.00
IUUC-Fal-036736 Ficedula albicollis 41.57 0.00e+00 634.00
IUUC-Fox-038045 Fusarium oxysporum 30.72 4.00e-28 120.00
IUUC-Fso-038416 Fusarium solani 33.67 2.00e-29 125.00
IUUC-Gmo-039168 Gadus morhua 52.38 1.00e-31 129.00
IUUC-Gga-040895 Gallus gallus 51.16 1.00e-168 587.00
IUUC-Gac-041712 Gasterosteus aculeatus 44.82 3.00e-69 254.00
IUUC-Gma-043078 Glycine max 31.23 5.00e-29 123.00
IUUC-Ggo-044423 Gorilla gorilla 69.55 0.00e+00 1353.00
IUUC-Hsa-046011 Homo sapiens 69.27 0.00e+00 1346.00
IUUC-Hvu-047202 Hordeum vulgare 30.59 8.00e-17 80.50
IUUC-Itr-048853 Ictidomys tridecemlineatus 70.72 0.00e+00 1365.00
IUUC-Lch-050229 Latimeria chalumnae 41.69 1.00e-115 410.00
IUUC-Loc-052810 Lepisosteus oculatus 41.61 2.00e-110 393.00
IUUC-Laf-053556 Loxodonta africana 72.07 0.00e+00 1246.00
IUUC-Mcc-055633 Macaca mulatta 69.80 0.00e+00 1351.00
IUUC-Mtr-058081 Medicago truncatula 29.32 1.00e-25 112.00
IUUC-Mga-059926 Meleagris gallopavo 50.96 2.00e-164 573.00
IUUC-Mmr-061064 Microcebus murinus 70.77 0.00e+00 1357.00
IUUC-Mdo-061950 Monodelphis domestica 55.94 0.00e+00 1045.00
IUUC-Mpu-066660 Mustela putorius furo 69.82 0.00e+00 1368.00
IUUC-Mlu-067173 Myotis lucifugus 68.48 0.00e+00 1179.00
IUUC-Nfi-068345 Neosartorya fischeri 39.52 2.00e-21 98.60
IUUC-Nle-070111 Nomascus leucogenys 69.84 0.00e+00 1350.00
IUUC-Opr-070785 Ochotona princeps 67.85 2.00e-159 556.00
IUUC-Ont-072672 Oreochromis niloticus 47.09 7.00e-94 337.00
IUUC-Oan-073520 Ornithorhynchus anatinus 50.61 0.00e+00 775.00
IUUC-Ocu-074146 Oryctolagus cuniculus 67.09 0.00e+00 1139.00
IUUC-Obr-076515 Oryza brachyantha 32.04 2.00e-29 124.00
IUUC-Ogl-077267 Oryza glaberrima 31.39 1.00e-29 125.00
IUUC-Oin-080091 Oryza indica 31.39 8.00e-30 126.00
IUUC-Osa-086169 Oryza sativa 31.39 8.00e-30 125.00
IUUC-Olu-087762 Ostreococcus lucimarinus 29.34 3.00e-31 130.00
IUUC-Oga-088400 Otolemur garnettii 69.31 0.00e+00 1281.00
IUUC-Oar-090273 Ovis aries 69.96 0.00e+00 1321.00
IUUC-Ptr-090796 Pan troglodytes 69.46 0.00e+00 1351.00
IUUC-Pan-091782 Papio anubis 68.09 0.00e+00 1164.00
IUUC-Psi-093935 Pelodiscus sinensis 54.50 0.00e+00 654.00
IUUC-Pno-094801 Phaeosphaeria nodorum 43.14 7.00e-19 89.70
IUUC-Ppa-095171 Physcomitrella patens 30.03 8.00e-27 115.00
IUUC-Pfo-096792 Poecilia formosa 45.11 5.00e-86 312.00
IUUC-Pab-098505 Pongo abelii 69.11 0.00e+00 1330.00
IUUC-Pop-099422 Populus trichocarpa 32.13 8.00e-27 116.00
IUUC-Pca-100196 Procavia capensis 88.59 4.00e-135 476.00
IUUC-Ppe-101347 Prunus persica 29.22 5.00e-21 96.70
IUUC-Pva-102390 Pteropus vampyrus 66.92 0.00e+00 1194.00
IUUC-Pte-104039 Pyrenophora teres 30.39 3.00e-17 84.70
IUUC-Rno-105145 Rattus norvegicus 88.82 0.00e+00 1716.00
IUUC-Sce-106359 Saccharomyces cerevisiae 23.73 6.00e-15 76.60
IUUC-Sha-107054 Sarcophilus harrisii 66.56 0.00e+00 825.00
IUUC-Sja-107700 Schizosaccharomyces japonicus 34.47 7.00e-35 142.00
IUUC-Spo-108052 Schizosaccharomyces pombe 34.29 5.00e-37 149.00
IUUC-Ssl-108654 Sclerotinia sclerotiorum 37.65 2.00e-12 67.80
IUUC-Smo-109565 Selaginella moellendorffii 29.84 8.00e-24 104.00
IUUC-Sit-110025 Setaria italica 31.91 1.00e-30 128.00
IUUC-Sly-111049 Solanum lycopersicum 29.69 3.00e-26 114.00
IUUC-Sar-113324 Sorex araneus 87.28 7.00e-180 624.00
IUUC-Sre-115211 Sporisorium reilianum 36.59 4.00e-17 84.30
IUUC-Ssc-116333 Sus scrofa 69.46 0.00e+00 1343.00
IUUC-Tgu-116626 Taeniopygia guttata 56.34 3.00e-150 525.00
IUUC-Tsy-119022 Tarsius syrichta 68.50 0.00e+00 1240.00
IUUC-Tni-120181 Tetraodon nigroviridis 54.60 8.00e-52 196.00
IUUC-Tca-121862 Theobroma cacao 30.82 6.00e-22 100.00
IUUC-Tre-121879 Trichoderma reesei 31.51 7.00e-29 122.00
IUUC-Tvi-122488 Trichoderma virens 30.30 1.00e-28 122.00
IUUC-Tae-125613 Triticum aestivum 33.01 6.00e-31 130.00
IUUC-Tbe-127624 Tupaia belangeri 73.07 7.00e-141 494.00
IUUC-Ttr-129225 Tursiops truncatus 67.37 0.00e+00 1288.00
IUUC-Uma-129452 Ustilago maydis 34.96 7.00e-17 83.60
IUUC-Vda-129950 Verticillium dahliae 27.73 7.00e-23 103.00
IUUC-Vpa-130805 Vicugna pacos 71.30 0.00e+00 1301.00
IUUC-Xtr-132908 Xenopus tropicalis 57.89 2.00e-116 412.00
IUUC-Xma-133567 Xiphophorus maculatus 48.28 1.00e-93 336.00
Created Date 25-Jun-2017

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