iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096337

Ensembl Protein ID

ENSPFOP00000004263.2

UniProt Accession

A0A087XER0; A0A087XER0_POEFO

Genbank Protein ID

ENSPFOP00000004263

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

AYCK01010688

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000004302.2	ENSPFOT00000004271.2	ENSPFOP00000004263.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-40	136.2	341	376
UBD/Beta-Prp	3.20e-46	158.4	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht+++t++++  s  + l+sGs D+ +k+WD+r+++
   Q: 341  HTGWITAVKWapSHeHQLISGSLDNLVKLWDTRSCK 376
           ***********754688**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ v s+ ++  ++ + s+s+d tir+wd+e g     tlsg + v nc++++p ++ l+s+s+Dr +rlWd +t++ 
   Q: 246  TRTPLMTLSGHNEAVSSVLWCD-SEEVCSASWDHTIRLWDVEAGVMKT-TLSGSK-VFNCISYSPLCRRLASASTDRHIRLWDPRTKDG 331
           67899*****************.8999*****************9998.999987.99**************************88775 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ ++ +++ ++   +l+sgsld+ vklwd +  +  ++ l +h+d v +v+ + ++ +++sg++D+ ++ +
   Q: 332  TLVLlslTS-HTGWITAVKWAPSHeHQLISGSLDNLVKLWDTRsCKAPLYDLAAHEDKVFCVDWT-DSGLMLSGGADNKLYTY 412
           555555477.**********9988788****************54566****************9.************99887 PP

Organism

Poecilia formosa

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQARFFT EDQRYVVDDV PFSIPAASEV QDLSNVINKL LEAKHASHSR VEFDFLVKGQ 60
FLRTQLATHM ETEGISTEDV VEIEYVQRIT APEPEECIMH DDWISSVEAD SEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGATCAACGA GTCGCCGAAC TCGATCGGTT TTCGACTTGA AAGTCTTCCC AGACAGCACA 60
TGGCGACACT GCATGAGAAT TGCATATGTT ATGAAGTGAA GCGGAATAGT TTTATGACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.55	4.00e-62	232.00
IUUC-Aml-001997	Ailuropoda melanoleuca	76.16	7.00e-180	623.00
IUUC-Atr-002544	Amborella trichopoda	33.81	2.00e-60	226.00
IUUC-Apl-003981	Anas platyrhynchos	76.46	1.00e-171	595.00
IUUC-Aca-004370	Anolis carolinensis	74.59	0.00e+00	666.00
IUUC-Aly-006455	Arabidopsis lyrata	33.81	7.00e-61	228.00
IUUC-Ath-006669	Arabidopsis thaliana	33.96	2.00e-56	213.00
IUUC-Ago-007864	Ashbya gossypii	29.77	9.00e-44	171.00
IUUC-Acl-008177	Aspergillus clavatus	28.64	5.00e-38	152.00
IUUC-Afl-008617	Aspergillus flavus	29.23	2.00e-39	157.00
IUUC-Afu-008752	Aspergillus fumigatus	27.44	6.00e-35	142.00
IUUC-Ani-009136	Aspergillus nidulans	28.57	1.00e-37	150.00
IUUC-Ang-009701	Aspergillus niger	27.69	4.00e-36	145.00
IUUC-Aor-009884	Aspergillus oryzae	28.72	2.00e-38	153.00
IUUC-Ame-011432	Astyanax mexicanus	82.27	0.00e+00	708.00
IUUC-Bgr-012218	Blumeria graminis	27.42	5.00e-38	152.00
IUUC-Bta-012829	Bos taurus	75.65	0.00e+00	645.00
IUUC-Bci-013953	Botrytis cinerea	28.33	8.00e-38	151.00
IUUC-Bdi-014351	Brachypodium distachyon	35.70	2.00e-59	223.00
IUUC-Bol-015618	Brassica oleracea	34.63	1.00e-57	217.00
IUUC-Bra-018095	Brassica rapa	33.25	3.00e-58	219.00
IUUC-Cel-018569	Caenorhabditis elegans	31.74	4.00e-53	202.00
IUUC-Cja-019468	Callithrix jacchus	74.94	2.00e-180	625.00
IUUC-Cfa-020471	Canis familiaris	75.65	0.00e+00	626.00
IUUC-Cpo-022260	Cavia porcellus	74.94	0.00e+00	630.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	32.24	4.00e-44	172.00
IUUC-Csa-023989	Chlorocebus sabaeus	74.70	1.00e-180	625.00
IUUC-Cho-024426	Choloepus hoffmanni	74.29	3.00e-134	471.00
IUUC-Cin-025789	Ciona intestinalis	42.82	5.00e-104	371.00
IUUC-Cne-027063	Cryptococcus neoformans	25.90	1.00e-14	74.70
IUUC-Dre-027907	Danio rerio	82.74	0.00e+00	720.00
IUUC-Dno-029225	Dasypus novemcinctus	75.18	0.00e+00	640.00
IUUC-Dor-031082	Dipodomys ordii	62.17	8.00e-137	480.00
IUUC-Dse-031308	Dothistroma septosporum	26.79	7.00e-38	151.00
IUUC-Dme-032189	Drosophila melanogaster	41.93	1.00e-98	353.00
IUUC-Ete-032247	Echinops telfairi	71.63	1.00e-170	592.00
IUUC-Eca-034285	Equus caballus	75.65	0.00e+00	644.00
IUUC-Eeu-035322	Erinaceus europaeus	69.35	2.00e-157	548.00
IUUC-Fca-036114	Felis catus	76.12	0.00e+00	647.00
IUUC-Fal-036891	Ficedula albicollis	77.12	4.00e-161	560.00
IUUC-Fox-037965	Fusarium oxysporum	24.52	4.00e-37	149.00
IUUC-Fso-038244	Fusarium solani	24.52	2.00e-35	143.00
IUUC-Gmo-039040	Gadus morhua	84.63	0.00e+00	741.00
IUUC-Ggr-040093	Gaeumannomyces graminis	26.48	8.00e-15	75.50
IUUC-Gga-040610	Gallus gallus	75.41	0.00e+00	662.00
IUUC-Gac-042117	Gasterosteus aculeatus	89.36	0.00e+00	759.00
IUUC-Gma-043146	Glycine max	36.45	1.00e-67	250.00
IUUC-Ggo-045179	Gorilla gorilla	74.70	1.00e-179	622.00
IUUC-Hsa-046114	Homo sapiens	75.18	4.00e-180	624.00
IUUC-Hvu-047331	Hordeum vulgare	33.59	2.00e-58	219.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	74.94	0.00e+00	641.00
IUUC-Kpa-049304	Komagataella pastoris	29.82	9.00e-45	174.00
IUUC-Lch-050655	Latimeria chalumnae	70.80	3.00e-135	474.00
IUUC-Lpe-051675	Leersia perrieri	34.68	9.00e-64	238.00
IUUC-Loc-052868	Lepisosteus oculatus	79.91	0.00e+00	686.00
IUUC-Lma-053258	Leptosphaeria maculans	25.92	1.00e-36	149.00
IUUC-Laf-053993	Loxodonta africana	75.41	0.00e+00	640.00
IUUC-Mcc-055128	Macaca mulatta	61.23	2.00e-138	484.00
IUUC-Meu-056501	Macropus eugenii	66.22	3.00e-142	498.00
IUUC-Mor-057114	Magnaporthe oryzae	25.33	1.00e-30	127.00
IUUC-Mtr-058367	Medicago truncatula	36.60	3.00e-62	232.00
IUUC-Mla-059107	Melampsora laricipopulina	26.08	3.00e-33	136.00
IUUC-Mga-059745	Meleagris gallopavo	74.40	0.00e+00	637.00
IUUC-Mvi-060362	Microbotryum violaceum	27.19	2.00e-35	143.00
IUUC-Mdo-062257	Monodelphis domestica	73.63	0.00e+00	658.00
IUUC-Mmu-063546	Mus musculus	75.65	0.00e+00	641.00
IUUC-Mac-065540	Musa acuminata	34.15	1.00e-62	233.00
IUUC-Mpu-066284	Mustela putorius furo	75.65	0.00e+00	645.00
IUUC-Mlu-067241	Myotis lucifugus	75.65	0.00e+00	643.00
IUUC-Nfi-068260	Neosartorya fischeri	27.88	9.00e-36	144.00
IUUC-Ncr-068719	Neurospora crassa	25.57	2.00e-30	127.00
IUUC-Nle-068981	Nomascus leucogenys	74.94	3.00e-176	611.00
IUUC-Opr-071218	Ochotona princeps	69.10	7.00e-163	566.00
IUUC-Ont-071646	Oreochromis niloticus	88.36	0.00e+00	748.00
IUUC-Oan-073453	Ornithorhynchus anatinus	77.07	0.00e+00	710.00
IUUC-Ocu-074008	Oryctolagus cuniculus	75.41	0.00e+00	643.00
IUUC-Oba-075712	Oryza barthii	30.84	2.00e-47	183.00
IUUC-Obr-076721	Oryza brachyantha	35.48	6.00e-64	238.00
IUUC-Ogl-077229	Oryza glaberrima	35.17	2.00e-63	236.00
IUUC-Ogu-078977	Oryza glumaepatula	30.84	2.00e-47	183.00
IUUC-Oin-079683	Oryza indica	35.41	4.00e-64	238.00
IUUC-Olo-080291	Oryza longistaminata	31.16	8.00e-32	130.00
IUUC-Ome-081834	Oryza meridionalis	35.65	7.00e-65	241.00
IUUC-Oni-082507	Oryza nivara	33.81	5.00e-59	221.00
IUUC-Opu-083396	Oryza punctata	34.93	8.00e-64	238.00
IUUC-Oru-085220	Oryza rufipogon	34.05	6.00e-59	221.00
IUUC-Osa-085767	Oryza sativa	35.41	4.00e-64	238.00
IUUC-Ola-087420	Oryzias latipes	89.36	0.00e+00	759.00
IUUC-Olu-087740	Ostreococcus lucimarinus	27.52	3.00e-41	162.00
IUUC-Oga-088264	Otolemur garnettii	74.47	6.00e-180	623.00
IUUC-Oar-089335	Ovis aries	75.18	0.00e+00	641.00
IUUC-Ptr-091320	Pan troglodytes	75.18	4.00e-180	624.00
IUUC-Pan-092833	Papio anubis	74.47	2.00e-179	622.00
IUUC-Psi-093504	Pelodiscus sinensis	76.60	0.00e+00	670.00
IUUC-Pma-094189	Petromyzon marinus	64.62	2.00e-164	572.00
IUUC-Pno-094929	Phaeosphaeria nodorum	25.86	2.00e-36	147.00
IUUC-Ppa-095429	Physcomitrella patens	36.15	3.00e-69	256.00
IUUC-Pab-097571	Pongo abelii	74.94	6.00e-180	623.00
IUUC-Pop-099977	Populus trichocarpa	34.53	5.00e-65	241.00
IUUC-Pca-100394	Procavia capensis	73.35	1.00e-164	572.00
IUUC-Ppe-101848	Prunus persica	35.10	6.00e-65	241.00
IUUC-Pva-102921	Pteropus vampyrus	73.68	2.00e-91	329.00
IUUC-Pgr-103637	Puccinia graminis	27.53	7.00e-41	161.00
IUUC-Ptt-103781	Puccinia triticina	27.96	1.00e-40	161.00
IUUC-Pte-104135	Pyrenophora teres	26.79	9.00e-36	146.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.50	9.00e-35	141.00
IUUC-Rno-105114	Rattus norvegicus	74.94	0.00e+00	636.00
IUUC-Sce-106401	Saccharomyces cerevisiae	28.82	2.00e-43	170.00
IUUC-Sha-107122	Sarcophilus harrisii	74.23	0.00e+00	627.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.48	1.00e-53	204.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.19	7.00e-44	171.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.20	2.00e-40	160.00
IUUC-Smo-108720	Selaginella moellendorffii	33.73	5.00e-62	231.00
IUUC-Sit-110311	Setaria italica	34.96	8.00e-62	231.00
IUUC-Sly-111178	Solanum lycopersicum	33.83	1.00e-62	233.00
IUUC-Stu-112778	Solanum tuberosum	34.84	1.00e-66	247.00
IUUC-Sar-113596	Sorex araneus	62.17	6.00e-143	500.00
IUUC-Sbi-114193	Sorghum bicolor	36.76	2.00e-64	240.00
IUUC-Sre-115002	Sporisorium reilianum	26.29	4.00e-18	86.30
IUUC-Ssc-116066	Sus scrofa	74.70	0.00e+00	637.00
IUUC-Tgu-117048	Taeniopygia guttata	76.46	1.00e-171	595.00
IUUC-Tsy-119573	Tarsius syrichta	48.56	1.00e-104	372.00
IUUC-Tni-119820	Tetraodon nigroviridis	86.76	0.00e+00	744.00
IUUC-Tca-121605	Theobroma cacao	34.62	3.00e-63	236.00
IUUC-Tre-121947	Trichoderma reesei	25.86	2.00e-35	143.00
IUUC-Tvi-122481	Trichoderma virens	26.08	4.00e-37	149.00
IUUC-Tae-125861	Triticum aestivum	32.78	2.00e-62	233.00
IUUC-Tur-126586	Triticum urartu	34.10	8.00e-61	227.00
IUUC-Tme-126900	Tuber melanosporum	30.73	5.00e-50	191.00
IUUC-Tbe-127736	Tupaia belangeri	56.28	3.00e-121	428.00
IUUC-Ttr-129041	Tursiops truncatus	64.54	4.00e-155	541.00
IUUC-Uma-129628	Ustilago maydis	28.89	4.00e-11	62.80
IUUC-Vpa-130260	Vicugna pacos	75.65	0.00e+00	645.00
IUUC-Vvi-131009	Vitis vinifera	35.31	1.00e-63	237.00
IUUC-Xtr-132083	Xenopus tropicalis	73.29	0.00e+00	636.00
IUUC-Xma-133094	Xiphophorus maculatus	97.40	0.00e+00	832.00
IUUC-Yli-134531	Yarrowia lipolytica	23.51	2.00e-23	103.00
IUUC-Zma-135509	Zea mays	34.76	5.00e-64	238.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence