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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063763
UUCD1 version UUC-MuM-00467
Ensembl Protein ID ENSMUSP00000021706.4
UniProt Accession Q60803; B2RPW3; Q62380; TRAF3_MOUSE
Genbank Protein ID AAC52175.1; AAC52710.1; EDL18642.1; AAI37635.1; AAI37636.1
Protein Name TNF receptor-associated factor 3; CD40 receptor-associated factor 1; RING-type E3 ubiquitin transferase TRAF3; TRAFAMN
Genbank Nucleotide ID U21050; U33840; CH466549; BC137634; BC137635
Gene Name Traf3; Craf1; Trafamn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021277.16 ENSMUST00000117269.7 ENSMUSP00000112517.1
ENSMUSG00000021277.16 ENSMUST00000021706.10 ENSMUSP00000021706.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 96.13 0.00e+00 1136.00 IUUC-Hsa-046957
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
 Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Protein Sequence
(Fasta)
MESSKKMDAA GTLQPNPPLK LQPDRGAGSV LVPEQGGYKE KFVKTVEDKY KCEKCRLVLC 60
NPKQTECGHR FCESCMAALL SSSSPKCTAC QESIIKDKVF KDNCCKREIL ALQVYCRNEG 120
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Protein Fasta Sequence


>IUUC-Mmu-063763|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGCGCGCGAG AGGAAGTGCC AGCGCGAGGG TGCGTGAGGC GGCGCGGCCG GCGGCCGCCG 60
CGTGCGCGAG CCGGGTTGCA GCCCAGCAGG GACTTTCCAG CCGGCGGCGG CGGCGGCGGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063763|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027128--TRAF3
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF
PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF
Pfam

PF02176--zf-TRAF
SMART

SM00061--MATH
Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005768--C:endosome
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0045087--P:innate immune response
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0042981--P:regulation of apoptotic process
GO:0001817--P:regulation of cytokine production
GO:0050688--P:regulation of defense response to virus
GO:0032648--P:regulation of interferon-beta production
GO:0030162--P:regulation of proteolysis
GO:0008063--P:Toll signaling pathway
GO:0002224--P:toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
KEGG mmu:22031
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002362 Ailuropoda melanoleuca 96.65 0.00e+00 1142.00
IUUC-Apl-004189 Anas platyrhynchos 88.22 0.00e+00 1055.00
IUUC-Aca-004540 Anolis carolinensis 84.56 0.00e+00 1020.00
IUUC-Ame-010645 Astyanax mexicanus 57.96 0.00e+00 652.00
IUUC-Bta-013140 Bos taurus 95.60 0.00e+00 1134.00
IUUC-Cja-019436 Callithrix jacchus 96.48 0.00e+00 1141.00
IUUC-Cfa-021072 Canis familiaris 96.30 0.00e+00 1142.00
IUUC-Cpo-022472 Cavia porcellus 96.30 0.00e+00 1145.00
IUUC-Csa-024217 Chlorocebus sabaeus 96.30 0.00e+00 1140.00
IUUC-Cho-025066 Choloepus hoffmanni 83.06 0.00e+00 834.00
IUUC-Cin-025234 Ciona intestinalis 29.57 4.00e-55 209.00
IUUC-Csv-026078 Ciona savignyi 68.54 8.00e-80 289.00
IUUC-Dre-028208 Danio rerio 55.40 5.00e-178 617.00
IUUC-Dno-028868 Dasypus novemcinctus 94.01 0.00e+00 1120.00
IUUC-Dor-031056 Dipodomys ordii 97.33 0.00e+00 991.00
IUUC-Ete-033005 Echinops telfairi 82.48 0.00e+00 788.00
IUUC-Eca-033717 Equus caballus 95.77 0.00e+00 1136.00
IUUC-Eeu-035172 Erinaceus europaeus 83.82 0.00e+00 630.00
IUUC-Fca-035688 Felis catus 96.31 0.00e+00 1138.00
IUUC-Fal-037176 Ficedula albicollis 87.48 0.00e+00 1056.00
IUUC-Gmo-038931 Gadus morhua 56.05 1.00e-170 592.00
IUUC-Gac-042019 Gasterosteus aculeatus 57.01 9.00e-180 623.00
IUUC-Ggo-044424 Gorilla gorilla 96.48 0.00e+00 1140.00
IUUC-Hsa-046957 Homo sapiens 96.13 0.00e+00 1136.00
IUUC-Itr-048352 Ictidomys tridecemlineatus 96.47 0.00e+00 1142.00
IUUC-Lch-050680 Latimeria chalumnae 69.76 0.00e+00 824.00
IUUC-Loc-052093 Lepisosteus oculatus 59.31 0.00e+00 695.00
IUUC-Laf-054573 Loxodonta africana 86.80 0.00e+00 1013.00
IUUC-Mcc-055049 Macaca mulatta 95.95 0.00e+00 1135.00
IUUC-Mor-057263 Magnaporthe oryzae 23.09 9.00e-17 82.00
IUUC-Mga-059244 Meleagris gallopavo 86.78 0.00e+00 1051.00
IUUC-Mmr-061469 Microcebus murinus 97.01 0.00e+00 1146.00
IUUC-Mdo-063049 Monodelphis domestica 92.61 0.00e+00 1096.00
IUUC-Mpu-065956 Mustela putorius furo 95.08 0.00e+00 1099.00
IUUC-Mlu-067482 Myotis lucifugus 94.01 0.00e+00 1115.00
IUUC-Nle-069941 Nomascus leucogenys 96.65 0.00e+00 1143.00
IUUC-Opr-071027 Ochotona princeps 81.34 0.00e+00 904.00
IUUC-Ont-071914 Oreochromis niloticus 57.64 0.00e+00 663.00
IUUC-Oan-072802 Ornithorhynchus anatinus 91.90 0.00e+00 1086.00
IUUC-Ocu-074075 Oryctolagus cuniculus 96.30 0.00e+00 1139.00
IUUC-Oba-075596 Oryza barthii 21.05 2.00e-05 45.40
IUUC-Ogu-078462 Oryza glumaepatula 21.05 2.00e-05 45.40
IUUC-Ome-082014 Oryza meridionalis 21.05 1.00e-05 46.20
IUUC-Oni-083105 Oryza nivara 21.05 2.00e-05 45.40
IUUC-Oru-084831 Oryza rufipogon 21.05 2.00e-05 45.40
IUUC-Oga-088149 Otolemur garnettii 96.13 0.00e+00 1141.00
IUUC-Oar-089922 Ovis aries 91.96 0.00e+00 1082.00
IUUC-Ptr-091412 Pan troglodytes 96.30 0.00e+00 1138.00
IUUC-Pan-092789 Papio anubis 96.30 0.00e+00 1140.00
IUUC-Psi-093603 Pelodiscus sinensis 85.02 0.00e+00 1033.00
IUUC-Pma-094463 Petromyzon marinus 49.79 7.00e-141 493.00
IUUC-Pfo-096518 Poecilia formosa 56.42 0.00e+00 656.00
IUUC-Pab-097664 Pongo abelii 96.48 0.00e+00 1140.00
IUUC-Pca-100821 Procavia capensis 85.39 0.00e+00 857.00
IUUC-Pva-103201 Pteropus vampyrus 83.63 0.00e+00 975.00
IUUC-Rno-105505 Rattus norvegicus 98.06 0.00e+00 1162.00
IUUC-Sha-107416 Sarcophilus harrisii 92.61 0.00e+00 1094.00
IUUC-Sar-113438 Sorex araneus 94.09 6.00e-101 360.00
IUUC-Ssc-115351 Sus scrofa 96.30 0.00e+00 1141.00
IUUC-Tgu-116608 Taeniopygia guttata 90.16 0.00e+00 1052.00
IUUC-Tru-117964 Takifugu rubripes 57.73 0.00e+00 630.00
IUUC-Tni-120211 Tetraodon nigroviridis 56.46 0.00e+00 640.00
IUUC-Tbe-127700 Tupaia belangeri 76.88 1.00e-138 486.00
IUUC-Ttr-128450 Tursiops truncatus 92.19 5.00e-176 609.00
IUUC-Vda-129938 Verticillium dahliae 25.59 4.00e-20 93.20
IUUC-Vpa-130074 Vicugna pacos 97.95 0.00e+00 897.00
IUUC-Xtr-132563 Xenopus tropicalis 79.23 0.00e+00 959.00
IUUC-Xma-133628 Xiphophorus maculatus 56.12 0.00e+00 655.00
Created Date 25-Jun-2017

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