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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045776
UUCD1 version UUC-HoS-00394
Ensembl Protein ID ENSP00000328059.6
UniProt Accession Q9NVW2; B2RBQ1; D3DTE0; Q96D38; Q9Y598; RNF12_HUMAN
Genbank Protein ID AAD42875.1; CAC14228.1; BAA91632.1; BAG37298.1; CAI41712.1; EAW98639.1; EAW98640.1; AAH13357.1
Protein Name E3 ubiquitin-protein ligase RLIM; LIM domain-interacting RING finger protein; RING finger LIM domain-binding protein; RING finger protein 12; RING-type E3 ubiquitin transferase RLIM; Renal carcinoma antigen NY-REN-43
Genbank Nucleotide ID AF155109; AJ271670; AK001334; AK314760; AL513007; CH471104; CH471104; BC013357
Gene Name RLIM; RNF12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131263.12 ENST00000332687.10 ENSP00000328059.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19683498; 17437998; 19117995; 19164295
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.10e-06 30.7 570 611
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C +++ +g  ++ lpC H +h +C+ +w       s + +CP+Cr
   Q: 570  CSVCITEYTEGnkLRKLPCSHEYHVHCIDRW------LSENSTCPICR 611
           9*******5554499****************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
 E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Protein Sequence
(Fasta)
MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN NLLGTPGEST 60
EEELLRRLQQ IKEGPPPQNS DENRGGDSSD DVSNGDSIID WLNSVRQTGN TTRSGQRGNQ 120
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Protein Fasta Sequence


>IUUC-Hsa-045776|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
TTTCCTGTCG CTGCTTGGTA ACAATGGGGA AGATAATGGC TGCCTGAGCA ACGTCTCCGA 60
GCAGGCGCTG GGCTAGAGGC GGGTCTCAAC CAGCTACTCA TTGGAGGCGG GCTTGAGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045776|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060816--P:random inactivation of X chromosome
GO:1900095--P:regulation of dosage compensation by inactivation of X chromosome
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:51132
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000316 Aegilops tauschii 42.37 6.00e-10 57.00
IUUC-Aml-001407 Ailuropoda melanoleuca 96.83 0.00e+00 704.00
IUUC-Atr-002539 Amborella trichopoda 47.54 2.00e-14 73.90
IUUC-Apl-003969 Anas platyrhynchos 76.89 2.00e-164 572.00
IUUC-Aca-005377 Anolis carolinensis 72.30 4.00e-82 299.00
IUUC-Aly-005870 Arabidopsis lyrata 42.70 3.00e-16 79.30
IUUC-Ath-007543 Arabidopsis thaliana 49.21 4.00e-15 74.70
IUUC-Bta-013113 Bos taurus 96.21 0.00e+00 730.00
IUUC-Bdi-014392 Brachypodium distachyon 47.06 3.00e-14 72.00
IUUC-Bol-015085 Brassica oleracea 41.94 7.00e-16 78.20
IUUC-Bra-018013 Brassica rapa 42.86 2.00e-16 79.70
IUUC-Cja-018860 Callithrix jacchus 98.17 0.00e+00 709.00
IUUC-Cfa-020358 Canis familiaris 96.61 0.00e+00 702.00
IUUC-Cpo-021533 Cavia porcellus 95.96 0.00e+00 652.00
IUUC-Cre-022755 Chlamydomonas reinhardtii 44.68 1.00e-13 67.40
IUUC-Csa-023242 Chlorocebus sabaeus 97.44 0.00e+00 901.00
IUUC-Cho-024536 Choloepus hoffmanni 87.41 8.00e-169 587.00
IUUC-Cne-026941 Cryptococcus neoformans 34.94 2.00e-10 61.60
IUUC-Dre-027894 Danio rerio 56.37 6.00e-108 385.00
IUUC-Dno-029606 Dasypus novemcinctus 96.12 0.00e+00 760.00
IUUC-Dor-031042 Dipodomys ordii 88.66 0.00e+00 652.00
IUUC-Ete-033099 Echinops telfairi 90.05 0.00e+00 648.00
IUUC-Eca-033976 Equus caballus 96.82 0.00e+00 766.00
IUUC-Eeu-034964 Erinaceus europaeus 86.12 6.00e-156 544.00
IUUC-Fca-035662 Felis catus 97.06 0.00e+00 705.00
IUUC-Fal-036996 Ficedula albicollis 78.35 2.00e-157 549.00
IUUC-Gmo-039207 Gadus morhua 76.86 1.00e-47 184.00
IUUC-Gma-043292 Glycine max 47.37 3.00e-16 79.70
