iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011893

Ensembl Protein ID

ENSAMXP00000019549.1

UniProt Accession

W5LI87; W5LI87_ASTMX

Genbank Protein ID

ENSAMXP00000019549

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

APWO01091650

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000018983.1	ENSAMXT00000019549.1	ENSAMXP00000019549.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-41	142.8	324	600
UBD/Alpha-Helix/UBA	7.20e-20	70.7	700	739

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk.....................av 68
           tG+kNlgN+CY+NSv+Q+L+ ip+++e + + + ek+ +e+p++p++++ ++++kl   l++++ +                      +
   Q: 324  TGMKNLGNSCYLNSVMQVLFTIPDFQEKYVS-NIEKILDEAPSDPTQDFKTQVAKLGYGLLSGEYSkpapdpgddpnasseprgdqvGI 411
           7******************************.8888889999******************633333334555566666666666666** PP
   S: 69   sprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcl 157
           +pr++++ +++ ++efs+++qqDaqEfl ++++ +e+++                             ++    s+ F++ ++++i+c+
   Q: 412  APRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSGPNPSEAFRFLVEERIVCQ 471
           ***************************************.............................556677999************ PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaek 219
           + ++ + ++   + ++lpvp+++ t++e                            ++ cL++ +++e+l++   ++++  ++k++a+k
   Q: 472  QSQKAKYTQRVDYIVQLPVPMDQATNTEelqeaerlreeaeasgsppppapraqiPFSVCLDALSEPETLTD---FWSSAVQGKTTATK 557
           ***********************99999*******************************************7...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           ++++ ++P++L++++k+f+f  + ++++k++ ++++p++Ldls 
   Q: 558  TTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIDVPDTLDLSA 600
           ********************997.******************96 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++e+ l+ +v+MGF+r++a +aLra++n le+Av++++++
   Q: 700  ISEEHLATIVSMGFSRDQATRALRATSNILERAVDWIFSH 739
           68999*********************************97 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MAEVSEVLMS VLSTVRVPRP GDRVHKDECA FSFASPESEG GLYVCMNSFL GFGSQFVERH 60
HARTGQKAYL HITRTRKAQK EDDNNSASGD PPKKKPTRLA IGMEGGFDVE QDQYEEDVKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTCGTTGC GCCTATAGGC GGCGGTTTAC GGTACAAACA CCGGAGCGGA CCCCGCAGCG 60
CCTCGGTGGC CTTGAATGGA GTGTAGCCGC TGGAGGAGCG CCGCGCTGAG AGAGAGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	64.91	0.00e+00	1037.00
IUUC-Apl-003774	Anas platyrhynchos	64.14	0.00e+00	1001.00
IUUC-Aca-005368	Anolis carolinensis	65.60	0.00e+00	1070.00
IUUC-Acl-008057	Aspergillus clavatus	34.81	2.00e-114	406.00
IUUC-Afl-008547	Aspergillus flavus	37.75	7.00e-105	374.00
IUUC-Afu-008805	Aspergillus fumigatus	34.11	2.00e-101	363.00
IUUC-Ani-009441	Aspergillus nidulans	34.58	4.00e-91	329.00
IUUC-Aor-010111	Aspergillus oryzae	35.00	1.00e-113	404.00
IUUC-Ate-010531	Aspergillus terreus	32.88	8.00e-92	331.00
IUUC-Bgr-012183	Blumeria graminis	33.73	3.00e-108	385.00
IUUC-Bta-013179	Bos taurus	65.32	0.00e+00	1043.00
IUUC-Bci-013858	Botrytis cinerea	34.90	1.00e-114	407.00
IUUC-Cja-019063	Callithrix jacchus	63.19	0.00e+00	1016.00
IUUC-Cfa-020976	Canis familiaris	67.57	0.00e+00	1060.00
IUUC-Cpo-022265	Cavia porcellus	67.19	0.00e+00	1059.00
IUUC-Csa-024177	Chlorocebus sabaeus	67.31	0.00e+00	1061.00
IUUC-Cho-024702	Choloepus hoffmanni	60.92	7.00e-180	624.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	33.11	2.00e-99	356.00
IUUC-Cme-027335	Cyanidioschyzon merolae	29.84	1.00e-40	162.00
IUUC-Dre-027982	Danio rerio	89.55	0.00e+00	1286.00
IUUC-Dno-029034	Dasypus novemcinctus	65.32	0.00e+00	1040.00
IUUC-Ete-032865	Echinops telfairi	58.98	0.00e+00	903.00
IUUC-Eca-034059	Equus caballus	64.79	0.00e+00	1038.00
IUUC-Eeu-035304	Erinaceus europaeus	61.16	0.00e+00	933.00
IUUC-Fca-035515	Felis catus	64.94	0.00e+00	1040.00
IUUC-Fal-037271	Ficedula albicollis	66.35	0.00e+00	994.00
IUUC-Fox-037745	Fusarium oxysporum	37.06	3.00e-118	419.00
IUUC-Fso-038158	Fusarium solani	35.75	3.00e-113	402.00
IUUC-Gmo-039071	Gadus morhua	87.23	0.00e+00	1288.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.60	1.00e-110	394.00
IUUC-Gga-040635	Gallus gallus	64.80	0.00e+00	1070.00
IUUC-Gac-042528	Gasterosteus aculeatus	86.23	0.00e+00	1282.00
IUUC-Ggo-044602	Gorilla gorilla	64.82	0.00e+00	1039.00
IUUC-Hsa-045959	Homo sapiens	64.82	0.00e+00	1039.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	64.23	0.00e+00	1037.00
IUUC-Lch-049648	Latimeria chalumnae	68.35	0.00e+00	1053.00
IUUC-Loc-052520	Lepisosteus oculatus	70.01	0.00e+00	1037.00
IUUC-Lma-053216	Leptosphaeria maculans	35.39	4.00e-100	360.00
IUUC-Laf-054327	Loxodonta africana	64.94	0.00e+00	1034.00
IUUC-Mcc-055443	Macaca mulatta	64.94	0.00e+00	1039.00
IUUC-Meu-056298	Macropus eugenii	68.80	0.00e+00	825.00
IUUC-Mor-057106	Magnaporthe oryzae	36.29	2.00e-120	426.00
IUUC-Mpo-057589	Magnaporthe poae	35.33	5.00e-117	415.00
IUUC-Mla-058903	Melampsora laricipopulina	34.85	7.00e-109	388.00
IUUC-Mga-059669	Meleagris gallopavo	63.91	0.00e+00	1003.00
IUUC-Mvi-060476	Microbotryum violaceum	36.75	1.00e-108	387.00
IUUC-Mmr-060575	Microcebus murinus	64.94	0.00e+00	1038.00
IUUC-Mdo-062183	Monodelphis domestica	65.98	0.00e+00	1036.00
IUUC-Mmu-063592	Mus musculus	65.07	0.00e+00	1041.00
IUUC-Mpu-066082	Mustela putorius furo	67.32	0.00e+00	1058.00
IUUC-Mlu-067345	Myotis lucifugus	63.94	0.00e+00	1029.00
IUUC-Nfi-068558	Neosartorya fischeri	35.98	1.00e-111	397.00
IUUC-Ncr-068960	Neurospora crassa	34.38	3.00e-105	376.00
IUUC-Nle-070173	Nomascus leucogenys	67.06	0.00e+00	1056.00
IUUC-Opr-070556	Ochotona princeps	66.08	0.00e+00	1056.00
IUUC-Ont-071502	Oreochromis niloticus	88.77	0.00e+00	1319.00
IUUC-Ocu-074861	Oryctolagus cuniculus	67.70	0.00e+00	1066.00
IUUC-Ola-086951	Oryzias latipes	86.12	0.00e+00	1256.00
IUUC-Oga-088625	Otolemur garnettii	63.73	0.00e+00	1028.00
IUUC-Oar-089995	Ovis aries	63.94	0.00e+00	1023.00
IUUC-Ptr-090640	Pan troglodytes	63.43	0.00e+00	1034.00
IUUC-Pan-091974	Papio anubis	63.94	0.00e+00	1030.00
IUUC-Psi-093957	Pelodiscus sinensis	64.55	0.00e+00	1066.00
IUUC-Pma-094242	Petromyzon marinus	69.29	6.00e-156	543.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.61	3.00e-92	333.00
IUUC-Pfo-097148	Poecilia formosa	88.27	0.00e+00	1302.00
IUUC-Pab-098068	Pongo abelii	59.70	0.00e+00	897.00
IUUC-Pva-102154	Pteropus vampyrus	65.07	0.00e+00	1038.00
IUUC-Pgr-103343	Puccinia graminis	35.64	4.00e-107	382.00
IUUC-Pte-104306	Pyrenophora teres	34.74	6.00e-93	335.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.12	4.00e-94	339.00
IUUC-Rno-105801	Rattus norvegicus	65.07	0.00e+00	1043.00
IUUC-Sha-107635	Sarcophilus harrisii	67.27	0.00e+00	1055.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.05	8.00e-91	328.00
IUUC-Sre-115225	Sporisorium reilianum	35.49	2.00e-106	380.00
IUUC-Ssc-115686	Sus scrofa	63.85	0.00e+00	1032.00
IUUC-Tgu-117346	Taeniopygia guttata	64.60	0.00e+00	1050.00
IUUC-Tru-118350	Takifugu rubripes	81.44	0.00e+00	1256.00
IUUC-Tni-120658	Tetraodon nigroviridis	83.42	0.00e+00	1242.00
IUUC-Tre-122043	Trichoderma reesei	34.46	2.00e-104	373.00
IUUC-Tvi-122303	Trichoderma virens	35.16	1.00e-105	377.00
IUUC-Tme-126909	Tuber melanosporum	35.51	1.00e-103	370.00
IUUC-Vda-129688	Verticillium dahliae	36.20	7.00e-110	391.00
IUUC-Xtr-131953	Xenopus tropicalis	64.21	0.00e+00	975.00
IUUC-Xma-133837	Xiphophorus maculatus	88.01	0.00e+00	1298.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence