iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037600

Ensembl Protein ID

ENSFALP00000008043.1

UniProt Accession

U3JZ39; U3JZ39_FICAL

Genbank Protein ID

ENSFALP00000008043

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AGTO01021407

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000007698.1	ENSFALT00000008076.1	ENSFALP00000008043.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.50e-117	391.8	20	529

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 4    QirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           Q rlwG+++qe+l+sa+v++++a+++G+E+lKnLvl G+g +t+vD+++v+ ++++++F+++++++g+++A++a+e l+eln+dv++ +
   Q: 20   QYRLWGDHGQEALESAHVCVINATATGTEILKNLVLPGIGAFTIVDGNRVSGEDVGNNFFLQKSHIGQNRAQSAMELLQELNSDVSGNF 108
           99*************************************************************************************** PP
   S: 93   heesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlk 177
           +ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n + pl++++t+Gl+G++rv+ik++t+ +s++d   +++++++Pf++l 
   Q: 109  VEESPEKLLDNDPsFFNRFNLVVATQLPESTLLRLAEVLWNSNTPLLICRTYGLVGYMRVVIKEHTVVESHPDnmlEDLRLDKPFPELT 197
           ***************************************************************************************** PP
   S: 178  etpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakttin 251
           e+++         +++++++w+v+++k+l ++  e++++ +++++eke++k+++++++ +      edeenfeeai+++++a+++t+ +
   Q: 198  EHVQdydlehmdkKDHSHTPWIVIVAKYLTKWFNEKSEQLPKSYKEKEAFKELIRQGILKnengtpEDEENFEEAIKNVNTALNRTEVP 286
           **99999999999***********************************************9**************************** PP
   S: 252  s.ikqllksfecdivtkskspfwv................................................................. 274
             i++l++++ c ++t+++s+fw+                                                                 
   Q: 287  RgIEELFNDDCCLKLTEQSSSFWIlvralkefvanegqgslpvrgtipdmiadsskfiklqnvyrekakkdiaavgshaakllqslgka 375
           ***************************************************************************************** PP
   S: 275  ..........sfcsnaealq...........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdl 335
                      fcsna+ l+           +p +  kd +++++++p     lyl+lra++rf k++gr+pg+ +++++dd+  + ++
   Q: 376  pesiserelkLFCSNAAFLRlvrcrslaeehSPNSCSKDAIISHMDNPdseivLYLMLRAVNRFYKQHGRYPGVYNYQVEDDIgkLKSC 464
           **********9********9999988888887777778888888887788888******************************999*** PP
   S: 336  vtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +t ++    +++g++ +++dd+++e++++++++ + ++a+ gG+aaqEviKv++g+f+ ++n+f++ ++
   Q: 465  LTGFL----QEHGLSVVVKDDYVHEFCRYGAAEPHAVAAFMGGAAAQEVIKVITGQFVIFNNTFIYSGM 529
           *****....********************************************************9876 PP

Organism

Ficedula albicollis

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MKCQGNCSLE SLRVFTFPSQ YRLWGDHGQE ALESAHVCVI NATATGTEIL KNLVLPGIGA 60
FTIVDGNRVS GEDVGNNFFL QKSHIGQNRA QSAMELLQEL NSDVSGNFVE ESPEKLLDND 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAATGTC AGGGAAACTG CTCTTTGGAA AGTCTCAGAG TTTTCACAGT AAGTTCCCTT 60
TAGGATGCTT ATTTTGGTTA GTGCTATTTA GGTCCTCAGC AGTGAATGCA CAGTAGCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	41.70	7.00e-120	424.00
IUUC-Aml-002333	Ailuropoda melanoleuca	80.15	0.00e+00	903.00
IUUC-Atr-002644	Amborella trichopoda	39.39	8.00e-109	387.00
IUUC-Apl-003446	Anas platyrhynchos	90.30	0.00e+00	979.00
IUUC-Aca-004450	Anolis carolinensis	76.70	0.00e+00	872.00
IUUC-Aly-006187	Arabidopsis lyrata	40.30	2.00e-122	432.00
IUUC-Ath-007600	Arabidopsis thaliana	39.69	1.00e-120	426.00
IUUC-Ago-007900	Ashbya gossypii	26.73	1.00e-36	147.00
IUUC-Acl-008333	Aspergillus clavatus	32.66	1.00e-73	270.00
IUUC-Afl-008529	Aspergillus flavus	34.18	8.00e-78	284.00
IUUC-Afu-009071	Aspergillus fumigatus	31.69	2.00e-71	262.00
IUUC-Ani-009443	Aspergillus nidulans	31.62	1.00e-69	257.00
IUUC-Ang-009669	Aspergillus niger	31.03	4.00e-73	268.00
IUUC-Aor-009914	Aspergillus oryzae	33.51	1.00e-74	273.00
IUUC-Ate-010450	Aspergillus terreus	32.30	2.00e-75	276.00
IUUC-Ame-011183	Astyanax mexicanus	71.07	0.00e+00	805.00
IUUC-Bgr-012111	Blumeria graminis	31.60	5.00e-56	211.00
IUUC-Bta-012583	Bos taurus	81.03	0.00e+00	912.00
IUUC-Bci-013892	Botrytis cinerea	32.71	5.00e-60	225.00
IUUC-Bdi-014592	Brachypodium distachyon	42.29	2.00e-121	429.00
IUUC-Bol-016399	Brassica oleracea	40.15	2.00e-121	429.00
IUUC-Bra-017506	Brassica rapa	39.28	7.00e-117	414.00
IUUC-Cel-018456	Caenorhabditis elegans	34.39	7.00e-89	320.00
IUUC-Cja-020007	Callithrix jacchus	80.38	0.00e+00	907.00
IUUC-Cfa-020324	Canis familiaris	81.23	0.00e+00	915.00
IUUC-Cpo-022248	Cavia porcellus	54.46	7.00e-149	520.00
IUUC-Csa-023149	Chlorocebus sabaeus	77.92	0.00e+00	784.00
IUUC-Cho-024537	Choloepus hoffmanni	70.50	0.00e+00	679.00
IUUC-Cin-025763	Ciona intestinalis	50.57	5.00e-154	537.00
IUUC-Csv-026113	Ciona savignyi	47.94	5.00e-142	497.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.13	8.00e-60	224.00
IUUC-Cne-026884	Cryptococcus neoformans	30.21	4.00e-67	248.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.70	1.00e-18	88.20
IUUC-Dre-028140	Danio rerio	72.41	0.00e+00	823.00
IUUC-Dno-030033	Dasypus novemcinctus	80.48	0.00e+00	798.00
IUUC-Dor-030513	Dipodomys ordii	55.91	6.00e-97	347.00
IUUC-Dse-031536	Dothistroma septosporum	32.55	2.00e-75	276.00
IUUC-Dme-031683	Drosophila melanogaster	44.57	7.00e-124	437.00
IUUC-Ete-032420	Echinops telfairi	71.51	0.00e+00	781.00
IUUC-Eca-033992	Equus caballus	80.67	0.00e+00	775.00
IUUC-Eeu-034713	Erinaceus europaeus	66.14	2.00e-98	352.00
IUUC-Fca-036548	Felis catus	79.89	0.00e+00	899.00
IUUC-Fox-038037	Fusarium oxysporum	31.19	4.00e-65	242.00
IUUC-Fso-038387	Fusarium solani	33.21	4.00e-72	265.00
IUUC-Gmo-038562	Gadus morhua	69.85	0.00e+00	796.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.28	2.00e-66	246.00
IUUC-Gga-041129	Gallus gallus	87.73	0.00e+00	966.00
IUUC-Gac-042558	Gasterosteus aculeatus	69.85	0.00e+00	796.00
IUUC-Gma-043610	Glycine max	40.27	3.00e-116	411.00
IUUC-Ggo-045611	Gorilla gorilla	80.38	0.00e+00	905.00
IUUC-Hsa-046563	Homo sapiens	80.65	0.00e+00	908.00
IUUC-Hvu-047790	Hordeum vulgare	38.42	1.00e-74	273.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	80.46	0.00e+00	904.00
IUUC-Kpa-049309	Komagataella pastoris	33.59	7.00e-76	277.00
IUUC-Lch-050038	Latimeria chalumnae	74.47	0.00e+00	827.00
IUUC-Lpe-051535	Leersia perrieri	40.16	8.00e-106	377.00
IUUC-Loc-051917	Lepisosteus oculatus	68.56	0.00e+00	751.00
IUUC-Lma-053112	Leptosphaeria maculans	35.23	2.00e-81	296.00
IUUC-Laf-053690	Loxodonta africana	80.46	0.00e+00	912.00
IUUC-Mcc-055117	Macaca mulatta	79.09	0.00e+00	890.00
IUUC-Meu-056761	Macropus eugenii	67.62	0.00e+00	722.00
IUUC-Mor-057230	Magnaporthe oryzae	32.06	2.00e-69	256.00
IUUC-Mpo-057514	Magnaporthe poae	31.87	2.00e-64	239.00
IUUC-Mtr-058551	Medicago truncatula	40.04	7.00e-115	407.00
IUUC-Mla-059183	Melampsora laricipopulina	36.98	2.00e-96	345.00
IUUC-Mga-060144	Meleagris gallopavo	90.04	0.00e+00	967.00
IUUC-Mvi-060221	Microbotryum violaceum	33.90	1.00e-74	273.00
IUUC-Mmr-061325	Microcebus murinus	80.95	0.00e+00	908.00
IUUC-Mdo-062532	Monodelphis domestica	81.23	0.00e+00	915.00
IUUC-Mmu-063956	Mus musculus	81.42	0.00e+00	914.00
IUUC-Mac-064521	Musa acuminata	40.42	2.00e-118	419.00
IUUC-Mpu-066716	Mustela putorius furo	79.59	0.00e+00	848.00
IUUC-Mlu-067459	Myotis lucifugus	80.11	0.00e+00	904.00
IUUC-Nfi-068245	Neosartorya fischeri	31.88	3.00e-72	265.00
IUUC-Ncr-068910	Neurospora crassa	31.33	2.00e-66	246.00
IUUC-Nle-070034	Nomascus leucogenys	79.73	0.00e+00	892.00
IUUC-Opr-070552	Ochotona princeps	72.87	0.00e+00	743.00
IUUC-Ont-071426	Oreochromis niloticus	70.69	0.00e+00	808.00
IUUC-Oan-073389	Ornithorhynchus anatinus	77.30	0.00e+00	723.00
IUUC-Ocu-074911	Oryctolagus cuniculus	81.03	0.00e+00	912.00
IUUC-Oba-075437	Oryza barthii	41.33	1.00e-111	396.00
IUUC-Obr-076684	Oryza brachyantha	41.87	3.00e-108	385.00
IUUC-Ogl-077170	Oryza glaberrima	41.33	1.00e-111	396.00
IUUC-Ogu-078844	Oryza glumaepatula	41.80	1.00e-105	376.00
IUUC-Oin-079105	Oryza indica	41.33	5.00e-111	394.00
IUUC-Olo-080943	Oryza longistaminata	38.76	9.00e-100	357.00
IUUC-Oni-082891	Oryza nivara	38.48	8.00e-105	374.00
IUUC-Opu-083457	Oryza punctata	41.33	3.00e-111	395.00
IUUC-Oru-084960	Oryza rufipogon	38.76	8.00e-100	357.00
IUUC-Osa-085358	Oryza sativa	41.49	1.00e-111	396.00
IUUC-Ola-086420	Oryzias latipes	70.51	7.00e-166	576.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.14	6.00e-62	231.00
IUUC-Oga-088810	Otolemur garnettii	80.27	0.00e+00	909.00
IUUC-Oar-089196	Ovis aries	80.38	0.00e+00	905.00
IUUC-Ptr-090617	Pan troglodytes	80.84	0.00e+00	910.00
IUUC-Pan-092761	Papio anubis	81.03	0.00e+00	912.00
IUUC-Psi-093191	Pelodiscus sinensis	83.56	0.00e+00	934.00
IUUC-Pma-094380	Petromyzon marinus	62.99	0.00e+00	656.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.84	9.00e-65	242.00
IUUC-Ppa-095875	Physcomitrella patens	41.76	2.00e-119	422.00
IUUC-Pfo-096467	Poecilia formosa	69.90	0.00e+00	790.00
IUUC-Pab-098255	Pongo abelii	78.49	0.00e+00	741.00
IUUC-Pop-099871	Populus trichocarpa	40.49	8.00e-123	433.00
IUUC-Pca-100807	Procavia capensis	69.43	7.00e-105	373.00
IUUC-Ppe-101280	Prunus persica	40.08	1.00e-117	416.00
IUUC-Pva-102333	Pteropus vampyrus	77.90	0.00e+00	859.00
IUUC-Pgr-103401	Puccinia graminis	31.30	2.00e-77	282.00
IUUC-Ptt-103889	Puccinia triticina	28.50	4.00e-62	232.00
IUUC-Pte-104355	Pyrenophora teres	34.85	3.00e-82	298.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	34.85	1.00e-82	300.00
IUUC-Rno-105810	Rattus norvegicus	81.61	0.00e+00	910.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.34	2.00e-35	143.00
IUUC-Sha-106770	Sarcophilus harrisii	81.78	3.00e-136	476.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.31	3.00e-70	258.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.52	3.00e-80	292.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.65	2.00e-61	230.00
IUUC-Smo-109296	Selaginella moellendorffii	41.79	1.00e-116	413.00
IUUC-Sit-110157	Setaria italica	43.24	4.00e-128	451.00
IUUC-Sly-111105	Solanum lycopersicum	39.48	1.00e-119	422.00
IUUC-Stu-112469	Solanum tuberosum	40.19	4.00e-122	431.00
IUUC-Sar-113083	Sorex araneus	62.60	0.00e+00	664.00
IUUC-Sbi-113813	Sorghum bicolor	42.86	2.00e-126	445.00
IUUC-Sre-115058	Sporisorium reilianum	39.55	7.00e-83	301.00
IUUC-Tgu-116772	Taeniopygia guttata	93.50	0.00e+00	997.00
IUUC-Tru-118686	Takifugu rubripes	69.92	0.00e+00	801.00
IUUC-Tsy-119111	Tarsius syrichta	76.38	1.00e-122	432.00
IUUC-Tni-120231	Tetraodon nigroviridis	68.89	0.00e+00	730.00
IUUC-Tca-121491	Theobroma cacao	39.96	8.00e-114	403.00
IUUC-Tre-122103	Trichoderma reesei	35.90	3.00e-75	275.00
IUUC-Tvi-122672	Trichoderma virens	35.02	2.00e-68	253.00
IUUC-Tae-125679	Triticum aestivum	42.29	5.00e-122	431.00
IUUC-Tur-126487	Triticum urartu	41.79	1.00e-118	419.00
IUUC-Tme-127097	Tuber melanosporum	35.78	1.00e-86	313.00
IUUC-Ttr-128465	Tursiops truncatus	75.62	0.00e+00	840.00
IUUC-Uma-129645	Ustilago maydis	34.39	2.00e-87	316.00
IUUC-Vda-129989	Verticillium dahliae	30.17	1.00e-51	197.00
IUUC-Vpa-130529	Vicugna pacos	77.52	0.00e+00	865.00
IUUC-Vvi-131059	Vitis vinifera	40.34	3.00e-117	415.00
IUUC-Xtr-132002	Xenopus tropicalis	74.71	0.00e+00	847.00
IUUC-Xma-133930	Xiphophorus maculatus	70.50	0.00e+00	798.00
IUUC-Yli-134505	Yarrowia lipolytica	34.01	7.00e-83	301.00
IUUC-Zma-135895	Zea mays	42.29	8.00e-125	440.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence