iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054068

UUCD1 version

UUC-LoA-00594

Ensembl Protein ID

ENSLAFP00000014456.3

UniProt Accession

G3TIH5; G3TIH5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000017234.3	ENSLAFT00000017242.3	ENSLAFP00000014456.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.10e-141	472.1	958	1519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 67   ktynreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvvesl 153
               ++W+ freql++++++f      y+++           +++w+++i ed +++ll+l+++l+ a+R+++ +++r+l++ +++ 
   Q: 958  GPKPTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDISED-RRNLLHLSSRLNGALRQEQDFADRFLPDEEAA- 1025
           555689***************......****...........***********.********************************. PP
   S: 154  veLslnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesl 239
                  +a++k+++Ea++++ +q+++++++a ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++      
   Q: 1026 -------QALGKTCWEALVSPLVQNITSPDEAGISPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP------ 1099
           .......9*************************************************************************...... PP
   S: 240  laelvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndak 324
            +++va++r k++++ +++++L++r+l+  ++++l+++++++++eq++++lt+ ++++d   +V+r++e+++klqk++se+F+++a+
   Q: 1100 -PPVVATPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWRAVVEEQVNKFLTSYWQDDD---FVPRYCEHFHKLQKSSSELFGPRAA 1182
           .**************************999*****************************...************************* PP
   S: 325  FlkaldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsg 407
           Fl al+++++ ++++ ++lkaa+++E+++r+iDq++++s ++g++++e++aql+++l+ + ++s++++   Fe+yY++++a+RLl  
   Q: 1183 FLLALQNGCAGALLRLPFLKAAHVSEQFSRHIDQRIQGSrMGGARGMEMLAQLQRCLETVLVFSGLEIattFEHYYQHYMADRLLG- 1268
           **************************************************************************************. PP
   S: 408  ksasseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk......................................... 452
            +  s++E++v+e++    g++f+++L ++M+q l++Se+l++qF+                                         
   Q: 1269 -VGPSWLEGAVLEQI----GPCFPNRLpQQMLQTLNTSEELQHQFHvyqlqrldqallkldntekkiqvgaragwskwkgreyewpg 1350
           .**************....******************************************************************** PP
   S: 453  ...........................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY...... 502
                                      e  + ++e +++e+svlvLs+++Wp +  s+   ++++LP++l+ t++++++fY      
   Q: 1351 anpvflqvghkasgqknekeeekeagvEAADLYYEGAMPEVSVLVLSPSCWPISsiSHLlsPRTCLPSYLRGTLNRYSNFYnksqsh 1437
           ***************************99*************************76555889************************* PP
   S: 503  ..lekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkk 585
             le++ +R+LqW++ lgrael++    g ++l+Vst+Qm++LL++n+ ++vsv+ l + ++l++++L+ ++++L+ss+   ++ ++
   Q: 1438 pgLERGLQRRLQWTW-LGRAELQF----GDQTLHVSTVQMWLLLYLNDLKAVSVQRLLELSGLSPDVLNPAIGPLTSSRgpLDLQEQ 1519
           ***************.********....*************************************************9955555444 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRSDD GDEGSTQVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQESDGEAG ALDKSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGAG AACTCCGCTA CAGGGAATTC AGGGTGCCCC TGGGGCCCGG CCTGCATGCC 60
TACCCCGATG AGCTGATCCG CCAGCGGGTG GGCCACGACG GACACCCTGA GTACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	86.37	0.00e+00	2770.00
IUUC-Aca-004752	Anolis carolinensis	47.05	0.00e+00	848.00
IUUC-Ame-010611	Astyanax mexicanus	53.55	0.00e+00	756.00
IUUC-Bta-013285	Bos taurus	84.87	0.00e+00	2762.00
IUUC-Cja-019033	Callithrix jacchus	81.59	0.00e+00	2622.00
IUUC-Cfa-020695	Canis familiaris	84.98	0.00e+00	1736.00
IUUC-Cpo-021513	Cavia porcellus	77.27	0.00e+00	2460.00
IUUC-Csa-023798	Chlorocebus sabaeus	84.42	0.00e+00	2731.00
IUUC-Cin-025402	Ciona intestinalis	30.81	3.00e-102	367.00
IUUC-Dno-029587	Dasypus novemcinctus	86.59	0.00e+00	1058.00
IUUC-Dor-030234	Dipodomys ordii	82.25	0.00e+00	2734.00
IUUC-Ete-032612	Echinops telfairi	79.42	0.00e+00	960.00
IUUC-Eca-033408	Equus caballus	87.51	0.00e+00	2751.00
IUUC-Eeu-035166	Erinaceus europaeus	72.84	0.00e+00	687.00
IUUC-Fca-035483	Felis catus	85.80	0.00e+00	2763.00
IUUC-Fal-036672	Ficedula albicollis	56.57	0.00e+00	731.00
IUUC-Gac-041628	Gasterosteus aculeatus	46.48	0.00e+00	1323.00
IUUC-Ggo-044721	Gorilla gorilla	85.33	0.00e+00	2723.00
IUUC-Hsa-046406	Homo sapiens	85.74	0.00e+00	2751.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	86.01	0.00e+00	2739.00
IUUC-Lch-049956	Latimeria chalumnae	43.83	0.00e+00	1054.00
IUUC-Loc-052706	Lepisosteus oculatus	54.53	0.00e+00	787.00
IUUC-Mcc-055464	Macaca mulatta	84.36	0.00e+00	2715.00
IUUC-Mmr-061464	Microcebus murinus	84.92	0.00e+00	2736.00
IUUC-Mmu-063413	Mus musculus	77.18	0.00e+00	2397.00
IUUC-Mpu-066146	Mustela putorius furo	87.09	0.00e+00	2707.00
IUUC-Mlu-067036	Myotis lucifugus	83.72	0.00e+00	2751.00
IUUC-Opr-070670	Ochotona princeps	76.55	0.00e+00	2433.00
IUUC-Ont-071953	Oreochromis niloticus	53.33	0.00e+00	770.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.03	0.00e+00	1166.00
IUUC-Ocu-074155	Oryctolagus cuniculus	81.93	0.00e+00	2633.00
IUUC-Ola-087072	Oryzias latipes	47.90	0.00e+00	941.00
IUUC-Oga-089084	Otolemur garnettii	84.46	0.00e+00	2805.00
IUUC-Oar-090029	Ovis aries	86.23	0.00e+00	2770.00
IUUC-Ptr-091282	Pan troglodytes	84.11	0.00e+00	2731.00
IUUC-Pan-091883	Papio anubis	84.42	0.00e+00	2734.00
IUUC-Pma-094192	Petromyzon marinus	48.39	0.00e+00	664.00
IUUC-Pab-098383	Pongo abelii	83.14	0.00e+00	2145.00
IUUC-Pca-100519	Procavia capensis	81.35	0.00e+00	900.00
IUUC-Pva-102417	Pteropus vampyrus	82.50	0.00e+00	2206.00
IUUC-Rno-105962	Rattus norvegicus	79.14	0.00e+00	2521.00
IUUC-Sar-113750	Sorex araneus	81.02	3.00e-170	593.00
IUUC-Ssc-115899	Sus scrofa	80.84	0.00e+00	2454.00
IUUC-Tgu-116915	Taeniopygia guttata	58.35	1.00e-133	469.00
IUUC-Tru-118013	Takifugu rubripes	55.08	0.00e+00	716.00
IUUC-Tsy-118860	Tarsius syrichta	82.67	0.00e+00	1118.00
IUUC-Tni-120062	Tetraodon nigroviridis	55.32	0.00e+00	733.00
IUUC-Tbe-127660	Tupaia belangeri	84.20	0.00e+00	1406.00
IUUC-Ttr-128973	Tursiops truncatus	85.05	0.00e+00	1858.00
IUUC-Vpa-130086	Vicugna pacos	62.56	8.00e-140	491.00
IUUC-Xtr-132882	Xenopus tropicalis	47.66	0.00e+00	853.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence