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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063866
Ensembl Protein ID ENSMUSP00000091135.4
UniProt Accession A6H603; Q3TRC9; Q8BS99; NWD1_MOUSE
Genbank Protein ID BAC28860.1; BAE37101.1; AAI45704.1
Protein Name NACHT domain- and WD repeat-containing protein 1
Genbank Nucleotide ID AK034868; AK162888; AC171917
Gene Name Nwd1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048148.17 ENSMUST00000161557.7 ENSMUSP00000125470.1
ENSMUSG00000048148.17 ENSMUST00000161254.8 ENSMUSP00000124804.1
ENSMUSG00000048148.17 ENSMUST00000093427.10 ENSMUSP00000091135.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.70e-23 81.4 908 942
UBD/Beta-Prp 8.60e-52 177.3 862 1040
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtcla.f.sdtllvsGsdDgtikvWDlrtg 33
           gHt++v c++ f ++tl +s+s D+t+++W+l +g
   Q: 908  GHTAEVKCVRvFaQGTLAISASKDHTLRLWSLLSG 942
           8********977988****************9777 PP
   

   UBD/Beta-Prp
   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee. 131
           ++l g+ +++ta+ +s ++k+lv g +D++  vwd++  + vh+l gh+++v +++++++g   +s+s+d t+r+w l +gq+  + 
   Q: 862  ATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTi 948
           689999999999999999999999999999999999999999999999999999999999999999999999999999999999998 PP
   S: 132  ....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec 214
                +++++   + ++v++ +n++ s s  r +++W+l+t kl+   tg+  d+  ++++   +  l++ s+ g+v lw+   g+ 
   Q: 949  ldggSQNPTEPQSWDLHVDERNNVVYSTSGAR-INMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKL 1034
           88777777777778888888888777777765.899999999999999999999999999999999999999999999999996655 PP
   S: 215  vrtlng 220
            ++ + 
   Q: 1035 QEKHQL 1040
           333222 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May play a role in the control of androgen receptor (AR) protein steady-state levels.
 May play a role in the control of androgen receptor (AR) protein steady-state levels.
Protein Sequence
(Fasta)
MDTEREALQC TAYPEVQSFC QRHGLAFEVV DLRWGIPNTQ ATDYLTTELC LEELERCQKT 60
SIGPAFVALL GDQYGPCPVP RRIEEKEWEA LRAQLTSRPR DLELVTRHFQ RDDNTIPPTY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063866|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACTTCCAAA TGACGCCCTC CATGGCAGCA AGAGGGAAGC GGGCATCTTG GAGAGAGCCT 60
GGAGTAGACG CTGCAAAAGG GCCCTTGAAG ATGCCTCATT CTTGCTGAGG TGTTTGCAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063866|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0005524--F:ATP binding
GO:0008380--P:RNA splicing
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001525 Ailuropoda melanoleuca 77.57 0.00e+00 2432.00
IUUC-Apl-003467 Anas platyrhynchos 61.37 1.00e-84 305.00
IUUC-Ame-011400 Astyanax mexicanus 35.61 0.00e+00 952.00
IUUC-Bta-013223 Bos taurus 76.44 0.00e+00 2058.00
IUUC-Cel-018404 Caenorhabditis elegans 28.99 9.00e-98 352.00
IUUC-Cja-018773 Callithrix jacchus 74.49 0.00e+00 1431.00
IUUC-Cfa-020334 Canis familiaris 77.97 0.00e+00 2417.00
IUUC-Cpo-022316 Cavia porcellus 64.71 0.00e+00 1888.00
IUUC-Csa-023631 Chlorocebus sabaeus 77.20 0.00e+00 2378.00
IUUC-Cin-025646 Ciona intestinalis 30.62 3.00e-117 416.00
IUUC-Csv-026191 Ciona savignyi 24.74 5.00e-23 102.00
IUUC-Dre-028241 Danio rerio 35.49 0.00e+00 903.00
IUUC-Dno-029990 Dasypus novemcinctus 76.07 0.00e+00 685.00
IUUC-Dor-030869 Dipodomys ordii 61.04 3.00e-175 609.00
IUUC-Ete-033059 Echinops telfairi 78.89 0.00e+00 801.00
IUUC-Eca-033718 Equus caballus 73.26 0.00e+00 2290.00
IUUC-Fca-035748 Felis catus 77.11 0.00e+00 2219.00
IUUC-Gac-041507 Gasterosteus aculeatus 34.99 0.00e+00 722.00
IUUC-Ggo-044551 Gorilla gorilla 74.82 0.00e+00 2289.00
IUUC-Hsa-046787 Homo sapiens 76.89 0.00e+00 2394.00
IUUC-Itr-048104 Ictidomys tridecemlineatus 61.91 0.00e+00 1748.00
IUUC-Lch-049578 Latimeria chalumnae 46.30 0.00e+00 1358.00
IUUC-Loc-052039 Lepisosteus oculatus 40.94 0.00e+00 1190.00
IUUC-Laf-054240 Loxodonta africana 77.33 0.00e+00 2480.00
IUUC-Mcc-054657 Macaca mulatta 70.25 0.00e+00 2041.00
IUUC-Meu-056591 Macropus eugenii 61.84 0.00e+00 1129.00
IUUC-Mmr-061577 Microcebus murinus 74.69 0.00e+00 2303.00
IUUC-Mdo-062895 Monodelphis domestica 58.43 0.00e+00 1671.00
IUUC-Mpu-066510 Mustela putorius furo 77.19 0.00e+00 2432.00
IUUC-Mlu-067855 Myotis lucifugus 77.19 0.00e+00 2346.00
IUUC-Nle-069557 Nomascus leucogenys 72.79 0.00e+00 2196.00
IUUC-Opr-071196 Ochotona princeps 62.41 7.00e-177 615.00
IUUC-Ont-072070 Oreochromis niloticus 34.91 0.00e+00 763.00
IUUC-Oan-073437 Ornithorhynchus anatinus 55.94 0.00e+00 1199.00
IUUC-Ocu-074941 Oryctolagus cuniculus 80.91 3.00e-51 194.00
IUUC-Ola-086624 Oryzias latipes 34.66 2.00e-127 450.00
IUUC-Oga-088313 Otolemur garnettii 78.21 0.00e+00 2208.00
IUUC-Oar-090123 Ovis aries 76.49 0.00e+00 2383.00
IUUC-Ptr-090552 Pan troglodytes 76.15 0.00e+00 1018.00
IUUC-Psi-093963 Pelodiscus sinensis 52.27 0.00e+00 1533.00
IUUC-Pfo-096197 Poecilia formosa 33.52 0.00e+00 769.00
IUUC-Pab-097755 Pongo abelii 75.31 0.00e+00 851.00
IUUC-Pca-100809 Procavia capensis 73.90 0.00e+00 1148.00
IUUC-Pva-102554 Pteropus vampyrus 74.30 0.00e+00 2050.00
IUUC-Rno-105174 Rattus norvegicus 84.78 0.00e+00 2476.00
IUUC-Sha-107304 Sarcophilus harrisii 58.89 0.00e+00 1878.00
IUUC-Sar-113168 Sorex araneus 63.02 0.00e+00 1312.00
IUUC-Tru-118251 Takifugu rubripes 36.08 0.00e+00 663.00
IUUC-Tsy-119276 Tarsius syrichta 73.48 7.00e-114 405.00
Created Date 25-Jun-2017

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