iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004899

UUCD1 version

UUC-AnC-00162

Ensembl Protein ID

ENSACAP00000002150.2

UniProt Accession

H9G617; H9G617_ANOCA

Protein Name

Uncharacterized protein

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000002124.2	ENSACAT00000002209.2	ENSACAP00000002150.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.10e-07	31.3	316	355

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 316  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 355
           99********.******************....5.555555****8 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

VVRLCQNPKL ALKNSPPYIL DLLPDTYQHL RTILSRYEGK METLGDNEYF RVFMENLMKK 60
TKQTISLFKE GKERMYEENS QPRRNLTKLS LIFSHMLAEL KGIFPSGLFQ GDNFRITKAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTGCGTT TGTGCCAGAA TCCCAAGCTG GCCCTGAAAA ACAGCCCTCC TTACATTCTA 60
GACCTGCTTC CTGACACTTA CCAGCACCTC CGCACCATCC TGTCTCGCTA TGAGGGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	82.00	0.00e+00	1274.00
IUUC-Apl-004041	Anas platyrhynchos	85.02	0.00e+00	1360.00
IUUC-Ame-010746	Astyanax mexicanus	59.95	2.00e-176	612.00
IUUC-Bta-012759	Bos taurus	81.37	0.00e+00	1275.00
IUUC-Cja-019207	Callithrix jacchus	80.72	0.00e+00	1263.00
IUUC-Cfa-020897	Canis familiaris	81.25	0.00e+00	1248.00
IUUC-Cpo-021453	Cavia porcellus	81.34	0.00e+00	1311.00
IUUC-Csa-023136	Chlorocebus sabaeus	81.30	0.00e+00	1258.00
IUUC-Cho-024282	Choloepus hoffmanni	73.75	0.00e+00	1041.00
IUUC-Csv-025938	Ciona savignyi	69.39	2.00e-167	581.00
IUUC-Dre-027644	Danio rerio	69.40	0.00e+00	999.00
IUUC-Dno-030025	Dasypus novemcinctus	81.67	0.00e+00	1283.00
IUUC-Eca-033900	Equus caballus	82.35	0.00e+00	1304.00
IUUC-Eeu-035142	Erinaceus europaeus	80.55	0.00e+00	865.00
IUUC-Fca-035455	Felis catus	81.25	0.00e+00	1267.00
IUUC-Fal-037182	Ficedula albicollis	96.63	0.00e+00	852.00
IUUC-Gmo-038698	Gadus morhua	87.69	0.00e+00	841.00
IUUC-Gga-040438	Gallus gallus	85.25	0.00e+00	1353.00
IUUC-Gac-042166	Gasterosteus aculeatus	76.11	0.00e+00	848.00
IUUC-Ggo-045618	Gorilla gorilla	81.30	0.00e+00	1268.00
IUUC-Hsa-046177	Homo sapiens	81.18	0.00e+00	1258.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	87.80	0.00e+00	885.00
IUUC-Lch-050095	Latimeria chalumnae	72.35	0.00e+00	1110.00
IUUC-Loc-052570	Lepisosteus oculatus	71.54	0.00e+00	1090.00
IUUC-Laf-054008	Loxodonta africana	80.95	0.00e+00	1282.00
IUUC-Mcc-054676	Macaca mulatta	81.18	0.00e+00	1254.00
IUUC-Mga-059239	Meleagris gallopavo	84.79	0.00e+00	1362.00
IUUC-Mmr-060907	Microcebus murinus	80.28	0.00e+00	1271.00
IUUC-Mdo-062595	Monodelphis domestica	83.51	0.00e+00	1310.00
IUUC-Mmu-063725	Mus musculus	81.90	0.00e+00	1327.00
IUUC-Mpu-066771	Mustela putorius furo	82.00	0.00e+00	1278.00
IUUC-Mlu-067206	Myotis lucifugus	71.79	0.00e+00	989.00
IUUC-Nle-069285	Nomascus leucogenys	79.56	0.00e+00	1198.00
IUUC-Opr-071026	Ochotona princeps	80.51	0.00e+00	1276.00
IUUC-Ont-071954	Oreochromis niloticus	69.56	0.00e+00	1030.00
IUUC-Ocu-074657	Oryctolagus cuniculus	81.88	0.00e+00	1265.00
IUUC-Ola-087165	Oryzias latipes	67.12	0.00e+00	1002.00
IUUC-Oga-088198	Otolemur garnettii	73.65	0.00e+00	1120.00
IUUC-Oar-090258	Ovis aries	81.37	0.00e+00	1261.00
IUUC-Ptr-090710	Pan troglodytes	81.18	0.00e+00	1258.00
IUUC-Pan-092785	Papio anubis	81.30	0.00e+00	1258.00
IUUC-Pfo-096990	Poecilia formosa	89.29	0.00e+00	785.00
IUUC-Pab-098526	Pongo abelii	81.07	0.00e+00	1256.00
IUUC-Pva-102352	Pteropus vampyrus	97.09	0.00e+00	823.00
IUUC-Rno-105876	Rattus norvegicus	81.44	0.00e+00	1299.00
IUUC-Sha-107588	Sarcophilus harrisii	81.23	0.00e+00	1156.00
IUUC-Sar-112959	Sorex araneus	79.79	0.00e+00	1283.00
IUUC-Ssc-115261	Sus scrofa	82.25	0.00e+00	1285.00
IUUC-Tgu-116580	Taeniopygia guttata	79.41	0.00e+00	1256.00
IUUC-Tru-118731	Takifugu rubripes	67.25	0.00e+00	1008.00
IUUC-Tsy-118982	Tarsius syrichta	71.79	0.00e+00	835.00
IUUC-Tni-120725	Tetraodon nigroviridis	67.35	0.00e+00	1001.00
IUUC-Tbe-128018	Tupaia belangeri	88.78	0.00e+00	1039.00
IUUC-Ttr-128927	Tursiops truncatus	81.09	0.00e+00	1302.00
IUUC-Vpa-130369	Vicugna pacos	81.09	0.00e+00	1238.00
IUUC-Xtr-132474	Xenopus tropicalis	73.64	0.00e+00	1101.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence