iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006868

UUCD1 version

UUC-ArT-01192

Ensembl Protein ID

AT4G33260.1

UniProt Accession

Q9S7I8; F4JW04; CDC22_ARATH

Genbank Protein ID

AAF14049.1; CAB38784.1; CAB80043.1; AEE86198.1; AEE86199.1

Protein Name

Cell division cycle 20.2, cofactor of APC complex

Genbank Nucleotide ID

AF029263; AL035678; AL161583; CP002687; CP002687

Gene Name

CDC20-2; CDC20_1; At4g33260; F17M5.20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G33260	AT4G33260.1	AT4G33260.1
AT4G33260	AT4G33260.2	AT4G33260.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	1.70e-125	419.2	119	425
E3 adaptor/Cullin RING/DCX/DWD	7.20e-30	102.6	254	284

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 2    ekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl.tghsa 97
           e+ ldap++ ddfylnLldW+s nvla+aL+++vylw+a+tg+ s+l  + eek  vts++w ++g ++avG +++ev+++D ++++++rtl  gh++
   Q: 119  ERTLDAPDIVDDFYLNLLDWGSANVLAIALDHTVYLWDASTGSTSELVTIdEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLkGGHQS 216
           689***********************************************888999************************************778*** PP
   S: 98   rvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse......PlkkfkehkaavkaiawsP 189
           rvg+L+Wn+++l++G+ dg i  +dvr++   ++t+++h+qevCGlkw+ ++++LasGGnDn+v++wd s  +       l++ +eh++avka+aw+P
   Q: 217  RVGSLAWNNHILTTGGMDGLIINNDVRIRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRSVASsnsttqWLHRLEEHTSAVKALAWCP 314
           ********************************************************************87555455666789999************* PP
   S: 190  wqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaag 287
           +q +lLa+GGG  Dr+ikfwnt tga+l+++dtgsqvcsllwsk+++el+s+hGf++n++tlwkyps+ k+ael+gh++Rvl++a spdg ++++aag
   Q: 315  FQANLLATGGGGGDRTIKFWNTHTGACLNSVDTGSQVCSLLWSKNERELLSSHGFTQNQLTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAG 412
           ************************************************************************************************** PP
   S: 288  Detlrfwklfdkk 300
           Detlrfw++f   
   Q: 413  DETLRFWNVFGVP 425
           **********765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWD 29
           gHt +v++l++  s+  l+sG++D+++++WD
   Q: 254  GHTQEVCGLKWsgSGQQLASGGNDNVVHIWD 284
           8**********976699************** PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

Protein Sequence
(Fasta)

MDAGLNRCPL QEHFLPRKNS KENLDRFIPN RSAMNFDYAH FALTEERKGK DQSATVSSPS 60
KEAYRKQLAE TMNLNHTRIL AFRNKPQAPV ELLPSNHSAS LHQQPKSVKP RRYIPQTSER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCATTTTC CGTAATTGAT CAACGGCTCT CTCAGAAATA TAGCCGTTAC CGACTTTCCG 60
ATTATAGAAA TTAGAGTCCT CCAAAACCCT AAATTGGCTC TACCCCTTTA TAAGCAACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0033597--C:mitotic checkpoint complex
GO:0005634--C:nucleus
GO:0019900--F:kinase binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination

KEGG

ath:AT4G33260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cin-025675	Ciona intestinalis	48.28	9.00e-111	393.00
IUUC-Ete-032387	Echinops telfairi	43.69	1.00e-93	336.00
IUUC-Mmr-061615	Microcebus murinus	48.06	5.00e-105	374.00
IUUC-Mpu-066502	Mustela putorius furo	46.91	8.00e-106	376.00
IUUC-Oar-090023	Ovis aries	47.78	3.00e-101	361.00
IUUC-Ppa-095457	Physcomitrella patens	60.48	2.00e-142	498.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	44.90	3.00e-94	338.00
IUUC-Spo-108075	Schizosaccharomyces pombe	44.47	1.00e-92	333.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence