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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105872
Ensembl Protein ID ENSRNOP00000011324.6
UniProt Accession F1M5N7; KI21B_RAT
Genbank Protein ID EDM09667.1
Protein Name Kinesin-like protein KIF21B
Genbank Nucleotide ID AABR07021001
Gene Name Kif21b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000008471.7 ENSRNOT00000090599.1 ENSRNOP00000074306.1
ENSRNOG00000008471.7 ENSRNOT00000011324.7 ENSRNOP00000011324.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-29 101.1 1541 1575
UBD/Beta-Prp 2.90e-41 142.0 1406 1611
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           H+d+v++laf ++ ++l+s+++ g ikvW+++ ++
   Q: 1541 HKDWVCALAFvPGrPMLLSACRAGFIKVWNVDNFT 1575
           ***********999****************98765 PP
   

   UBD/Beta-Prp
   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sg.dklvsGshdrtirvwdletgqclee. 131
           s+ e +++++ +sp+g +++ +++ +++++w+l+ ++++ +l+gh   v++l++ +  ++ d +v+Gs+d +++++  + g c+   
   Q: 1406 SQGEHQINQMALSPSG-TMLYVASGNAVRIWELNRFQPIGKLTGHIGPVMCLTVTQtsNQhDLVVTGSKDHYVKMF--QLGDCVTGt 1489
           667888*********9.9999*********************************9998445***************..567777667 PP
   S: 132  ......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
                 ++ +h + + c+++++  ++l+sGs D+ ++ Wdl +++l+++   +h+d v  l+f + ++ l+s+ + g +k+w++ + 
   Q: 1490 igpthnFEPPHYDGIECLAIQG--DILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNF 1574
           899899999************9..9*************************999********************************** PP
   S: 213  ecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           + + + +gh+++++ + +   ++++ ++ssD  +++W++
   Q: 1575 TPIGEIKGHDSPINAICTN--SKHIFTASSDCRVKLWNY 1611
           **************77777..****************96 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
 Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
Protein Sequence
(Fasta)
MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY DFVFDLDTWQ 60
EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG FDTVTSEEEQ GIIPRAIAHL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105872|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGTGGCGG TCCGGGTGGG AGGTGTGTGC GCGCGCGTGT GCCGCGCTGT AGGGAGCTGC 60
GGGTCTCACT GCCCGCTGTC AACGAGCTCA ACACCTCCGC GCGATGGCTG GAGAAGAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105872|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00225--Kinesin
PF00400--WD40
PRINTS

PR00380--KINESINHEAVY
SMART

SM00129--KISc
SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0030426--C:growth cone
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement
KEGG rno:289397
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001279 Ailuropoda melanoleuca 93.89 0.00e+00 2787.00
IUUC-Apl-003204 Anas platyrhynchos 87.42 0.00e+00 867.00
IUUC-Aca-004506 Anolis carolinensis 82.45 0.00e+00 1642.00
IUUC-Ame-011515 Astyanax mexicanus 75.67 0.00e+00 1469.00
IUUC-Bta-013185 Bos taurus 74.51 0.00e+00 2159.00
IUUC-Cel-018402 Caenorhabditis elegans 52.76 1.00e-152 534.00
IUUC-Cja-018844 Callithrix jacchus 91.30 0.00e+00 2789.00
IUUC-Cfa-021187 Canis familiaris 95.06 0.00e+00 2855.00
IUUC-Cpo-022444 Cavia porcellus 94.27 0.00e+00 2824.00
IUUC-Csa-023852 Chlorocebus sabaeus 95.36 0.00e+00 2875.00
IUUC-Csv-026158 Ciona savignyi 59.18 8.00e-179 621.00
IUUC-Dre-027839 Danio rerio 74.70 0.00e+00 1436.00
IUUC-Dno-030058 Dasypus novemcinctus 91.68 0.00e+00 2758.00
IUUC-Dor-030673 Dipodomys ordii 91.76 0.00e+00 2692.00
IUUC-Ete-032705 Echinops telfairi 83.21 0.00e+00 896.00
IUUC-Eca-033885 Equus caballus 93.60 0.00e+00 2774.00
IUUC-Eeu-035338 Erinaceus europaeus 80.47 0.00e+00 2173.00
IUUC-Fca-035388 Felis catus 94.82 0.00e+00 2665.00
IUUC-Fal-037044 Ficedula albicollis 86.36 0.00e+00 2685.00
IUUC-Gmo-039034 Gadus morhua 68.20 0.00e+00 1266.00
IUUC-Gac-041328 Gasterosteus aculeatus 72.73 0.00e+00 2272.00
IUUC-Ggo-045392 Gorilla gorilla 94.84 0.00e+00 2860.00
IUUC-Hsa-046713 Homo sapiens 95.42 0.00e+00 2879.00
IUUC-Itr-049068 Ictidomys tridecemlineatus 96.91 0.00e+00 1682.00
IUUC-Loc-052703 Lepisosteus oculatus 79.89 0.00e+00 2506.00
IUUC-Laf-054193 Loxodonta africana 84.76 0.00e+00 2472.00
IUUC-Mcc-055484 Macaca mulatta 93.70 0.00e+00 2828.00
IUUC-Meu-056278 Macropus eugenii 85.52 0.00e+00 1197.00
IUUC-Mga-059816 Meleagris gallopavo 83.82 0.00e+00 2573.00
IUUC-Mmr-061071 Microcebus murinus 91.88 0.00e+00 2757.00
IUUC-Mdo-062845 Monodelphis domestica 90.24 0.00e+00 2795.00
IUUC-Mmu-063967 Mus musculus 97.44 0.00e+00 2919.00
IUUC-Mpu-066448 Mustela putorius furo 93.90 0.00e+00 2856.00
IUUC-Nle-070037 Nomascus leucogenys 93.57 0.00e+00 2212.00
IUUC-Opr-070325 Ochotona princeps 89.70 0.00e+00 2623.00
IUUC-Ont-071851 Oreochromis niloticus 73.01 0.00e+00 2304.00
IUUC-Oan-073615 Ornithorhynchus anatinus 87.78 0.00e+00 2524.00
IUUC-Ocu-073855 Oryctolagus cuniculus 94.09 0.00e+00 2812.00
IUUC-Ola-086703 Oryzias latipes 73.97 0.00e+00 1475.00
IUUC-Oga-088171 Otolemur garnettii 93.20 0.00e+00 2781.00
IUUC-Oar-089693 Ovis aries 77.35 0.00e+00 1223.00
IUUC-Ptr-090535 Pan troglodytes 95.05 0.00e+00 1805.00
IUUC-Pan-091917 Papio anubis 95.00 0.00e+00 2643.00
IUUC-Psi-093752 Pelodiscus sinensis 78.06 0.00e+00 1402.00
IUUC-Pfo-096827 Poecilia formosa 69.81 0.00e+00 1351.00
IUUC-Pab-098441 Pongo abelii 95.67 0.00e+00 2892.00
IUUC-Pca-100781 Procavia capensis 95.81 0.00e+00 904.00
IUUC-Pva-103099 Pteropus vampyrus 90.64 0.00e+00 1351.00
IUUC-Sha-107097 Sarcophilus harrisii 89.46 0.00e+00 2646.00
IUUC-Ssc-115638 Sus scrofa 93.07 0.00e+00 2439.00
IUUC-Tgu-116504 Taeniopygia guttata 85.78 0.00e+00 1691.00
IUUC-Tru-118242 Takifugu rubripes 72.82 0.00e+00 2293.00
IUUC-Ttr-128824 Tursiops truncatus 89.69 0.00e+00 2254.00
IUUC-Xtr-131798 Xenopus tropicalis 64.71 0.00e+00 1889.00
Created Date 25-Jun-2017

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