IUUC-Ggo-044754 Gorilla gorilla 100.00 0.00e+00 979.00
IUUC-Hvu-047745 Hordeum vulgare 52.94 1.00e-14 74.30
IUUC-Itr-048044 Ictidomys tridecemlineatus 95.69 0.00e+00 721.00
IUUC-Lch-050178 Latimeria chalumnae 67.40 3.00e-131 462.00
IUUC-Lpe-051680 Leersia perrieri 42.86 2.00e-14 73.90
IUUC-Loc-052124 Lepisosteus oculatus 59.07 4.00e-106 378.00
IUUC-Laf-054328 Loxodonta africana 95.46 0.00e+00 715.00
IUUC-Mcc-054739 Macaca mulatta 99.52 0.00e+00 975.00
IUUC-Meu-056359 Macropus eugenii 76.85 1.00e-148 520.00
IUUC-Mtr-058167 Medicago truncatula 47.37 2.00e-15 76.60
IUUC-Mga-059838 Meleagris gallopavo 79.01 2.00e-167 582.00
IUUC-Mmr-060608 Microcebus murinus 95.03 0.00e+00 696.00
IUUC-Mdo-061961 Monodelphis domestica 78.57 6.00e-153 534.00
IUUC-Mmu-064278 Mus musculus 87.65 2.00e-171 595.00
IUUC-Mac-065396 Musa acuminata 43.42 2.00e-14 73.20
IUUC-Mpu-066258 Mustela putorius furo 95.65 3.00e-165 575.00
IUUC-Mlu-066930 Myotis lucifugus 95.24 0.00e+00 755.00
IUUC-Nle-069311 Nomascus leucogenys 97.76 0.00e+00 970.00
IUUC-Opr-071124 Ochotona princeps 93.26 2.00e-89 323.00
IUUC-Oan-073036 Ornithorhynchus anatinus 74.71 4.00e-152 531.00
IUUC-Ocu-073795 Oryctolagus cuniculus 95.46 0.00e+00 675.00
IUUC-Oba-075403 Oryza barthii 42.86 2.00e-14 73.90
IUUC-Obr-076503 Oryza brachyantha 42.86 3.00e-14 73.20
IUUC-Ogl-077574 Oryza glaberrima 42.86 2.00e-14 73.90
IUUC-Ogu-077986 Oryza glumaepatula 42.86 2.00e-14 73.90
IUUC-Oin-079091 Oryza indica 42.86 2.00e-14 73.90
IUUC-Olo-080996 Oryza longistaminata 37.63 7.00e-14 71.60
IUUC-Ome-081627 Oryza meridionalis 42.86 2.00e-14 73.90
IUUC-Oni-082260 Oryza nivara 42.86 2.00e-14 73.90
IUUC-Opu-083578 Oryza punctata 42.86 2.00e-14 74.30
IUUC-Oru-084794 Oryza rufipogon 42.86 2.00e-14 73.90
IUUC-Osa-085348 Oryza sativa 42.86 2.00e-14 73.90
IUUC-Olu-087781 Ostreococcus lucimarinus 40.30 8.00e-13 66.20
IUUC-Oga-088022 Otolemur garnettii 95.82 0.00e+00 739.00
IUUC-Oar-089348 Ovis aries 96.20 0.00e+00 731.00
IUUC-Ptr-090604 Pan troglodytes 97.76 0.00e+00 972.00
IUUC-Pan-092322 Papio anubis 99.52 0.00e+00 975.00
IUUC-Psi-093936 Pelodiscus sinensis 72.81 3.00e-149 521.00
IUUC-Ppa-095197 Physcomitrella patens 46.58 2.00e-16 80.90
IUUC-Pab-098671 Pongo abelii 99.68 0.00e+00 976.00
IUUC-Pop-099808 Populus trichocarpa 45.95 9.00e-16 77.80
IUUC-Pca-100263 Procavia capensis 95.01 0.00e+00 703.00
IUUC-Ppe-101202 Prunus persica 43.59 2.00e-15 77.00
IUUC-Pva-102709 Pteropus vampyrus 93.20 0.00e+00 663.00
IUUC-Ptt-103976 Puccinia triticina 43.75 2.00e-10 59.30
IUUC-Rno-105759 Rattus norvegicus 89.73 2.00e-178 619.00
IUUC-Sha-106792 Sarcophilus harrisii 77.59 8.00e-139 487.00
IUUC-Smo-109572 Selaginella moellendorffii 44.09 2.00e-15 75.90
IUUC-Sit-109852 Setaria italica 42.86 2.00e-14 73.90
IUUC-Sly-111747 Solanum lycopersicum 62.86 2.00e-12 67.40
IUUC-Stu-112609 Solanum tuberosum 47.22 2.00e-16 79.70
IUUC-Sar-113271 Sorex araneus 86.20 5.00e-179 620.00
IUUC-Sbi-114435 Sorghum bicolor 44.16 2.00e-14 73.90
IUUC-Ssc-115738 Sus scrofa 96.15 0.00e+00 736.00
IUUC-Tgu-117205 Taeniopygia guttata 76.85 7.00e-159 554.00
IUUC-Tru-118123 Takifugu rubripes 87.62 4.00e-55 209.00
IUUC-Tsy-119421 Tarsius syrichta 96.83 0.00e+00 768.00
IUUC-Tca-121367 Theobroma cacao 47.37 2.00e-16 79.70
IUUC-Tae-123264 Triticum aestivum 35.29 2.00e-15 77.00
IUUC-Tur-126084 Triticum urartu 42.86 2.00e-13 72.00
IUUC-Tbe-127543 Tupaia belangeri 96.38 0.00e+00 758.00
IUUC-Vpa-130058 Vicugna pacos 97.29 0.00e+00 711.00
IUUC-Vvi-131093 Vitis vinifera 47.37 1.00e-16 80.90
IUUC-Xtr-132663 Xenopus tropicalis 62.02 5.00e-108 385.00
IUUC-Yli-134448 Yarrowia lipolytica 34.12 5.00e-10 57.40
Created Date 25-Jun-2017

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