iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045888

Ensembl Protein ID

ENSP00000356233.2

UniProt Accession

Q9UGL1; O95811; Q15752; Q9Y3Q5; KDM5B_HUMAN

Genbank Protein ID

CAB43532.1; AAD16061.1; CAB63108.1; ENSP00000356233

Protein Name

Lysine-specific demethylase 5B; Cancer/testis antigen 31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1

Genbank Nucleotide ID

AJ132440; AF087481; AJ243706; AC098934

Gene Name

KDM5B; JARID1B; PLU1; RBBP2H1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000117139.16	ENST00000367265.7	ENSP00000356234.3
ENSG00000117139.16	ENST00000367264.6	ENSP00000356233.2
ENSG00000117139.16	ENST00000602511.1	ENSP00000473481.1

Annotation

Cancer Mutation
TCGA	ICGC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	7.20e-21	75.8	347	393

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           vCl+Cg+g +++  l+ C+ C++ +H  Cl ++   ++p+ + w CpkC 
   Q: 347  VCLLCGSGNDED-RLLLCDGCDDSYHTFCLIPP-LHDVPKGD-WRCPKCL 393
           8********988.6*******************.*******7.******5 PP

Organism

Homo sapiens

Functional Description
(View)

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Protein Sequence
(Fasta)

MEAATTLHPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH KIRPIAEQTG 60
ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK LNFLDQIAKY WELQGSTLKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAGTCTGT TGAAGGATAC CCCGTTGTGT ATTTCTACCT GTATGTACCA GAGACACCTC 60
AAATTCAAAA TGTCCAGAAA TGAACACAGT ATCTTCTTCC CTTGAGTAAC TCGCCTTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2

SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0034648--F:histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034647--F:histone demethylase activity (H3-trimethyl-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0044344--P:cellular response to fibroblast growth factor stimulus
GO:0034720--P:histone H3-K4 demethylation
GO:0070306--P:lens fiber cell differentiation
GO:0060763--P:mammary duct terminal end bud growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010628--P:positive regulation of gene expression
GO:0033601--P:positive regulation of mammary gland epithelial cell proliferation
GO:0009791--P:post-embryonic development
GO:2000864--P:regulation of estradiol secretion
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060992--P:response to fungicide
GO:0048511--P:rhythmic process
GO:0007338--P:single fertilization
GO:0006351--P:transcription, DNA-templated
GO:0061038--P:uterus morphogenesis

KEGG

hsa:10765

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000552	Aegilops tauschii	32.35	5.00e-102	367.00
IUUC-Aml-001963	Ailuropoda melanoleuca	94.38	0.00e+00	2784.00
IUUC-Apl-003770	Anas platyrhynchos	83.54	0.00e+00	2151.00
IUUC-Aca-004867	Anolis carolinensis	80.28	0.00e+00	2489.00
IUUC-Ath-007218	Arabidopsis thaliana	35.56	5.00e-09	58.50
IUUC-Acl-008162	Aspergillus clavatus	31.61	1.00e-114	409.00
IUUC-Ani-009139	Aspergillus nidulans	30.95	4.00e-109	390.00
IUUC-Ame-010620	Astyanax mexicanus	61.41	0.00e+00	1911.00
IUUC-Bta-012733	Bos taurus	89.47	0.00e+00	2654.00
IUUC-Bol-015336	Brassica oleracea	36.45	3.00e-14	75.50
IUUC-Cja-019050	Callithrix jacchus	96.19	0.00e+00	2925.00
IUUC-Cfa-021015	Canis familiaris	94.38	0.00e+00	2773.00
IUUC-Cpo-022340	Cavia porcellus	94.11	0.00e+00	2733.00
IUUC-Csa-023441	Chlorocebus sabaeus	96.97	0.00e+00	2899.00
IUUC-Cho-024823	Choloepus hoffmanni	94.36	0.00e+00	1700.00
IUUC-Cgl-026613	Colletotrichum gloeosporioides	29.74	1.00e-107	385.00
IUUC-Cne-026851	Cryptococcus neoformans	28.46	8.00e-112	399.00
IUUC-Dre-027707	Danio rerio	60.28	0.00e+00	1828.00
IUUC-Dno-028978	Dasypus novemcinctus	94.32	0.00e+00	2836.00
IUUC-Dor-030854	Dipodomys ordii	86.67	0.00e+00	1925.00
IUUC-Ete-032760	Echinops telfairi	91.00	0.00e+00	1855.00
IUUC-Eca-034370	Equus caballus	94.71	0.00e+00	2713.00
IUUC-Eeu-035012	Erinaceus europaeus	81.46	0.00e+00	1757.00
IUUC-Fca-035494	Felis catus	95.11	0.00e+00	2777.00
IUUC-Fal-037631	Ficedula albicollis	81.07	0.00e+00	2397.00
IUUC-Gmo-039522	Gadus morhua	57.94	0.00e+00	1722.00
IUUC-Gga-040802	Gallus gallus	81.85	0.00e+00	2442.00
IUUC-Gac-041563	Gasterosteus aculeatus	61.26	0.00e+00	1853.00
IUUC-Gma-042675	Glycine max	32.50	4.00e-101	363.00
IUUC-Ggo-044856	Gorilla gorilla	79.28	0.00e+00	2202.00
IUUC-Hvu-047583	Hordeum vulgare	43.04	1.00e-15	79.00
IUUC-Itr-048297	Ictidomys tridecemlineatus	95.29	0.00e+00	2842.00
IUUC-Lch-050483	Latimeria chalumnae	65.22	0.00e+00	2024.00
IUUC-Lpe-051537	Leersia perrieri	32.05	1.00e-91	332.00
IUUC-Loc-052550	Lepisosteus oculatus	69.60	0.00e+00	2108.00
IUUC-Laf-053761	Loxodonta africana	92.46	0.00e+00	2709.00
IUUC-Mcc-055505	Macaca mulatta	98.97	0.00e+00	2975.00
IUUC-Mpo-057317	Magnaporthe poae	28.75	5.00e-106	380.00
IUUC-Mga-059358	Meleagris gallopavo	80.66	0.00e+00	2409.00
IUUC-Mmr-060863	Microcebus murinus	95.36	0.00e+00	2865.00
IUUC-Mdo-061957	Monodelphis domestica	87.61	0.00e+00	2692.00
IUUC-Mmu-063944	Mus musculus	92.00	0.00e+00	2761.00
IUUC-Mac-065069	Musa acuminata	36.04	2.00e-08	55.80
IUUC-Mpu-066719	Mustela putorius furo	92.95	0.00e+00	2835.00
IUUC-Mlu-067366	Myotis lucifugus	84.39	0.00e+00	2549.00
IUUC-Nle-069256	Nomascus leucogenys	98.38	0.00e+00	2949.00
IUUC-Ont-071756	Oreochromis niloticus	61.31	0.00e+00	1887.00
IUUC-Oan-073568	Ornithorhynchus anatinus	87.95	0.00e+00	2686.00
IUUC-Ocu-073961	Oryctolagus cuniculus	91.01	0.00e+00	2758.00
IUUC-Ogl-077886	Oryza glaberrima	38.83	1.00e-16	82.40
IUUC-Olo-080668	Oryza longistaminata	38.83	4.00e-16	81.60
IUUC-Osa-085487	Oryza sativa	38.83	1.00e-16	82.40
IUUC-Ola-086448	Oryzias latipes	62.60	0.00e+00	1877.00
IUUC-Oga-088501	Otolemur garnettii	90.56	0.00e+00	2390.00
IUUC-Oar-090162	Ovis aries	88.82	0.00e+00	2633.00
IUUC-Ptr-090816	Pan troglodytes	99.48	0.00e+00	2999.00
IUUC-Pan-092764	Papio anubis	97.03	0.00e+00	2905.00
IUUC-Psi-093918	Pelodiscus sinensis	80.75	0.00e+00	2217.00
IUUC-Pfo-096672	Poecilia formosa	61.10	0.00e+00	1821.00
IUUC-Pab-097854	Pongo abelii	93.03	0.00e+00	2218.00
IUUC-Pca-100241	Procavia capensis	91.76	0.00e+00	1810.00
IUUC-Pva-103035	Pteropus vampyrus	83.16	0.00e+00	2194.00
IUUC-Rno-105574	Rattus norvegicus	90.77	0.00e+00	2698.00
IUUC-Sce-106207	Saccharomyces cerevisiae	35.59	5.00e-74	272.00
IUUC-Sly-111298	Solanum lycopersicum	42.44	9.00e-103	369.00
IUUC-Sar-113477	Sorex araneus	88.78	0.00e+00	2419.00
IUUC-Ssc-116132	Sus scrofa	92.51	0.00e+00	2424.00
IUUC-Tgu-117452	Taeniopygia guttata	81.64	0.00e+00	2402.00
IUUC-Tru-117561	Takifugu rubripes	63.96	0.00e+00	1749.00
IUUC-Tsy-119271	Tarsius syrichta	95.44	0.00e+00	2191.00
IUUC-Tni-119650	Tetraodon nigroviridis	60.10	0.00e+00	1820.00
IUUC-Tur-126632	Triticum urartu	32.35	3.00e-101	363.00
IUUC-Tbe-127890	Tupaia belangeri	91.26	0.00e+00	1563.00
IUUC-Ttr-128546	Tursiops truncatus	88.10	0.00e+00	2008.00
IUUC-Vpa-130432	Vicugna pacos	89.85	0.00e+00	1585.00
IUUC-Xtr-132008	Xenopus tropicalis	69.81	0.00e+00	2122.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence