iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004840

UUCD1 version

UUC-AnC-00226

Ensembl Protein ID

ENSACAP00000016010.1

UniProt Accession

H9GN32; H9GN32_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SOCS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016300.1	ENSACAT00000016330.1	ENSACAP00000016010.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	6.70e-15	54.7	374	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l r+ p+SLqh+CR +I++c++++++   d+LP P+s k YL++++y+
   Q: 374  STPLNRTFPFSLQHICRTVICNCTTYDGI---DALPVPPSVKLYLKEYHYK 421
           5678899**********************...****************985 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAENKEKSSK NTDVRPKTSR SRSADRKDGY VWSGKKLSWT KRRESSSDAE TASISGKSSC 60
GLRNQERKHS CSSTELDLER SCGHRFLGRS LKQKLQDAMG QCFPIKNCSS RHSSVLPSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGAAA ATAAAGAAAA GAGTTCTAAA AATACCGATG TCCGACCTAA AACGAGCCGG 60
AGCAGAAGTG CAGATAGAAA AGATGGATAT GTGTGGAGCG GAAAGAAACT TTCCTGGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

acs:100561266

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	79.22	0.00e+00	672.00
IUUC-Apl-003839	Anas platyrhynchos	80.46	0.00e+00	664.00
IUUC-Bta-012503	Bos taurus	79.50	0.00e+00	671.00
IUUC-Bol-016597	Brassica oleracea	31.65	1.30e-02	34.70
IUUC-Cja-019284	Callithrix jacchus	79.27	0.00e+00	671.00
IUUC-Cfa-020890	Canis familiaris	79.27	0.00e+00	672.00
IUUC-Cpo-022081	Cavia porcellus	72.73	3.00e-180	624.00
IUUC-Csa-023076	Chlorocebus sabaeus	80.41	0.00e+00	679.00
IUUC-Cho-024700	Choloepus hoffmanni	78.64	0.00e+00	694.00
IUUC-Dno-029961	Dasypus novemcinctus	79.09	0.00e+00	700.00
IUUC-Dor-030273	Dipodomys ordii	78.86	0.00e+00	672.00
IUUC-Ete-032972	Echinops telfairi	78.46	8.00e-148	515.00
IUUC-Eca-034289	Equus caballus	79.55	0.00e+00	674.00
IUUC-Eeu-035208	Erinaceus europaeus	78.34	0.00e+00	652.00
IUUC-Fal-036829	Ficedula albicollis	80.92	0.00e+00	655.00
IUUC-Gga-040725	Gallus gallus	80.00	0.00e+00	682.00
IUUC-Ggo-044886	Gorilla gorilla	80.41	0.00e+00	677.00
IUUC-Hsa-046322	Homo sapiens	80.18	0.00e+00	675.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	79.91	0.00e+00	670.00
IUUC-Lch-049459	Latimeria chalumnae	57.37	1.00e-140	492.00
IUUC-Loc-052058	Lepisosteus oculatus	47.82	4.00e-95	341.00
IUUC-Laf-053484	Loxodonta africana	79.31	0.00e+00	663.00
IUUC-Mcc-054890	Macaca mulatta	80.18	0.00e+00	677.00
IUUC-Meu-056532	Macropus eugenii	75.25	1.00e-170	592.00
IUUC-Mmr-061714	Microcebus murinus	79.09	0.00e+00	669.00
IUUC-Mmu-063161	Mus musculus	74.94	3.00e-180	624.00
IUUC-Mpu-066499	Mustela putorius furo	79.55	0.00e+00	697.00
IUUC-Mlu-066945	Myotis lucifugus	77.27	0.00e+00	653.00
IUUC-Nle-069976	Nomascus leucogenys	80.18	0.00e+00	673.00
IUUC-Opr-070255	Ochotona princeps	77.90	0.00e+00	657.00
IUUC-Ocu-074764	Oryctolagus cuniculus	77.73	0.00e+00	662.00
IUUC-Oga-088910	Otolemur garnettii	77.10	0.00e+00	670.00
IUUC-Oar-090330	Ovis aries	79.27	0.00e+00	669.00
IUUC-Ptr-090709	Pan troglodytes	80.41	0.00e+00	677.00
IUUC-Pan-092540	Papio anubis	80.41	0.00e+00	679.00
IUUC-Psi-093678	Pelodiscus sinensis	83.68	0.00e+00	780.00
IUUC-Pfo-097139	Poecilia formosa	79.19	6.00e-87	314.00
IUUC-Pab-097970	Pongo abelii	77.75	3.00e-156	544.00
IUUC-Pca-100211	Procavia capensis	68.64	4.00e-161	560.00
IUUC-Pgr-103610	Puccinia graminis	52.38	5.10e+00	26.20
IUUC-Rno-106014	Rattus norvegicus	73.58	1.00e-180	625.00
IUUC-Sha-106822	Sarcophilus harrisii	76.77	0.00e+00	664.00
IUUC-Ssc-115821	Sus scrofa	78.64	0.00e+00	663.00
IUUC-Tgu-117117	Taeniopygia guttata	80.92	0.00e+00	654.00
IUUC-Tsy-118979	Tarsius syrichta	87.66	2.00e-118	417.00
IUUC-Tca-121131	Theobroma cacao	30.77	6.00e-03	35.00
IUUC-Vpa-130626	Vicugna pacos	79.09	0.00e+00	671.00
IUUC-Vvi-131327	Vitis vinifera	43.24	7.80e-02	31.60
IUUC-Xtr-132138	Xenopus tropicalis	71.40	7.00e-175	606.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence