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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106212
UUCD1 version UUC-SaC-00228
Ensembl Protein ID YER100W
UniProt Accession P33296; D3DM07; UBC6_YEAST
Genbank Protein ID CAA51706.1; AAB64655.1; DAA07761.1
Protein Name Ubiquitin-conjugating enzyme E2 6; E2 ubiquitin-conjugating enzyme 6; Ubiquitin carrier protein UBC6; Ubiquitin-protein ligase UBC6
Genbank Nucleotide ID X73234; U18839; BK006939
Gene Name UBC6; DOA2; YER100W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YER100W YER100W YER100W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 19951915; 16437165
Classification
Family E-value Score Start End
E2/UBC 1.60e-31 107.4 9 123
Active Site
Position(s) Description Evidence
87 Glycyl thioester intermediate N/A
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.eeekWspalsvesv 101
           Rl+ke+k + ++pp++i a+p+++ ++ ew++ i+Gp+dtpY+gg+++ +++fp+dYP+kPP ++++t+  ++ +++n+++Cls+ + ++++W+p +sv+++
   Q: 9    RLTKEYKLMVENPPPYILARPNED-NILEWHYIITGPADTPYKGGQYHGTLTFPSDYPYKPPAIRMITP--NGRFKPNTRLCLSMSDyHPDTWNPGWSVSTI 107
           99**********************.9*******************************************..55555559*******889************* PP
   S: 102  llsiqsllaepnpesp 117
           l ++ s++++ +   +
   Q: 108  LNGLLSFMTSDEATTG 123
           ********66444333 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
 Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
Protein Sequence
(Fasta)
MATKQAHKRL TKEYKLMVEN PPPYILARPN EDNILEWHYI ITGPADTPYK GGQYHGTLTF 60
PSDYPYKPPA IRMITPNGRF KPNTRLCLSM SDYHPDTWNP GWSVSTILNG LLSFMTSDEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106212|E2,E2/UBC|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCTACAA AGCAGGCTCA CAAGAGATTG ACGAAAGAGT ACAAGTTGAT GGTGGAAAAC 60
CCTCCACCAT ATATTCTTGC TCGCCCCAAC GAAGATAATA TTTTAGAGTG GCACTATATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106212|E2,E2/UBC|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG sce:YER100W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001180 Aegilops tauschii 49.32 1.00e-23 101.00
IUUC-Aml-002152 Ailuropoda melanoleuca 58.49 3.00e-53 199.00
IUUC-Atr-003156 Amborella trichopoda 45.77 1.00e-51 193.00
IUUC-Apl-004224 Anas platyrhynchos 57.14 1.00e-49 187.00
IUUC-Aca-005049 Anolis carolinensis 57.23 5.00e-52 195.00
IUUC-Aly-006195 Arabidopsis lyrata 42.66 3.00e-50 189.00
IUUC-Ath-006640 Arabidopsis thaliana 51.25 3.00e-50 189.00
IUUC-Ago-007987 Ashbya gossypii 60.18 1.00e-75 273.00
IUUC-Acl-008060 Aspergillus clavatus 48.39 4.00e-56 209.00
IUUC-Afl-008561 Aspergillus flavus 49.07 1.00e-55 207.00
IUUC-Afu-008860 Aspergillus fumigatus 48.85 6.00e-57 212.00
IUUC-Ani-009333 Aspergillus nidulans 47.93 1.00e-55 207.00
IUUC-Ang-009810 Aspergillus niger 42.03 1.00e-56 210.00
IUUC-Aor-010127 Aspergillus oryzae 49.07 1.00e-55 207.00
IUUC-Ate-010362 Aspergillus terreus 48.39 1.00e-55 207.00
IUUC-Ame-010627 Astyanax mexicanus 57.86 2.00e-52 196.00
IUUC-Bgr-012069 Blumeria graminis 49.27 8.00e-56 207.00
IUUC-Bta-012472 Bos taurus 58.49 7.00e-53 198.00
IUUC-Bci-013843 Botrytis cinerea 51.05 2.00e-54 203.00
IUUC-Bdi-014467 Brachypodium distachyon 54.94 3.00e-53 199.00
IUUC-Bol-016116 Brassica oleracea 50.00 5.00e-49 185.00
IUUC-Bra-017777 Brassica rapa 50.00 3.00e-48 182.00
IUUC-Cel-018278 Caenorhabditis elegans 52.35 1.00e-43 167.00
IUUC-Cja-018817 Callithrix jacchus 60.47 3.00e-44 169.00
IUUC-Cfa-020885 Canis familiaris 58.49 4.00e-53 199.00
IUUC-Cpo-022326 Cavia porcellus 58.49 8.00e-53 197.00
IUUC-Cre-022635 Chlamydomonas reinhardtii 55.62 6.00e-53 197.00
IUUC-Csa-023646 Chlorocebus sabaeus 58.49 4.00e-53 199.00
IUUC-Cho-025075 Choloepus hoffmanni 48.61 1.00e-33 133.00
IUUC-Cin-025389 Ciona intestinalis 55.21 5.00e-52 194.00
IUUC-Csv-026315 Ciona savignyi 44.49 1.00e-55 207.00
IUUC-Cgl-026602 Colletotrichum gloeosporioides 51.85 8.00e-56 207.00
IUUC-Cne-026808 Cryptococcus neoformans 51.77 4.00e-46 174.00
IUUC-Cme-027189 Cyanidioschyzon merolae 31.03 3.00e-23 100.00
IUUC-Dre-028455 Danio rerio 57.86 1.00e-52 197.00
IUUC-Dno-029667 Dasypus novemcinctus 57.86 9.00e-53 197.00
IUUC-Dor-030747 Dipodomys ordii 54.86 4.00e-42 162.00
IUUC-Dse-031231 Dothistroma septosporum 49.03 8.00e-54 201.00
IUUC-Dme-031841 Drosophila melanogaster 55.48 7.00e-52 195.00
IUUC-Ete-032258 Echinops telfairi 39.78 7.00e-48 181.00
IUUC-Eca-034179 Equus caballus 41.30 7.00e-32 128.00
IUUC-Eeu-034443 Erinaceus europaeus 63.30 5.00e-38 148.00
IUUC-Fca-036167 Felis catus 51.55 2.00e-40 156.00
IUUC-Fal-037114 Ficedula albicollis 57.14 1.00e-49 187.00
IUUC-Fox-037957 Fusarium oxysporum 53.43 6.00e-56 208.00
IUUC-Fso-038277 Fusarium solani 55.50 2.00e-59 219.00
IUUC-Gmo-039501 Gadus morhua 54.24 2.00e-52 197.00
IUUC-Ggr-040010 Gaeumannomyces graminis 55.21 8.00e-57 211.00
IUUC-Gga-041257 Gallus gallus 57.14 6.00e-50 188.00
IUUC-Gac-041433 Gasterosteus aculeatus 54.24 6.00e-53 198.00
IUUC-Gma-044091 Glycine max 47.59 5.00e-51 191.00
IUUC-Ggo-044437 Gorilla gorilla 62.60 4.00e-44 169.00
IUUC-Hsa-046693 Homo sapiens 58.49 4.00e-53 199.00
IUUC-Hvu-047328 Hordeum vulgare 44.44 5.00e-34 135.00
IUUC-Itr-048477 Ictidomys tridecemlineatus 58.49 7.00e-53 198.00
IUUC-Kpa-049391 Komagataella pastoris 51.21 4.00e-65 238.00
IUUC-Lch-049617 Latimeria chalumnae 57.79 1.00e-50 190.00
IUUC-Lpe-050949 Leersia perrieri 53.70 9.00e-52 194.00
IUUC-Loc-052157 Lepisosteus oculatus 55.56 1.00e-52 197.00
IUUC-Lma-053128 Leptosphaeria maculans 53.85 6.00e-57 211.00
IUUC-Laf-054455 Loxodonta africana 57.86 2.00e-52 197.00
IUUC-Mcc-054756 Macaca mulatta 58.49 4.00e-53 199.00
IUUC-Meu-056106 Macropus eugenii 63.30 2.00e-38 150.00
IUUC-Mor-057202 Magnaporthe oryzae 51.71 1.00e-56 210.00
IUUC-Mpo-057349 Magnaporthe poae 51.76 3.00e-56 209.00
IUUC-Mtr-058271 Medicago truncatula 47.31 1.00e-47 180.00
IUUC-Mla-058894 Melampsora laricipopulina 60.27 6.00e-56 207.00
IUUC-Mga-059493 Meleagris gallopavo 57.14 6.00e-50 188.00
IUUC-Mvi-060232 Microbotryum violaceum 60.26 4.00e-58 215.00
IUUC-Mmr-060957 Microcebus murinus 57.86 2.00e-52 196.00
IUUC-Mdo-062141 Monodelphis domestica 59.12 1.00e-53 200.00
IUUC-Mmu-063882 Mus musculus 59.12 4.00e-53 199.00
IUUC-Mac-064510 Musa acuminata 53.70 1.00e-52 197.00
IUUC-Mpu-065902 Mustela putorius furo 58.49 3.00e-53 199.00
IUUC-Mlu-068008 Myotis lucifugus 57.86 6.00e-51 191.00
IUUC-Nfi-068515 Neosartorya fischeri 48.85 5.00e-57 212.00
IUUC-Ncr-068755 Neurospora crassa 65.28 5.00e-56 208.00
IUUC-Nle-069166 Nomascus leucogenys 41.30 1.00e-31 128.00
IUUC-Opr-071201 Ochotona princeps 58.12 2.00e-37 146.00
IUUC-Ont-071311 Oreochromis niloticus 57.23 1.00e-52 197.00
IUUC-Oan-073310 Ornithorhynchus anatinus 57.86 3.00e-52 196.00
IUUC-Ocu-074514 Oryctolagus cuniculus 57.23 2.00e-52 196.00
IUUC-Oba-075200 Oryza barthii 53.70 9.00e-52 194.00
IUUC-Obr-076396 Oryza brachyantha 53.70 5.00e-52 195.00
IUUC-Ogl-077398 Oryza glaberrima 53.70 1.00e-51 194.00
IUUC-Ogu-078362 Oryza glumaepatula 53.70 9.00e-52 194.00
IUUC-Oin-079625 Oryza indica 53.70 9.00e-52 194.00
IUUC-Olo-080620 Oryza longistaminata 59.26 6.00e-30 122.00
IUUC-Ome-081187 Oryza meridionalis 53.09 2.00e-51 193.00
IUUC-Oni-082271 Oryza nivara 53.70 1.00e-51 194.00
IUUC-Opu-083487 Oryza punctata 53.70 1.00e-51 194.00
IUUC-Oru-085263 Oryza rufipogon 53.70 9.00e-52 194.00
IUUC-Osa-085694 Oryza sativa 53.70 9.00e-52 194.00
IUUC-Ola-086450 Oryzias latipes 54.24 4.00e-53 198.00
IUUC-Olu-087733 Ostreococcus lucimarinus 38.46 1.00e-30 123.00
IUUC-Oga-088054 Otolemur garnettii 52.57 4.00e-48 182.00
IUUC-Oar-089486 Ovis aries 58.49 9.00e-53 197.00
IUUC-Ptr-091314 Pan troglodytes 41.30 1.00e-31 128.00
IUUC-Pan-092633 Papio anubis 58.49 4.00e-53 199.00
IUUC-Psi-093668 Pelodiscus sinensis 40.48 2.00e-30 123.00
IUUC-Pno-095025 Phaeosphaeria nodorum 49.50 2.00e-57 213.00
IUUC-Ppa-095641 Physcomitrella patens 53.37 1.00e-54 203.00
IUUC-Pfo-096423 Poecilia formosa 56.77 1.00e-50 190.00
IUUC-Pab-097771 Pongo abelii 58.49 4.00e-53 199.00
IUUC-Pop-099714 Populus trichocarpa 43.75 6.00e-52 194.00
IUUC-Pca-100493 Procavia capensis 51.22 4.00e-31 125.00
IUUC-Ppe-102054 Prunus persica 39.92 8.00e-53 197.00
IUUC-Pva-102224 Pteropus vampyrus 57.86 3.00e-52 196.00
IUUC-Pgr-103332 Puccinia graminis 58.97 2.00e-57 213.00
IUUC-Ptt-103776 Puccinia triticina 59.62 7.00e-58 214.00
IUUC-Pte-104166 Pyrenophora teres 51.79 3.00e-56 209.00
IUUC-Pyt-104570 Pyrenophora triticirepentis 51.79 4.00e-56 209.00
IUUC-Rno-105593 Rattus norvegicus 59.12 3.00e-53 199.00
IUUC-Sha-106767 Sarcophilus harrisii 57.86 8.00e-53 197.00
IUUC-Sja-107907 Schizosaccharomyces japonicus 56.61 8.00e-64 234.00
IUUC-Spo-108094 Schizosaccharomyces pombe 61.21 7.00e-61 224.00
IUUC-Ssl-108556 Sclerotinia sclerotiorum 60.93 4.00e-55 205.00
IUUC-Smo-108965 Selaginella moellendorffii 52.20 6.00e-57 211.00
IUUC-Sit-110407 Setaria italica 55.56 5.00e-53 198.00
IUUC-Sly-110845 Solanum lycopersicum 50.31 7.00e-46 174.00
IUUC-Stu-112336 Solanum tuberosum 50.62 7.00e-46 174.00
IUUC-Sar-113063 Sorex araneus 41.91 1.00e-32 131.00
IUUC-Sbi-114327 Sorghum bicolor 55.56 3.00e-53 199.00
IUUC-Sre-115170 Sporisorium reilianum 60.61 5.00e-53 199.00
IUUC-Ssc-116385 Sus scrofa 58.49 7.00e-53 198.00
IUUC-Tgu-117041 Taeniopygia guttata 57.14 6.00e-50 188.00
IUUC-Tru-117697 Takifugu rubripes 57.86 4.00e-53 199.00
IUUC-Tsy-119024 Tarsius syrichta 50.29 2.00e-43 167.00
IUUC-Tni-120466 Tetraodon nigroviridis 55.56 4.00e-50 189.00
IUUC-Tca-121569 Theobroma cacao 39.76 1.00e-48 184.00
IUUC-Tre-121882 Trichoderma reesei 57.07 1.00e-60 224.00
IUUC-Tvi-122466 Trichoderma virens 56.16 3.00e-60 223.00
IUUC-Tae-124592 Triticum aestivum 53.22 4.00e-53 199.00
IUUC-Tur-126536 Triticum urartu 44.59 2.00e-52 196.00
IUUC-Tme-127051 Tuber melanosporum 65.97 7.00e-58 214.00
IUUC-Tbe-128095 Tupaia belangeri 63.55 9.00e-38 147.00
IUUC-Ttr-128466 Tursiops truncatus 58.49 8.00e-53 197.00
IUUC-Uma-129383 Ustilago maydis 60.00 3.00e-52 196.00
IUUC-Vda-130013 Verticillium dahliae 52.75 2.00e-54 203.00
IUUC-Vpa-130404 Vicugna pacos 41.18 1.00e-31 128.00
IUUC-Vvi-131251 Vitis vinifera 51.88 9.00e-47 178.00
IUUC-Xtr-132408 Xenopus tropicalis 58.49 4.00e-53 199.00
IUUC-Xma-133893 Xiphophorus maculatus 56.77 1.00e-50 190.00
IUUC-Yli-134618 Yarrowia lipolytica 69.93 9.00e-61 224.00
IUUC-Zma-135216 Zea mays 53.57 5.00e-53 198.00
Created Date 25-Jun-2017

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