iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040438

Ensembl Protein ID

ENSGALP00000010935.4

UniProt Accession

F1NXW5; F1NXW5_CHICK

Genbank Protein ID

ENSGALP00000010935

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000116

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000029077.2	ENSGALT00000010949.4	ENSGALP00000010935.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.70e-08	32.8	365	404

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 365  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 404
           99********.******************....5.555555****8 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MSAPLKKGPG GLIGLMKDAF QPHHHHLGPH QPGAVDKKMV EKCWKLMDKV VRLCQNPKLA 60
LKNSPPYILD LLPDTYQHLR TILSRYEGKM ETLGENEYFR VFMENLMKKT KQTISLFKEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCAGCGCG CGGCGTGGCC GGGGCGAAGG GCGGAGCGGC GCTGGAGCCG GGCGCCCCCC 60
GCCGCCGCTG CCGCCGCCAC CGCCCGCGGC TCCCTCTGTC GCCGCCCGCC CGGCCCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	84.80	0.00e+00	1366.00
IUUC-Apl-004041	Anas platyrhynchos	96.84	0.00e+00	1574.00
IUUC-Aca-004899	Anolis carolinensis	85.60	0.00e+00	1343.00
IUUC-Ame-010746	Astyanax mexicanus	61.52	0.00e+00	649.00
IUUC-Bta-012759	Bos taurus	84.34	0.00e+00	1410.00
IUUC-Cja-019207	Callithrix jacchus	83.22	0.00e+00	1398.00
IUUC-Cfa-020897	Canis familiaris	84.26	0.00e+00	1388.00
IUUC-Cpo-021453	Cavia porcellus	83.82	0.00e+00	1397.00
IUUC-Csa-023136	Chlorocebus sabaeus	83.30	0.00e+00	1388.00
IUUC-Cho-024282	Choloepus hoffmanni	75.59	0.00e+00	1147.00
IUUC-Cin-025574	Ciona intestinalis	70.81	1.00e-178	619.00
IUUC-Csv-025938	Ciona savignyi	69.37	7.00e-173	599.00
IUUC-Dre-027644	Danio rerio	71.44	0.00e+00	1073.00
IUUC-Dno-030025	Dasypus novemcinctus	84.53	0.00e+00	1375.00
IUUC-Dme-032213	Drosophila melanogaster	74.23	0.00e+00	644.00
IUUC-Ete-033118	Echinops telfairi	69.32	0.00e+00	709.00
IUUC-Eca-033900	Equus caballus	85.66	0.00e+00	1395.00
IUUC-Eeu-035142	Erinaceus europaeus	80.76	0.00e+00	894.00
IUUC-Fca-035455	Felis catus	84.08	0.00e+00	1391.00
IUUC-Fal-037182	Ficedula albicollis	99.16	0.00e+00	930.00
IUUC-Gmo-038698	Gadus morhua	88.69	0.00e+00	883.00
IUUC-Gac-042166	Gasterosteus aculeatus	73.56	0.00e+00	912.00
IUUC-Ggo-045618	Gorilla gorilla	84.06	0.00e+00	1407.00
IUUC-Hsa-046177	Homo sapiens	83.50	0.00e+00	1394.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	89.24	0.00e+00	935.00
IUUC-Lch-050095	Latimeria chalumnae	84.66	0.00e+00	1046.00
IUUC-Loc-052570	Lepisosteus oculatus	73.51	0.00e+00	1143.00
IUUC-Laf-054008	Loxodonta africana	83.89	0.00e+00	1406.00
IUUC-Mcc-054676	Macaca mulatta	83.18	0.00e+00	1385.00
IUUC-Mga-059239	Meleagris gallopavo	98.44	0.00e+00	1665.00
IUUC-Mmr-060907	Microcebus murinus	82.29	0.00e+00	1384.00
IUUC-Mdo-062595	Monodelphis domestica	86.90	0.00e+00	1385.00
IUUC-Mmu-063725	Mus musculus	84.19	0.00e+00	1449.00
IUUC-Mpu-066771	Mustela putorius furo	84.13	0.00e+00	1398.00
IUUC-Mlu-067206	Myotis lucifugus	72.06	0.00e+00	1025.00
IUUC-Nle-069285	Nomascus leucogenys	81.33	0.00e+00	1312.00
IUUC-Opr-071026	Ochotona princeps	83.80	0.00e+00	1364.00
IUUC-Ont-071954	Oreochromis niloticus	72.03	0.00e+00	1084.00
IUUC-Ocu-074657	Oryctolagus cuniculus	84.80	0.00e+00	1350.00
IUUC-Ola-087165	Oryzias latipes	68.86	0.00e+00	1083.00
IUUC-Oga-088198	Otolemur garnettii	74.75	0.00e+00	1224.00
IUUC-Oar-090258	Ovis aries	84.71	0.00e+00	1354.00
IUUC-Ptr-090710	Pan troglodytes	83.50	0.00e+00	1394.00
IUUC-Pan-092785	Papio anubis	83.30	0.00e+00	1388.00
IUUC-Psi-093431	Pelodiscus sinensis	83.52	0.00e+00	783.00
IUUC-Pfo-096990	Poecilia formosa	90.51	0.00e+00	831.00
IUUC-Pab-098526	Pongo abelii	83.48	0.00e+00	1396.00
IUUC-Pva-102352	Pteropus vampyrus	95.37	0.00e+00	881.00
IUUC-Rno-105876	Rattus norvegicus	82.98	0.00e+00	1416.00
IUUC-Sha-107588	Sarcophilus harrisii	85.05	0.00e+00	1216.00
IUUC-Sar-112959	Sorex araneus	81.73	0.00e+00	1334.00
IUUC-Ssc-115261	Sus scrofa	84.49	0.00e+00	1410.00
IUUC-Tgu-116580	Taeniopygia guttata	91.12	0.00e+00	1459.00
IUUC-Tru-118731	Takifugu rubripes	69.90	0.00e+00	1067.00
IUUC-Tsy-118982	Tarsius syrichta	74.44	0.00e+00	890.00
IUUC-Tni-120725	Tetraodon nigroviridis	69.61	0.00e+00	1063.00
IUUC-Tbe-128018	Tupaia belangeri	90.86	0.00e+00	1097.00
IUUC-Ttr-128927	Tursiops truncatus	84.56	0.00e+00	1439.00
IUUC-Vpa-130369	Vicugna pacos	84.09	0.00e+00	1310.00
IUUC-Xtr-132474	Xenopus tropicalis	74.78	0.00e+00	1193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence